Growth Hormone Resistance-Special Focus on Inflammatory Bowel Disease.

Abstract:

:Growth hormone (GH) plays major anabolic and catabolic roles in the body and is important for regulating several aspects of growth. During an inflammatory process, cells may develop a state of GH resistance during which their response to GH stimulation is limited. In this review, we will emphasize specific mechanisms governing the formation of GH resistance in the active phase of inflammatory bowel disease. The specific molecular effects mediated through individual inflammatory mediators and processes will be highlighted to provide an overview of the transcriptional, translational and post-translational inflammation-mediated impacts on the GH receptor (GHR) along with the impacts on GH-induced intracellular signaling. We also will review GH's effects on mucosal healing and immune cells in the context of experimental colitis, human inflammatory bowel disease and in patients with short bowel syndrome.

journal_name

Int J Mol Sci

authors

Soendergaard C,Young JA,Kopchick JJ

doi

10.3390/ijms18051019

subject

Has Abstract

pub_date

2017-05-09 00:00:00

issue

5

issn

1422-0067

pii

ijms18051019

journal_volume

18

pub_type

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