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Small engine, big power: microRNAs as regulators of cardiac diseases and regeneration.

Abstract：

:Cardiac diseases are the predominant cause of human mortality in the United States and around the world. MicroRNAs (miRNAs) are small non-coding RNAs that have been shown to modulate a wide range of biological functions under various pathophysiological conditions. miRNAs alter target expression by post-transcriptional regulation of gene expression. Numerous studies have implicated specific miRNAs in cardiovascular development, pathology, regeneration and repair. These observations suggest that miRNAs are potential therapeutic targets to prevent or treat cardiovascular diseases. This review focuses on the emerging role of miRNAs in cardiac development, pathogenesis of cardiovascular diseases, cardiac regeneration and stem cell-mediated cardiac repair. We also discuss the novel diagnostic and therapeutic potential of these miRNAs and their targets in patients with cardiac diseases.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Joladarashi D,Thandavarayan RA,Babu SS,Krishnamurthy P

doi

10.3390/ijms150915891

subject

Has Abstract

pub_date

2014-09-09 00:00:00

pages

15891-911

issue

9

issn

1422-0067

pii

ijms150915891

journal_volume

15

pub_type

杂志文章,评审

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