Abstract:
:Cancers are heterogeneous at the cell level, and the mechanisms leading to cancer heterogeneity could be clonal evolution or cancer stem cells. Cancer stem cells are resistant to most anti-cancer treatments and could be preferential targets to reverse this resistance, either targeting stemness pathways or cancer stem cell surface markers. Gold nanoparticles have emerged as innovative tools, particularly for photo-thermal therapy since they can be excited by laser to induce hyperthermia. Gold nanoparticles can be functionalized with antibodies to specifically target cancer stem cells. Preclinical studies using photo-thermal therapy have demonstrated the feasibility of targeting chemo-resistant cancer cells to reverse clinical chemoresistance. Here, we review the data linking cancer stem cells and chemoresistance and discuss the way to target them to reverse resistance. We particularly focus on the use of functionalized gold nanoparticles in the treatment of chemo-resistant metastatic cancers.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Nunes T,Hamdan D,Leboeuf C,El Bouchtaoui M,Gapihan G,Nguyen TT,Meles S,Angeli E,Ratajczak P,Lu H,Di Benedetto M,Bousquet G,Janin Adoi
10.3390/ijms19124036subject
Has Abstractpub_date
2018-12-13 00:00:00issue
12issn
1422-0067pii
ijms19124036journal_volume
19pub_type
杂志文章,评审abstract::Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is known to regulate mitochondrial biogenesis. Resveratrol is present in a variety of plants, including the skin of grapes, blueberries, raspberries, mulberries, and peanuts. It has been shown to offer protective effects against a number of ...
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journal_title:International journal of molecular sciences
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abstract::Enteroaggregative Escherichia coli (EAEC) is an emerging pathogen frequently associated with acute diarrhea in children and travelers to endemic regions. EAEC was found the most prevalent bacterial diarrheal pathogen from hospitalized Bolivian children less than five years of age with acute diarrhea from 2007 to 2010....
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