Abstract：
:The development of neural circuits is a complex process that relies on the proper navigation of axons through their environment to their appropriate targets. While axon-environment and axon-target interactions have long been known as essential for circuit formation, communication between axons themselves has only more recently emerged as another crucial mechanism. Trans-axonal signaling governs many axonal behaviors, including fasciculation for proper guidance to targets, defasciculation for pathfinding at important choice points, repulsion along and within tracts for pre-target sorting and target selection, repulsion at the target for precise synaptic connectivity, and potentially selective degeneration for circuit refinement. This review outlines the recent advances in identifying the molecular mechanisms of trans-axonal signaling and discusses the role of axon-axon interactions during the different steps of neural circuit formation.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Spead O,Poulain FEdoi
10.3390/ijms21145170subject
Has Abstractpub_date
2020-07-21 00:00:00issue
14issn
1422-0067pii
ijms21145170journal_volume
21pub_type
杂志文章,评审abstract：:Persistent inflammation is a complication associated with many ocular diseases. Changes in ocular vessels can amplify disease responses and contribute to vision loss by influencing the delivery of leukocytes to the eye, vascular leakage, and perfusion. Here, we report the anti-inflammatory activity for AXT107, a non-R...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21145142
更新日期：2020-07-21 00:00:00
abstract：:The silencing of thyroid-related genes presents difficulties in radioiodine therapy for anaplastic thyroid cancers (ATCs). Tunicamycin (TM), an N-linked glycosylation inhibitor, is an anticancer drug. Herein, we investigated TM-induced restoration of responsiveness to radioiodine therapy in radioiodine refractory ATCs...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22031077
更新日期：2021-01-22 00:00:00
abstract：:Sugars, which are important signaling molecules, regulate diverse biological processes in plants. However, the convergent regulatory mechanisms governing these physiological activities have not been fully elucidated. MODIFIER OF snc1-1 (MOS1), a modulator of plant immunity, also regulates floral transition, cell cycle...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21197095
更新日期：2020-09-26 00:00:00
abstract：:Nitrogen (N) is essential for plant growth and crop productivity. Organic N is a major form of remobilized N in plants' response to N limitation. It is necessary to understand the regulatory role of N limitation adaption (NLA) in organic N remobilization for this adaptive response. Transcriptional and proteomic analys...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21062171
更新日期：2020-03-21 00:00:00
abstract：:One of the most common causes of mortality and morbidity in children is perinatal hypoxia-ischemia (HI). In spite of the advances in neonatology, its incidence is not diminishing, generating a pediatric population that will require an extended amount of chronic care throughout their lifetime. For this reason, new and ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms14059379
更新日期：2013-04-29 00:00:00
abstract：:Civilization diseases associated with memory disorders are important health problems occurring due to a prolonged life span. The manuscript shows the results of an in vivo study targeting the emergence of two drug candidates with anti-amnestic properties. The preceding quantitative structure-activity relationship (QSA...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18122511
更新日期：2017-11-24 00:00:00
abstract：:Due to its health benefits, resveratrol (RE) is one of the most researched natural polyphenols. Resveratrol's health benefits were first highlighted in the early 1990s in the French paradox study, which opened extensive research activity into this compound. Ever since, several pharmacological activities including anti...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21062084
更新日期：2020-03-18 00:00:00
abstract：:Intrinsically disordered proteins (IDPs) do not have rigid 3D structures, showing changes in their folding depending on the environment or ligands. Intrinsically disordered proteins are widely spread in eukaryotic genomes, and these proteins participate in many cell regulatory metabolism processes. Some IDPs, when abe...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20061322
更新日期：2019-03-15 00:00:00
abstract：:Gain-of-function mutations in human androgen receptor (AR) are among the major causes of drug resistance in prostate cancer (PCa). Identifying mutations that cause resistant phenotype is of critical importance for guiding treatment protocols, as well as for designing drugs that do not elicit adverse responses. However...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21165847
更新日期：2020-08-14 00:00:00
abstract：:In this report, the effects of two oligochitosans, i.e., oligochitosan A (OCHA) and oligochitosan B (OCHB), on control of dry rot of Zanthoxylum bungeanum (Z. bungeanum) caused by Fusarium sambucinum (F. sambucinum) were evaluated. First, both oligochitosans show desirable ability to decrease the infection of F. sambu...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17071044
更新日期：2016-06-30 00:00:00
abstract：:Chronic hepatitis C is a serious liver disease that often results in cirrhosis or hepatocellular carcinoma. The aim of this study was to assess the association of human leukocyte antigen-DP (HLA-DP) variants with risk of chronic hepatitis C virus (HCV) or anti-F antibody generation. We selected two single nucleotide p...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms15069826
更新日期：2014-06-03 00:00:00
abstract：:Maize can form symbiotic relationships with arbuscular mycorrhiza (AM) fungus to increase productivity and resistance, but the miRNAs in maize responsible for this process have not been discovered. In this study, 155 known and 28 novel miRNAs were identified by performing high-throughput sequencing of sRNA in maize ro...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19103201
更新日期：2018-10-16 00:00:00
abstract：:The edible and medicinal perennial herb Aster scaber is known to have anticancer, antioxidant, and immunomodulatory properties. However, the biological effects of its polysaccharides are not well understood. Here, we aimed to extract novel polysaccharides with enhanced biological properties from Aster scaber using enz...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19092839
更新日期：2018-09-19 00:00:00
abstract：:One of the most important adaptations of seagrasses during sea colonization was the capacity to grow at the low micromolar nitrate concentrations present in the sea. In contrast to terrestrial plants that use H+ symporters for high-affinity NO3- uptake, seagrasses such as Zostera marina L. use a Na+-dependent high-aff...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20153650
更新日期：2019-07-26 00:00:00
abstract：:Benzo[a]pyrene (B[a]P), a polycyclic aromatic hydrocarbon, is a group 1 carcinogen that introduces mutagenic DNA adducts into the genome. In this study, we investigated the molecular mechanisms underlying the involvement of silymarin in the reduction of DNA adduct formation by B[a]P-7,8-dihydrodiol-9,10-epoxide (BPDE)...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21072369
更新日期：2020-03-30 00:00:00
abstract：:As a response to environmental changes driven by the Earth's axial rotation, most organisms evolved an internal biological timer-the so called circadian clock-which regulates physiology and behavior in a rhythmic fashion. Emerging evidence suggests an intimate interplay between the circadian clock and another fundamen...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18040873
更新日期：2017-04-20 00:00:00
abstract：:The plant disease Phytophthora blight, caused by the oomycete pathogen Phytophthora capsici, is responsible for major economic losses in pepper production. Microtubules have been an attractive target for many antifungal agents as they are involved in key cellular events such as cell proliferation, signaling, and migra...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20112641
更新日期：2019-05-29 00:00:00
abstract：:Over the last few decades, vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) have emerged as multifaceted players in not only the pathogenesis, but potential treatment, of numerous diseases. They activate diverse intracellular signaling cascades known to have extensive crosstalk, a...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms11082875
更新日期：2010-08-05 00:00:00
abstract：:Presently, many studies have focused on exploring in silico approaches in the identification and development of alternative therapy for the treatment and management of cancer. Solute carrier family-2-member-4-gene (Slc2a4) which encodes glucose transporter 4 protein (GLUT4), has been identified as a promising therapeu...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19020386
更新日期：2018-01-28 00:00:00
abstract：:B-lymphocyte differentiation is one of the best understood developmental pathways in the hematopoietic system. Our understanding of the developmental trajectories linking the multipotent hematopoietic stem cell to the mature functional B-lymphocyte is extensive as a result of efforts to identify and prospectively isol...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19071928
更新日期：2018-06-30 00:00:00
abstract：:The variable nature of vascular dysfunction in diabetes is not well understood. We explored the functional adaptation of different arteries in db/db mice in relation to increased severity and duration of diabetes. We compared endothelium-dependent and -independent vasodilation in the aortae, as well as the carotid and...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21176147
更新日期：2020-08-26 00:00:00
abstract：:Collagen prolyl 4-hydroxylase 1 (C-P4H1) is an α-ketoglutarate (α-KG)-dependent dioxygenase that catalyzes 4-hydroxylation of proline on collagen. C-P4H1-induced prolyl hydroxylation is required for proper collagen deposition and cancer metastasis. Therefore, targeting C-P4H1 is considered a potential therapeutic stra...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21186613
更新日期：2020-09-10 00:00:00
abstract：:Lung cancer is the most common cancer worldwide. Disappointingly, despite great effort in encouraging screening or, at least, a close surveillance of high-risk individuals, most of lung cancers are diagnosed when already surgically unresectable because of local advancement or metastasis. In these cases, the treatment ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18071374
更新日期：2017-06-27 00:00:00
abstract：:Powdery mildew caused by Blumeria graminis f. sp. hordei (Bgh) is one of the most serious diseases in barley. The numerous barley varieties across China provide valuable genetic resources to screen the resistant germplasm and to discover the primary genes of resistance to powdery mildew. In this study, Chinese barley ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21010151
更新日期：2019-12-24 00:00:00
abstract：:The endocannabinoid system is a component of the neuroprotective mechanisms that an organism displays after traumatic brain injury (TBI). A diurnal variation in several components of this system has been reported. This variation may influence the recovery and survival rate after TBI. We have previously reported that t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms141223341
更新日期：2013-11-27 00:00:00
abstract：:The development of stimulus-responsive photosensitizer delivery systems that carry a high payload of photosensitizers is of great importance in photodynamic therapy. In this study, redox-responsive polysilsesquioxane nanoparticles (PSilQNPs) built by a reverse microemulsion approach using 5,10,15,20-tetrakis(carboxyph...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17010056
更新日期：2015-12-31 00:00:00
abstract：:Cadmium (Cd) is an anthropogenic as well as a naturally occurring toxicant associated with prediabetes and T2DM in humans and experimental models of Cd exposure. However, relatively few studies have examined the mechanism(s) of Cd-induced hyperglycemia. The purpose of this study was to examine the role of pancreatic i...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22010360
更新日期：2020-12-31 00:00:00
abstract：:Although the application of cardioprotective ischaemia/reperfusion (I/R) stimuli after myocardial infarction (MI) is a promising concept for salvaging the myocardium, translation to a clinical scenario has not fulfilled expectations. We have previously shown that in pigs, ischaemic postconditioning (IPostC) reduces my...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20020344
更新日期：2019-01-15 00:00:00
abstract：:Pepper originated from the Capsicum genus, which is recognized as one of the most predominant and globally distributed genera of the Solanaceae family. It is a diverse genus, consisting of more than 31 different species including five domesticated species, Capsicum baccatum, C. annuum, C. pubescen, C. frutescens, and ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21155179
更新日期：2020-07-22 00:00:00
abstract：:Protein-protein interactions are important for biochemical processes in biological systems. The 3D structure of the macromolecular complex resulting from the protein-protein association is a very useful source to understand its specific functions. This work focuses on computational study for protein-protein docking, w...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms9010065
更新日期：2008-01-01 00:00:00
