Immunogenomic Classification of Colorectal Cancer and Therapeutic Implications.

abstract：:Previously, we developed a novel microRNA (miRNA) delivery system based on bacteriophage MS2 virus-like particles (MS2 VLPs). In this current study, we used this system to transport miR-146a into human peripheral blood mononuclear cells (PBMCs), and demonstrated the inhibition of osteoclastogenesis in precursors. Two ...

journal_title：International journal of molecular sciences

authors： Yao Y,Jia T,Pan Y,Gou H,Li Y,Sun Y,Zhang R,Zhang K,Lin G,Xie J,Li J,Wang L

更新日期：2015-04-14 00:00:00

abstract：:Acipenseriformes are composed of 25 sturgeon species and two paddlefish species distributed exclusively in the northern hemisphere. The Danube River and the Black Sea were originally inhabited by six sturgeon species but two are extinct and only four are still reproducing currently in the Lower Danube: Huso huso, Acip...

journal_title：International journal of molecular sciences

authors： Dudu A,Suciu R,Paraschiv M,Georgescu SE,Costache M,Berrebi P

更新日期：2011-01-01 00:00:00

abstract：:To date, viruses are reported to be responsible for more than 15% of all tumors worldwide. The oncogenesis could be influenced directly by the activity of viral oncoproteins or by the chronic infection or inflammation. The group of human oncoviruses includes Epstein–Barr virus (EBV), human papillomavirus (HPV), ...

journal_title：International journal of molecular sciences

authors： Vojtechova Z,Tachezy R

更新日期：2018-04-17 00:00:00

abstract：:The objective of this study was to determine the effects of feeding protein-iron complex (PIC) on productive performance and indicators of iron metabolism, hematology parameters, antioxidant and immune status during first 35 days of a calf's life. Preparation of the complex involved enzymatic hydrolysis of milk casein...

journal_title：International journal of molecular sciences

authors： Kupczyński R,Bednarski M,Śpitalniak K,Pogoda-Sewerniak K

更新日期：2017-07-12 00:00:00

abstract：:Glutamate (Glu)-mediated excitotoxicity is a major cause of amyotrophic lateral sclerosis (ALS) and our previous work highlighted that abnormal Glu release may represent a leading mechanism for excessive synaptic Glu. We demonstrated that group I metabotropic Glu receptors (mGluR1, mGluR5) produced abnormal Glu releas...

journal_title：International journal of molecular sciences

authors： Bonifacino T,Rebosio C,Provenzano F,Torazza C,Balbi M,Milanese M,Raiteri L,Usai C,Fedele E,Bonanno G

更新日期：2019-09-13 00:00:00

abstract：:Urinary tract infections (UTIs) and catheter-associated UTIs (CAUTIs) are the principal hospital-acquired infections. Proteus mirabilis is characterized by several virulence factors able to promote adhesion and biofilm formation and ameliorate the colonization of urinary tract and the formation of crystalline biofilms...

journal_title：International journal of molecular sciences

authors： Fusco A,Coretti L,Savio V,Buommino E,Lembo F,Donnarumma G

更新日期：2017-02-15 00:00:00

abstract：:Cyclin-dependent kinase 5 regulatory subunit 1 (CDK5R1) gene encodes for p35, the main activator of Cyclin-dependent kinase 5 (CDK5). The active p35/CDK5 complex is involved in numerous aspects of brain development and function, and its deregulation is closely associated to Alzheimer's disease (AD) onset and progressi...

journal_title：International journal of molecular sciences

authors： Spreafico M,Grillo B,Rusconi F,Battaglioli E,Venturin M

更新日期：2018-07-11 00:00:00

abstract：:In Arabidopsis basal hypocotyls of dark-grown seedlings, xylary cells may form from the pericycle as an alternative to adventitious roots. Several hormones may induce xylogenesis, as Jasmonic acid (JA), as well as indole-3-acetic acid (IAA) and indole-3-butyric acid (IBA) auxins, which also affect xylary identity. Stu...

journal_title：International journal of molecular sciences

authors： Della Rovere F,Fattorini L,Ronzan M,Falasca G,Altamura MM,Betti C

更新日期：2019-09-10 00:00:00

abstract：:Type I collagen is the most abundant structural protein in all vertebrates, but its constitutive rate of synthesis is low due to long half-life of the protein (60-70 days). However, several hundred fold increased production of type I collagen is often seen in reparative or reactive fibrosis. The mechanism which is res...

journal_title：International journal of molecular sciences

authors： Zhang Y,Stefanovic B

更新日期：2016-03-22 00:00:00

abstract：:Findings from previous studies reporting the levels of serum brain-derived neurotrophic factor (BDNF) in patients with Alzheimer's disease (AD) and individuals with mild cognitive impairment (MCI) have been conflicting. Hence, we performed a meta-analysis to examine the aggregate levels of serum BDNF in patients with ...

journal_title：International journal of molecular sciences

authors： Ng TKS,Ho CSH,Tam WWS,Kua EH,Ho RC

更新日期：2019-01-10 00:00:00

abstract：:Accumulating evidence indicates that oxidative stress plays a critical role in initiating the progression of inflammatory and fibrotic liver diseases, including cholestatic hepatitis. Peroxiredoxin 4 (PRDX4) is a secretory antioxidase that protects against oxidative damage by scavenging reactive oxygen species (ROS) i...

journal_title：International journal of molecular sciences

authors： Zhang J,Guo X,Hamada T,Yokoyama S,Nakamura Y,Zheng J,Kurose N,Ishigaki Y,Uramoto H,Tanimoto A,Yamada S

更新日期：2018-08-24 00:00:00

abstract：:Aquaporins (AQPs) play a pivotal role in gut homeostasis since their distribution and function is modulated both in physiological and in pathophysiological conditions. The transport of water and solutes through gut epithelia is essential for osmoregulation and digestive and absorptive functions. This passage is regula...

journal_title：International journal of molecular sciences

authors： Pelagalli A,Squillacioti C,Mirabella N,Meli R

更新日期：2016-07-27 00:00:00

abstract：:Conventional photodynamic therapy (PDT) is limited by its penetration depth due to the photosensitizer and light source. In this study, we developed X-ray induced photodynamic therapy that applied X-ray as the light source to activate Ce-doped CaCO₃ (CaCO₃:Ce) to generate an intracellular reactive oxygen species (ROS)...

journal_title：International journal of molecular sciences

authors： Yang CC,Wang WY,Lin FH,Hou CH

更新日期：2019-03-06 00:00:00

abstract：:The role of the collagen-platelet interaction is of crucial importance to the haemostatic response during both injury and pathogenesis of the blood vessel wall. Of particular interest is the high affinity interaction of the platelet transmembrane receptor, alpha 2 beta 1, responsible for firm attachment of platelets t...

journal_title：International journal of molecular sciences

authors： Attwood SJ,Simpson AM,Hamaia SW,Bihan D,Roy D,Farndale RW,Welland ME

更新日期：2013-01-29 00:00:00

abstract：:Given their extremely small size and light weight, carbon nanotubes (CNTs) can be readily inhaled by human lungs resulting in increased rates of pulmonary disorders, particularly fibrosis. Although the fibrogenic potential of CNTs is well established, there is a lack of consensus regarding the contribution of physicoc...

journal_title：International journal of molecular sciences

authors： Manke A,Luanpitpong S,Dong C,Wang L,He X,Battelli L,Derk R,Stueckle TA,Porter DW,Sager T,Gou H,Dinu CZ,Wu N,Mercer RR,Rojanasakul Y

更新日期：2014-04-29 00:00:00

abstract：BACKGROUND:Carbapenems (ertapenem, imipenem, meropenem) are used to treat multidrug-resistant (MDR-) and extensively drug-resistant tuberculosis (XDR-TB), even if the published evidence is limited, particularly when it is otherwise difficult to identify the recommended four active drugs to be included in the regimen. N...

journal_title：International journal of molecular sciences

authors： Sotgiu G,D'Ambrosio L,Centis R,Tiberi S,Esposito S,Dore S,Spanevello A,Migliori GB

更新日期：2016-03-12 00:00:00

abstract：:Exceptionally long-lived individuals (ELLI) who are the focus of many healthy longevity studies around the globe are now being studied in Israel. The Israeli Multi-Ethnic Centenarian Study (IMECS) cohort is utilized here for assessment of various DNA methylation clocks. Thorough phenotypic characterization and whole b...

journal_title：International journal of molecular sciences

authors： Gutman D,Rivkin E,Fadida A,Sharvit L,Hermush V,Rubin E,Kirshner D,Sabin I,Dwolatzky T,Atzmon G

更新日期：2020-01-17 00:00:00

abstract：:Scaffolds made of biodegradable biomaterials are widely used to guide bone regeneration. Commonly, in vitro assessment of scaffolds' osteogenesis potential has been performed predominantly in monoculture settings. Hence, this study evaluated the potential of an unstimulated, growth factor-free co-culture system compri...

journal_title：International journal of molecular sciences

authors： Hammerl A,Diaz Cano CE,De-Juan-Pardo EM,van Griensven M,Poh PSP

更新日期：2019-03-01 00:00:00

abstract：:Polysaccharides from Morchella esculenta have been proven to be functional and helpful for humans. The purpose of this study was to investigate the chemical structure and anti-proliferating and antitumor activities of a Morchella esculenta polysaccharide (MEP) extracted by pulsed electric field (PEF) in submerged ferm...

journal_title：International journal of molecular sciences

authors： Liu C,Sun Y,Mao Q,Guo X,Li P,Liu Y,Xu N

更新日期：2016-06-22 00:00:00

abstract：:In this study, we investigated the anticancer effects of a new benzimidazole derivative, 1-benzyl-2-phenyl -benzimidazole (BPB), in human chondrosarcoma cells. BPB-mediated apoptosis was assessed by the MTT assay and flow cytometry analysis. The in vivo efficacy was examined in a JJ012 xenograft model. Here we found t...

journal_title：International journal of molecular sciences

authors： Liu JF,Huang YL,Yang WH,Chang CS,Tang CH

更新日期：2012-12-04 00:00:00

abstract：:Transcription factors play vital roles in the developmental processes of plants. The SQUAMOSA promoter binding protein (SBP) genes encode a family of plant-specific transcription factors and plays many crucial roles in plant development. In this study, 16 SBP-box gene family members were identified in Ziziphus jujuba ...

journal_title：International journal of molecular sciences

authors： Song S,Zhou H,Sheng S,Cao M,Li Y,Pang X

更新日期：2017-08-15 00:00:00

abstract：:Natural autoantibodies to the IGF1 receptor (IGF1R-aAb) have been described in relation to Graves' ophthalmopathy. Other physiological roles of natural IGF1R-aAb are not known. We hypothesized that IGF1R-aAb may be related to muscle development. Serum samples (n = 408) from young overweight subjects (n = 143) were col...

journal_title：International journal of molecular sciences

authors： Schwiebert C,Kühnen P,Becker NP,Welsink T,Keller T,Minich WB,Wiegand S,Schomburg L

更新日期：2020-01-11 00:00:00

abstract：:Melatonin has long been recognized as a positive signaling molecule and potent antioxidant in plants, which alleviates damage caused by adverse conditions such as salt, cold, and heat stress. In this study, we found a paradoxical role for melatonin in abiotic stress responses. Suppression of the serotonin N-acetyltran...

journal_title：International journal of molecular sciences

authors： Hwang OJ,Back K

更新日期：2019-10-18 00:00:00

abstract：:Both genetic and epigenetic alterations can control the progression of cancer. Genetic alterations are impossible to reverse, while epigenetic alterations are reversible. This advantage suggests that epigenetic modifications should be preferred in therapy applications. DNA methyltransferases and histone deacetylases h...

journal_title：International journal of molecular sciences

authors： Cai FF,Kohler C,Zhang B,Wang MH,Chen WJ,Zhong XY

更新日期：2011-01-01 00:00:00

abstract：:Oral biofilms attach onto both teeth surfaces and dental material surfaces in oral cavities. In the meantime, oral biofilms are not only the pathogenesis of dental caries and periodontitis, but also secondary caries and peri-implantitis, which would lead to the failure of clinical treatments. The material surfaces exp...

journal_title：International journal of molecular sciences

authors： Hao Y,Huang X,Zhou X,Li M,Ren B,Peng X,Cheng L

更新日期：2018-10-14 00:00:00

abstract：:Leishmania is a protozoan parasite that causes a wide range of different clinical manifestations in mammalian hosts. It is a major public health risk on different continents and represents one of the most important neglected diseases. Due to the high toxicity of the drugs currently used, and in the light of increasing...

journal_title：International journal of molecular sciences

authors： Veras PS,Bezerra de Menezes JP

更新日期：2016-08-19 00:00:00

abstract：:Polyamines (PAs) are natural compounds involved in many growth and developmental processes in plants, and, specifically in fruits, play a vital role regulating its development, ripening and senescence processes. Putrescine (PUT), spermine (SPE), and spermidine (SPD) are prominent PAs applied exogenously to extend shel...

journal_title：International journal of molecular sciences

authors： Sharma S,Pareek S,Sagar NA,Valero D,Serrano M

更新日期：2017-08-17 00:00:00

abstract：:Molecular motors are microtubule-based proteins which contribute to many cell functions, such as intracellular transportation and cell division. The details of the nature of the mutual interactions between motors and microtubules still needs to be extensively explored. However, electrostatic interaction is known as on...

journal_title：International journal of molecular sciences

authors： Feizabadi MS,Alejilat RS,Duffy AB,Breslin JC,Akintola II

更新日期：2020-07-13 00:00:00

abstract：:Type 2 innate lymphoid cells (ILC2s) and their adaptive counterpart type 2 T helper (TH2) cells respond to interleukin-33 (IL-33) by producing IL-5, which is a crucial cytokine for eosinophil development in the bone marrow. The aim of this study was to determine if bone marrow ILC2s, TH cells, and eosinophils are loca...

journal_title：International journal of molecular sciences

authors： Boberg E,Johansson K,Malmhäll C,Weidner J,Rådinger M

更新日期：2020-05-26 00:00:00

abstract：:The extracellular matrix (ECM) provides structural support for tissue architecture and is a major effector of cell behavior during skin repair and inflammation. Macrophages are involved in all stages of skin repair but only limited knowledge exists about macrophage-specific expression and regulation of ECM components....

journal_title：International journal of molecular sciences

authors： Etich J,Koch M,Wagener R,Zaucke F,Fabri M,Brachvogel B

更新日期：2019-10-14 00:00:00