当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES期刊下所有文献 > Cardiac Fas-dependent and mitochondria-dependent apoptosis after chronic cocaine abuse.

Cardiac Fas-dependent and mitochondria-dependent apoptosis after chronic cocaine abuse.

Abstract：

:To evaluate whether chronic cocaine abuse will increase cardiac Fas-dependent and mitochondria-dependent apoptotic pathways, thirty-two male Wistar rats at 3-4 months of age were randomly divided into a vehicle-treated group (phosphate-buffered saline, PBS, 0.5 mL, SQ per day) and a cocaine-treated group (Cocaine, 10 mg/kg, SQ per day). After 3 months of treatment, the excised left ventricles were measured by H&E staining, Western blotting, DAPI staining and TUNEL assays. More cardiac TUNEL-positive apoptotic cells were observed in the Cocaine group than the PBS group. Protein levels of TNF-alpha, Fas ligand, Fas death receptor, FADD, activated caspase-8, and activated caspase-3 (Fas-dependent apoptosis) extracted from excised hearts in the Cocaine group were significantly increased, compared to the PBS group. Protein levels of cardiac Bax, cytosolic cytochrome c, t-Bid-to-Bid, Bak-to-Bcl-xL, Bax-to-Bcl-2 ratio, activated caspase-9, and activated caspase-3 (mitochondria-dependent apoptosis) were significantly increased in the Cocaine group, compared to the PBS group. Chronic cocaine exposure appeared to activate the cardiac Fas-dependent and mitochondria-dependent apoptosis, which may indicate a possible mechanism for the development of cardiac abnormalities in humans with chronic cocaine abuse.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Liou CM,Tsai SC,Kuo CH,Ting H,Lee SD

doi

10.3390/ijms15045988

subject

Has Abstract

pub_date

2014-04-09 00:00:00

pages

5988-6001

issue

4

issn

1422-0067

pii

ijms15045988

journal_volume

15

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES文献大全
  • Stability Profiles and Therapeutic Effect of Cu/Zn Superoxide Dismutase Chemically Coupled to O-Quaternary Chitosan Derivatives against Dextran Sodium Sulfate-Induced Colitis.

    abstract：:Superoxide dismutase (SOD) has attracted considerable attention on treatment of reactive oxygen species (ROS)-related disorders. We previously conjugated Cu/Zn SOD to O-quaternary chitosan derivatives (O-HTCC) to yield a polymer-enzyme conjugate O-HTCC-SOD that demonstrated superior therapeutic effect to native SOD. T...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms18061121

    authors： Zhao N,Feng Z,Shao M,Cao J,Wang F,Liu C

    更新日期：2017-05-24 00:00:00

  • The Function of Transthyretin Complexes with Metallothionein in Alzheimer's Disease.

    abstract：:Alzheimer's disease (AD) is one of the most frequently diagnosed types of dementia in the elderly. An important pathological feature in AD is the aggregation and deposition of the β-amyloid (Aβ) in extracellular plaques. Transthyretin (TTR) can cleave Aβ, resulting in the formation of short peptides with less activity...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21239003

    authors： Zaręba N,Kepinska M

    更新日期：2020-11-26 00:00:00

  • Jasmonic Acid Methyl Ester Induces Xylogenesis and Modulates Auxin-Induced Xylary Cell Identity with NO Involvement.

    abstract：:In Arabidopsis basal hypocotyls of dark-grown seedlings, xylary cells may form from the pericycle as an alternative to adventitious roots. Several hormones may induce xylogenesis, as Jasmonic acid (JA), as well as indole-3-acetic acid (IAA) and indole-3-butyric acid (IBA) auxins, which also affect xylary identity. Stu...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20184469

    authors： Della Rovere F,Fattorini L,Ronzan M,Falasca G,Altamura MM,Betti C

    更新日期：2019-09-10 00:00:00

  • SERS-Based Biosensors for Virus Determination with Oligonucleotides as Recognition Elements.

    abstract：:Viral infections are among the main causes of morbidity and mortality of humans; sensitive and specific diagnostic methods for the rapid identification of viral pathogens are required. Surface-enhanced Raman spectroscopy (SERS) is one of the most promising techniques for routine analysis due to its excellent sensitivi...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21093373

    authors： Ambartsumyan O,Gribanyov D,Kukushkin V,Kopylov A,Zavyalova E

    更新日期：2020-05-10 00:00:00

  • Stem cell-based neuroprotective and neurorestorative strategies.

    abstract：:Stem cells, a special subset of cells derived from embryo or adult tissues, are known to present the characteristics of self-renewal, multiple lineages of differentiation, high plastic capability, and long-term maintenance. Recent reports have further suggested that neural stem cells (NSCs) derived from the adult hipp...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms11052039

    authors： Hung CW,Liou YJ,Lu SW,Tseng LM,Kao CL,Chen SJ,Chiou SH,Chang CJ

    更新日期：2010-05-05 00:00:00

  • Analysis of Hypericin-Mediated Effects and Implications for Targeted Photodynamic Therapy.

    abstract：:The phototoxic effect of hypericin can be utilized for Photodynamic Therapy (PDT) of cancer. After intravenous application and systemic distribution of the drug in the patient's body, the tumor site is exposed to light. Subsequently, toxic reactive oxygen species (ROS) are generated, inducing tumor cell death. To prev...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms18071388

    authors： Mühleisen L,Alev M,Unterweger H,Subatzus D,Pöttler M,Friedrich RP,Alexiou C,Janko C

    更新日期：2017-06-29 00:00:00

  • Structural Studies of Predicted Ligand Binding Sites and Molecular Docking Analysis of Slc2a4 as a Therapeutic Target for the Treatment of Cancer.

    abstract：:Presently, many studies have focused on exploring in silico approaches in the identification and development of alternative therapy for the treatment and management of cancer. Solute carrier family-2-member-4-gene (Slc2a4) which encodes glucose transporter 4 protein (GLUT4), has been identified as a promising therapeu...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19020386

    authors： Aruleba RT,Adekiya TA,Oyinloye BE,Kappo AP

    更新日期：2018-01-28 00:00:00

  • The Effect of Uncoated SPIONs on hiPSC-Differentiated Endothelial Cells.

    abstract：BACKGROUND:Endothelial progenitor cells (EPCs) were indicated in vascular repair, angiogenesis of ischemic organs, and inhibition of formation of initial hyperplasia. Differentiation of endothelial cells (ECs) from human induced pluripotent stem cells (hiPSC)-derived endothelial cells (hiPSC-ECs) provides an unlimited ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20143536

    authors： Salingova B,Simara P,Matula P,Zajickova L,Synek P,Jasek O,Veverkova L,Sedlackova M,Nichtova Z,Koutna I

    更新日期：2019-07-19 00:00:00

  • Asymmetric dimethylarginine as a surrogate marker of endothelial dysfunction and cardiovascular risk in patients with systemic rheumatic diseases.

    abstract：:The last few decades have witnessed an increased life expectancy of patients suffering with systemic rheumatic diseases, mainly due to improved management, advanced therapies and preventative measures. However, autoimmune disorders are associated with significantly enhanced cardiovascular morbidity and mortality not f...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms131012315

    authors： Dimitroulas T,Sandoo A,Kitas GD

    更新日期：2012-09-26 00:00:00

  • Profiling the proteome of exhaled breath condensate in healthy smokers and COPD patients by LC-MS/MS.

    abstract：:Three pools of exhaled breath condensate (EBC) from non-smokers plus healthy smokers (NS + HS, n = 45); chronic obstructive pulmonary disease (COPD) without emphysema (COPD, n = 15) and subjects with pulmonary emphysema associated with α(1)-antitrypsin deficiency (AATD, n = 23) were used for an exploratory proteomic ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms131113894

    authors： Fumagalli M,Ferrari F,Luisetti M,Stolk J,Hiemstra PS,Capuano D,Viglio S,Fregonese L,Cerveri I,Corana F,Tinelli C,Iadarola P

    更新日期：2012-10-29 00:00:00

  • PD-1 and PD-L1 Expression on Circulating Lymphocytes as a Marker of Epstein-Barr Virus Reactivation-Associated Proliferative Glomerulonephritis.

    abstract：:Alterations to the programmed cell death protein-1 (PD-1) pathway were previously shown to be involved in a poorer prognosis for patients with proliferative glomerulonephritis (PGN). Here, we investigated the association between several infectious agents and the expression of PD-1 and its ligand (PD-L1) on T and B lym...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21218001

    authors： Grywalska E,Smarz-Widelska I,Korona-Głowniak I,Mertowski S,Gosik K,Hymos A,Ludian J,Niedźwiedzka-Rystwej P,Roliński J,Załuska W

    更新日期：2020-10-27 00:00:00

  • Protective Effects of α-Tocopherol, γ-Tocopherol and Oleic Acid, Three Compounds of Olive Oils, and No Effect of Trolox, on 7-Ketocholesterol-Induced Mitochondrial and Peroxisomal Dysfunction in Microglial BV-2 Cells.

    abstract：:Lipid peroxidation products, such as 7-ketocholesterol (7KC), may be increased in the body fluids and tissues of patients with neurodegenerative diseases and trigger microglial dysfunction involved in neurodegeneration. It is therefore important to identify synthetic and natural molecules able to impair the toxic effe...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms17121973

    authors： Debbabi M,Nury T,Zarrouk A,Mekahli N,Bezine M,Sghaier R,Grégoire S,Martine L,Durand P,Camus E,Vejux A,Jabrane A,Bretillon L,Prost M,Moreau T,Ammou SB,Hammami M,Lizard G

    更新日期：2016-11-25 00:00:00

  • Resistance to Spot Blotch in Two Mapping Populations of Common Wheat Is Controlled by Multiple QTL of Minor Effects.

    abstract：:Spot blotch (SB) is an important fungal disease of wheat in South Asia and South America. Host resistance is regarded as an economical and environmentally friendly approach of controlling SB, and the inheritance of resistance is mostly quantitative. In order to gain a better understanding on the SB resistance mechanis...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19124054

    authors： Singh PK,He X,Sansaloni CP,Juliana P,Dreisigacker S,Duveiller E,Kumar U,Joshi AK,Singh RP

    更新日期：2018-12-14 00:00:00

  • psbE-psbL and ndhA Intron, the Promising Plastid DNA Barcode of Fagopyrum.

    abstract：:Buckwheat is an important functional food material with high nutritional value. However, it is still a difficult task for the taxonomy studies of wild buckwheat that are only based on morphology. In order to demonstrate the most efficient DNA barcode in the phylogenetic research of buckwheat, promote the investigation...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20143455

    authors： Huang Y,Li Z,Wang C,Zou C,Wen W,Shao J,Zhu X

    更新日期：2019-07-14 00:00:00

  • Titanium immobilized with an antimicrobial peptide derived from histatin accelerates the differentiation of osteoblastic cell line, MC3T3-E1.

    abstract：:The objective of this study was to evaluate the effect of titanium immobilized with a cationic antimicrobial peptide (JH8194) derived from histatin on the biofilm formation of Porphyromonas gingivalis and differentiation of osteoblastic cells (MC3T3-E1). The titanium specimens (Ti) were immobilized with JH8194, accord...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms11041458

    authors： Makihira S,Shuto T,Nikawa H,Okamoto K,Mine Y,Takamoto Y,Ohara M,Tsuji K

    更新日期：2010-04-02 00:00:00

  • BCL11A mRNA Targeting by miR-210: A Possible Network Regulating γ-Globin Gene Expression.

    abstract：:The involvement of microRNAs in the control of repressors of human γ-globin gene transcription has been firmly demonstrated, as described for the miR-486-3p mediated down-regulation of BCL11A. On the other hand, we have reported that miR-210 is involved in erythroid differentiation and, possibly, in γ-globin gene up-r...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms18122530

    authors： Gasparello J,Fabbri E,Bianchi N,Breveglieri G,Zuccato C,Borgatti M,Gambari R,Finotti A

    更新日期：2017-11-26 00:00:00

  • Cryopreservation Differentially Alters the Proteome of Epididymal and Ejaculated Pig Spermatozoa.

    abstract：:Cryopreservation induces differential remodeling of the proteome in mammalian spermatozoa. How these proteome changes relate to the loss of sperm function during cryopreservation remains unsolved. The present study aimed to clarify this issue evaluating differential changes in the proteome of fresh and frozen-thawed p...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20071791

    authors： Perez-Patiño C,Barranco I,Li J,Padilla L,Martinez EA,Rodriguez-Martinez H,Roca J,Parrilla I

    更新日期：2019-04-11 00:00:00

  • VDAC1 and the TSPO: Expression, Interactions, and Associated Functions in Health and Disease States.

    abstract：:The translocator protein (TSPO), located at the outer mitochondrial membrane (OMM), serves multiple functions and contributes to numerous processes, including cholesterol import, mitochondrial metabolism, apoptosis, cell proliferation, Ca2+ signaling, oxidative stress, and inflammation. TSPO forms a complex with the v...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20133348

    authors： Shoshan-Barmatz V,Pittala S,Mizrachi D

    更新日期：2019-07-08 00:00:00

  • Insights into the Impact of Linker Flexibility and Fragment Ionization on the Design of CK2 Allosteric Inhibitors: Comparative Molecular Dynamics Simulation Studies.

    abstract：:Protein kinase is a novel therapeutic target for human diseases. The off-target and side effects of ATP-competitive inhibitors preclude them from the clinically relevant drugs. The compounds targeting the druggable allosteric sites outside the highly conversed ATP binding pocket have been identified as promising alter...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19010111

    authors： Zhou Y,Zhang N,Qi X,Tang S,Sun G,Zhao L,Zhong R,Peng Y

    更新日期：2018-01-01 00:00:00

  • Systemically Administered, Target Organ-Specific Therapies for Regenerative Medicine.

    abstract：:Growth factors and other agents that could potentially enhance tissue regeneration have been identified, but their therapeutic value in clinical medicine has been limited for reasons such as difficulty to maintain bioactivity of locally applied therapeutics in the protease-rich environment of regenerating tissues. Alt...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms161023556

    authors： Järvinen TA,May U,Prince S

    更新日期：2015-09-30 00:00:00

  • Human Germ Cell Tumors are Developmental Cancers: Impact of Epigenetics on Pathobiology and Clinic.

    abstract：:Current (high throughput omics-based) data support the model that human (malignant) germ cell tumors are not initiated by somatic mutations, but, instead through a defined locked epigenetic status, representative of their cell of origin. This elegantly explains the role of both genetic susceptibility as well as enviro...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20020258

    authors： Lobo J,Gillis AJM,Jerónimo C,Henrique R,Looijenga LHJ

    更新日期：2019-01-10 00:00:00

  • Antiphospholipid Antibodies and Autoimmune Haemolytic Anaemia: A Systematic Review and Meta-Analysis.

    abstract：:The relationship between antiphospholipid antibodies (aPL) and autoimmune haemolytic anaemia (AIHA) has never been systematically addressed. The aim of this study is to assess the link between aPL and AIHA in adult systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). This study performed an EMBASE/P...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21114120

    authors： Ames PRJ,Merashli M,Bucci T,Pastori D,Pignatelli P,Arcaro A,Gentile F

    更新日期：2020-06-09 00:00:00

  • Regulation of Epithelial Cell Functions by the Osmolality and Hydrostatic Pressure Gradients: A Possible Role of the Tight Junction as a Sensor.

    abstract：:Epithelia act as a barrier to the external environment. The extracellular environment constantly changes, and the epithelia are required to regulate their function in accordance with the changes in the environment. It has been reported that a difference of the environment between the apical and basal sides of epitheli...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20143513

    authors： Tokuda S,Yu ASL

    更新日期：2019-07-17 00:00:00

  • Androgen receptor phosphorylation at serine 308 and serine 791 predicts enhanced survival in castrate resistant prostate cancer patients.

    abstract：:We previously reported that AR phosphorylation at serine 213 was associated with poor outcome and may contribute to prostate cancer development and progression. This study investigates if specific AR phosphorylation sites have differing roles in the progression of hormone naïve prostate cancer (HNPC) to castrate resis...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms140816656

    authors： McCall P,Adams CE,Willder JM,Bennett L,Qayyum T,Orange C,Underwood MA,Edwards J

    更新日期：2013-08-13 00:00:00

  • Proteomic Differences in Feline Fibrosarcomas Grown Using Doxorubicin-Sensitive and -Resistant Cell Lines in the Chick Embryo Model.

    abstract：:Proteomic analyses are rapid and powerful tools that are used to increase the understanding of cancer pathogenesis, discover cancer biomarkers and predictive markers, and select and monitor novel targets for cancer therapy. Feline injection-site sarcomas (FISS) are aggressive skin tumours with high recurrence rates, d...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19020576

    authors： Zabielska-Koczywąs K,Michalak K,Wojtalewicz A,Winiarczyk M,Adaszek Ł,Winiarczyk S,Lechowski R

    更新日期：2018-02-14 00:00:00

  • Clinical Trials with Combination of Cytokine-Induced Killer Cells and Dendritic Cells for Cancer Therapy.

    abstract：:Adoptive cellular immunotherapy (ACI) is a promising treatment for a number of cancers. Cytokine-induced killer cells (CIKs) are considered to be major cytotoxic immunologic effector cells. Usually cancer cells are able to suppress antitumor responses by secreting immunosuppressive factors. CIKs have significant antit...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20174307

    authors： Garofano F,Gonzalez-Carmona MA,Skowasch D,Schmidt-Wolf R,Abramian A,Hauser S,Strassburg CP,Schmidt-Wolf IGH

    更新日期：2019-09-03 00:00:00

  • Histone Lysine Methylation and Neurodevelopmental Disorders.

    abstract：:Methylation of several lysine residues of histones is a crucial mechanism for relatively long-term regulation of genomic activity. Recent molecular biological studies have demonstrated that the function of histone methylation is more diverse and complex than previously thought. Moreover, studies using newly available ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms18071404

    authors： Kim JH,Lee JH,Lee IS,Lee SB,Cho KS

    更新日期：2017-06-30 00:00:00

  • Estrogen Induces Selective Transcription of Caveolin1 Variants in Human Breast Cancer through Estrogen Responsive Element-Dependent Mechanisms.

    abstract：:The estrogen receptor (ER) signaling regulates numerous physiological processes mainly through activation of gene transcription (genomic pathways). Caveolin1 (CAV1) is a membrane-resident protein that behaves as platform to enable different signaling molecules and receptors for membrane-initiated pathways. CAV1 direct...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21175989

    authors： Romano A,Feola A,Porcellini A,Gigantino V,Di Bonito M,Di Mauro A,Caggiano R,Faraonio R,Zuchegna C

    更新日期：2020-08-20 00:00:00

  • Regenerative Effects of Heme Oxygenase Metabolites on Neuroinflammatory Diseases.

    abstract：:Heme oxygenase (HO) catabolizes heme to produce HO metabolites, such as carbon monoxide (CO) and bilirubin (BR), which have gained recognition as biological signal transduction effectors. The neurovascular unit refers to a highly evolved network among endothelial cells, pericytes, astrocytes, microglia, neurons, and n...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20010078

    authors： Lee H,Choi YK

    更新日期：2018-12-25 00:00:00

  • Review: Receptor Targeted Nuclear Imaging of Breast Cancer.

    abstract：:Receptor targeted nuclear imaging directed against molecular markers overexpressed on breast cancer (BC) cells offers a sensitive and specific method for BC imaging. Currently, a few targets such as estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), somatostatin recept...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms18020260

    authors： Dalm SU,Verzijlbergen JF,De Jong M

    更新日期：2017-01-26 00:00:00