Abstract：
:The let-7 family is the second microRNA found in C. elegans. Recent researches have found it is highly expressed in the cardiovascular system. Studies have revealed the aberrant expression of let-7 members in cardiovascular diseases, such as heart hypertrophy, cardiac fibrosis, dilated cardiomyopathy (DCM), myocardial infarction (MI), arrhythmia, angiogenesis, atherosclerosis, and hypertension. Let-7 also participates in cardiovascular differentiation of embryonic stem cells. TLR4, LOX-1, Bcl-xl and AGO1 are by now the identified target genes of let-7. The circulating let-7b is suspected to be the biomarker of acute MI and let-7i, the biomarker of DCM. Further studies are necessary for identifying the gene targets and signaling pathways of let-7 in cardiovascular diseases. Let-7 might be a potential therapeutic target for cardiovascular diseases. This review focuses on the research progresses regarding the roles of let-7 in cardiovascular development and diseases.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Bao MH,Feng X,Zhang YW,Lou XY,Cheng Y,Zhou HHdoi
10.3390/ijms141123086subject
Has Abstractpub_date
2013-11-21 00:00:00pages
23086-102issue
11issn
1422-0067pii
ijms141123086journal_volume
14pub_type
杂志文章,评审abstract：:Understanding the composition and structure of the acquired enamel pellicle (AEP) has been a major goal in oral biology. Our lab has conducted studies on the composition of AEP formed on permanent enamel. The exhaustive exploration has provided a comprehensive identification of more than 100 proteins from AEP formed o...
journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2014-04-04 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2013-07-29 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-12-22 00:00:00
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