Epigenetic therapy for breast cancer.

abstract：:As most chemotherapeutic drugs are ineffective in the treatment of chondrosarcoma, we studied the expression pattern and function of SOX9, the master transcription factor for chondrogenesis, in chondrosarcoma, to understand the basic molecular principles needed for engineering new targeted therapies. Our study shows a...

journal_title：International journal of molecular sciences

authors： Stöckl S,Lindner G,Li S,Schuster P,Haferkamp S,Wagner F,Prodinger PM,Multhoff G,Boxberg M,Hillmann A,Bauer RJ,Grässel S

更新日期：2020-10-15 00:00:00

abstract：BACKGROUND:Patients with breast cancer-the deadliest cancer among women-are at constant risk of developing metastasis. Oxidative stress and hypoxia are common feature of tumor cells that can proliferate even in a resultant metabolic acidosis. Despite the low extracellular pH, intracellular pH of tumor cells remains rel...

journal_title：International journal of molecular sciences

authors： Luz MC,Perez MM,Azzalis LA,Sousa LV,Adami F,Fonseca FL,Alves BD

更新日期：2017-03-23 00:00:00

abstract：:The role of the gut microbiome in human health and disease is the focus of much attention. It has been widely agreed upon that our gut bacteria play a role in host immunity, nutrient absorption, digestion, metabolism, and other key drivers of health. Furthermore, certain microbial signatures and specific taxa have als...

journal_title：International journal of molecular sciences

authors： Lawrence GW,Begley M,Cotter PD,Guinane CM

更新日期：2020-01-30 00:00:00

abstract：:Food packaging is not only a simple protective barrier, but a real "active" component, which is expected to preserve food quality, safety and shelf-life. Therefore, the materials used for packaging production should show peculiar features and properties. Specifically, antimicrobial packaging has recently gained great ...

journal_title：International journal of molecular sciences

authors： Agrillo B,Balestrieri M,Gogliettino M,Palmieri G,Moretta R,Proroga YTR,Rea I,Cornacchia A,Capuano F,Smaldone G,De Stefano L

更新日期：2019-01-30 00:00:00

abstract：:Estrogen receptor-α positive (ERα⁺) breast cancers represent 75% of all invasive breast cancer cases, while de novo or acquired resistance to ER-directed therapy is also on the rise. Numerous factors contribute to this phenomenon including the recently-reported ESR1 gene mutations such as Y537S, which amplifies co-act...

journal_title：International journal of molecular sciences

authors： Singh K,Munuganti RSN,Lallous N,Dalal K,Yoon JS,Sharma A,Yamazaki T,Cherkasov A,Rennie PS

更新日期：2018-02-15 00:00:00

abstract：:(1) Background: A high incidence of intervening sequence (IVS)4+919 G>A mutation with later-onset cardiac phenotype have been reported in a majority of Taiwan Fabry cohorts. Some evidence indicated that conventional biomarkers failed to predict the long-term progression and therapeutic outcome; (2) Methods: In this st...

journal_title：International journal of molecular sciences

authors： Chien Y,Chou SJ,Chang YL,Leu HB,Yang YP,Tsai PH,Lai YH,Chen KH,Chang WC,Sung SH,Yu WC

更新日期：2018-05-16 00:00:00

abstract：:In this work, we studied the antimicrobial properties of a nanocomposite system based on a lactose-substituted chitosan and silver nanoparticles: Chitlac-nAg. Twofold serial dilutions of the colloidal Chitlac-nAg solution were both tested on Streptococcus mitis, Streptococcus mutans, and Streptococcus oralis planktoni...

journal_title：International journal of molecular sciences

authors： Di Giulio M,Di Bartolomeo S,Di Campli E,Sancilio S,Marsich E,Travan A,Cataldi A,Cellini L

更新日期：2013-06-28 00:00:00

abstract：:Ankyrin repeat (AR) domains are considered the most abundant repeat motif found in eukaryotic proteins. AR domains are predominantly known to mediate specific protein-protein interactions (PPIs) without necessarily recognizing specific primary sequences, nor requiring strict conformity within its own primary sequence....

journal_title：International journal of molecular sciences

authors： Kane EI,Spratt DE

更新日期：2021-01-09 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, and thus better understanding of its molecular pathology is crucial for us to devise more effective treatment of this deadly disease. As cancer cell line remains a convenient starting point for discovery and proof-of-concept studies, here ...

journal_title：International journal of molecular sciences

authors： Shen Y,Pu K,Zheng K,Ma X,Qin J,Jiang L,Li J

更新日期：2019-09-10 00:00:00

abstract：:Inflammatory bowel diseases (IBD) are chronic, inflammatory processes that affect the gastrointestinal tract and are mainly represented by ulcerative colitis (UC) and Crohn's disease (CD). Omega 3 (ω3) fatty acids (eicosapentanoic acid and docosahexaenoic acid) show an indispensable role in the inflammatory processes ...

journal_title：International journal of molecular sciences

authors： Marton LT,Goulart RA,Carvalho ACA,Barbalho SM

更新日期：2019-09-30 00:00:00

abstract：:A common problem in the immunodetection of structurally close compounds is understanding the regularities of immune recognition, and elucidating the basic structural elements that provide it. Correct identification of these elements would allow for select immunogens to obtain antibodies with either wide specificity to...

journal_title：International journal of molecular sciences

authors： Buglak AA,Shanin IA,Eremin SA,Lei HT,Li X,Zherdev AV,Dzantiev BB

更新日期：2019-01-11 00:00:00

abstract：:Collaterals are unique blood vessels present in the microcirculation of most tissues that, by cross-connecting a small fraction of the outer branches of adjacent arterial trees, provide alternate routes of perfusion. However, collaterals are especially susceptible to rarefaction caused by aging, other vascular risk fa...

journal_title：International journal of molecular sciences

authors： Zhang H,Chalothorn D,Faber JE

更新日期：2019-07-24 00:00:00

abstract：:Chemoresistance is a leading cause of morbidity and mortality in cancer and it continues to be a challenge in cancer treatment. Chemoresistance is influenced by genetic and epigenetic alterations which affect drug uptake, metabolism and export of drugs at the cellular levels. While most research has focused on tumor c...

journal_title：International journal of molecular sciences

authors： Senthebane DA,Rowe A,Thomford NE,Shipanga H,Munro D,Mazeedi MAMA,Almazyadi HAM,Kallmeyer K,Dandara C,Pepper MS,Parker MI,Dzobo K

更新日期：2017-07-21 00:00:00

abstract：:Reactive Oxygen Species or "ROS" encompass several molecules derived from oxygen that can oxidize other molecules and subsequently transition rapidly between species. The key roles of ROS in biological processes are cell signaling, biosynthetic processes, and host defense. In cancer cells, increased ROS production and...

journal_title：International journal of molecular sciences

authors： Ghoneum A,Abdulfattah AY,Warren BO,Shu J,Said N

更新日期：2020-04-28 00:00:00

abstract：:The first algorithm for Emulsion Stability Simulations (ESS) was presented at the V Conferencia Iberoamericana sobre Equilibrio de Fases y Diseño de Procesos [Luis, J.; García-Sucre, M.; Urbina-Villalba, G. Brownian Dynamics Simulation of Emulsion Stability In: Equifase 99. Libro de Actas, 1(st) Ed., Tojo J., Arce, A....

journal_title：International journal of molecular sciences

authors： Urbina-Villalba G

更新日期：2009-03-01 00:00:00

abstract：:The quaternary transition between the relaxed (R) and tense (T) states of heme-binding proteins is a textbook example for the allosteric structural transition. Homodimeric hemoglobin (HbI) from Scapharca inaequivalvis is a useful model system for investigating the allosteric behavior because of the relatively simple q...

journal_title：International journal of molecular sciences

authors： Yang C,Choi M,Kim JG,Kim H,Muniyappan S,Nozawa S,Adachi SI,Henning R,Kosheleva I,Ihee H

更新日期：2018-11-18 00:00:00

abstract：:Mutations on epidermal growth factor receptor (EGFR) of adenocarcinomas of lung have been found to be associated with increased sensitivity to EGFR tyrosine kinase inhibitors and K-ras mutations may correlate with primary resistance. We aimed to explore the discordant mutation statuses of EGFR and K-ras between primar...

journal_title：International journal of molecular sciences

authors： Rau KM,Chen HK,Shiu LY,Chao TL,Lo YP,Wang CC,Lin MC,Huang CC

更新日期：2016-04-07 00:00:00

abstract：:Despite the critical role of melanin in the protection of skin against UV radiation, excess production of melanin can lead to hyperpigmentation and skin cancer. Pear fruits are often used in traditional medicine for the treatment of melasma; therefore, we investigated the effects of pear extract (PE) and its component...

journal_title：International journal of molecular sciences

authors： Truong XT,Park SH,Lee YG,Jeong HY,Moon JH,Jeon TI

更新日期：2017-08-21 00:00:00

abstract：:Histone deacetylases have been a target of therapy for organ fibrosis. Here, we report the protective effect of CG200745 (CG), a novel histone deacetylase inhibitor, on tubulointerstitial fibrosis in Col4a3-/- mice, a murine model of Alport syndrome. Morphological analyses revealed CG treatment markedly alleviated kid...

journal_title：International journal of molecular sciences

authors： Suh SH,Choi HS,Kim CS,Kim IJ,Cha H,Cho JM,Ma SK,Kim SW,Bae EH

更新日期：2020-02-21 00:00:00

abstract：:Autophagy, a self-defense mechanism, has been found to be associated with drug resistance in hepatocellular carcinoma (HCC). Our study was designed to investigate the role and related mechanisms of autophagy in matrine-induced apoptosis in hepatoma cells of HepG2 and Bel7402. Cell apoptosis was detected by flow cytome...

journal_title：International journal of molecular sciences

authors： Wang L,Gao C,Yao S,Xie B

更新日期：2013-11-25 00:00:00

abstract：:Emotional and cognitive information processing represent higher-order brain functions. They require coordinated interaction of specialized brain areas via a complex spatial and temporal equilibrium among neuronal cell-autonomous, circuitry, and network mechanisms. The delicate balance can be corrupted by stressful exp...

journal_title：International journal of molecular sciences

authors： Italia M,Forastieri C,Longaretti A,Battaglioli E,Rusconi F

更新日期：2020-10-09 00:00:00

abstract：:Transforming growth factor beta 3 (TGFβ3) promotes tenogenic differentiation and may enhance tendon regeneration in vivo. This study aimed to apply TGFβ3 absorbed in decellularized equine superficial digital flexor tendon scaffolds, and to investigate the bioactivity of scaffold-associated TGFβ3 in an in vitro model. ...

journal_title：International journal of molecular sciences

authors： Roth SP,Brehm W,Groß C,Scheibe P,Schubert S,Burk J

更新日期：2019-11-03 00:00:00

abstract：:The mushroom Inonotus obliquus has been widely used as a folk medicine in Russia, Poland and most of the Baltic countries. In this study, water-soluble and alkali-soluble crude polysaccharides (IOW and IOA) were isolated from I. obliquus, and the carbohydrate-rich fractions IOW-1 and IOA-1 were obtained respectively a...

journal_title：International journal of molecular sciences

authors： Mu H,Zhang A,Zhang W,Cui G,Wang S,Duan J

更新日期：2012-01-01 00:00:00

abstract：:We have previously shown that neural precursor cell-expressed developmentally downregulated gene 4-2 (Nedd4-2) isoforms with a C2 domain are closely related to ubiquitination of epithelial sodium channel (ENaC), resulting in salt-sensitive hypertension by Nedd4-2 C2 targeting in mice. The sodium voltage-gated channel ...

journal_title：International journal of molecular sciences

authors： Minegishi S,Ishigami T,Kawamura H,Kino T,Chen L,Nakashima-Sasaki R,Doi H,Azushima K,Wakui H,Chiba Y,Tamura K

更新日期：2017-06-14 00:00:00

abstract：:The translation of metallothioneins (MTs) is one of the defense strategies by which organisms protect themselves from metal-induced toxicity. MTs belong to a family of proteins comprising MT-1, MT-2, MT-3, and MT-4 classes, with multiple isoforms within each class. The main aim of this study was to determine the behav...

journal_title：International journal of molecular sciences

authors： Merlos Rodrigo MA,Molina-López J,Jimenez Jimenez AM,Planells Del Pozo E,Adam P,Eckschlager T,Zitka O,Richtera L,Adam V

更新日期：2017-03-11 00:00:00

abstract：:Genistein has been reported to stimulate luminal HCO3(-) secretion. We hypothesized that genistein mediates this effect via SLC26A6 and SLC4A4 (NBCe1) transporters. Our study aimed to: investigate changes in uterine fluid pH, Na+ and HCO3(-) concentration and expression of uterine SLC26A6 and NBCe1 under genistein eff...

journal_title：International journal of molecular sciences

authors： Chinigarzadeh A,Kasim NF,Muniandy S,Kassim NM,Salleh N

更新日期：2014-01-10 00:00:00

abstract：:Molecular factors involved in neuroprotection are key in the design of novel multitarget drugs in aging and neurodegeneration. AVCRI104P3 is a huprine derivative that exhibits potent inhibitory effects on human AChE, BuChE, and BACE-1 activities, as well as on AChE-induced and self-induced Aβ aggregation. More recentl...

journal_title：International journal of molecular sciences

authors： Relat J,Come J,Perez B,Camps P,Muñoz-Torrero D,Badia A,Gimenez-Llort L,Clos MV

更新日期：2018-09-04 00:00:00

abstract：:The presence of calcium deposits in human lesions is largely used as imaging biomarkers of human diseases such as breast cancer. Indeed, the presence of micro- or macrocalcifications is frequently associated with the development of both benign and malignant lesions. Nevertheless, the molecular mechanisms involved in t...

journal_title：International journal of molecular sciences

authors： Bonfiglio R,Granaglia A,Giocondo R,Scimeca M,Bonanno E

更新日期：2020-12-24 00:00:00

abstract：:Transcription factors are proteins able to bind DNA and induce the transcription of specific genes. Consequently, they play a pivotal role in multiple cellular pathways and are frequently over-expressed or dysregulated in cancer. Here, we will focus on a specific "signal transducer and activator of transcription" (STA...

journal_title：International journal of molecular sciences

authors： Sgrignani J,Garofalo M,Matkovic M,Merulla J,Catapano CV,Cavalli A

更新日期：2018-05-28 00:00:00

abstract：:The Asian cycads are mostly allopatric, distributed in small population sizes. Hybridization between allopatric species provides clues in determining the mechanism of species divergence. Horticultural introduction provides the chance of interspecific gene flow between allopatric species. Two allopatrically eastern Asi...

journal_title：International journal of molecular sciences

authors： Chiang YC,Huang BH,Chang CW,Wan YT,Lai SJ,Huang S,Liao PC

更新日期：2013-04-15 00:00:00