Abstract:
:Many microbial ecology studies have demonstrated profound changes in community composition caused by environmental pollution, as well as adaptation processes allowing survival of microbes in polluted ecosystems. Soil microbial communities in polluted areas with a long-term history of contamination have been shown to maintain their function by developing metal-tolerance mechanisms. In the present work, we review recent experiments, with specific emphasis on studies that have been conducted in polluted areas with a long-term history of contamination that also applied DNA-based approaches. We evaluate how the "costs" of adaptation to metals affect the responses of metal-tolerant communities to other stress factors ("stress-on-stress"). We discuss recent studies on the stability of microbial communities, in terms of resistance and resilience to additional stressors, focusing on metal pollution as the initial stress, and discuss possible factors influencing the functional and structural stability of microbial communities towards secondary stressors. There is increasing evidence that the history of environmental conditions and disturbance regimes play central roles in responses of microbial communities towards secondary stressors.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Azarbad H,van Gestel CA,Niklińska M,Laskowski R,Röling WF,van Straalen NMdoi
10.3390/ijms17060933subject
Has Abstractpub_date
2016-06-14 00:00:00issue
6issn
1422-0067pii
ijms17060933journal_volume
17pub_type
杂志文章,评审abstract::The prostate gland contains a high level of intracellular zinc, which is dramatically diminished during prostate cancer (PCa) development. Owing to the unclear role of zinc in this process, therapeutic applications using zinc are limited. This study aimed to clarify the role of zinc and its underlying mechanism in the...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19103062
更新日期:2018-10-08 00:00:00
abstract::Zebrafish is a well-recognized organism for investigating vertebrate development and human diseases. However, the data on zebrafish proteome are scarce, particularly during embryogenesis. This is mostly due to the overwhelming abundance of egg yolk proteins, which tend to mask the detectable presence of less abundant ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20246359
更新日期:2019-12-17 00:00:00
abstract::Mango is affected by different decline disorders causing significant losses to mango growers. In the United Arab Emirates (UAE), the pathogen was isolated from all tissues sampled from diseased trees affected by Lasiodiplodia theobromae. Symptoms at early stages of the disease included general wilting appearance of ma...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18102086
更新日期:2017-10-20 00:00:00
abstract::Oxygen homeostasis regulation is the most fundamental cellular process for adjusting physiological oxygen variations, and its irregularity leads to various human diseases, including cancer. Hypoxia is closely associated with cancer development, and hypoxia/oxygen-sensing signaling plays critical roles in the modulatio...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21218162
更新日期:2020-10-31 00:00:00
abstract::Tuberculosis (TB) is a global epidemic caused by the infection of human macrophages with the world's most deadly single bacterial pathogen, Mycobacterium tuberculosis (M.tb). M.tb resides in a phagosomal niche within macrophages, where trace element concentrations impact the immune response, bacterial metal metabolism...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms18112375
更新日期:2017-11-09 00:00:00
abstract::Radiation has a wide variety of effects on the liver. Fibrosis is a concern in medical fields as one of the acute effects of high-dose irradiation, such as with cancer radiotherapies. Cancer is also an important concern following exposure to radiation. The liver has an active metabolism and reacts to radiations. In ad...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19123855
更新日期:2018-12-03 00:00:00
abstract::Although the role of platelet-rich plasma (PRP) in tissue regeneration has been confirmed in many studies, the mechanism of this process is still not fully understood. Human keratinocytes (HaCaT) cells were used as an experimental model for studies on the effects of PRP on cell proliferation, migration, collagen biosy...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22020936
更新日期:2021-01-19 00:00:00
abstract::In the central nervous system omega-3 fatty acids modulate cell signaling and affect dopaminergic and serotonergic pathways. On this basis, a new application for omega-3 fatty acids has been proposed, concerning the treatment of several psychiatric disorders. The present article is an update of a previous systematic r...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20215257
更新日期:2019-10-23 00:00:00
abstract::Maurizio Battino, Ph.D., Associate Professor of Biochemistry in the Department of Clinical Sciences, Faculty of Medicine, Università Politecnica delle Marche (Italy), is the Director of the Centre for Health and Nutrition, Universidad Europea del Atlantico (Santander, Spain) and Director of Nutrition and Health projec...
journal_title:International journal of molecular sciences
pub_type: 面试
doi:10.3390/ijms17071038
更新日期:2016-07-05 00:00:00
abstract::Three quinary polar intermetallic compounds in the (Eu(1-x)Ca(x))9In8(Ge(1-y)Sn(y))8 (x = 0.66, y = 0.03) and the (Eu(1-x)Ca(x))3In(Ge(3-y)Sn(1+y)) (x = 0.66, 0.68; y = 0.13, 0.27) phases have been synthesized using the molten In-metal flux method, and the crystal structures are characterized by powder and single-crys...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms16049017
更新日期:2015-04-22 00:00:00
abstract::The aim of this review article is to introduce the reader to the state-of-the-art of the contribution that proteomics and metabolomics sciences are currently providing for cystic fibrosis (CF) research: from the understanding of cystic fibrosis transmembrane conductance regulator (CFTR) biology to biomarker discovery ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21155439
更新日期:2020-07-30 00:00:00
abstract::In the development of drugs, we sometimes encounter fatty change of the hepatocytes (steatosis) which is not accompanied by degenerative change in the liver in non-clinical toxicity studies. In this study, we investigated the relationships between fatty change of the hepatocytes noted in non-clinical toxicity studies ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18040810
更新日期:2017-04-12 00:00:00
abstract::NAC (NAM, ATAF1/2, and CUC2) transcription factors play important roles in many biological processes, and mainly bind to the NACRS with core sequences "CACG" or "CATGTG" to regulate gene expression. However, whether NAC proteins can bind to other motifs without these core sequences remains unknown. In this study, we e...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19103271
更新日期:2018-10-21 00:00:00
abstract::Mycobacterium immunogenum, a newly identified member of the Mycobacterium chelonae_M. abscessus complex is considered a potential etiological agent for hypersensitivity pneumonitis (HP) in machine workers exposed to contaminated metalworking fluid (MWF). This study investigated the biocidal efficacy of the frequently ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms12010725
更新日期:2011-01-20 00:00:00
abstract::Non-coding RNA species contribute more than 90% of all transcripts and have gained increasing attention in the last decade. One of the most recent members of this group are long non-coding RNAs (lncRNAs) which are characterized by a length of more than 200 nucleotides and a lack of coding potential. However, in contra...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20133276
更新日期:2019-07-03 00:00:00
abstract::: Background: The aberrant expression of microRNAs (miRNAs) has been associated with several diseases, including cancer, inflammatory, and autoimmune conditions. Interest in salivary miRNAs as non-invasive tools for the diagnosis of malignancies and systemic diseases is rapidly increasing. The present systematic revie...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21030907
更新日期:2020-01-30 00:00:00
abstract::Blunt snout bream (Megalobrama amblycephala) is a widely favored herbivorous fish species and is a frequentlyused fish model for studying the metabolism physiology. This study aimed to provide a comprehensive illustration of the mechanisms of a high-starch diet (HSD) induced lipid metabolic disorder by identifying mic...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18061161
更新日期:2017-05-31 00:00:00
abstract::Well-run screening programs for cervical cancer in the population at risk have been shown to result in a sharp decrease in the incidence and mortality of cervical cancer in a number of large populations. Expression patterns of a recently identified biomarker family, microRNA, appear to be characteristic of tumor type ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms15010758
更新日期:2014-01-08 00:00:00
abstract::Dry eye syndrome is the most common eye disease and it is caused by various reasons. As the balance of the tear film that protects the eyes is broken due to various causes, it becomes impossible to properly protect the eyes. In this study, the protective effects and underlying mechanisms of topical (E)-4-(2-(6-(2,6-di...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21103729
更新日期:2020-05-25 00:00:00
abstract::Osteoarthritis (OA) is the most common type of arthritis that occurs in an aged population. It affects any joints in the body and degenerates the articular cartilage and the subchondral bone. Despite the pathophysiology of OA being different, cartilage resorption is still a symbol of osteoarthritis. Matrix metalloprot...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21144931
更新日期:2020-07-13 00:00:00
abstract::Coffee is a popular drink consumed all over the world. Besides its long-recognized stimulant effect, it has important nutritional and health effects. However, the type of bean processing modifies the composition of brewed coffee and possibly its bioactivity. In this study, extracts obtained from green and roasted bean...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19113407
更新日期:2018-10-31 00:00:00
abstract:BACKGROUND:Growth failure and delayed puberty are well known features of children and adolescents with inflammatory bowel disease (IBD), in addition to the chronic course of the disease. Urinary metabonomics was applied in order to better understand metabolic changes between healthy and IBD children. METHODS:21 Pediat...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms17081310
更新日期:2016-08-11 00:00:00
abstract::Fumarylacetoacetate hydrolase (FAH) is the last enzyme in the degradation pathway of the amino acids tyrosine and phenylalanine in mammals that catalyzes the hydrolysis of 4-fumarylacetoacetate into acetoacetate and fumarate. Mutations of the FAH gene are associated with hereditary tyrosinemia type I (HT1), resulting ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21228719
更新日期:2020-11-18 00:00:00
abstract::(1) The TBX2 subfamily of transcription factors (TBXs 2, 3, 4 and 5) are markedly down-regulated in human non-small cell lung cancer (NSCLC) and exert tumor suppressor effects in lung malignancy. Yet, mechanisms underlying suppressed expression of the TBX2 subfamily in NSCLC are elusive. Here, we interrogated probable...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20051159
更新日期:2019-03-07 00:00:00
abstract::The last step in the biosynthesis of flavin adenine dinucleotide (FAD) is considered a target for the design of antimicrobial drugs because it is carried out by two non-homologous proteins in eukaryotic and prokaryotic organisms. Monofunctional FMN: adenylyltransferases (FMNAT) in Eukarya and FMNAT modules of bifuncti...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21103738
更新日期:2020-05-25 00:00:00
abstract:BACKGROUND:It is well known that diabetes mellitus impairs immunity and therefore is an independent risk factor for tuberculosis. However, the influence of associated metabolic factors, such as hypertension, dyslipidemia and gout has yet to be confirmed. This study aimed to investigate whether the strong association be...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms160511369
更新日期:2015-05-18 00:00:00
abstract::Fractalkine/CX3C chemokine ligand 1 (CX3CL1) is a chemokine involved in the anticancer function of lymphocytes-mainly NK cells, T cells and dendritic cells. Its increased levels in tumors improve the prognosis for cancer patients, although it is also associated with a poorer prognosis in some types of cancers, such as...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21103723
更新日期:2020-05-25 00:00:00
abstract::Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder caused by mutations in the acid β-glucosidase gene (GBA1). Besides causing GD, GBA1 mutations constitute the main genetic risk factor for developing Parkinson's disease. The molecular basis of neurological manifestations in GD remain elusive. Ho...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21093268
更新日期:2020-05-05 00:00:00
abstract::A split plot 3 by 4 experiment was designed to characterize the relationship between production of gluthatione (GSH), oxidized gluthatione (GSSG), total flavonoid, anthocyanin, ascorbic acid and antioxidant activities (FRAP and DPPH) in three varieties of Labisia pumila Blume, namely the varieties alata, pumila and la...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms13010393
更新日期:2012-01-01 00:00:00
abstract::One of the hallmarks of the acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a drastically reduced feed intake by an unknown mechanism. To further elucidate this wasting syndrome, we followed the effects of a single large dose (100 μg/kg) of TCDD on the serum levels of several energy balance-influencing...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms150813938
更新日期:2014-08-12 00:00:00