Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data.

Abstract:

:The human peptide GHK (glycyl-l-histidyl-l-lysine) has multiple biological actions, all of which, according to our current knowledge, appear to be health positive. It stimulates blood vessel and nerve outgrowth, increases collagen, elastin, and glycosaminoglycan synthesis, as well as supports the function of dermal fibroblasts. GHK’s ability to improve tissue repair has been demonstrated for skin, lung connective tissue, boney tissue, liver, and stomach lining. GHK has also been found to possess powerful cell protective actions, such as multiple anti-cancer activities and anti-inflammatory actions, lung protection and restoration of chronic obstructive pulmonary disease (COPD) fibroblasts, suppression of molecules thought to accelerate the diseases of aging such as NFκB, anti-anxiety, anti-pain and anti-aggression activities, DNA repair, and activation of cell cleansing via the proteasome system. Recent genetic data may explain such diverse protective and healing actions of one molecule, revealing multiple biochemical pathways regulated by GHK.

journal_name

Int J Mol Sci

authors

Pickart L,Margolina A

doi

10.3390/ijms19071987

subject

Has Abstract

pub_date

2018-07-07 00:00:00

issue

7

issn

1422-0067

pii

ijms19071987

journal_volume

19

pub_type

杂志文章,评审
  • p53 as a Dichotomous Regulator of Liver Disease: The Dose Makes the Medicine.

    abstract::Lifestyle-related disorders, such as the metabolic syndrome, have become a primary risk factor for the development of liver pathologies that can progress from hepatic steatosis, hepatic insulin resistance, steatohepatitis, fibrosis and cirrhosis, to the most severe condition of hepatocellular carcinoma (HCC). While th...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms19030921

    authors: Krstic J,Galhuber M,Schulz TJ,Schupp M,Prokesch A

    更新日期:2018-03-20 00:00:00

  • The Endocannabinoid System and Autism Spectrum Disorders: Insights from Animal Models.

    abstract::Autism spectrum disorder (ASD) defines a group of neurodevelopmental disorders whose symptoms include impaired communication and social interaction with restricted or repetitive motor movements, frequently associated with general cognitive deficits. Although it is among the most severe chronic childhood disorders in t...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms18091916

    authors: Zamberletti E,Gabaglio M,Parolaro D

    更新日期:2017-09-07 00:00:00

  • AtSK11 and AtSK12 Mediate the Mild Osmotic Stress-Induced Root Growth Response in Arabidopsis.

    abstract::Although most osmotic stresses are harmful to plant growth and development, certain drought- or polyethylene glycol (PEG)-induced mild osmotic stresses promote plant root growth. The underlying regulatory mechanisms of this response remain elusive. Here, we report that the GLYCOGEN SYNTHASE KINASE 3 (GSK3) genes ARABI...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21113991

    authors: Dong L,Wang Z,Liu J,Wang X

    更新日期:2020-06-02 00:00:00

  • Insights into the Antimicrobial Mechanism of Action of Human RNase6: Structural Determinants for Bacterial Cell Agglutination and Membrane Permeation.

    abstract::Human Ribonuclease 6 is a secreted protein belonging to the ribonuclease A (RNaseA) superfamily, a vertebrate specific family suggested to arise with an ancestral host defense role. Tissue distribution analysis revealed its expression in innate cell types, showing abundance in monocytes and neutrophils. Recent evidenc...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms17040552

    authors: Pulido D,Arranz-Trullén J,Prats-Ejarque G,Velázquez D,Torrent M,Moussaoui M,Boix E

    更新日期:2016-04-13 00:00:00

  • Sequence of Polyurethane Ionomers Determinative for Core Structure of Surfactant-Copolymer Complexes.

    abstract::The core of micelles self-assembled from amphiphiles is hydrophobic and contains little water, whereas complex coacervate core micelles co-assembled from oppositely charged hydrophilic polymers have a hydrophilic core with a high water content. Co-assembly of ionic surfactants with ionic-neutral copolymers yields surf...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms22010337

    authors: Timmers EM,Magana JR,Schoenmakers SMC,Fransen PM,Janssen HM,Voets IK

    更新日期:2020-12-30 00:00:00

  • The critical role of potassium in plant stress response.

    abstract::Agricultural production continues to be constrained by a number of biotic and abiotic factors that can reduce crop yield quantity and quality. Potassium (K) is an essential nutrient that affects most of the biochemical and physiological processes that influence plant growth and metabolism. It also contributes to the s...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms14047370

    authors: Wang M,Zheng Q,Shen Q,Guo S

    更新日期:2013-04-02 00:00:00

  • Potential Use of Biotherapeutic Bacteria to Target Colorectal Cancer-Associated Taxa.

    abstract::The role of the gut microbiome in human health and disease is the focus of much attention. It has been widely agreed upon that our gut bacteria play a role in host immunity, nutrient absorption, digestion, metabolism, and other key drivers of health. Furthermore, certain microbial signatures and specific taxa have als...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21030924

    authors: Lawrence GW,Begley M,Cotter PD,Guinane CM

    更新日期:2020-01-30 00:00:00

  • Mesenchymal Stem Cells: Cell Fate Decision to Osteoblast or Adipocyte and Application in Osteoporosis Treatment.

    abstract::Osteoporosis is a progressive skeletal disease characterized by decreased bone mass and degraded bone microstructure, which leads to increased bone fragility and risks of bone fracture. Osteoporosis is generally age related and has become a major disease of the world. Uncovering the molecular mechanisms underlying ost...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms19020360

    authors: Hu L,Yin C,Zhao F,Ali A,Ma J,Qian A

    更新日期:2018-01-25 00:00:00

  • Proteomics Analysis of Early Developmental Stages of Zebrafish Embryos.

    abstract::Zebrafish is a well-recognized organism for investigating vertebrate development and human diseases. However, the data on zebrafish proteome are scarce, particularly during embryogenesis. This is mostly due to the overwhelming abundance of egg yolk proteins, which tend to mask the detectable presence of less abundant ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20246359

    authors: Purushothaman K,Das PP,Presslauer C,Lim TK,Johansen SD,Lin Q,Babiak I

    更新日期:2019-12-17 00:00:00

  • Verticillium dahliae VdTHI20, Involved in Pyrimidine Biosynthesis, Is Required for DNA Repair Functions and Pathogenicity.

    abstract::Verticillium dahliae (V. dahliae) infects roots and colonizes the vascular vessels of host plants, significantly reducing the economic yield of cotton and other crops. In this study, the protein VdTHI20, which is involved in the thiamine biosynthesis pathway, was characterized by knocking out the corresponding VdTHI20...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21041378

    authors: Qin T,Hao W,Sun R,Li Y,Wang Y,Wei C,Dong T,Wu B,Dong N,Wang W,Sun J,Yang Q,Zhang Y,Yang S,Wang Q

    更新日期:2020-02-18 00:00:00

  • Renal Sympathetic Nerve-Derived Signaling in Acute and Chronic kidney Diseases.

    abstract::The kidney is innervated by afferent sensory and efferent sympathetic nerve fibers. Norepinephrine (NE) is the primary neurotransmitter for post-ganglionic sympathetic adrenergic nerves, and its signaling, regulated through adrenergic receptors (AR), modulates renal function and pathophysiology under disease condition...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21051647

    authors: Noh MR,Jang HS,Kim J,Padanilam BJ

    更新日期:2020-02-28 00:00:00

  • DNA repair gene XRCC4 codon 247 polymorphism modified diffusely infiltrating astrocytoma risk and prognosis.

    abstract::The DNA repair gene X-ray cross-complementary group 4 (XRCC4), an important caretaker of the overall genome stability, is thought to play a major role in human tumorigenesis. We investigated the association between an important polymorphic variant of this gene at codon 247 (rs373409) and diffusely infiltrating astrocy...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms15010250

    authors: Lin ZH,Chen JC,Wang YS,Huang TJ,Wang J,Long XD

    更新日期:2013-12-27 00:00:00

  • Functional Characterization of Waterlogging and Heat Stresses Tolerance Gene Pyruvate decarboxylase 2 from Actinidia deliciosa.

    abstract::A previous report showed that both Pyruvatedecarboxylase (PDC) genes were significantly upregulated in kiwifruit after waterlogging treatment using Illumina sequencing technology, and that the kiwifruit AdPDC1 gene was required during waterlogging, but might not be required during other environmental stresses. Here, t...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms18112377

    authors: Luo HT,Zhang JY,Wang G,Jia ZH,Huang SN,Wang T,Guo ZR

    更新日期:2017-11-09 00:00:00

  • Regulation of Autophagic Signaling by Mechanical Loading and Inflammation in Human PDL Fibroblasts.

    abstract::Autophagy (cellular self-consumption) is a crucial adaptation mechanism during cellular stress conditions. This study aimed to examine how this important process is regulated in human periodontal ligament (PDL) fibroblasts by mechanical and inflammatory stress conditions and whether the mammalian target of rapamycin (...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21249446

    authors: Blawat K,Mayr A,Hardt M,Kirschneck C,Nokhbehsaim M,Behl C,Deschner J,Jäger A,Memmert S

    更新日期:2020-12-11 00:00:00

  • Differential Regulation of Type I and Type III Interferon Signaling.

    abstract::Interferons (IFNs) are very powerful cytokines, which play a key role in combatting pathogen infections by controlling inflammation and immune response by directly inducing anti-pathogen molecular countermeasures. There are three classes of IFNs: type I, type II and type III. While type II IFN is specific for immune c...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms20061445

    authors: Stanifer ML,Pervolaraki K,Boulant S

    更新日期:2019-03-21 00:00:00

  • Resistance to Spot Blotch in Two Mapping Populations of Common Wheat Is Controlled by Multiple QTL of Minor Effects.

    abstract::Spot blotch (SB) is an important fungal disease of wheat in South Asia and South America. Host resistance is regarded as an economical and environmentally friendly approach of controlling SB, and the inheritance of resistance is mostly quantitative. In order to gain a better understanding on the SB resistance mechanis...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms19124054

    authors: Singh PK,He X,Sansaloni CP,Juliana P,Dreisigacker S,Duveiller E,Kumar U,Joshi AK,Singh RP

    更新日期:2018-12-14 00:00:00

  • Oxaloacetate Ameliorates Chemical Liver Injury via Oxidative Stress Reduction and Enhancement of Bioenergetic Fluxes.

    abstract::Chemical injury is partly due to free radical lipid peroxidation, which can induce oxidative stress and produce a large number of reactive oxygen species (ROS). Oxaloacetic acid is an important intermediary in the tricarboxylic acid cycle (TCA cycle) and participates in metabolism and energy production. In our study, ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms19061626

    authors: Kuang Y,Han X,Xu M,Wang Y,Zhao Y,Yang Q

    更新日期:2018-05-31 00:00:00

  • Autologous Platelet Concentrates in Treatment of Furcation Defects-A Systematic Review and Meta-Analysis.

    abstract:BACKGROUND:The aim of this review was to evaluate the adjunctive effect of autologous platelet concentrates (APCs) for the treatment of furcation defects, in terms of scientific quality of the clinical trials and regeneration parameters assessment. METHODS:A systematic search was carried out in the electronic database...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,meta分析

    doi:10.3390/ijms20061347

    authors: Panda S,Karanxha L,Goker F,Satpathy A,Taschieri S,Francetti L,Das AC,Kumar M,Panda S,Fabbro MD

    更新日期:2019-03-17 00:00:00

  • Detection of Antigen-Specific T Cells Using In Situ MHC Tetramer Staining.

    abstract::The development of in situ major histocompatibility complex (MHC) tetramer (IST) staining to detect antigen (Ag)-specific T cells in tissues has radically revolutionized our knowledge of the local cellular immune response to viral and bacterial infections, cancers, and autoimmunity. IST combined with immunohistochemis...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms20205165

    authors: Abdelaal HM,Cartwright EK,Skinner PJ

    更新日期:2019-10-18 00:00:00

  • IGF-1 Deficiency Rescue and Intracellular Calcium Blockade Improves Survival and Corresponding Mechanisms in a Mouse Model of Acute Kidney Injury.

    abstract::This study was undertaken to test two therapies for acute kidney injury (AKI) prevention, IGF-1, which is renal protective, and BTP-2, which is a calcium entry (SOCE) inhibitor. We utilized lipopolysaccharide (LPS) IP, as a systemic model of AKI and studied in five groups of animals. Three experiments showed that at 7...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21114095

    authors: Wasnik S,Tang X,Bi H,Abdipour A,E Carreon E,Sutjiadi B,Lyu J,Zhang J,Wilson S,Baylink DJ

    更新日期:2020-06-08 00:00:00

  • TRAF6 Silencing Attenuates Multiple Myeloma Cell Adhesion to Bone Marrow Stromal Cells.

    abstract::The bone marrow (BM) microenvironment plays an important role in supporting proliferation, survival and drug resistance of Multiple Myeloma (MM) cells. MM cells adhere to bone marrow stromal cells leading to the activation of tumour-promoting signaling pathways. Activation of the NFκB pathway, in particular, is centra...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20030702

    authors: Morgan JJ,McAvera RM,Crawford LJ

    更新日期:2019-02-06 00:00:00

  • LARP6 Meets Collagen mRNA: Specific Regulation of Type I Collagen Expression.

    abstract::Type I collagen is the most abundant structural protein in all vertebrates, but its constitutive rate of synthesis is low due to long half-life of the protein (60-70 days). However, several hundred fold increased production of type I collagen is often seen in reparative or reactive fibrosis. The mechanism which is res...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms17030419

    authors: Zhang Y,Stefanovic B

    更新日期:2016-03-22 00:00:00

  • Extracellular Vesicles, Influential Players of Intercellular Communication within Adult Neurogenic Niches.

    abstract::Adult neurogenesis, involving the generation of functional neurons from adult neural stem cells (NSCs), occurs constitutively in discrete brain regions such as hippocampus, sub-ventricular zone (SVZ) and hypothalamus. The intrinsic structural plasticity of the neurogenic process allows the adult brain to face the cont...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21228819

    authors: Losurdo M,Grilli M

    更新日期:2020-11-21 00:00:00

  • Adenosine Receptor Profiling Reveals an Association between the Presence of Spare Receptors and Cardiovascular Disorders.

    abstract::Adenosine and its receptors exert a potent control on the cardiovascular system. This review aims to present emerging experimental evidence supporting the existence and implication in cardiovascular disorders of specific adenosinergic pharmacological profiles, conforming to the concept of "receptor reserve", also know...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms20235964

    authors: Fenouillet E,Mottola G,Kipson N,Paganelli F,Guieu R,Ruf J

    更新日期:2019-11-27 00:00:00

  • Aberrant expression of posterior HOX genes in well differentiated histotypes of thyroid cancers.

    abstract::Molecular etiology of thyroid cancers has been widely studied, and several molecular alterations have been identified mainly associated with follicular and papillary histotypes. However, the molecular bases of the complex pathogenesis of thyroid carcinomas remain poorly understood. HOX genes regulate normal embryonic ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms141121727

    authors: Cantile M,Scognamiglio G,La Sala L,La Mantia E,Scaramuzza V,Valentino E,Tatangelo F,Losito S,Pezzullo L,Chiofalo MG,Fulciniti F,Franco R,Botti G

    更新日期:2013-11-01 00:00:00

  • Cellular Localization of Wheat High Molecular Weight Glutenin Subunits in Transgenic Rice Grain.

    abstract::Rice (Oryza sativa L.) is a primary global food cereal. However, when compared to wheat, rice has poor food processing qualities. Dough that is made from rice flour has low viscoelasticity because rice seed lacks storage proteins that are comparable to gluten protein from wheat. Thus, current research efforts aim to i...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms18112458

    authors: Jo YM,Cho K,Lee HJ,Lim SH,Kim JS,Kim YM,Lee JY

    更新日期:2017-11-18 00:00:00

  • Antiproliferative effects of cucurbitacin B in breast cancer cells: down-regulation of the c-Myc/hTERT/telomerase pathway and obstruction of the cell cycle.

    abstract::Naturally occurring cucurbitacins have been shown to have anticancer, antimicrobial and anti-inflammatory activities. In this study, we determined the effects of cucurbitacin B extracted from the Thai herb Trichosanthes cucumerina L. on telomerase regulation in three human breast cancer cell lines (T47D, SKBR-3, and M...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms11125323

    authors: Duangmano S,Dakeng S,Jiratchariyakul W,Suksamrarn A,Smith DR,Patmasiriwat P

    更新日期:2010-01-01 00:00:00

  • Screening the Marker Components in Psoralea corylifolia L. with the Aids of Spectrum-Effect Relationship and Component Knock-Out by UPLC-MS².

    abstract::Psoralea corylifolia L., (P. corylifolia), which is used for treating vitiligo in clinic, shows inhibitory and activating effects on tyrosinase, a rate-limiting enzyme of melanogenesis. This study aimed to determine the active ingredients in the ethenal extracts of P. corylifolia on tyrosinase activity. The spectrum-e...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms19113439

    authors: Shi M,Zhang Y,Song M,Sun Y,Li C,Kang W

    更新日期:2018-11-02 00:00:00

  • Differentiation of Adsorptive and Viscous Effects of Dietary Fibres on Bile Acid Release by Means of In Vitro Digestion and Dialysis.

    abstract::To explain the cholesterol-reducing effects of dietary fibres, one of the major mechanisms proposed is the reduced reabsorption of bile acids in the ileum. The interaction of dietary fibres with bile acids is associated with their viscous or adsorptive effects. Since these fibre characteristics are difficult to invest...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms19082193

    authors: Naumann S,Schweiggert-Weisz U,Bader-Mittermaier S,Haller D,Eisner P

    更新日期:2018-07-27 00:00:00

  • Rice Genome Resequencing Reveals a Major Quantitative Trait Locus for Resistance to Bakanae Disease Caused by Fusarium fujikuroi.

    abstract::Bakanae disease (BD), caused by the fungal pathogen Fusarium fujikuroi, has become a serious threat in rice-cultivating regions worldwide. In the present study, quantitative trait locus (QTL) mapping was performed using F2 and F3 plants derived after crossing a BD-resistant and a BD-susceptible Korean japonica rice va...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20102598

    authors: Kang DY,Cheon KS,Oh J,Oh H,Kim SL,Kim N,Lee E,Choi I,Baek J,Kim KH,Chung NJ,Ji H

    更新日期:2019-05-27 00:00:00