Abstract：
:Tissues in the body are hierarchically structured composite materials with tissue-specific properties. Urea self-assembles via hydrogen bonding interactions into crystalline supracolloidal assemblies that can be used to impart macroscopic pores to polymer-based tissue scaffolds. In this communication, we explain the solvent interactions governing the solubility of urea and thereby the scope of compatible polymers. We also highlight the role of solvent interactions on the morphology of the resulting supracolloidal crystals. We elucidate the role of polymer-urea interactions on the morphology of the pores in the resulting biomaterials. Finally, we demonstrate that it is possible to use our urea templating methodology to prepare Bombyx mori silk protein-based biomaterials with pores that human dermal fibroblasts respond to by aligning with the long axis of the pores. This methodology has potential for application in a variety of different tissue engineering niches in which cell alignment is observed, including skin, bone, muscle and nerve.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Hardy JG,Ghezzi CE,Saballos RJ,Kaplan DL,Schmidt CEdoi
10.3390/ijms160920511subject
Has Abstractpub_date
2015-08-28 00:00:00pages
20511-22issue
9issn
1422-0067pii
ijms160920511journal_volume
16pub_type
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