Natural Bioactive Compounds: The Way Shown by Professor Maurizio Battino and His Group in an Italian Cutting-Edge Laboratory.

abstract：:The mouse model of Alzheimer's disease (AD), Tg2576 mice (APP), has provided valuable information, such as the role of the metallothionein (MT) family in their behavioral and amyloidosis phenotypes. In this study, we further characterize the role of MT-1 by crossing Mt1-overexpressing mice with Tg2576 mice (APPTgMT). ...

journal_title：International journal of molecular sciences

authors： Comes G,Manso Y,Escrig A,Fernandez-Gayol O,Sanchis P,Molinero A,Giralt M,Carrasco J,Hidalgo J

更新日期：2017-01-26 00:00:00

abstract：:Epigenetic modifications including DNA methylation, histone modifications, and chromatin remodeling are crucial regulators of chromatin architecture and gene expression in plants. Their dynamics are significantly influenced by oxidants, such as reactive oxygen species (ROS) and nitric oxide (NO), and antioxidants, lik...

journal_title：International journal of molecular sciences

authors： R M SK,Wang Y,Zhang X,Cheng H,Sun L,He S,Hao F

更新日期：2020-02-19 00:00:00

abstract：:Stearoyl-CoA desaturase 1 (SCD1), an enzyme that is involved in the biosynthesis of monounsaturated fatty acids, induces the reprogramming of cardiomyocyte metabolism. Thyroid hormones (THs) activate both lipolysis and lipogenesis. Many genes that are involved in lipid metabolism, including Scd1, are regulated by THs....

journal_title：International journal of molecular sciences

authors： Olichwier A,Balatskyi VV,Wolosiewicz M,Ntambi JM,Dobrzyn P

更新日期：2020-12-24 00:00:00

abstract：:Extramammary Paget's disease (EMPD) is a rare skin cancer arising in the anogenital area. Most EMPD tumors remain dormant as in situ lesions, but the outcomes of patients with metastatic EMPD are poor because of the lack of effective systemic therapies. Nectin cell adhesion molecule 4 (NECTIN4) has attracted attention...

journal_title：International journal of molecular sciences

authors： Murata M,Ito T,Tanaka Y,Kaku-Ito Y,Furue M

更新日期：2020-08-16 00:00:00

abstract：:High dietary salt intake has been listed among the top ten risk factors for disability-adjusted life years. We discuss the role of endogenous cardiotonic steroids in mediating the dietary salt-induced hypertension and organ damage. ...

journal_title：International journal of molecular sciences

authors： Paczula A,Wiecek A,Piecha G

更新日期：2019-01-30 00:00:00

abstract：:The survival kinase protein kinase B (Akt) participates in the regulation of essential subcellular processes, e.g., proliferation, growth, survival, and apoptosis, and has a documented role in promoting resistance against genotoxic stress including radiotherapy, presumably by influencing the DNA damage response and DN...

journal_title：International journal of molecular sciences

authors： Szymonowicz K,Oeck S,Krysztofiak A,van der Linden J,Iliakis G,Jendrossek V

更新日期：2018-07-31 00:00:00

abstract：:: Mitochondrial respiratory chain supercomplexes (RCS), particularly, the respirasome, which contains complexes I, III, and IV, have been suggested to participate in facilitating electron transport, reducing the production of reactive oxygen species (ROS), and maintaining the structural integrity of individual electro...

journal_title：International journal of molecular sciences

authors： Chapa-Dubocq XR,Rodríguez-Graciani KM,Guzmán-Hernández RA,Jang S,Brookes PS,Javadov S

更新日期：2020-02-25 00:00:00

abstract：:The concept of "Sweet Immunity" postulates that sugar metabolism and signaling influence plant immune networks. In this study, we tested the potential of commercially available inulin-type fructans to limit disease symptoms caused by Botrytis cinerea in lettuce. Spraying mature lettuce leaves, with inulin-type fructan...

journal_title：International journal of molecular sciences

authors： Tarkowski ŁP,Van de Poel B,Höfte M,Van den Ende W

更新日期：2019-02-28 00:00:00

abstract：:The physic nut shrub, Jatropha curcas (Euphorbiaceae), has been considered as a "miracle tree", particularly as a source of alternate fuel. Various extracts of the plant have been reported to have insecticidal/acaricidal or molluscicidal/anthelminthic activities on vectors of medical or veterinary interest or on agric...

journal_title：International journal of molecular sciences

authors： Ratnadass A,Wink M

更新日期：2012-11-30 00:00:00

abstract：:Geobacter species are capable of utilizing solid-state compounds, including anodic electrodes, as electron acceptors of respiration via extracellular electron transfer (EET) and have attracted considerable attention for their crucial role as biocatalysts of bioelectrochemical systems (BES's). Recent studies disclosed ...

journal_title：International journal of molecular sciences

authors： Kato S

更新日期：2017-01-06 00:00:00

abstract：:Inorganic phosphate (Pi) is an essential nutrient for the maintenance of cells. In healthy mammals, extracellular Pi is maintained within a narrow concentration range of 0.70 to 1.55 mM. Mammalian cells depend on Na+/Pi cotransporters for Pi absorption, which have been well studied. However, a new type of sodium-indep...

journal_title：International journal of molecular sciences

authors： Lacerda-Abreu MA,Russo-Abrahão T,Meyer-Fernandes JR

更新日期：2020-12-06 00:00:00

abstract：:Self-assembled peptide nanofibers (NFs) obtained from β-sheet peptides conjugated with drugs, including antigenic peptides, have recently attracted significant attention. However, extensive studies on the interactions of β-sheet peptide NFs with model cell membranes have not been reported. In this study, we investigat...

journal_title：International journal of molecular sciences

authors： Waku T,Kasai A,Kobori A,Tanaka N

更新日期：2020-12-14 00:00:00

abstract：:Protein microarrays are powerful tools that are widely used in systems biology research. For infectious diseases, proteome microarrays assembled from proteins of pathogens will play an increasingly important role in discovery of diagnostic markers, vaccines, and therapeutics. Distinct formats of protein microarrays ha...

journal_title：International journal of molecular sciences

authors： Natesan M,Ulrich RG

更新日期：2010-01-01 00:00:00

abstract：:In this review, the effect of pharmaceuticals (PHRs) and personal care products (PCPs) on microalgal growth and metabolism is reported. Concentrations of various PHRs and PCPs that cause inhibition and toxicity to growths of different microalgal strains are summarized and compared. The effect of PHRs and PCPs on micro...

journal_title：International journal of molecular sciences

authors： Miazek K,Brozek-Pluska B

更新日期：2019-05-20 00:00:00

abstract：:The abundance of intrinsic disorder in the protein realm and its role in a variety of physiological and pathological cellular events have strengthened the interest of the scientific community in understanding the structural and dynamical properties of intrinsically disordered proteins (IDPs) and regions (IDRs). Attemp...

journal_title：International journal of molecular sciences

authors： Bianchi G,Longhi S,Grandori R,Brocca S

更新日期：2020-08-27 00:00:00

abstract：:Bakanae disease (BD), caused by the fungal pathogen Fusarium fujikuroi, has become a serious threat in rice-cultivating regions worldwide. In the present study, quantitative trait locus (QTL) mapping was performed using F2 and F3 plants derived after crossing a BD-resistant and a BD-susceptible Korean japonica rice va...

journal_title：International journal of molecular sciences

authors： Kang DY,Cheon KS,Oh J,Oh H,Kim SL,Kim N,Lee E,Choi I,Baek J,Kim KH,Chung NJ,Ji H

更新日期：2019-05-27 00:00:00

abstract：:Growing importance has been attributed to interactions between tumors, the stromal microenvironment and adult mesenchymal stem cells. Adipose-derived stem cells (ASCs) are routinely employed in regenerative medicine and in autologous fat transfer procedures. To date, clinical trials have failed to demonstrate the pote...

journal_title：International journal of molecular sciences

authors： Scioli MG,Storti G,D'Amico F,Gentile P,Kim BS,Cervelli V,Orlandi A

更新日期：2019-07-04 00:00:00

abstract：:A major hallmark of diabetes is a constant high blood glucose level (hyperglycaemia), resulting in endothelial dysfunction. Transient or prolonged hyperglycemia can cause diabetic vasculopathy, a secondary systemic damage. C-Peptide is a product of cleavage of proinsulin by a serine protease that occurs within the pan...

journal_title：International journal of molecular sciences

authors： Souto SB,Campos JR,Fangueiro JF,Silva AM,Cicero N,Lucarini M,Durazzo A,Santini A,Souto EB

更新日期：2020-01-18 00:00:00

abstract：:The phenol-degrading efficiency of Pseudochrobactrum sp. was enhanced by ultraviolet (UV) irradiation. First, a bacterial strain, Pseudochrobactrum sp. XF1, was isolated from the activated sludge in a coking plant. It was subjected to mutation by UV radiation for 120 s and a mutant strain with higher phenol-degrading ...

journal_title：International journal of molecular sciences

authors： Mao Z,Yu C,Xin L

更新日期：2015-04-01 00:00:00

abstract：:Water limitation represents the main environmental constraint affecting crop yield worldwide. Photosynthesis is a primary drought target, resulting in over-reduction of the photosynthetic electron transport chain and increased production of reactive oxygen species in plastids. Manipulation of chloroplast electron dist...

journal_title：International journal of molecular sciences

authors： Karlusich JJP,Arce RC,Shahinnia F,Sonnewald S,Sonnewald U,Zurbriggen MD,Hajirezaei MR,Carrillo N

更新日期：2020-09-29 00:00:00

abstract：:Uterine fibroids (UFs) are benign tumors of the female genital tract made of the smooth muscle of the uterus. UF growth depends mostly on the influence of the steroid hormones and selected growth factors. Transforming growth factor β (TGF-βs) is a polypeptide that consists of three isoforms: TGF-β1, TGF-β2, and TGF-β3...

journal_title：International journal of molecular sciences

authors： Ciebiera M,Włodarczyk M,Wrzosek M,Męczekalski B,Nowicka G,Łukaszuk K,Ciebiera M,Słabuszewska-Jóźwiak A,Jakiel G

更新日期：2017-11-17 00:00:00

abstract：:A state of the art proteomic methodology using Matrix Assisted Laser Desorption/Ionization-Time of Flight (MALDI TOF) has been employed to characterize peptides modulated in the date palm stem subsequent to infestation with red palm weevil (RPW). Our analyses revealed 32 differentially expressed peptides associated wi...

journal_title：International journal of molecular sciences

authors： Rasool KG,Khan MA,Aldawood AS,Tufail M,Mukhtar M,Takeda M

更新日期：2015-08-17 00:00:00

abstract：:G protein-coupled receptors (GPCRs) have a substantial role in tumorigenesis and are described as a "cancer driver". Aberrant expression or activation of GPCRs leads to the deregulation of downstream signaling pathways, thereby promoting cancer progression. In hepatocellular carcinoma (HCC), the Wnt signaling pathway ...

journal_title：International journal of molecular sciences

authors： Chan KK,Lo RC

更新日期：2018-01-21 00:00:00

abstract：:SIRT1, an NAD(+)-dependent deacetylase, has been described in the literature as a major player in the regulation of cellular stress responses. Its expression has been shown to be altered in cancer cells, and it targets both histone and non-histone proteins for deacetylation and thereby alters metabolic programs in res...

journal_title：International journal of molecular sciences

authors： Simmons GE Jr,Pruitt WM,Pruitt K

更新日期：2015-01-05 00:00:00

abstract：:Pea (Pisum sativum L.), as a major source of plant protein, is becoming one of the major cultivated crop species worldwide. In pea, the pericarp is an important determinant of the morphological characteristics and seed yield. To investigate the molecular mechanism of pericarp elongation as well as sucrose and starch a...

journal_title：International journal of molecular sciences

authors： Yang P,Li Z,Wu C,Luo Y,Li J,Wang P,Gao X,Gao J,Feng B

更新日期：2019-12-05 00:00:00

abstract：:The G protein-coupled cannabinoid receptors type 1 (CB1R) and type 2 (CB2R), and their endocannabinoid (eCBs) ligands, have been implicated in several aspects of brain wiring during development. Here we aim to assess whether interfering with CB1R affects development, neuritogenesis and pathfinding of GnRH and AgRP neu...

journal_title：International journal of molecular sciences

authors： Zuccarini G,D'Atri I,Cottone E,Mackie K,Shainer I,Gothilf Y,Provero P,Bovolin P,Merlo GR

更新日期：2019-12-25 00:00:00

abstract：:Tryptanthrin, a kind of indole quinazoline alkaloid, has been shown to exhibit anti-microbial, anti-inflammation and anti-tumor effects both in vivo and in vitro. However, its biological activity on human chronic myeloid leukemia cell line K562 is not fully understood. In the present study, we investigated the prolife...

journal_title：International journal of molecular sciences

authors： Miao S,Shi X,Zhang H,Wang S,Sun J,Hua W,Miao Q,Zhao Y,Zhang C

更新日期：2011-01-01 00:00:00

abstract：:Altered microRNA expression is implicated in cardiovascular diseases. Our objective was to determine microRNA signatures in thoracic aortic aneurysms (TAAs) and abdominal aortic aneurysms (AAAs) compared with control non-aneurysmal aortic specimens. We evaluated the expression of fifteen selected microRNA in human TAA...

journal_title：International journal of molecular sciences

authors： Venkatesh P,Phillippi J,Chukkapalli S,Rivera-Kweh M,Velsko I,Gleason T,VanRyzin P,Aalaei-Andabili SH,Ghanta RK,Beaver T,Chan EKL,Kesavalu L

更新日期：2017-04-20 00:00:00

abstract：:Phostensin is encoded by KIAA1949. 5'-RACEanalysis has been used to identify the translation start site of phostensin mRNA, indicating that it encodes 165 amino acids with an apparent molecular weight of 26 kDa on SDS-PAGE. This low-molecular-weight phostensin is present in human peripheral blood mononuclear cells and...

journal_title：International journal of molecular sciences

authors： Lin YS,Huang HL,Liu WT,Lin TH,Huang HB

更新日期：2014-01-15 00:00:00

abstract：:Non-alcoholic steatohepatitis (NASH) is characterized by the presence of steatosis, inflammation and hepatocyte injury and constitutes hepatic manifestation of the metabolic syndrome. The pathogenesis of NASH is complex and implicates cross-talk between different metabolically active sites, such as liver and adipose t...

journal_title：International journal of molecular sciences

authors： Vonghia L,Michielsen P,Francque S

更新日期：2013-10-01 00:00:00