Abstract：
:Small RNAs are essential for a variety of cellular functions. Argonaute (AGO) proteins are associated with all of the different classes of small RNAs, and are indispensable in small RNA-mediated regulatory pathways. AGO proteins have been identified in various types of stem cells in diverse species from plants and animals. This review article highlights recent progress on how AGO proteins and AGO-bound small RNAs regulate the self-renewal and differentiation of distinct stem cell types, including pluripotent, germline, somatic, and cancer stem cells.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Zhai L,Wang L,Teng F,Zhou L,Zhang W,Xiao J,Liu Y,Deng Wdoi
10.3390/ijms17020208subject
Has Abstractpub_date
2016-02-04 00:00:00pages
208issue
2issn
1422-0067pii
ijms17020208journal_volume
17pub_type
杂志文章,评审abstract：:The mitogen-activated protein kinase-activated protein kinase MK5 is a substrate of the mitogen-activated protein kinases p38, ERK3 and ERK4. Cell culture and animal studies have demonstrated that MK5 is involved in tumour suppression and promotion, embryogenesis, anxiety, cell motility and cell cycle regulation. In t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms15034878
更新日期：2014-03-19 00:00:00
abstract：:Hemophilia A (HA) is associated with defects in the F8 gene, encoding coagulation factor VIII (FVIII). Our previous studies show that F8-targeting micro RNAs (miRNAs), a group of small RNAs involved in gene regulation, can downregulate F8 expression causing HA in individuals with normal F8-genotypes and increased HA s...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21165621
更新日期：2020-08-06 00:00:00
abstract：:WRKY transcription factors constitute one of the largest transcription factor families in plants, and play crucial roles in plant growth and development, defense regulation and stress responses. However, knowledge about this family in maize is limited. In the present study, we identified a drought-induced WRKY gene, Z...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19103046
更新日期：2018-10-06 00:00:00
abstract：:An imbalance of excitatory and inhibitory neurotransmission leading to over excitation plays a crucial role in generating seizures, while enhancing GABAergic mechanisms are critical in terminating seizures. In recent years, it has been reported in many studies that astrocytes are deeply involved in synaptic transmissi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20122964
更新日期：2019-06-18 00:00:00
abstract：:Point mutations in genes encoding isoforms of skeletal muscle tropomyosin may cause nemaline myopathy, cap myopathy (Cap), congenital fiber-type disproportion (CFTD), and distal arthrogryposis. The molecular mechanisms of muscle dysfunction in these diseases remain unclear. We studied the effect of the E173A, R90P, E1...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19123975
更新日期：2018-12-10 00:00:00
abstract：:The establishment of a proangiogenic phenotype and epithelial-to-mesenchymal transition (EMT) are considered as critical events that promote the induction of invasive growth in epithelial tumors, and stimulation of lymphangiogenesis is believed to confer the capacity for early dissemination to cancer cells. Recent res...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21186515
更新日期：2020-09-06 00:00:00
abstract：:Hepatitis C virus (HCV) is an RNA virus that can efficiently establish chronic infection in humans. The overlap between the HCV replication cycle and lipid metabolism is considered to be one of the primary means by which HCV efficiently develops chronic infections. In the blood, HCV is complex with lipoproteins to for...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20082037
更新日期：2019-04-25 00:00:00
abstract：:Glutamine synthetase 2 (GS2) is a key enzyme involved in the ammonium metabolism in plant leaves. In our previous study, we obtained GS2-cosuppressed plants, which displayed a normal growth phenotype at the seedling stage, while at the tillering stage they showed a chlorosis phenotype. In this study, to investigate th...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160612713
更新日期：2015-06-04 00:00:00
abstract：:Hormonal dynamics after Plasmodiophora brassicae infection were compared in two Brassica napus cultivars-more resistant SY Alister and more sensitive Hornet, in order to elucidate responses associated with efficient defense. Both cultivars responded to infection by the early transient elevation of active cytokinins (p...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19124024
更新日期：2018-12-13 00:00:00
abstract：:Psoriasis is a chronic inflammatory cutaneous disease, characterized by activated plasmacytoid dendritic cells, myeloid dendritic cells, Th17 cells, and hyperproliferating keratinocytes. Recent studies revealed skin-resident cells have pivotal roles in developing psoriatic skin lesions. The balance in effector T cells...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21072582
更新日期：2020-04-08 00:00:00
abstract：:Basic fibroblast growth factor (bFGF) is a multifunctional factor in acceleration of cell proliferation, differentiation and transference, and therefore widely used in clinical applications. In this study, expression vector pWX-Nt03 harboring a codon-optimized bFGF gene was constructed and introduced into the tobacco ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17010019
更新日期：2015-12-23 00:00:00
abstract：:Due to the central role of liver tissue in partitioning and metabolizing of nutrients, molecular liver-specific alterations are of considerable interest to characterize an efficient conversion and usage of feed in livestock. To deduce tissue-specific and systemic effects on nutrient metabolism and feed efficiency (FE)...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18081674
更新日期：2017-08-01 00:00:00
abstract：:Hypoxic-ischemic encephalopathy (HIE) resulting from asphyxia in the peripartum period is the most common cause of neonatal brain damage and can result in significant neurologic sequelae, including cerebral palsy. Currently therapeutic hypothermia is the only accepted treatment in addition to supportive care for infan...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18010017
更新日期：2016-12-22 00:00:00
abstract：:Bone is a peculiar tissue subjected to a continuous process of self-renewal essential to assure the integrity of the skeleton and to explicate the endocrine functions. The study of bone diseases characterized by increased or reduced bone mass due to osteoclast alterations has been essential to understand the great rol...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20184502
更新日期：2019-09-11 00:00:00
abstract：:Cisplatin is the first-line treatment for different types of solid tumors, such as ovarian, testicular, bladder, cervical, head and neck, lung, and esophageal cancers. The main problem related to its clinical use is the onset of drug resistance. In the last decades, among the studied molecular mechanisms of cisplatin ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21030937
更新日期：2020-01-31 00:00:00
abstract：:Oxidative stress plays a key role for the development of cardiovascular, metabolic, and neurodegenerative disease. This concept has been proven by using the approach of genetic deletion of reactive oxygen and nitrogen species (RONS) producing, pro-oxidant enzymes as well as by the overexpression of RONS detoxifying, a...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21103405
更新日期：2020-05-12 00:00:00
abstract：:MicroRNAs (miRNAs) are small non-coding RNAs with a known role as mediators of gene expression in crucial biological processes, which converts them into high potential contenders in the ongoing search for effective therapeutic strategies. However, extracellular RNAs are unstable and rapidly degraded, reducing the poss...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22031105
更新日期：2021-01-22 00:00:00
abstract：:Connexin hemichannels play an important role in the control of cellular signaling and behaviors. Given that lowering extracellular Ca2+, a condition that activates hemichannels, is a well-characterized stimulator of renin in juxtaglomerular cells, we, therefore, tested a potential implication of hemichannels in the re...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21124462
更新日期：2020-06-23 00:00:00
abstract：:Acetylation of nuclear apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE1/Ref-1) is associated with its extracellular secretion, despite the lack of an N-terminal protein secretion signal. In this study, we investigated plasma membrane targeting and translocation of APE1/Ref-1 in HEK293T cells with enhanced ace...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20133178
更新日期：2019-06-28 00:00:00
abstract：:Micro Electromechanical Systems (MEMS) based microfluidic devices have gained popularity in biomedicine field over the last few years. In this paper, a comprehensive overview of microfluidic devices such as micropumps and microneedles has been presented for biomedical applications. The aim of this paper is to present ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms12063648
更新日期：2011-01-01 00:00:00
abstract：:The use of platelet-rich fibrin (PRF) is investigated in ulcer management because it provides a healing milieu rich in growth factors and cytokines. Although crucial, the relevance of secondary dressings is under-researched and no data support the use of any particular dressing in preference to another. We assessed th...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21020624
更新日期：2020-01-17 00:00:00
abstract：:Dihydroxyacetone (DHA) kinase from Citrobacter freundii provides an easy entry for the preparation of DHA phosphate; a very important C3 building block in nature. To modify the phosphoryl donor specificity of this enzyme from ATP to inorganic polyphosphate (poly-P); a directed evolution program has been initiated. In ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms161126073
更新日期：2015-11-24 00:00:00
abstract：:Double-spikes Phalaenopsis orchids have greater market value than those with single-spike. In this study, a gene designated as Spike Activator 1 (SPK1), which encodes a basic helix-loop-helix (bHLH) transcription factor, was isolated and characterized from Phalaenopsis aphrodite (moth orchid). SPK1 was highly expresse...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20215406
更新日期：2019-10-30 00:00:00
abstract：:Realizing the full potential of magnetic nanoparticles (MNPs) in nanomedicine requires the optimization of their physical and chemical properties. Elucidation of the effects of these properties on clinical diagnostic or therapeutic properties, however, requires the synthesis or purification of homogenous samples, whic...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160820001
更新日期：2015-08-21 00:00:00
abstract：:The frequency and volume of Asian sand dust (ASD) (Kosa) are increasing in Japan, and it has been reported that ASD may cause adverse respiratory effects. The pulmonary toxicity of ASD has been previously analyzed in mice exposed to ASD particles by intratracheal instillation. To study the pulmonary toxicity induced b...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19020416
更新日期：2018-01-31 00:00:00
abstract：:Poly(glutamic acid) has been studied with a nanosecond T-jump experiment. A new experimental set-up based on the frequency-quadrupling of an 82 MHz Titanium-Sapphire laser allows rapid CD measurements to be performed. Combining time-resolved absorption and circular dichroism at 204 and 220 nm, we are able to measure p...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13022239
更新日期：2012-01-01 00:00:00
abstract：:Non-alcoholic steatohepatitis (NASH) is characterized by the presence of steatosis, inflammation and hepatocyte injury and constitutes hepatic manifestation of the metabolic syndrome. The pathogenesis of NASH is complex and implicates cross-talk between different metabolically active sites, such as liver and adipose t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms141019867
更新日期：2013-10-01 00:00:00
abstract：:Two new ergostane-type sterols; (22E)-5α,6α-epoxyergosta-8,14,22-triene-3β,7β-diol (1) and 5α,6α-epoxyergost-8(14)-ene-3β,7α-diol (2) were isolated from the fruiting bodies of king trumpet mushroom (Pleurotus eryngii), along with eight known compounds (3-10). All isolated compounds were evaluated for their inhibitory ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18112479
更新日期：2017-11-21 00:00:00
abstract：:We investigated TLR10 expression in human monocytes, THP-1 cells, cultured in hypoxia (3% O(2)). Levels of both TLR10 mRNA and protein in THP-1 cells cultured in hypoxia were significantly higher than those cultured in normoxia (20% O(2)). We examined intracellular reactive oxygen species (ROS) content in hypoxic cell...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms11103769
更新日期：2010-09-29 00:00:00
abstract：:Addition of hydrogen peroxide (H2O2) is a method commonly used to trigger cellular oxidative stress. However, the doses used (often hundreds of micromolar) are disproportionally high with regard to physiological oxygen concentration (low micromolar). In this study using polarographic measurement of oxygen concentratio...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21239149
更新日期：2020-11-30 00:00:00
