Abstract：
:Polymer-based piezoelectric biomaterials have already proven their relevance for tissue engineering applications. Furthermore, the morphology of the scaffolds plays also an important role in cell proliferation and differentiation. The present work reports on poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV), a biocompatible, biodegradable, and piezoelectric biopolymer that has been processed in different morphologies, including films, fibers, microspheres, and 3D scaffolds. The corresponding magnetically active PHBV-based composites were also produced. The effect of the morphology on physico-chemical, thermal, magnetic, and mechanical properties of pristine and composite samples was evaluated, as well as their cytotoxicity. It was observed that the morphology does not strongly affect the properties of the pristine samples but the introduction of cobalt ferrites induces changes in the degree of crystallinity that could affect the applicability of prepared biomaterials. Young's modulus is dependent of the morphology and also increases with the addition of cobalt ferrites. Both pristine and PHBV/cobalt ferrite composite samples are not cytotoxic, indicating their suitability for tissue engineering applications.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Amaro L,Correia DM,Marques-Almeida T,Martins PM,Pérez L,Vilas JL,Botelho G,Lanceros-Mendez S,Ribeiro Cdoi
10.3390/ijms19082149subject
Has Abstractpub_date
2018-07-24 00:00:00issue
8issn
1422-0067pii
ijms19082149journal_volume
19pub_type
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