Abstract：
:Intra-articular injection of platelet-rich plasma (PRP) has been established as a suitable treatment for knee osteoarthritis. Here, we present a double-blind randomized controlled clinical trial, conducted in a public Hospital of the Spanish National Health Care System, to evaluate the efficacy of injecting autologous PRP versus hyaluronic acid (HA) in knee osteoarthritis. PRP was manufactured in Malaga's Regional Blood Center (Spain). Patients that met the eligibility criteria were randomized into a PRP group or a HA group. Pain and functional improvements were assessed pre- and post-treatment (three and six months follow-up) using the Visual Analogue Scale (VAS); the Knee and Osteoarthritis Outcome System (KOOS) scale and the European Quality of Life scale (EUROQOL). Both groups presented pain reduction at six months. The VAS scores for the PRP group improved by at least 50% from their initial value, particularly at three months following the final infiltration, with results resembling those of the HA group at six months. PRP was more effective in patients with lower osteoarthritis grades. Both treatments improved pain in knee osteoarthritis patients without statistically significant differences between them. However, PRP injection was proved to improve pain three months after the final infiltration and to be more effective in lower osteoarthritis grades.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Montañez-Heredia E,Irízar S,Huertas PJ,Otero E,Del Valle M,Prat I,Díaz-Gallardo MS,Perán M,Marchal JA,Hernandez-Lamas Mdel Cdoi
10.3390/ijms17071064subject
Has Abstractpub_date
2016-07-02 00:00:00issue
7issn
1422-0067pii
ijms17071064journal_volume
17pub_type
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