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Behavioral impairment and oxidative damage induced by chronic application of nonylphenol.

Abstract：

:Nonylphenol (NP) is a degradation product of nonylphenol polyethoxylates, which are widely used in the production of industrial and consumer surfactants. The aim of the present study was to evaluate the effect of NP on the antioxidant capacity and cognitive ability of mice. NP was given orally by gavages at doses of 0, 50, 100, and 200 mg kg(-1) d(-1) for 90 days. The results showed that NP significantly decreased the activity of superoxide dismutases (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) and at the same time increased malondialdehyde (MDA) levels in mice brains. Exploration, memory function and ability to learn a novel task were significantly decreased in NP fed mice. These results indicate that chronic high dose of NP exposure has the potential to generate oxidative stress and induce the cognitive impairment in male mice.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Mao Z,Zheng YL,Zhang YQ

doi

10.3390/ijms12010114

subject

Has Abstract

pub_date

2010-12-30 00:00:00

pages

114-27

issue

1

issn

1422-0067

journal_volume

12

pub_type

杂志文章

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