Inhibitory Effect of Alisma canaliculatum Ethanolic Extract on NF-κB-Dependent CXCR3 and CXCL10 Expression in TNFα-Exposed MDA-MB-231 Breast Cancer Cells.

Abstract:

:CXC motif chemokine ligand 10 (CXCL10) and its receptor CXC motif chemokine receptor 3 (CXCR3), play important roles in the motility of breast cancer cells. Alisma canaliculatum is a herb that has been used as a traditional medicine for thousands of years in Korea and China. Whether A. canaliculatum inhibits the motility of metastatic breast cancer cells is not clear yet. In this study, we show that A. canaliculatum ethanolic extract (ACE) prevented tumor necrosis factor-alpha (TNFα)-induced migration of MDA-MB-231 cells. ACE significantly attenuated TNFα-induced upregulation of CXCL10 and CXCR3 expression at the gene promoter level. Mechanistically, ACE inhibits TNFα-induced phosphorylation of inhibitor of κB (IκB) kinase (IKK), IκB and p65/RelA, leading to the suppression of nuclear translocation of p65/RelA nuclear factor kappa-B (NF-κB). Also, ACE inhibited NF-κB-dependent CXCR3 and CXCL10 promoter activities. These results suggest that ACE abrogates TNFα-induced migration of MDA-MB-231 breast cancer cells through down-regulation of IKK-NF-κB-dependent CXCR3 and CXCL10 expression. Our results suggest that ACE has potential as a herbal supplement for the inhibition of breast cancer metastasis.

journal_name

Int J Mol Sci

authors

Choi J,Ahn SS,Lim Y,Lee YH,Shin SY

doi

10.3390/ijms19092607

subject

Has Abstract

pub_date

2018-09-03 00:00:00

issue

9

issn

1422-0067

pii

ijms19092607

journal_volume

19

pub_type

杂志文章
  • Regulation of Vascular Function and Inflammation via Cross Talk of Reactive Oxygen and Nitrogen Species from Mitochondria or NADPH Oxidase-Implications for Diabetes Progression.

    abstract::Oxidative stress plays a key role for the development of cardiovascular, metabolic, and neurodegenerative disease. This concept has been proven by using the approach of genetic deletion of reactive oxygen and nitrogen species (RONS) producing, pro-oxidant enzymes as well as by the overexpression of RONS detoxifying, a...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21103405

    authors: Daiber A,Steven S,Vujacic-Mirski K,Kalinovic S,Oelze M,Di Lisa F,Münzel T

    更新日期:2020-05-12 00:00:00

  • Metabolomics and Transcriptomics Identify Multiple Downstream Targets of Paraburkholderia phymatum σ54 During Symbiosis with Phaseolus vulgaris.

    abstract::RpoN (or σ54) is the key sigma factor for the regulation of transcription of nitrogen fixation genes in diazotrophic bacteria, which include α- and β-rhizobia. Our previous studies showed that an rpoN mutant of the β-rhizobial strain Paraburkholderia phymatum STM815T formed root nodules on Phaseolus vulgaris cv. Negro...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms19041049

    authors: Lardi M,Liu Y,Giudice G,Ahrens CH,Zamboni N,Pessi G

    更新日期:2018-04-01 00:00:00

  • Surface-Modified Biochar with Polydentate Binding Sites for the Removal of Cadmium.

    abstract::In this study, a surface chemical-modified rice husk biochar with abundant amino groups and disulfide bonds for the removal of cadmium was prepared using cystamine dihydrochloride as a modification ligand and glutaraldehyde as a crosslinker. The biochars were characterized by Fourier transform infrared spectrometry (F...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20071775

    authors: Chen R,Zhao X,Jiao J,Li Y,Wei M

    更新日期:2019-04-10 00:00:00

  • Induction of Oxidative Stress and Mitochondrial Dysfunction by Juglone Affects the Development of Bovine Oocytes.

    abstract::Juglone, a major naphthalenedione component of walnut trees, has long been used in traditional medicine as an antimicrobial and antitumor agent. Nonetheless, its impact on oocyte and preimplantation embryo development has not been entirely clarified. Using the bovine model, we sought to elucidate the impact of juglone...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms22010168

    authors: Mesalam AA,El-Sheikh M,Joo MD,Khalil AAK,Mesalam A,Ahn MJ,Kong IK

    更新日期:2020-12-26 00:00:00

  • Anti-inflammatory effect of emodin via attenuation of NLRP3 inflammasome activation.

    abstract::Emodin, an active constituent of oriental herbs, is widely used to treat allergy, inflammation, and other symptoms. This study provides the scientific basis for the anti-inflammasome effects of emodin on both in vitro and in vivo experimental models. Bone marrow-derived macrophages were used to study the effects of em...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms16048102

    authors: Han JW,Shim DW,Shin WY,Heo KH,Kwak SB,Sim EJ,Jeong JH,Kang TB,Lee KH

    更新日期:2015-04-10 00:00:00

  • Genome-Wide Identification, Molecular Evolution, and Expression Divergence of Aluminum-Activated Malate Transporters in Apples.

    abstract::Aluminum-activated malate transporters (ALMTs) play an important role in aluminum tolerance, stomatal opening, and fruit acidity in plants. However, the evolutionary pattern of the ALMT gene family in apples remains relatively unknown. In this study, a total of 25 MdALMT genes were identified from the apple reference ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms19092807

    authors: Ma B,Yuan Y,Gao M,Qi T,Li M,Ma F

    更新日期:2018-09-18 00:00:00

  • Involvement of nitrogen on flavonoids, glutathione, anthocyanin, ascorbic acid and antioxidant activities of Malaysian medicinal plant Labisia pumila Blume (Kacip Fatimah).

    abstract::A split plot 3 by 4 experiment was designed to characterize the relationship between production of gluthatione (GSH), oxidized gluthatione (GSSG), total flavonoid, anthocyanin, ascorbic acid and antioxidant activities (FRAP and DPPH) in three varieties of Labisia pumila Blume, namely the varieties alata, pumila and la...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms13010393

    authors: Ibrahim MH,Jaafar HZ,Rahmat A,Rahman ZA

    更新日期:2012-01-01 00:00:00

  • Protective Effects of Caffeic Acid Phenethyl Ester (CAPE) and Novel Cape Analogue as Inducers of Heme Oxygenase-1 in Streptozotocin-Induced Type 1 Diabetic Rats.

    abstract::Type 1 diabetes mellitus (T1D) is a chronic autoimmune disease resulting in the destruction of insulin producing β-cells of the pancreas, with consequent insulin deficiency and excessive glucose production. Hyperglycemia results in increased levels of reactive oxygen species (ROS) and nitrogen species (RNS) with conse...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20102441

    authors: Sorrenti V,Raffaele M,Vanella L,Acquaviva R,Salerno L,Pittalà V,Intagliata S,Di Giacomo C

    更新日期:2019-05-17 00:00:00

  • Lactate Metabolism in Breast Cancer Microenvironment: Contribution Focused on Associated Adipose Tissue and Obesity.

    abstract::Metabolic reprogramming that favors high glycolytic flux with lactate production in normoxia is among cancer hallmarks. Lactate is an essential oncometabolite regulating cellular redox homeostasis, energy substrate partitioning, and intracellular signaling. Moreover, malignant phenotype's chief characteristics are dep...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21249676

    authors: Kalezic A,Udicki M,Srdic Galic B,Aleksic M,Korac A,Jankovic A,Korac B

    更新日期:2020-12-18 00:00:00

  • Biosynthesis and Signal Transduction of ABA, JA, and BRs in Response to Drought Stress of Kentucky Bluegrass.

    abstract::Kentucky bluegrass (KB, Poa pratensis) is one of the most widely used cool-season turfgrass species, but it is sensitive to drought stress. Molecular studies in KB are hindered by its large and complex genome structure. In this study, a comparative transcriptomic study was conducted between a short and long period of ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20061289

    authors: Chen Y,Chen Y,Shi Z,Jin Y,Sun H,Xie F,Zhang L

    更新日期:2019-03-14 00:00:00

  • Hydroxypyridinone Chelators: From Iron Scavenging to Radiopharmaceuticals for PET Imaging with Gallium-68.

    abstract::Derivatives of 3,4-hydroxypyridinones have been extensively studied for in vivo Fe3+ sequestration. Deferiprone, a 1,2-dimethyl-3,4-hydroxypyridinone, is now routinely used for clinical treatment of iron overload disease. Hexadentate tris(3,4-hydroxypyridinone) ligands (THP) complex Fe3+ at very low iron concentration...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms18010116

    authors: Cusnir R,Imberti C,Hider RC,Blower PJ,Ma MT

    更新日期:2017-01-08 00:00:00

  • Biological activities of Toninia candida and Usnea barbata together with their norstictic acid and usnic acid constituents.

    abstract::The aim of this study was to investigate the chemical composition of acetone extracts of the lichens Toninia candida and Usnea barbata and in vitro antioxidant, antimicrobial, and anticancer activities of these extracts together with some of their major metabolites. The chemical composition of T. candida and U. barbat...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms131114707

    authors: Ranković B,Kosanić M,Stanojković T,Vasiljević P,Manojlović N

    更新日期:2012-11-12 00:00:00

  • Dinuclear Copper(II) Complexes with Schiff Bases Derived from 2-Hydroxy-5-Methylisophthalaldehyde and Histamine or 2-(2-Aminoethyl)pyridine and Their Application as Magnetic and Fluorescent Materials in Thin Film Deposition.

    abstract::Two Cu(II) complexes, 1 and 2, with tridentate Schiff bases derived from 2-hydroxy-5-methylisophthalaldehyde and histamine HL1 or 2-(2-aminoethyl)pyridine HL2, respectively, were obtained and characterized by X-ray crystallography, spectroscopic (UV-vis, fluorescence, IR, and EPR), magnetic, and thermal methods. Despi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21134587

    authors: Barwiolek M,Kaczmarek-Kędziera A,Muziol TM,Jankowska D,Jezierska J,Bieńko A

    更新日期:2020-06-28 00:00:00

  • Platelet-Rich Plasma Promotes the Proliferation of Human Keratinocytes via a Progression of the Cell Cycle. A Role of Prolidase.

    abstract::Although the role of platelet-rich plasma (PRP) in tissue regeneration has been confirmed in many studies, the mechanism of this process is still not fully understood. Human keratinocytes (HaCaT) cells were used as an experimental model for studies on the effects of PRP on cell proliferation, migration, collagen biosy...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms22020936

    authors: Misiura M,Guszczyn T,Oscilowska I,Baszanowska W,Palka J,Miltyk W

    更新日期:2021-01-19 00:00:00

  • Symmetrical Modification of Minimized Dermaseptins to Extend the Spectrum of Antimicrobials with Endotoxin Neutralization Potency.

    abstract::Antimicrobial peptides (AMPs) have emerged as a promising class of antimicrobial agents that could potentially address the global antibiotic resistance. Generating mirror-like peptides by minimizing dermaseptin family sequences is an effective strategy for designing AMPs. However, the previous research still had some ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20061417

    authors: Shao C,Li W,Tan P,Shan A,Dou X,Ma D,Liu C

    更新日期:2019-03-20 00:00:00

  • Common Amino Acid Subsequences in a Universal Proteome--Relevance for Food Science.

    abstract::A common subsequence is a fragment of the amino acid chain that occurs in more than one protein. Common subsequences may be an object of interest for food scientists as biologically active peptides, epitopes, and/or protein markers that are used in comparative proteomics. An individual bioactive fragment, in particula...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms160920748

    authors: Minkiewicz P,Darewicz M,Iwaniak A,Sokołowska J,Starowicz P,Bucholska J,Hrynkiewicz M

    更新日期:2015-09-01 00:00:00

  • Foam Cell Induction Activates AMPK But Uncouples Its Regulation of Autophagy and Lysosomal Homeostasis.

    abstract::The dysregulation of macrophage lipid metabolism drives atherosclerosis. AMP-activated protein kinase (AMPK) is a master regulator of cellular energetics and plays essential roles regulating macrophage lipid dynamics. Here, we investigated the consequences of atherogenic lipoprotein-induced foam cell formation on down...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21239033

    authors: LeBlond ND,Nunes JRC,Smith TKT,O'Dwyer C,Robichaud S,Gadde S,Côté M,Kemp BE,Ouimet M,Fullerton MD

    更新日期:2020-11-27 00:00:00

  • Structural and functional characterization of two alternative splicing variants of mouse Endothelial Cell-Specific Chemotaxis Regulator (ECSCR).

    abstract::Endothelial cells (ECs) that line the lumen of blood vessels are important players in blood vessel formation, and EC migration is a key component of the angiogenic process. Thus, identification of genes that are specifically or preferentially expressed in vascular ECs and in-depth understanding of their biological fun...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms13044920

    authors: Wu W,Shi C,Ma F,Balducci J,Huang H,Ji HL,Chang Y,Huang Y

    更新日期:2012-01-01 00:00:00

  • Clinical Application of Targeted Next Generation Sequencing for Colorectal Cancers.

    abstract::Promising targeted therapy and personalized medicine are making molecular profiling of tumours a priority. For colorectal cancer (CRC) patients, international guidelines made RAS (KRAS and NRAS) status a prerequisite for the use of anti-epidermal growth factor receptor agents (anti-EGFR). Daily, new data emerge on the...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms17122117

    authors: Fontanges Q,De Mendonca R,Salmon I,Le Mercier M,D'Haene N

    更新日期:2016-12-16 00:00:00

  • Omega-3 Fatty Acid-Derived Resolvin D2 Regulates Human Placental Vascular Smooth Muscle and Extravillous Trophoblast Activities.

    abstract::Omega-3 fatty acids are important to pregnancy and neonatal development and health. One mechanism by which omega-3 fatty acids exert their protective effects is through serving as substrates for the generation of specialized pro-resolving lipid mediators (SPM) that potently limit and resolve inflammatory processes. We...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20184402

    authors: Ulu A,Sahoo PK,Yuil-Valdes AG,Mukherjee M,Van Ormer M,Muthuraj PG,Thompson M,Anderson Berry A,Hanson CK,Natarajan SK,Nordgren TM

    更新日期:2019-09-07 00:00:00

  • The Ubiquitin Proteasome System in Neuromuscular Disorders: Moving Beyond Movement.

    abstract::Neuromuscular disorders (NMDs) affect 1 in 3000 people worldwide. There are more than 150 different types of NMDs, where the common feature is the loss of muscle strength. These disorders are classified according to their neuroanatomical location, as motor neuron diseases, peripheral nerve diseases, neuromuscular junc...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21176429

    authors: Bachiller S,Alonso-Bellido IM,Real LM,Pérez-Villegas EM,Venero JL,Deierborg T,Armengol JÁ,Ruiz R

    更新日期:2020-09-03 00:00:00

  • Optogenetic Stimulation of Prelimbic Pyramidal Neurons Maintains Fear Memories and Modulates Amygdala Pyramidal Neuron Transcriptome.

    abstract::Fear extinction requires coordinated neural activity within the amygdala and medial prefrontal cortex (mPFC). Any behavior has a transcriptomic signature that is modified by environmental experiences, and specific genes are involved in functional plasticity and synaptic wiring during fear extinction. Here, we investig...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms22020810

    authors: Laricchiuta D,Sciamanna G,Gimenez J,Termine A,Fabrizio C,Caioli S,Balsamo F,Panuccio A,De Bardi M,Saba L,Passarello N,Cutuli D,Mattioni A,Zona C,Orlando V,Petrosini L

    更新日期:2021-01-15 00:00:00

  • Pigment Epithelium-Derived Factor (PEDF) Receptors Are Involved in Survival of Retinal Neurons.

    abstract::The demise of retinal ganglion cells (RGCs) is characteristic of diseases of the retina such as glaucoma and diabetic or ischemic retinopathies. Pigment epithelium-derived factor (PEDF) is a multifunctional secreted protein that mediates neuroprotection and inhibition of angiogenesis in the retina. We have studied exp...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms22010369

    authors: Bürger S,Meng J,Zwanzig A,Beck M,Pankonin M,Wiedemann P,Eichler W,Unterlauft JD

    更新日期:2020-12-31 00:00:00

  • GPER1 and microRNA: Two Players in Breast Cancer Progression.

    abstract::Breast cancer is the main cause of morbidity and mortality in women worldwide. However, the molecular pathogenesis of breast cancer remains poorly defined due to its heterogeneity. Several studies have reported that G Protein-Coupled Estrogen Receptor 1 (GPER1) plays a crucial role in breast cancer progression, by bin...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms22010098

    authors: Vivacqua A

    更新日期:2020-12-24 00:00:00

  • Extracellular-Signal Regulated Kinase: A Central Molecule Driving Epithelial-Mesenchymal Transition in Cancer.

    abstract::Epithelial-mesenchymal transition (EMT) is a reversible cellular process, characterized by changes in gene expression and activation of proteins, favoring the trans-differentiation of the epithelial phenotype to a mesenchymal phenotype. This process increases cell migration and invasion of tumor cells, progression of ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms20122885

    authors: Olea-Flores M,Zuñiga-Eulogio MD,Mendoza-Catalán MA,Rodríguez-Ruiz HA,Castañeda-Saucedo E,Ortuño-Pineda C,Padilla-Benavides T,Navarro-Tito N

    更新日期:2019-06-13 00:00:00

  • Overexpression of the Auxin Receptor AFB3 in Arabidopsis Results in Salt Stress Resistance and the Modulation of NAC4 and SZF1.

    abstract::Soil salinity is a key problem for crop production worldwide. High salt concentration in soil negatively modulates plant growth and development. In roots, salinity affects the growth and development of both primary and lateral roots. The phytohormone auxin regulates various developmental processes during the plant's l...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21249528

    authors: Garrido-Vargas F,Godoy T,Tejos R,O'Brien JA

    更新日期:2020-12-15 00:00:00

  • Non-Ionizing Radiation for Cardiac Human Amniotic Mesenchymal Stromal Cell Commitment: A Physical Strategy in Regenerative Medicine.

    abstract::Cell therapy is an innovative strategy for tissue repair, since adult stem cells could have limited regenerative ability as in the case of myocardial damage. This leads to a local contractile dysfunction due to scar formation. For these reasons, refining strategy approaches for "in vitro" stem cell commitment, prepara...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms19082324

    authors: Ledda M,D'Emilia E,Lolli MG,Marchese R,De Lazzari C,Lisi A

    更新日期:2018-08-08 00:00:00

  • Ceramide Metabolism Balance, a Multifaceted Factor in Critical Steps of Breast Cancer Development.

    abstract::Ceramides are key lipids in energetic-metabolic pathways and signaling cascades, modulating critical physiological functions in cells. While synthesis of ceramides is performed in endoplasmic reticulum (ER), which is altered under overnutrition conditions, proteins associated with ceramide metabolism are located on me...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms19092527

    authors: García-González V,Díaz-Villanueva JF,Galindo-Hernández O,Martínez-Navarro I,Hurtado-Ureta G,Pérez-Arias AA

    更新日期:2018-08-26 00:00:00

  • Colistin Dependence in Extensively Drug-Resistant Acinetobacter baumannii Strain Is Associated with ISAjo2 and ISAba13 Insertions and Multiple Cellular Responses.

    abstract::The nosocomial opportunistic Gram-negative bacterial pathogen Acinetobacter baumannii is resistant to multiple antimicrobial agents and an emerging global health problem. The polymyxin antibiotic colistin, targeting the negatively charged lipid A component of the lipopolysaccharide on the bacterial cell surface, is of...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms22020576

    authors: Chamoun S,Welander J,Martis-Thiele MM,Ntzouni M,Claesson C,Vikström E,Turkina MV

    更新日期:2021-01-08 00:00:00

  • Possible Role of Amyloidogenic Evolvability in Dementia with Lewy Bodies: Insights from Transgenic Mice Expressing P123H β-Synuclein.

    abstract::Dementia with Lewy bodies (DLB) is the second most prevalent neurodegenerative dementia after Alzheimer's disease, and is pathologically characterized by formation of intracellular inclusions called Lewy bodies, the major constituent of which is aggregated α-synuclein (αS). Currently, neither a mechanistic etiology no...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21082849

    authors: Fujita M,Ho G,Takamatsu Y,Wada R,Ikeda K,Hashimoto M

    更新日期:2020-04-19 00:00:00