Abstract：
:Growth hormone (GH) plays major anabolic and catabolic roles in the body and is important for regulating several aspects of growth. During an inflammatory process, cells may develop a state of GH resistance during which their response to GH stimulation is limited. In this review, we will emphasize specific mechanisms governing the formation of GH resistance in the active phase of inflammatory bowel disease. The specific molecular effects mediated through individual inflammatory mediators and processes will be highlighted to provide an overview of the transcriptional, translational and post-translational inflammation-mediated impacts on the GH receptor (GHR) along with the impacts on GH-induced intracellular signaling. We also will review GH's effects on mucosal healing and immune cells in the context of experimental colitis, human inflammatory bowel disease and in patients with short bowel syndrome.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Soendergaard C,Young JA,Kopchick JJdoi
10.3390/ijms18051019subject
Has Abstractpub_date
2017-05-09 00:00:00issue
5issn
1422-0067pii
ijms18051019journal_volume
18pub_type
杂志文章,评审abstract：:The ageing of human populations has become a problem throughout the world. In this context, increasing the healthy lifespan of individuals has become an important target for medical research and governments. Cardiac disease remains the leading cause of morbidity and mortality in ageing populations and results in signi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21239238
更新日期：2020-12-03 00:00:00
abstract：:Laser printer-emitted nanoparticles (PEPs) generated from toners during printing represent one of the most common types of life cycle released particulate matter from nano-enabled products. Toxicological assessment of PEPs is therefore important for occupational and consumer health protection. Our group recently repor...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20246348
更新日期：2019-12-16 00:00:00
abstract：:Arterial calcification, the deposition of calcium-phosphate crystals in the extracellular matrix, resembles physiological bone mineralization. It is well-known that extracellular nucleotides regulate bone homeostasis raising an emerging interest in the role of these molecules on arterial calcification. The purinergic ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21207636
更新日期：2020-10-15 00:00:00
abstract：:The authors describe a new type of titanium (Ti) implant as a Modi-anodized (ANO) Ti implant, the surface of which was treated by sandblasting, acid etching (SLA), and anodized techniques. The aim of the present study was to evaluate the adhesion of MG-63 cells to Modi-ANO surface treated Ti in vitro and to investigat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160510324
更新日期：2015-05-06 00:00:00
abstract：:Inflammation is the body's response to injury or infection. As early as 2000 years ago, the Roman encyclopaedist Aulus Cornelius Celsus recognised four cardinal signs of this response-redness, heat, swelling and pain; a fifth sign is loss of function.[...]. ...
journal_title：International journal of molecular sciences
pub_type： 社论
doi：10.3390/ijms18112415
更新日期：2017-11-14 00:00:00
abstract：:Alpha thalassaemia is highly prevalent in the plural society of Malaysia and is a public health problem. Haematological and molecular data from 5016 unrelated patients referred from various hospitals to the Institute for Medical Research for α thalassaemia screening from 2007 to 2010 were retrieved. The aims of this r...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms140918599
更新日期：2013-09-10 00:00:00
abstract：:Metabolic reprogramming that favors high glycolytic flux with lactate production in normoxia is among cancer hallmarks. Lactate is an essential oncometabolite regulating cellular redox homeostasis, energy substrate partitioning, and intracellular signaling. Moreover, malignant phenotype's chief characteristics are dep...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21249676
更新日期：2020-12-18 00:00:00
abstract：:The solvatochromic characteristics of flavone and 7-hydroxyflavone were investigated in neat and binary solvent mixtures. The spectral shifts of these solutes were correlated with the Kamlet and Taft parameters (α, β and π*) using linear solvation energy relationships. The multiparametric analysis indicates that both ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms12128895
更新日期：2011-01-01 00:00:00
abstract：:Hybrid magnetorheological elastomers (hMREs) were manufactured based on silicone rubber, silicone oil, carbonyl iron microparticles, graphene nanoparticles and cotton fabric. Using the hMREs, flat capacitors (FCs) were made. Using the installation described in this paper, the electrical capacitance and the coefficient...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20174201
更新日期：2019-08-27 00:00:00
abstract：:Hubs are proteins with a large number of interactions in a protein-protein interaction network. They are the principal agents in the interaction network and affect its function and stability. Their specific recognition of many different protein partners is of great interest from the structural viewpoint. Over the last...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms11041930
更新日期：2010-04-26 00:00:00
abstract：:: Mitochondrial respiratory chain supercomplexes (RCS), particularly, the respirasome, which contains complexes I, III, and IV, have been suggested to participate in facilitating electron transport, reducing the production of reactive oxygen species (ROS), and maintaining the structural integrity of individual electro...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21051555
更新日期：2020-02-25 00:00:00
abstract：:Determination of the thermal characteristics and temperature-dependent rheological properties of the magnetorheological elastomers (MREs) is of paramount importance particularly with regards to MRE applications. Hitherto, a paucity of temperature dependent analysis has been conducted by MRE researchers. In this study,...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20030746
更新日期：2019-02-10 00:00:00
abstract：:Molecular motors are microtubule-based proteins which contribute to many cell functions, such as intracellular transportation and cell division. The details of the nature of the mutual interactions between motors and microtubules still needs to be extensively explored. However, electrostatic interaction is known as on...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21144935
更新日期：2020-07-13 00:00:00
abstract：:Galectins are a family of animal lectins with high affinity for β-galactosides. Galectins are able to bind to bacteria, and a few mammalian galectins are known to kill the bound bacteria. In fish, no galectins with direct bactericidal effect have been reported. In the present study, we identified and characterized a t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22010376
更新日期：2020-12-31 00:00:00
abstract：:Gram-negative bacteria have an outer membrane inhibiting the entry of antibiotics. Porins, found within the outer membrane, are involved in regulating the permeability of β-lactam antibiotics. β-lactamases are enzymes that are able to inactivate the antibacterial properties of β-lactam antibiotics. Interestingly, pori...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21082822
更新日期：2020-04-17 00:00:00
abstract：:Engineering rubber composites have been widely used as main components in many fields including vehicle engineering and biomedical applications. However, when a rubber composite surface area is exposed to heat or sunlight and over a long-term accelerated exposure and lifecycle of test, the rubber becomes hard, thus in...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21239007
更新日期：2020-11-27 00:00:00
abstract：:Tacrolimus has been used to induce remission in patients with steroid-refractory ulcerative colitis. It poses a problem of large individual differences in dosage necessary to attain target blood concentration and, often, this leads to drug inefficacy. We examined the difference in mRNA expression levels of ATP binding...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21124347
更新日期：2020-06-18 00:00:00
abstract：:Amino acid transporters alanine-serine-cysteine transporter 2 (ASCT2) and L-Type Amino Acid Transporter 1 (LAT1) are coordinately enhanced in human cancers where among other roles, they are thought to drive mechanistic target-of-rapamycin (mTOR) growth signaling. To assess ASCT2 and LAT1 as therapeutic targets, nine u...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19072093
更新日期：2018-07-19 00:00:00
abstract：:Over 70 different genetic variants with a significant association with rheumatoid arthritis (RA) have been discovered. Anti-citrullination protein antibodies (ACPA)-positive RA variants are more well-defined than their ACPA-negative counterparts. The human leukocyte antigen, HLA-DRB1 locus remains the prime suspect in...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms17060900
更新日期：2016-06-08 00:00:00
abstract：:The mushroom Inonotus obliquus has been widely used as a folk medicine in Russia, Poland and most of the Baltic countries. In this study, water-soluble and alkali-soluble crude polysaccharides (IOW and IOA) were isolated from I. obliquus, and the carbohydrate-rich fractions IOW-1 and IOA-1 were obtained respectively a...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13079194
更新日期：2012-01-01 00:00:00
abstract：:Rates of loco-regional recurrence and distant metastasis remain high among head and neck squamous cell carcinoma (HNSCC) patients, despite advancing cancer treatment modalities and therapeutic agents. One area that has generated considerable interest is the immune landscape of the tumour, heralding a wave of immune ch...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21218229
更新日期：2020-11-03 00:00:00
abstract：:Eggplant cultivation is limited by numerous diseases, including the devastating bacterial wilt (BW) caused by the Ralstonia solanacearum species complex (RSSC). Within the RSSC, Ralstonia pseudosolanacearum (including phylotypes I and III) causes severe damage to all solanaceous crops, including eggplant. Therefore, t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19020357
更新日期：2018-01-25 00:00:00
abstract：:Human cytomegalovirus (HCMV) is a ubiquitous betaherpesvirus that frequently causes morbidity and mortality in individuals with insufficient immunity, such as transplant recipients, AIDS patients, and congenitally infected newborns. Several antiviral drugs are approved to treat HCMV infections. However, resistant HCMV...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20071636
更新日期：2019-04-02 00:00:00
abstract：:The exact cause of multiple sclerosis (MS) remains elusive. Various factors, however, have been identified that increase an individual's risk of developing this central nervous system (CNS) demyelinating disease and are associated with an acceleration in disease severity. Besides genetic determinants, environmental fa...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20010218
更新日期：2019-01-08 00:00:00
abstract：:Wheat protein is considered a major type of food allergen in many countries including the USA. The mechanisms of allergenicity of wheat proteins are not well understood at present. Both adjuvant-based and adjuvant-free mouse models are reported for this food allergy. However, it is unclear whether the mechanisms under...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21093205
更新日期：2020-05-01 00:00:00
abstract：:The WRKY transcription factor superfamily is known to participate in plant growth and stress response. However, the role of this family in wheat (Triticum aestivum L.) is largely unknown. Here, a salt-induced gene TaWRKY13 was identified in an RNA-Seq data set from salt-treated wheat. The results of RT-qPCR analysis s...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20225712
更新日期：2019-11-14 00:00:00
abstract：:Protein kinases of the CK1 family can be involved in numerous physiological and pathophysiological processes. Dysregulated expression and/or activity as well as mutation of CK1 isoforms have previously been linked to tumorigenesis. Among all neoplastic diseases, colon and rectal cancer (CRC) represent the fourth leadi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20246184
更新日期：2019-12-07 00:00:00
abstract：:Fibroblast growth factor 21 (FGF-21) is known to be a biomarker for mitochondrial disorders. An upregulation of FGF-21 in serum and muscle of carnitine palmitoyltransferase I (CPT I) and carnitine palmitoyltransferase II (CPT II) knock-out mice has been reported. In human CPT II deficiency, enzyme activity and protein...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20061400
更新日期：2019-03-20 00:00:00
abstract：:Yeonsan Ogye is a rare Korean domestic chicken breed whose entire body, including feathers and skin, has a unique black coloring. Although some protein-coding genes related to this unique feature have been examined, non-coding elements have not been widely investigated. Thus, we evaluated coding and non-coding transcr...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19082359
更新日期：2018-08-10 00:00:00
abstract：:Increased platelet activation and apoptosis are characteristic of diabetic (DM) platelets, where a Parkin-dependent mitophagy serves a major endogenous protective role. We now demonstrate that Parkin is highly expressed in both healthy platelets and diabetic platelets, compared to other mitochondria-enriched tissues s...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21165869
更新日期：2020-08-15 00:00:00
