Abstract：
:The extracellular signal-regulated kinases (ERKs) comprise a particular branch of the mitogen-activated protein kinase cascades (MAPK) that transmits extracellular signals into the intracellular environment to trigger cellular growth responses. Similar to other MAPK cascades, the MAPK-ERK pathway signals through three core kinases-Raf, MAPK/ERK kinase (MEK), and ERK-which drive the signaling mechanisms responsible for the induction of cellular responses from extracellular stimuli including differentiation, proliferation, and cellular survival. However, pathogens like DNA viruses alter MAPK-ERK signaling in order to access DNA replication machineries, induce a proliferative state in the cell, or even prevent cell death mechanisms in response to pathogen recognition. Differential utilization of this pathway by multiple DNA viruses highlights the dynamic nature of the MAPK-ERK pathway within the cell and the importance of its function in regulating a wide variety of cellular fates that ultimately influence viral infection and, in some cases, result in tumorigenesis.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
DuShane JK,Maginnis MSdoi
10.3390/ijms20143427subject
Has Abstractpub_date
2019-07-12 00:00:00issue
14issn
1422-0067pii
ijms20143427journal_volume
20pub_type
杂志文章,评审abstract：:A series of gold(I) complexes of the general composition [Au(naza)(PPh₃)] (1-8) was prepared and thoroughly characterized (e.g., electrospray ionization (ESI) mass spectrometry and multinuclear nuclear magnetic resonance (NMR) spectroscopy). The N1-deprotonated anions of 7-azaindole or its derivatives (naza) are coord...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17122084
更新日期：2016-12-11 00:00:00
abstract：:Extracellular vesicles (EVs) are membrane-bound particles involved in intercellular communication. They carry proteins, lipids, and nucleotides such as microRNAs (miRNAs) from the secreting cell that can modulate target cells. We and others have previously described the presence of EVs in peripheral blood of multiple ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19082448
更新日期：2018-08-19 00:00:00
abstract：:The purpose of the study was to investigate the antioxidant characteristics of Anisomeles indica methanol extract and the inhibitory effect of ovatodiolide on melanogenesis. In the study, the antioxidant capacities of A. indica methanol extract such as DPPH assay, ABTS radical scavenging assay, reducing capacity and m...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13056220
更新日期：2012-01-01 00:00:00
abstract：:Type 2 diabetes mellitus (T2D) is a chronic metabolic disease resulting from insulin resistance and progressively reduced insulin secretion, which leads to impaired glucose utilization, dyslipidemia and hyperinsulinemia and progressive pancreatic beta cell dysfunction. The incidence of type 2 diabetes mellitus is incr...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21186842
更新日期：2020-09-18 00:00:00
abstract：:Previous study revealed that a specific lignin-carbohydrate preparation, named as lignin-rich enzyme lignin (LREL) derived from plant husk, is a novel toll-like receptor 4 ligand and shows a potent immune-stimulatory activity against dendritic cells (DCs) in vitro. In this report, we investigated immune-stimulatory ac...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19010064
更新日期：2017-12-26 00:00:00
abstract：:NAC (NAM, ATAF1/2, and CUC2) transcription factors play important roles in many biological processes, and mainly bind to the NACRS with core sequences "CACG" or "CATGTG" to regulate gene expression. However, whether NAC proteins can bind to other motifs without these core sequences remains unknown. In this study, we e...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19103271
更新日期：2018-10-21 00:00:00
abstract：:Accumulating evidence indicates that oxidative stress plays a critical role in initiating the progression of inflammatory and fibrotic liver diseases, including cholestatic hepatitis. Peroxiredoxin 4 (PRDX4) is a secretory antioxidase that protects against oxidative damage by scavenging reactive oxygen species (ROS) i...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19092509
更新日期：2018-08-24 00:00:00
abstract：:Vascular inflammation plays a key role in the pathogenesis and progression of atherosclerosis, a main complication of diabetes. The present study investigated whether an aqueous extract of Portulaca oleracea (AP) prevents the TNF-α-induced vascular inflammatory process in the human umbilical vein endothelial cell (HUV...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13055628
更新日期：2012-01-01 00:00:00
abstract：:RNA binding protein (RBPs) and microRNAs (miRNAs or miRs) are post-transcriptional regulators of gene expression that are implicated in development of cancers. Although their individual roles have been studied, the crosstalk between RBPs and miRNAs is under intense investigation. Here, we show that in breast cancer ce...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms16047112
更新日期：2015-03-30 00:00:00
abstract：:A novel quadruplex ligand based on 1,10-phenanthroline and incorporating two guanyl hydrazone functionalities, PhenQE8, is reported herein. Synthetic access was gained in a two-step procedure with an overall yield of 61%. X-ray diffraction studies revealed that PhenQE8 can adopt an extended conformation that may be op...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22020749
更新日期：2021-01-13 00:00:00
abstract：:Merkel cell carcinomas (MCCs) are rare, aggressive, cutaneous neuroendocrine tumours, approximately 80% of which are caused by the genomic integration of Merkel cell polyomavirus (MCPyV). MCPyV-positive MCCs carry poor prognosis in approximately 70% of cases, highlighting the need for greater understanding of the onco...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21218222
更新日期：2020-11-03 00:00:00
abstract：:The immune system has a substantial effect on colorectal cancer (CRC) progression. Additionally, the response to immunotherapeutics and conventional treatment options (e.g., chemotherapy, radiotherapy and targeted therapies) is influenced by the immune system. The molecular characterization of colorectal cancer (CRC) ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18102229
更新日期：2017-10-24 00:00:00
abstract：:This study aimed to elucidate the mechanisms explaining the persistence of anemia and resistance to recombinant human erythropoietin (rHuEPO) therapy in a rat model of chronic kidney disease (CKD)-associated anemia with formation of anti-rHuEPO antibodies. The remnant kidney rat model of CKD induced by 5/6 nephrectomy...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17010028
更新日期：2015-12-25 00:00:00
abstract：:The objectives of this study were to evaluate the binding behavior of Cu(II) and Eu(III) with water extractable organic matter (WEOM) in soil, and assess the competitive effect of the cations. Excitation-emission matrix (EEM) fluorescence spectrometry was used in combination with parallel factor analysis (PARAFAC) to ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160714464
更新日期：2015-06-25 00:00:00
abstract：:Mucin1 (MUC1) is aberrantly glycosylated and overexpressed in various cancers, and it plays a crucial role in cancerogenesis. MUC1 is a type I membranous protein composed of α and β subunits. MUC1-α can be cleaved in cancers, exposing MUC1-β (MUC1-C). MUC1-C is involved with multiple cancer cellular functions, which m...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21093258
更新日期：2020-05-05 00:00:00
abstract：:Spirulina maxima, a microalga containing high levels of protein and many polyphenols, including chlorophyll a and C-phycocyanin, has antioxidant and anti-inflammatory therapeutic effects. However, the mechanisms where by Spirulina maxima ameliorates cognitive disorders induced by amyloid-β 1-42 (Aβ1-42) are not fully ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18112401
更新日期：2017-11-13 00:00:00
abstract：:Creatine is a metabolite important for cellular energy homeostasis as it provides spatio-temporal adenosine triphosphate (ATP) buffering for cells with fluctuating energy demands. Here, we examined whether placental creatine metabolism was altered in cases of early-onset pre-eclampsia (PE), a condition known to cause ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21030806
更新日期：2020-01-26 00:00:00
abstract：:Mast cells are pluripotent leukocytes that reside in the mucosa and connective tissue. Recent studies show an increased prevalence of cardiovascular disease among patients with mastocytosis, which is a hematological disease that is characterized by the accumulation of mast cells due to clonal proliferation. This assoc...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20143395
更新日期：2019-07-10 00:00:00
abstract：:The extracellular matrix (ECM) provides structural support for tissue architecture and is a major effector of cell behavior during skin repair and inflammation. Macrophages are involved in all stages of skin repair but only limited knowledge exists about macrophage-specific expression and regulation of ECM components....
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20205086
更新日期：2019-10-14 00:00:00
abstract：:Earthworms express, as most animals, metallothioneins (MTs)-small, cysteine-rich proteins that bind d(10) metal ions (Zn(II), Cd(II), or Cu(I)) in clusters. Three MT homologues are known for Lumbricus rubellus, the common red earthworm, one of which, wMT-2, is strongly induced by exposure of worms to cadmium. This stu...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17010065
更新日期：2016-01-05 00:00:00
abstract：:We would like to submit the following correction to the published paper [1], the reason for this action is that the data in Table 3 were reanalyzed by one more accurate statistic method: On page 12, the sentence of paragraph three "OR and 95% CI were calculated by limited backward-LR (likelihood ratio) logistic regres...
journal_title：International journal of molecular sciences
pub_type： 已发布勘误
doi：10.3390/ijms18091899
更新日期：2017-09-04 00:00:00
abstract：:A new aromaticity definition is advanced as the compactness formulation through the ratio between atoms-in-molecule and orbital molecular facets of the same chemical reactivity property around the pre- and post-bonding stabilization limit, respectively. Geometrical reactivity index of polarizability was assumed as pro...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms11041269
更新日期：2010-03-26 00:00:00
abstract：:Photodynamic diagnosis (PDD) can improve diagnostic accuracy by using PDD agents such as 5-aminolevulinic acid (ALA). However, the weakness and photobleaching of fluorescence of PDD agents may lead to insufficient fluorescence visibility for the detection of cancer during resection operations. We focused on the "fluor...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20153698
更新日期：2019-07-28 00:00:00
abstract：:Riboflavin is the biological precursor of two important flavin cofactors-flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN)-that are critical prosthetic groups in several redox enzymes. While dietary supplementation with riboflavin is a recognized support therapy in several inborn errors of metabolism, ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21197063
更新日期：2020-09-25 00:00:00
abstract：:Naturally existing Chlorogenic acid (CGA) is an antioxidant-rich compound reported to act a chemopreventive agent by scavenging free radicals and suppressing cancer-causing mechanisms. Conversely, the compound's poor thermal and pH (neutral and basic) stability, poor solubility, and low cellular permeability have been...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20194667
更新日期：2019-09-20 00:00:00
abstract：:Molecular Dynamics is a method of choice for membrane simulations and the rising of coarse-grained forcefields has opened the way to longer simulations with reduced calculations times. Here, we present an elastic network, SAHBNET (Surface Accessibility Hydrogen-Bonds elastic NETwork), that will maintain the structure ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms140611510
更新日期：2013-05-30 00:00:00
abstract：:Grape hyacinth (Muscari spp.) is a popular ornamental plant with bulbous flowers noted for their rich blue color. Muscari species have been thought to accumulate delphinidin and cyanidin rather than pelargonidin-type anthocyanins because their dihydroflavonol 4-reductase (DFR) does not efficiently reduce dihydrokaempf...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20194743
更新日期：2019-09-24 00:00:00
abstract：:In this paper, nanofibrous membranes based on chitosan (CS), poly (vinyl alcohol) (PVA) and graphene oxide (GO) composites, loaded with antibiotic drugs, such as Ciprofloxacin (Cip) and Ciprofloxacin hydrochloride (CipHcl) were prepared via the electrospinning technique. The uniform and defect-free CS/PVA nanofibers w...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20184395
更新日期：2019-09-06 00:00:00
abstract：:Vitamin D receptor (VDR) is present in multiple blood cells, and the hormonal form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) is essential for the proper functioning of the immune system. The role of retinoic acid receptor α (RARα) in hematopoiesis is very important, as the fusion of RARα gene with PML gene initiat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18061323
更新日期：2017-06-21 00:00:00
abstract：:Proteinuria is a marker of incipient kidney injury in many disorders, including obesity. Previously, we demonstrated that megalin, a receptor endocytotic protein in the proximal tubule, is downregulated in obese mice, which was prevented by inhibition of dipeptidyl protease 4 (DPP4). Obesity is thought to be associate...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17050780
更新日期：2016-05-20 00:00:00
