Abstract：
:A series of novel purpurinimides with long wavelength absorption were designed and synthesized to develop novel and potential photosensitizers. These compounds were investigated through reduction, oxidation, rearrangement reaction and amidation reactions of methyl pheophorbide a. They demonstrated a considerable bathochromic shift of the major absorption band in the red region of the optical spectrum (695-704 nm). Newly synthesized purpurinimides were screened for their antitumor activities, and showed higher photodynamic efficiency against A549 cell lines as compared to purpurin-18 methyl ester. The results revealed the novel purpurinimides could be potential photosensitizers.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Cui BC,Yoon I,Li JZ,Lee WK,Shim YKdoi
10.3390/ijms15058091subject
Has Abstractpub_date
2014-05-08 00:00:00pages
8091-105issue
5issn
1422-0067pii
ijms15058091journal_volume
15pub_type
杂志文章abstract：:Apolipoprotein E (APOE) ε4 gene allele and type 2 diabetes mellitus (T2DM) are prime risk factors for Alzheimer's disease (AD). Despite evidence linking T2DM and apoE4, the mechanism underlying their interaction is yet to be determined. In the present study, we employed a model of APOE-targeted replacement mice and hi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
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abstract：:Agricultural production continues to be constrained by a number of biotic and abiotic factors that can reduce crop yield quantity and quality. Potassium (K) is an essential nutrient that affects most of the biochemical and physiological processes that influence plant growth and metabolism. It also contributes to the s...
journal_title：International journal of molecular sciences
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更新日期：2013-04-02 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2016-03-15 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2017-11-28 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2018-12-13 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2018-04-09 00:00:00
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pub_type： 杂志文章
doi：10.3390/ijms13021733
更新日期：2012-01-01 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2013-03-18 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2014-11-25 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2017-06-26 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2020-06-24 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2017-02-20 00:00:00
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