Pharmacogenetics of Type 2 Diabetes-Progress and Prospects.

Abstract:

:Type 2 diabetes mellitus (T2D) is a chronic metabolic disease resulting from insulin resistance and progressively reduced insulin secretion, which leads to impaired glucose utilization, dyslipidemia and hyperinsulinemia and progressive pancreatic beta cell dysfunction. The incidence of type 2 diabetes mellitus is increasing worldwide and nowadays T2D already became a global epidemic. The well-known interindividual variability of T2D drug actions such as biguanides, sulfonylureas/meglitinides, DPP-4 inhibitors/GLP1R agonists and SGLT-2 inhibitors may be caused, among other things, by genetic factors. Pharmacogenetic findings may aid in identifying new drug targets and obtaining in-depth knowledge of the causes of disease and its physiological processes, thereby, providing an opportunity to elaborate an algorithm for tailor or precision treatment. The aim of this article is to summarize recent progress and discoveries for T2D pharmacogenetics and to discuss the factors which limit the furthering accumulation of genetic variability knowledge in patient response to therapy that will allow improvement the personalized treatment of T2D.

journal_name

Int J Mol Sci

authors

Nasykhova YA,Tonyan ZN,Mikhailova AA,Danilova MM,Glotov AS

doi

10.3390/ijms21186842

subject

Has Abstract

pub_date

2020-09-18 00:00:00

issue

18

issn

1422-0067

pii

ijms21186842

journal_volume

21

pub_type

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