Abstract：
:Natural Killer (NK) cells are innate lymphocytes that contribute to immune protection by cytosis, cytokine secretion, and regulation of adaptive responses of T cells. NK cells distinguish between healthy and ill cells, and generate a cytotoxic response, being cumulatively regulated by environmental signals delivered through their diverse receptors. Recent advances in biomaterials and device engineering paved the way to numerous artificial microenvironments for cells, which produce synthetic signals identical or similar to those provided by the physiological environment. In this paper, we review recent advances in materials and devices for artificial signaling, which have been applied to regulate NK cells, and systematically study the role of these signals in NK cell function.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Le Saux G,Schvartzman Mdoi
10.3390/ijms20030646subject
Has Abstractpub_date
2019-02-02 00:00:00issue
3issn
1422-0067pii
ijms20030646journal_volume
20pub_type
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