Abstract:
:Reactive Oxygen Species or "ROS" encompass several molecules derived from oxygen that can oxidize other molecules and subsequently transition rapidly between species. The key roles of ROS in biological processes are cell signaling, biosynthetic processes, and host defense. In cancer cells, increased ROS production and oxidative stress are instigated by carcinogens, oncogenic mutations, and importantly, metabolic reprograming of the rapidly proliferating cancer cells. Increased ROS production activates myriad downstream survival pathways that further cancer progression and metastasis. In this review, we highlight the relation between ROS, the metabolic programing of cancer, and stromal and immune cells with emphasis on and the transcription machinery involved in redox homeostasis, metabolic programing and malignant phenotype. We also shed light on the therapeutic targeting of metabolic pathways generating ROS as we investigate: Orlistat, Biguandes, AICAR, 2 Deoxyglucose, CPI-613, and Etomoxir.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Ghoneum A,Abdulfattah AY,Warren BO,Shu J,Said Ndoi
10.3390/ijms21093100subject
Has Abstractpub_date
2020-04-28 00:00:00issue
9issn
1422-0067pii
ijms21093100journal_volume
21pub_type
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