Classical Soybean (Glycine max (L.) Merr) Symbionts, Sinorhizobium fredii USDA191 and Bradyrhizobium diazoefficiens USDA110, Reveal Contrasting Symbiotic Phenotype on Pigeon Pea (Cajanus cajan (L.) Millsp).

abstract：:Curcumin diglutaric acid (CurDG), an ester prodrug of curcumin, has the potential to be developed as an anti-inflammatory agent due to its improved solubility and stability. In this study, the anti-inflammatory effects of CurDG were evaluated. The effects of CurDG on inflammatory mediators were evaluated in LPS-stimul...

journal_title：International journal of molecular sciences

authors： Phumsuay R,Muangnoi C,Dasuni Wasana PW,Hasriadi,Vajragupta O,Rojsitthisak P,Towiwat P

更新日期：2020-08-09 00:00:00

abstract：:Maize ZmC1 and ZmR transcription factors belong to the MYB-type and bHLH families, respectively, and control anthocyanin biosynthesis. In this study, Agrobacterium-mediated transformation was used to generate transgenic wheat plants that overexpress ZmC1 and ZmR or both, with the objective of developing anthocyanin-en...

journal_title：International journal of molecular sciences

authors： Riaz B,Chen H,Wang J,Du L,Wang K,Ye X

更新日期：2019-11-19 00:00:00

abstract：:Vitamin D deficiency is the most common nutritional deficiency, affecting almost one billion people worldwide. Vitamin D is mostly known for its role in intestinal calcium absorption and bone mineralization. However, the observation of seasonal changes in blood pressure and the subsequent identification of vitamin D r...

journal_title：International journal of molecular sciences

authors： Latic N,Erben RG

更新日期：2020-09-04 00:00:00

abstract：:The present study aimed to explore the possible radioprotective effects of celastrol and relevant molecular mechanisms in an in vitro cell and in vivo mouse models exposed to gamma radiation. Human keratinocytes (HaCaT) and foreskin fibroblast (BJ) cells were exposed to gamma radiation of 20Gy, followed by treatment w...

journal_title：International journal of molecular sciences

authors： Wang H,Ahn KS,Alharbi SA,Shair OH,Arfuso F,Sethi G,Chinnathambi A,Tang FR

更新日期：2020-02-06 00:00:00

abstract：:Cementum is a mineralized layer on the tooth's root surface and facilitates the biomechanical anchoring of fibrous connective tissues as a part of tooth-supportive complexes. Previously, we observed that OCCM30 cementoblasts cultured on fibrin matrices underwent apoptosis due to fibrin degradation through the expressi...

journal_title：International journal of molecular sciences

authors： Rahman SU,Park CH,Baek JH,Ryoo HM,Woo KM

更新日期：2017-11-09 00:00:00

abstract：:Mitochondria are complex organelles that play critical roles in diverse aspects of cellular function. Heart disease and a number of other pathologies are associated with perturbations in the molecular machinery of the mitochondria. Therefore, comprehensive, unbiased examination of the mitochondrial proteome represents...

journal_title：International journal of molecular sciences

authors： Giorgianni F,Koirala D,Weber KT,Beranova-Giorgianni S

更新日期：2014-05-26 00:00:00

abstract：:Despite improvements in diagnosis and treatment, breast cancer is still the most common cancer type among non-smoking females. TGF-β can inhibit breast cancer development by inducing cell cycle arrest in both, cancer cells and, as part of a senescence program in normal human mammary epithelial cells (HMEC). Moreover, ...

journal_title：International journal of molecular sciences

authors： Melzer C,von der Ohe J,Hass R,Ungefroren H

更新日期：2017-07-20 00:00:00

abstract：:Short-term abiotic stress treatment before harvest can enhance the quality of horticultural crops cultivated in controlled environments. Here, we investigated the effects of combined chilling and UV-A treatment on the accumulation of phenolic compounds in kale (Brassica oleracea var. acephala). Five-week-old plants we...

journal_title：International journal of molecular sciences

authors： Lee JH,Kwon MC,Jung ES,Lee CH,Oh MM

更新日期：2019-10-08 00:00:00

abstract：:Alterations of the β-adrenergic signalling, structural remodelling, and electrical failure of T-tubules are hallmarks of heart failure (HF). Here, we assess the effect of β-adrenoceptor activation on local Ca(2+) release in electrically coupled and uncoupled T-tubules in ventricular myocytes from HF rats. We employ an...

journal_title：International journal of molecular sciences

authors： Crocini C,Coppini R,Ferrantini C,Yan P,Loew LM,Poggesi C,Cerbai E,Pavone FS,Sacconi L

更新日期：2016-09-03 00:00:00

abstract：:Temperature-responsive photonic coatings are appealing for a variety of applications, including smart windows. However, the fabrication of such reflective polymer coatings remains a challenge. In this work, we report the development of a temperature-responsive, infrared-reflective coating consisting of a polymer-stabi...

journal_title：International journal of molecular sciences

authors： Zhang W,Lub J,Schenning APHJ,Zhou G,de Haan LT

更新日期：2020-03-06 00:00:00

abstract：BACKGROUND:There are eighteen species within the Penicillium genus section chrysogena, including the original penicillin producers Penicillium notatum (Fleming strain) and Penicillium chrysogenum NRRL 1951. Other wild type isolates of the Penicillium genus are relevant for the production of useful proteins and primary ...

journal_title：International journal of molecular sciences

authors： Martín JF

更新日期：2020-05-30 00:00:00

abstract：:To date, viruses are reported to be responsible for more than 15% of all tumors worldwide. The oncogenesis could be influenced directly by the activity of viral oncoproteins or by the chronic infection or inflammation. The group of human oncoviruses includes Epstein–Barr virus (EBV), human papillomavirus (HPV), ...

journal_title：International journal of molecular sciences

authors： Vojtechova Z,Tachezy R

更新日期：2018-04-17 00:00:00

abstract：:Both positive and negative aspects of sport performance are currently considered. The aim of our study was to determine time- and intensity-dependent effects of a single exercise bout on redox and inflammatory status. The experiment was performed on 40 male Wistar rats subjected to treadmill running for 30 min with th...

journal_title：International journal of molecular sciences

authors： Supruniuk E,Maciejczyk M,Zalewska A,Górski J,Chabowski A

更新日期：2020-10-29 00:00:00

abstract：:Chitin synthase synthesizes chitin, which is critical for the arthropod exoskeleton. In this study, we cloned the cDNA sequences of a chitin synthase 1 gene, PcCHS1, in the citrus red mite, Panonychus citri (McGregor), which is one of the most economically important pests of citrus worldwide. The full-length cDNA of P...

journal_title：International journal of molecular sciences

authors： Xia WK,Ding TB,Niu JZ,Liao CY,Zhong R,Yang WJ,Liu B,Dou W,Wang JJ

更新日期：2014-02-28 00:00:00

abstract：:Serotonin (5-HT) is a critical player in brain development and neuropsychiatric disorders. Fetal 5-HT levels can be influenced by several gestational factors, such as maternal genotype, diet, stress, medication, and immune activation. In this review, addressing both human and animal studies, we discuss how these gesta...

journal_title：International journal of molecular sciences

authors： Hanswijk SI,Spoelder M,Shan L,Verheij MMM,Muilwijk OG,Li W,Liu C,Kolk SM,Homberg JR

更新日期：2020-08-14 00:00:00

abstract：:An inflammatory milieu breaks down the cartilage matrix and induces chondrocyte apoptosis, resulting in cartilage destruction in patients with cartilage degenerative diseases, such as rheumatoid arthritis or osteoarthritis. Because of the limited regenerative ability of chondrocytes, defects in cartilage are irreversi...

journal_title：International journal of molecular sciences

authors： Kondo M,Yamaoka K,Tanaka Y

更新日期：2014-11-17 00:00:00

abstract：:Diabetic nephropathy is an unmet therapeutic need, and the search for new therapeutic strategies is warranted. Previous data point to histamine H1 receptor as a possible target for glomerular dysfunction associated with long term hyperglycaemia. Therefore, this study investigated the effects of the H1 receptor antagon...

journal_title：International journal of molecular sciences

authors： Verta R,Grange C,Gurrieri M,Borga S,Nardini P,Argenziano M,Ghè C,Cavalli R,Benetti E,Miglio G,Bussolati B,Pini A,Rosa AC

更新日期：2019-05-24 00:00:00

abstract：:VDACs (voltage-dependent anion-selective channels) are pore-forming proteins of the outer mitochondrial membrane, whose permeability is primarily due to VDACs' presence. In higher eukaryotes, three isoforms are raised during the evolution: they have the same exon-intron organization, and the proteins show the same cha...

journal_title：International journal of molecular sciences

authors： Zinghirino F,Pappalardo XG,Messina A,Guarino F,De Pinto V

更新日期：2020-10-07 00:00:00

abstract：:Caspase-8 was originally identified as a central player of programmed cell death triggered by death receptor stimulation. In that context, its activity is tightly regulated through several mechanisms, with the best established being the expression of FLICE-like inhibitory protein (FLIP) family proteins and the Src-dep...

journal_title：International journal of molecular sciences

authors： Fianco G,Contadini C,Ferri A,Cirotti C,Stagni V,Barilà D

更新日期：2018-11-29 00:00:00

abstract：:The rapidly activating delayed rectifier potassium current (IKr) plays a critical role in cardiac repolarization. Although IKr is known to be regulated by both α1- and β1-adrenergic receptors (ARs), the cross-talk and feedback mechanisms that dictate its response to α1- and β1-AR activation are not known. In the prese...

journal_title：International journal of molecular sciences

authors： Xu D,Wang S,Wu TT,Wang XY,Qian J,Guo Y

更新日期：2014-08-15 00:00:00

abstract：:Extracellular vesicles (EVs) are a heterogeneous group of particles, between 15 nanometers and 10 microns in diameter, released by almost all cell types in physiological and pathological conditions, including tumors. EVs have recently emerged as particularly interesting informative vehicles, so that they could be cons...

journal_title：International journal of molecular sciences

authors： Caivano A,La Rocca F,Laurenzana I,Trino S,De Luca L,Lamorte D,Del Vecchio L,Musto P

更新日期：2017-06-02 00:00:00

abstract：:In this report, the effects of two oligochitosans, i.e., oligochitosan A (OCHA) and oligochitosan B (OCHB), on control of dry rot of Zanthoxylum bungeanum (Z. bungeanum) caused by Fusarium sambucinum (F. sambucinum) were evaluated. First, both oligochitosans show desirable ability to decrease the infection of F. sambu...

journal_title：International journal of molecular sciences

authors： Li P,Cao Z,Wu Z,Wang X,Li X

更新日期：2016-06-30 00:00:00

abstract：:Calmodulin (CaM) is the principal Ca2+ sensor in eukaryotic cells, orchestrating the activity of hundreds of proteins. Disease causing mutations at any of the three genes that encode identical CaM proteins lead to major cardiac dysfunction, revealing the importance in the regulation of excitability. In turn, some muta...

journal_title：International journal of molecular sciences

authors： Urrutia J,Aguado A,Muguruza-Montero A,Núñez E,Malo C,Casis O,Villarroel A

更新日期：2019-01-18 00:00:00

abstract：:Lattice degeneration involves thinning of the retina that occurs over time. Here we performed an immunohistological study of tissue sections of human peripheral retinal lattice degeneration to investigate if retinal pigment epithelium (RPE) cells are involved in the pathogenesis of this condition. In two cases of reti...

journal_title：International journal of molecular sciences

authors： Mizuno H,Fukumoto M,Sato T,Horie T,Kida T,Oku H,Nakamura K,Jin D,Takai S,Ikeda T

更新日期：2020-10-05 00:00:00

abstract：:Understanding the importance of oral microbiota in human health and disease also leads to an expansion of the knowledge on functional, metabolic, and molecular alterations directly contributing to oral and systemic pathologies. To date, a compelling number of studies have documented the crucial role of some oral cavit...

journal_title：International journal of molecular sciences

authors： Suprewicz Ł,Tokajuk G,Cieśluk M,Deptuła P,Sierpińska T,Wolak P,Wollny T,Tokajuk J,Głuszek S,Piktel E,Bucki R

更新日期：2020-10-24 00:00:00

abstract：:In the central nervous system omega-3 fatty acids modulate cell signaling and affect dopaminergic and serotonergic pathways. On this basis, a new application for omega-3 fatty acids has been proposed, concerning the treatment of several psychiatric disorders. The present article is an update of a previous systematic r...

journal_title：International journal of molecular sciences

authors： Bozzatello P,Rocca P,Mantelli E,Bellino S

更新日期：2019-10-23 00:00:00

abstract：:The mushroom Inonotus obliquus has been widely used as a folk medicine in Russia, Poland and most of the Baltic countries. In this study, water-soluble and alkali-soluble crude polysaccharides (IOW and IOA) were isolated from I. obliquus, and the carbohydrate-rich fractions IOW-1 and IOA-1 were obtained respectively a...

journal_title：International journal of molecular sciences

authors： Mu H,Zhang A,Zhang W,Cui G,Wang S,Duan J

更新日期：2012-01-01 00:00:00

abstract：:Citrate is a key intermediate of the tricarboxylic acid cycle and acts as an allosteric signal to regulate the production of cellular ATP. An elevated cytosolic citrate concentration inhibits growth in several types of human cancer cells; however, the underlying mechanism by which citrate induces the growth arrest of ...

journal_title：International journal of molecular sciences

authors： Hung KC,Wang SG,Lin ML,Chen SS

更新日期：2019-04-29 00:00:00

abstract：:Patients with advanced skeletal metastases arising from primary cancers including breast, lung, and prostate suffer from extreme pain, bone loss, and frequent fractures. While the importance of interactions between bone and tumors is well-established, our understanding of complex cell-cell and cell-microenvironment in...

journal_title：International journal of molecular sciences

authors： Dadwal UC,Merkel AR,Page JM,Kwakwa KA,Kessler M,Rhoades JA

更新日期：2020-09-21 00:00:00

abstract：:Diabetic retinopathy (DR) is a severe and recurrent microvascular complication in diabetes. The multifunctional response gene to complement 32 (RGC-32) is involved in the regulation of cell cycle, proliferation, and apoptosis. To investigate the role of RGC-32 in the development of DR, we used human retinal microvascu...

journal_title：International journal of molecular sciences

authors： Liao WL,Lin JM,Liu SP,Chen SY,Lin HJ,Wang YH,Lei YJ,Huang YC,Tsai FJ

更新日期：2018-11-17 00:00:00