当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES期刊下所有文献 > Lipopolysaccharide-Preconditioned Periodontal Ligament Stem Cells Induce M1 Polarization of Macrophages through Extracellular Vesicles.

Lipopolysaccharide-Preconditioned Periodontal Ligament Stem Cells Induce M1 Polarization of Macrophages through Extracellular Vesicles.

Abstract：

:Periodontitis is a common disease characterized by chronic inflammation and tissue destruction of gums. Human periodontal ligament stem cells (PDLSCs), derived from the periodontium, have stem cell properties similar to those of mesenchymal stem cells. PDLSCs possess not only the potential to differentiate into other tissues, but also immunomodulatory abilities. Macrophages play a critical role in periodontal disease, but little is known regarding the role of PDLSCs in macrophage modulation during inflammation. In this study, we investigated the effect of PDLSCs on the macrophage cell line. While the conditioned media from PDLSCs under normal culture conditions did not affect macrophage polarization, the lipopolysaccharide (LPS)-preconditioned PDLSCs induced significant changes in M1 polarization. Extracellular vesicles (EVs) isolated from the conditioned media of LPS-preconditioned PDLSCs induced strong M1 polarization of macrophages. Additionally, the M1 polarization was abolished by DNase I treatment of EVs. Therefore, the LPS-stimulated PDLSCs induce M1 polarization of macrophages through EVs, suggesting that the EVs from PDLSCs might be a potential therapeutic target for inflammation in the periodontium.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Kang H,Lee MJ,Park SJ,Lee MS

doi

10.3390/ijms19123843

subject

Has Abstract

pub_date

2018-12-03 00:00:00

issue

12

issn

1422-0067

pii

ijms19123843

journal_volume

19

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES文献大全
  • The Surprising Effect of Phenformin on Cutaneous Darkening and Characterization of Its Underlying Mechanism by a Forward Chemical Genetics Approach.

    abstract：:Melanin in the epidermis is known to ultimately regulate human skin pigmentation. Recently, we exploited a phenotypic-based screening system composed of ex vivo human skin cultures to search for effective materials to regulate skin pigmentation. Since a previous study reported the potent inhibitory effect of metformin...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21041451

    authors： Takano K,Hachiya A,Murase D,Kawasaki A,Uda H,Kasamatsu S,Sugai Y,Takahashi Y,Hase T,Ohuchi A,Suzuki T

    更新日期：2020-02-20 00:00:00

  • Role of Nitric Oxide in the Cardiovascular and Renal Systems.

    abstract：:The gasotransmitters are a family of gaseous signaling molecules which are produced endogenously and act at specific receptors to play imperative roles in physiologic and pathophysiologic processes. As a well-known gasotransmitter along with hydrogen sulfide and carbon monoxide, nitric oxide (NO) has earned repute as ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms19092605

    authors： Ahmad A,Dempsey SK,Daneva Z,Azam M,Li N,Li PL,Ritter JK

    更新日期：2018-09-03 00:00:00

  • Mechanisms Applied by Protein Inhibitors to Inhibit Cysteine Proteases.

    abstract：:Protein inhibitors of proteases are an important tool of nature to regulate and control proteolysis in living organisms under physiological and pathological conditions. In this review, we analyzed the mechanisms of inhibition of cysteine proteases on the basis of structural information and compiled kinetic data. The g...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms22030997

    authors： Tušar L,Usenik A,Turk B,Turk D

    更新日期：2021-01-20 00:00:00

  • Chemical and Molecular Approach to Tumor Metastases.

    abstract：:Tumours are not merely masses of abnormally proliferating cancer cells[...]. ...

    journal_title：International journal of molecular sciences

    pub_type： 社论

    doi：10.3390/ijms19030843

    authors： Bergamo A,Sava G

    更新日期：2018-03-14 00:00:00

  • Improving protein crystal quality by the without-oil microbatch method: crystallization and preliminary X-ray diffraction analysis of glutathione synthetase from Pseudoalteromonas haloplanktis.

    abstract：:Glutathione synthetases catalyze the ATP-dependent synthesis of glutathione from l-γ-glutamyl- l-cysteine and glycine. Although these enzymes have been sequenced and characterized from a variety of biological sources, their exact catalytic mechanism is not fully understood and nothing is known about their adaptation a...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms12096312

    authors： Merlino A,Russo Krauss I,Albino A,Pica A,Vergara A,Masullo M,De Vendittis E,Sica F

    更新日期：2011-01-01 00:00:00

  • Increase in Efficacy of Checkpoint Inhibition by Cytokine-Induced-Killer Cells as a Combination Immunotherapy for Renal Cancer.

    abstract：:Cytokine-induced killer (CIK) cells are heterogeneous, major histocompatibility complex (MHC)-unrestricted T lymphocytes that have acquired the expression of several natural killer (NK) cell surface markers following the addition of interferon gamma (IFN-γ), OKT3 and interleukin-2 (IL-2). Treatment with CIK cells demo...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21093078

    authors： Dehno MN,Li Y,Weiher H,Schmidt-Wolf IGH

    更新日期：2020-04-27 00:00:00

  • L-DOPA in Parkinson's Disease: Looking at the "False" Neurotransmitters and Their Meaning.

    abstract：:L-3,4-dihydroxyphenylalanine (L-DOPA) has been successfully used in the treatment of Parkinson's disease (PD) for more than 50 years. It fulfilled the criteria to cross the blood-brain barrier and counteract the biochemical defect of dopamine (DA). It remarkably worked after some adjustments in line with the initial h...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21010294

    authors： Chagraoui A,Boulain M,Juvin L,Anouar Y,Barrière G,Deurwaerdère P

    更新日期：2019-12-31 00:00:00

  • Develop a High-Throughput Screening Method to Identify C-P4H1 (Collagen Prolyl 4-Hydroxylase 1) Inhibitors from FDA-Approved Chemicals.

    abstract：:Collagen prolyl 4-hydroxylase 1 (C-P4H1) is an α-ketoglutarate (α-KG)-dependent dioxygenase that catalyzes 4-hydroxylation of proline on collagen. C-P4H1-induced prolyl hydroxylation is required for proper collagen deposition and cancer metastasis. Therefore, targeting C-P4H1 is considered a potential therapeutic stra...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21186613

    authors： Wang S,Lee KH,Araujo NV,Zhan CG,Rangnekar VM,Xu R

    更新日期：2020-09-10 00:00:00

  • Immobilization of Lipase A from Candida antarctica onto Chitosan-Coated Magnetic Nanoparticles.

    abstract：:In this communication, lipase A from Candida antarctica (CALA) was immobilized by covalent bonding on magnetic nanoparticles coated with chitosan and activated with glutaraldehyde, labelled CALA-MNP, (immobilization parameters: 84.1% ± 1.0 for immobilization yield and 208.0 ± 3.0 U/g ± 1.1 for derivative activity). CA...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20164018

    authors： Monteiro RRC,Lima PJM,Pinheiro BB,Freire TM,Dutra LMU,Fechine PBA,Gonçalves LRB,de Souza MCM,Dos Santos JCS,Fernandez-Lafuente R

    更新日期：2019-08-17 00:00:00

  • Icariin protects rat cardiac H9c2 cells from apoptosis by inhibiting endoplasmic reticulum stress.

    abstract：:Endoplasmic reticulum stress (ERS) is one of the mechanisms of apoptotic cell death. Inhibiting the apoptosis induced by ERS may be a novel therapeutic target in cardiovascular diseases. Icariin, a flavonoid isolated from Epimedium brevicornum Maxim, has been demonstrated to have cardiovascular protective effects, but...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms140917845

    authors： Zhang Q,Li H,Wang S,Liu M,Feng Y,Wang X

    更新日期：2013-08-30 00:00:00

  • 3D-Reconstructed Retinal Pigment Epithelial Cells Provide Insights into the Anatomy of the Outer Retina.

    abstract：:The retinal pigment epithelium (RPE) is located between the neuroretina and the choroid, and plays a critical role in vision. RPE cells internalise outer segments (OS) from overlying photoreceptors in the daily photoreceptor renewal. Changes to RPE structure are linked with age and retinopathy, which has been describe...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21218408

    authors： Keeling E,Chatelet DS,Tan NYT,Khan F,Richards R,Thisainathan T,Goggin P,Page A,Tumbarello DA,Lotery AJ,Ratnayaka JA

    更新日期：2020-11-09 00:00:00

  • FRCaMP, a Red Fluorescent Genetically Encoded Calcium Indicator Based on Calmodulin from Schizosaccharomyces Pombe Fungus.

    abstract：:Red fluorescent genetically encoded calcium indicators (GECIs) have expanded the available pallet of colors used for the visualization of neuronal calcium activity in vivo. However, their calcium-binding domain is restricted by calmodulin from metazoans. In this study, we developed red GECI, called FRCaMP, using calmo...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms22010111

    authors： Subach OM,Barykina NV,Chefanova ES,Vlaskina AV,Sotskov VP,Ivashkina OI,Anokhin KV,Subach FV

    更新日期：2020-12-24 00:00:00

  • Molecular Characterization and Overexpression of SmJMT Increases the Production of Phenolic Acids in Salvia miltiorrhiza.

    abstract：:Jasmonic acid (JA) carboxyl methyltransferase (JMT), a key enzyme in jasmonate-regulated plant responses, may be involved in plant defense and development by methylating JA to MeJA, thus influencing the concentrations of MeJA in plant. In this study, we isolated the JMT gene from Salvia miltiorrhiza, an important medi...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19123788

    authors： Wang B,Niu J,Li B,Huang Y,Han L,Liu Y,Zhou W,Hu S,Li L,Wang D,Wang S,Cao X,Wang Z

    更新日期：2018-11-28 00:00:00

  • N-Terminal Regions of Prion Protein: Functions and Roles in Prion Diseases.

    abstract：:The normal cellular isoform of prion protein, designated PrPC, is constitutively converted to the abnormally folded, amyloidogenic isoform, PrPSc, in prion diseases, which include Creutzfeldt-Jakob disease in humans and scrapie and bovine spongiform encephalopathy in animals. PrPC is a membrane glycoprotein consisting...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21176233

    authors： Hara H,Sakaguchi S

    更新日期：2020-08-28 00:00:00

  • Role of akirin in skeletal myogenesis.

    abstract：:Akirin is a recently discovered nuclear factor that plays an important role in innate immune responses. Beyond its role in innate immune responses, Akirin has recently been shown to play an important role in skeletal myogenesis. In this article, we will briefly review the structure and tissue distribution of Akirin an...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms14023817

    authors： Chen X,Huang Z,Wang H,Jia G,Liu G,Guo X,Tang R,Long D

    更新日期：2013-02-08 00:00:00

  • Spontaneous Mutations in HIV-1 Gag, Protease, RT p66 in the First Replication Cycle and How They Appear: Insights from an In Vitro Assay on Mutation Rates and Types.

    abstract：:While drug resistant mutations in HIV-1 are largely credited to its error prone HIV-1 RT, the time point in the infection cycle that these mutations can arise and if they appear spontaneously without selection pressures both remained enigmatic. Many HIV-1 RT mutational in vitro studies utilized reporter genes (LacZ) a...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms22010370

    authors： Yeo JY,Koh DW,Yap P,Goh GR,Gan SK

    更新日期：2020-12-31 00:00:00

  • Preanalytical Biases in the Measurement of Human Blood Sphingolipids.

    abstract：:Dysregulation of blood sphingolipids is an emerging topic in clinical science. The objective of this study was to determine preanalytical biases that typically occur in clinical and translational studies and that influence measured blood sphingolipid levels. Therefore, we collected blood samples from four healthy male...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19051390

    authors： Brunkhorst R,Pfeilschifter W,Patyna S,Büttner S,Eckes T,Trautmann S,Thomas D,Pfeilschifter J,Koch A

    更新日期：2018-05-07 00:00:00

  • Discovery of Tricyclic Pyranochromenone as Novel Bruton's Tyrosine Kinase Inhibitors with in Vivo Antirheumatic Activity.

    abstract：:Bruton's tyrosine kinase (BTK) is an attractive target for treating patients with B cell malignancies and autoimmune diseases. Many BTK inhibitors have been identified; however, like other kinase inhibitors, they lack diversity in their core structures. Therefore, it is important to secure a novel scaffold that occupi...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21217919

    authors： Cho H,Lee E,Kwon HA,Seul L,Jeon HJ,Yu JH,Ryu JH,Jeon R

    更新日期：2020-10-25 00:00:00

  • New Insight into the Octamer of TYMS Stabilized by Intermolecular Cys43-Disulfide.

    abstract：:Thymidylate synthase (TYMS) is an essential enzyme for the de novo synthesis of deoxythymidine monophosphate (dTMP) and has been a primary target for cancer chemotherapy. Although the physical structure of TYMS and the molecular mechanisms of TYMS catalyzing the conversion of deoxyuridine monophosphate (dUMP) to dTMP ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19051393

    authors： Xie D,Wang L,Xiao Q,Wu X,Zhang L,Yang Q,Wang L

    更新日期：2018-05-07 00:00:00

  • Diverse Regulation of Vitamin D Receptor Gene Expression by 1,25-Dihydroxyvitamin D and ATRA in Murine and Human Blood Cells at Early Stages of Their Differentiation.

    abstract：:Vitamin D receptor (VDR) is present in multiple blood cells, and the hormonal form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) is essential for the proper functioning of the immune system. The role of retinoic acid receptor α (RARα) in hematopoiesis is very important, as the fusion of RARα gene with PML gene initiat...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms18061323

    authors： Janik S,Nowak U,Łaszkiewicz A,Satyr A,Majkowski M,Marchwicka A,Śnieżewski Ł,Berkowska K,Gabryś M,Cebrat M,Marcinkowska E

    更新日期：2017-06-21 00:00:00

  • Isolation and heterologous expression of a polygalacturonase produced by Fusarium oxysporum f. sp. cubense race 1 and 4.

    abstract：:Fusarium wilt (Panama disease) caused by Fusarium oxysporum f. sp. cubense (FOC) represents a significant threat to banana (Musa spp.) production. Musa AAB is susceptible to Race 1 (FOC1) and Race 4 (FOC4), while Cavendish Musa AAA is found to be resistant to FOC1 but still susceptible to Race 4. A polygalacturonase (...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms16047595

    authors： Dong Z,Wang Z

    更新日期：2015-04-03 00:00:00

  • Analysis of Protein Conformational Strains-A Key for New Diagnostic Methods of Human Diseases.

    abstract：:α-Synuclein is a naturally unfolded protein which easily aggregates and forms toxic inclusions and deposits. It is associated with several neurodegenerative diseases, including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). These diseases, called synucleinopathies, have o...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21082801

    authors： Surguchov A

    更新日期：2020-04-17 00:00:00

  • δ-Tocotrienol, Isolated from Rice Bran, Exerts an Anti-Inflammatory Effect via MAPKs and PPARs Signaling Pathways in Lipopolysaccharide-Stimulated Macrophages.

    abstract：:δ-Tocotrienol, an important component of vitamin E, has been reported to possess some physiological functions, such as anticancer and anti-inflammation, however their molecular mechanisms are not clear. In this study, δ-tocotrienol was isolated and purified from rice bran. The anti-inflammatory effect and mechanism of...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19103022

    authors： Shen J,Yang T,Xu Y,Luo Y,Zhong X,Shi L,Hu T,Guo T,Nie Y,Luo F,Lin Q

    更新日期：2018-10-04 00:00:00

  • From Olive Fruits to Olive Oil: Phenolic Compound Transfer in Six Different Olive Cultivars Grown under the Same Agronomical Conditions.

    abstract：:Phenolic compounds are responsible of the nutritional and sensory quality of extra-virgin olive oil (EVOO). The composition of phenolic compounds in EVOO is related to the initial content of phenolic compounds in the olive-fruit tissues and the activity of enzymes acting on these compounds during the industrial proces...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms17030337

    authors： Talhaoui N,Gómez-Caravaca AM,León L,De la Rosa R,Fernández-Gutiérrez A,Segura-Carretero A

    更新日期：2016-03-04 00:00:00

  • A Proteome Approach Reveals Differences between Fertile Women and Patients with Repeated Implantation Failure on Endometrial Level⁻Does hCG Render the Endometrium of RIF Patients?

    abstract：BACKGROUND:The molecular signature of endometrial receptivity still remains barely understood, especially when focused on the possible benefit of therapeutical interventions and implantation-related pathologies. Therefore, the protein composition of tissue and isolated primary cells (endometrial stromal cells, ESCs) fr...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20020425

    authors： Bielfeld AP,Pour SJ,Poschmann G,Stühler K,Krüssel JS,Baston-Büst DM

    更新日期：2019-01-19 00:00:00

  • Early-Life Maternal Deprivation Predicts Stronger Sickness Behaviour and Reduced Immune Responses to Acute Endotoxaemia in a Pig Model.

    abstract：:Early-life adversity may have programming effects on neuroendocrine and immune adaptation mechanisms in humans and socially living animals. Using a pig model, we investigated the effect of daily 2-h maternal and littermate deprivation from postnatal days 2-15, either alone (DA) or in a group of littermates (DG) on the...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21155212

    authors： Brückmann R,Tuchscherer M,Tuchscherer A,Gimsa U,Kanitz E

    更新日期：2020-07-23 00:00:00

  • Non-Alcoholic Fatty Liver Disease and Metabolic Syndrome after Liver Transplant.

    abstract：:Liver transplant is the unique curative therapy for patients with acute liver failure or end-stage liver disease, with or without hepatocellular carcinoma. Increase of body weight, onset of insulin resistance and drug-induced alterations of metabolism are reported in liver transplant recipients. In this context, post-...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms17040490

    authors： Gitto S,Villa E

    更新日期：2016-04-02 00:00:00

  • The Evolution of Duplicated Genes of the Cpi-17/Phi-1 (ppp1r14) Family of Protein Phosphatase 1 Inhibitors in Teleosts.

    abstract：:The Cpi-17 (ppp1r14) gene family is an evolutionarily conserved, vertebrate specific group of protein phosphatase 1 (PP1) inhibitors. When phosphorylated, Cpi-17 is a potent inhibitor of myosin phosphatase (MP), a holoenzyme complex of the regulatory subunit Mypt1 and the catalytic subunit PP1. Myosin phosphatase deph...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21165709

    authors： Lang I,Virk G,Zheng DC,Young J,Nguyen MJ,Amiri R,Fong M,Arata A,Chadaideh KS,Walsh S,Weiser DC

    更新日期：2020-08-09 00:00:00

  • Histone H1 Post-Translational Modifications: Update and Future Perspectives.

    abstract：:Histone H1 is the most variable histone and its role at the epigenetic level is less characterized than that of core histones. In vertebrates, H1 is a multigene family, which can encode up to 11 subtypes. The H1 subtype composition is different among cell types during the cell cycle and differentiation. Mass spectrome...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21165941

    authors： Andrés M,García-Gomis D,Ponte I,Suau P,Roque A

    更新日期：2020-08-18 00:00:00

  • A Novel Function of the Lysophosphatidic Acid Receptor 3 (LPAR3) Gene in Zebrafish on Modulating Anxiety, Circadian Rhythm Locomotor Activity, and Short-Term Memory.

    abstract：:Lysophosphatidic acid (LPA) is a small lysophospholipid molecule that activates multiple cellular functions through pathways with G-protein-coupled receptors. So far, six LPA receptors (LPAR1 to LPAR6) have been discovered and each one of them can connect to the downstream cell message-transmitting network. A previous...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21082837

    authors： Lin YN,Audira G,Malhotra N,Ngoc Anh NT,Siregar P,Lu JH,Lee H,Hsiao CD

    更新日期：2020-04-18 00:00:00