Abstract：
:Receptor targeted nuclear imaging directed against molecular markers overexpressed on breast cancer (BC) cells offers a sensitive and specific method for BC imaging. Currently, a few targets such as estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), somatostatin receptor (SSTR), and the gastrin releasing peptide receptor (GRPR) are being investigated for this purpose. Expression of these targets is BC subtype dependent and information that can be gained from lesion visualization is dependent on the target; ER-targeting radiotracers, e.g., can be used to monitor response to anti-estrogen treatment. Here we give an overview of the studies currently under investigation for receptor targeted nuclear imaging of BC. Main findings of imaging studies are summarized and (potential) purposes of lesion visualization by targeting these molecular markers are discussed. Since BC is a very heterogeneous disease and molecular target expression can vary per subtype, but also during disease progression or under influence of treatment, radiotracers for selected imaging purposes should be chosen carefully.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Dalm SU,Verzijlbergen JF,De Jong Mdoi
10.3390/ijms18020260subject
Has Abstractpub_date
2017-01-26 00:00:00issue
2issn
1422-0067pii
ijms18020260journal_volume
18pub_type
杂志文章,评审abstract：:Phosphatidylcholine (PC) translocation into mucus of the intestine was shown to occur via a paracellular transport across the apical/lateral tight junction (TJ) barrier. In case this could also be operative in biliary epithelial cells, this may have implication for the pathogenesis of primary sclerosing cholangitis (P...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20164034
更新日期：2019-08-19 00:00:00
abstract：:Arachidonic acid (AA) is a phospholipase A2 metabolite that has been reported to mediate a plethora of cellular mechanisms involved in healthy and pathological states such as platelet aggregation, lymphocyte activation, and tissue inflammation. AA has been described to activate Ca2+ entry through the arachidonate-regu...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21093315
更新日期：2020-05-07 00:00:00
abstract：:A flexible methacrylate powder dressing (Altrazeal®) transforms into a wound contour conforming matrix once in contact with wound exudate. We hypothesised that it may also serve as a drug delivery vehicle for antiseptics. The antimicrobial efficacy and influence on bacterial growth kinetics in combination with three a...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms140510582
更新日期：2013-05-21 00:00:00
abstract：:In vitro chondrogenically differentiated mesenchymal stem cells (MSCs) have a tendency to undergo hypertrophy, mirroring the fate of transient "chondrocytes" in the growth plate. As hypertrophy would result in ossification, this fact limits their use in cartilage tissue engineering applications. During limb developmen...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21041444
更新日期：2020-02-20 00:00:00
abstract：:Fabry disease (FD) is a lysosomal storage disorder caused by mutations of the GLA gene that lead to a deficiency of the enzymatic activity of α-galactosidase A. Available therapies for FD include enzyme replacement therapy (ERT) (agalsidase alfa and agalsidase beta) and the chaperone migalastat. Despite the large body...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms22010206
更新日期：2020-12-28 00:00:00
abstract：:The unfolded protein response (UPR) is a cell-signaling system that detects the accumulation of unfolded protein within the endoplasmic reticulum (ER) and initiates a number of cellular responses to restore ER homeostasis. The presence of unfolded protein is detected by the ER-luminal sensor domains of the three UPR-t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms14036454
更新日期：2013-03-21 00:00:00
abstract：:Grasses represent a major family of monocots comprising mostly cereals. When compared to their eudicot counterparts, cereals show a remarkable morphological diversity. Understanding the molecular basis of floral organ identity and inflorescence development is crucial to gain insight into the grain development for yiel...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20112743
更新日期：2019-06-04 00:00:00
abstract：:The effects of zinc supplementation on hippocampal neurogenesis in diabetes mellitus have not been studied. Herein, we investigated the effects of zinc plus cyclo-(His-Pro) (ZC) on neurogenesis occurring in the subgranular zone of dentate gyrus after streptozotocin (STZ)-induced diabetes. ZC (27 mg/kg) was administere...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18010073
更新日期：2017-01-01 00:00:00
abstract：:Plants encounter a variety of mechanical stimuli during their growth and development. It is currently believed that mechanosensitive ion channels play an essential role in the initial perception of mechanical force in plants. Over the past decade, the study of Piezo, a mechanosensitive ion channel in animals, has made...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22010467
更新日期：2021-01-05 00:00:00
abstract：BACKGROUND:Left atrial appendage closure (LAAC) represents the interventional alternative to oral anticoagulation for stroke prevention in atrial fibrillation (AF). The metabolism of acylcarnitines was shown to affect cardiovascular diseases. This study evaluates the influence of successful LAAC on the metabolism of ac...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19020500
更新日期：2018-02-07 00:00:00
abstract：:Suboptimal early-life conditions affect the developing kidney, resulting in long-term programming effects, namely renal programming. Adverse renal programming increases the risk for developing hypertension and kidney disease in adulthood. Conversely, reprogramming is a strategy aimed at reversing the programming proce...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19061744
更新日期：2018-06-12 00:00:00
abstract：:Candida auris is a potential multidrug-resistant pathogen able to persist on indwelling devices as a biofilm, which serve as a source of catheter-associated infections. Neosartorya fischeri antifungal protein 2 (NFAP2) is a cysteine-rich, cationic protein with potent anti-Candida activity. We studied the in vitro acti...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22020771
更新日期：2021-01-14 00:00:00
abstract：:Climate change-induced abiotic stress results in crop yield and production losses. These stresses result in changes at the physiological and molecular level that affect the development and growth of the plant. Reactive oxygen species (ROS) is formed at high levels due to abiotic stress within different organelles, lea...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21155208
更新日期：2020-07-23 00:00:00
abstract：:Anthocyanins as natural pigments are colorful and environmentally compatible dyes for dye-sensitized solar cells (DSSCs). To increase the efficiency, we designed and synthesized unnatural O-methylflavonols and O-methylcyanidins that possess an aryl group at the 8-position. We synthesized per-O-methylquercetin from que...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18020427
更新日期：2017-02-16 00:00:00
abstract：:Mercaptopyruvate sulfurtransferase (Mpst) and its homolog thiosulfate sulfurtransferase (Tst = rhodanese) detoxify cyanide to thiocyanate. Mpst is attracting attention as one of the four endogenous hydrogen sulfide (H2S)/reactive sulfur species (RSS)-producing enzymes, along with cystathionine β-synthase (Cbs), cystat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21030818
更新日期：2020-01-27 00:00:00
abstract：:Articular cartilage is compressed with joint-loading and weight-bearing stresses, followed by a bulging of the tissue during times of off-loading. This loading and off-loading causes changes in water content, and thus alterations in osmotic pressure. Another unique characteristic of articular cartilage is that it has ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19051507
更新日期：2018-05-18 00:00:00
abstract：:To decrease the cost of bioethanol production, biomass recalcitrance needs to be overcome so that the conversion of biomass to bioethanol becomes more efficient. CO(2) laser irradiation can disrupt the lignocellulosic physical structure and reduce the average size of fiber. Analyses with Fourier transform infrared spe...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13044141
更新日期：2012-01-01 00:00:00
abstract：:Panicle degeneration, also known as panicle abortion, is a serious defect and causes heavy losses to reproductive yield in cereals. Several mutants have been reported to display the phenotype of spikelet abortion in rice. Recent findings have resulted in significant breakthroughs, but comprehensive understanding about...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20071613
更新日期：2019-04-01 00:00:00
abstract：:The p38 MAPK pathway is known to influence the anti-tumor effects of several chemotherapeutics, including that of organometallic drugs. Previous studies have demonstrated the important role of p38 both as a regulator and a sensor of cellular reactive oxygen species (ROS) levels. Investigating the anti-cancer propertie...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19123964
更新日期：2018-12-09 00:00:00
abstract：:Histone acetylation plays an important role in plant growth and development. Here, we investigated the effect of sodium butyrate (NaB), a histone deacetylase inhibitor, on adventitious shoot formation from protoplast-derived calli and cotyledon explants of tobacco (Nicotiana benthamiana) and tomato (Solanum lycopersic...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21228451
更新日期：2020-11-10 00:00:00
abstract：:Peritoneal dialysis effluent (PDE) potentially carries an archive of peptides relevant to pathological processes in abdominal and surrounding tissues. Magnetic beads and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry is one such approach that offers a unique tool for profiling of peptides...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms15011162
更新日期：2014-01-16 00:00:00
abstract：:Poplars have evolved various strategies to optimize acclimation responses to environmental conditions. However, how poplars balance growth and nitrogen deficiency remains to be elucidated. In the present study, changes in root development, carbon and nitrogen physiology, and the transcript abundance of associated gene...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19082302
更新日期：2018-08-06 00:00:00
abstract：:Chronic immune response to bone implant may lead to delayed healing and its failure. Thus, newly developed biomaterials should be characterized by high biocompatibility. Moreover, it is well known that macrophages play a crucial role in the controlling of biomaterial-induced inflammatory response. Immune cells synthes...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22031109
更新日期：2021-01-23 00:00:00
abstract：:In this work, Au-Bi(2)Te(3) nanocomposite thermoelectric film with a hierarchical sub-micron antireflection quasi-periodic structure was synthesized via a low-temperature chemical route using Troides helena (Linnaeus) forewing (T_FW) as the biomimetic template. This method combines chemosynthesis with biomimetic techn...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160612547
更新日期：2015-06-03 00:00:00
abstract：:Differentiation and variation in body color has been a growing limitation to the commercial value of red tilapia. Limited microRNA (miRNA) information is available on skin color differentiation and variation in fish so far. In this study, a high-throughput Illumina sequencing of sRNAs was conducted on three color vari...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19041209
更新日期：2018-04-16 00:00:00
abstract：:Fetal programming implies that the maternal diet during pregnancy affects the long-term health of offspring. Although maternal diet influences metabolic disorders and non-alcoholic fatty liver disease in offspring, the hepatic mechanisms related to metabolites are still unknown. Here, we investigated the maternal diet...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21239060
更新日期：2020-11-28 00:00:00
abstract：:The use of animal models in fundamental or pre-clinical research remains an absolute requirement for understanding human pathologies and developing new drugs. In order to transpose these results into clinical practice, many parameters must be taken into account to limit bias. Attention has recently been focused on the...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22020774
更新日期：2021-01-14 00:00:00
abstract：:Spätzle family proteins activate the Toll pathway and induce antimicrobial peptide (AMP) production against microbial infections. However, the functional importance of Tmspätzle4 (TmSpz4) in the immune response of Tenebrio molitor has not been reported. Therefore, here, we have identified and functionally characterize...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21051878
更新日期：2020-03-09 00:00:00
abstract：:Podocytes are visceral epithelial cells covering the outer surface of glomerular capillaries in the kidney. Blood is filtered through the slit diaphragm of podocytes to form urine. The functional and structural integrity of podocytes is essential for the normal function of the kidney. As a membrane-bound organelle, ly...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21051559
更新日期：2020-02-25 00:00:00
abstract：:The multifunctional tissue transglutaminase has been demonstrated to act as α1-adrenergic receptor-coupled G protein with GTPase activity in several cell types. To explore further the pathophysiological significance of this function we investigated the in vivo effects of the α1-adrenergic receptor agonist phenylephrin...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21113865
更新日期：2020-05-29 00:00:00
