Abstract:
:Membrane regulators such as sterols and hopanoids play a major role in the physiological and physicochemical adaptation of the different plasmic membranes in Eukarya and Bacteria. They are key to the functionalization and the spatialization of the membrane, and therefore indispensable for the cell cycle. No archaeon has been found to be able to synthesize sterols or hopanoids to date. They also lack homologs of the genes responsible for the synthesis of these membrane regulators. Due to their divergent membrane lipid composition, the question whether archaea require membrane regulators, and if so, what is their nature, remains open. In this review, we review evidence for the existence of membrane regulators in Archaea, and propose tentative location and biological functions. It is likely that no membrane regulator is shared by all archaea, but that they may use different polyterpenes, such as carotenoids, polyprenols, quinones and apolar polyisoprenoids, in response to specific stressors or physiological needs.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Salvador-Castell M,Tourte M,Oger PMdoi
10.3390/ijms20184434subject
Has Abstractpub_date
2019-09-09 00:00:00issue
18issn
1422-0067pii
ijms20184434journal_volume
20pub_type
杂志文章,评审abstract::There is a growing body of evidence showing the importance of physical activity against acute ischemic events in various organs. Ischemia/reperfusion injury (I/R) is characterized by tissue damage as a result of restriction and subsequent restoration of blood supply to an organ. Oxidative stress due to increased react...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21249382
更新日期:2020-12-09 00:00:00
abstract::Gastrointestinal stromal tumors (GIST) carrying the D842V activating mutation in the platelet-derived growth factor receptor alpha (PDGFRA) gene are a very rare subgroup of GIST (about 10%) known to be resistant to conventional tyrosine kinase inhibitors (TKIs) and to show an indolent behavior. In this study, we perfo...
journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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更新日期:2019-07-19 00:00:00
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journal_title:International journal of molecular sciences
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更新日期:2020-12-26 00:00:00
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journal_title:International journal of molecular sciences
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abstract::Friedreich's ataxia (FA) is a trinucleotide repeats expansion neurodegenerative disorder, for which no cure or approved therapies are present. In most cases, GAA trinucleotide repetitions in the first intron of the FXN gene are the genetic trigger of FA, determining a strong reduction of frataxin, a mitochondrial prot...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
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更新日期:2020-01-30 00:00:00
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journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms15034583
更新日期:2014-03-17 00:00:00
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journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
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更新日期:2021-01-06 00:00:00
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journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18071502
更新日期:2017-07-12 00:00:00
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journal_title:International journal of molecular sciences
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更新日期:2020-07-23 00:00:00
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journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms17020217
更新日期:2016-02-05 00:00:00
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journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms18112277
更新日期:2017-10-30 00:00:00
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journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19030895
更新日期:2018-03-17 00:00:00
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journal_title:International journal of molecular sciences
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更新日期:2020-08-28 00:00:00
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journal_title:International journal of molecular sciences
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更新日期:2020-04-19 00:00:00
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journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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更新日期:2018-10-24 00:00:00
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journal_title:International journal of molecular sciences
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更新日期:2019-12-13 00:00:00
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journal_title:International journal of molecular sciences
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更新日期:2016-05-06 00:00:00
abstract::In our ongoing research to discover natural products with neuroprotective effects, hyperoside (quercetin 3-O-galactoside) was isolated from Acer tegmentosum, which has been used in Korean traditional medicine to treat liver-related disorders. Here, we demonstrated that hyperoside protects cultured dopaminergic neurons...
journal_title:International journal of molecular sciences
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更新日期:2019-11-20 00:00:00
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journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21197203
更新日期:2020-09-29 00:00:00
abstract::Chondral or osteochondral defects are still controversial problems in orthopedics. Here, chondrocytes labeled with magnetic nanoparticles were cultivated on a biphasic, type II collagen-chitosan/poly(lactic-co-glycolic acid) scaffold in an attempt to develop cultures with trackable cells exhibiting growth, differentia...
journal_title:International journal of molecular sciences
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更新日期:2017-01-04 00:00:00
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journal_title:International journal of molecular sciences
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更新日期:2019-06-28 00:00:00
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更新日期:2016-01-29 00:00:00