Abstract：
:Myeloid immune cells, such as dendritic cells, monocytes, and macrophages, play a central role in the generation of immune responses and thus are often either disabled or even hijacked by tumors. These new tolerogenic activities of tumor-associated myeloid cells are controlled by an oncogenic transcription factor, signal transducer and activator of transcription 3 (STAT3). STAT3 multitasks to ensure tumors escape immune detection by impairing antigen presentation and reducing production of immunostimulatory molecules while augmenting the release of tolerogenic mediators, thereby reducing innate and adaptive antitumor immunity. Tumor-associated myeloid cells and STAT3 signaling in this compartment are now commonly recognized as an attractive cellular target for improving efficacy of standard therapies and immunotherapies. Hereby, we review the importance and functional complexity of STAT3 signaling in this immune cell compartment as well as potential strategies for cancer therapy.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Su YL,Banerjee S,White SV,Kortylewski Mdoi
10.3390/ijms19061803subject
Has Abstractpub_date
2018-06-19 00:00:00issue
6issn
1422-0067pii
ijms19061803journal_volume
19pub_type
杂志文章,评审abstract：:Vortioxetine is a novel, multimodal antidepressant with unique targets, including the inhibition of the serotonin transporter (SET), of serotonin 5-HT3 (5-HT3R), and of 5-HT7 (5-HT7R) receptors and partial agonism to serotonin 5-HT1A (5-HT1AR) receptors in humans. Vortioxetine has a lower affinity to 5-HT1AR and 5-HT7...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20246235
更新日期：2019-12-10 00:00:00
abstract：:Drought stress is a major obstacle to agriculture. Although many studies have reported on plant drought tolerance achieved via genetic modification, application of plant growth-promoting rhizobacteria (PGPR) to achieve tolerance has rarely been studied. In this study, the ability of three isolates, including Bacillus ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20246271
更新日期：2019-12-12 00:00:00
abstract：:Broad Copy Number Gains (BCNGs) are copy-number increases of chromosomes or large segments of chromosomal arms. Publicly-available single-nucleotide polymorphism (SNP) array and RNA-Seq data of colon adenocarcinoma (COAD) samples from The Cancer Genome Atlas (TCGA) consortium allowed us to design better control groups...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20184652
更新日期：2019-09-19 00:00:00
abstract：:The At-Hook Motif Nuclear Localized Protein (AHL) gene family encodes embryophyte-specific nuclear proteins with DNA binding activity. They modulate gene expression and affect various developmental processes in plants. We identify AHL18 (At3G60870) as a developmental modulator of root system architecture and growth. A...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21051886
更新日期：2020-03-10 00:00:00
abstract：:miR-29a is a conserved miRNA that participates in bone formation and immune response in vertebrates. miR-29a of Pinctada martensii (Pm-miR-29a) was identified in the previous research though deep sequencing. In this report, the precise sequence of mature Pm-miR-29a was validated using miRNA rapid amplification of cDNA...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms161226182
更新日期：2015-12-10 00:00:00
abstract：:Colorectal cancer is one of the leading causes of death, and the third most diagnosed type of cancer, worldwide. It is most common amongst men and women over 50 years old. Risk factors include smoking, alcohol, diet, physical inactivity, genetics, alterations in gut microbiota, and associated pathologies (diabetes, ob...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19123787
更新日期：2018-11-28 00:00:00
abstract：:Oxylipins generated by the lipoxygenase (LOX) pathway play an important role in plant defense against biotic and abiotic stress. In chitosan-treated Adelostemma gracillimum seedlings, obvious accumulation of 9-LOX-derived oxylipins, namely 9,10,11-trihydroxy-12-octadecenoic acid, was detected. Using degenerate primers...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13010540
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:P1G10 is a cysteine proteolytic fraction from Vasconcellea cundinamarcensis latex, obtained by chromatographic separation on Sephadex-G10 and ultrafiltration. This fraction enhances healing in different models of skin lesions, and displays a protective/healing effect against gastric ulcers, where it was sugg...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20184373
更新日期：2019-09-06 00:00:00
abstract：:Cerium dioxide nanoparticles (C(e)O₂ ENPs) are on the priority list of nanomaterials requiring evaluation. We performed in vitro assays on mature mouse oocytes incubated with C(e)O₂ ENPs to study (1) physicochemical biotransformation of ENPs in culture medium; (2) ultrastructural interactions with follicular cells and...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms141121613
更新日期：2013-10-31 00:00:00
abstract：:This review covers recent advances and work on the microstructure features, mechanical properties and cracking processes of conducting polymer film/coating- substrate structures under different testing conditions. An attempt is made to characterize and quantify the relationships between mechanical properties and micro...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms10125257
更新日期：2009-12-08 00:00:00
abstract：:The folding of protein molecules in the GroEL inner cavity under the co-chaperonin GroES lid is widely accepted as a crucial event of GroEL-assisted protein folding. This review is focused on the data showing that GroEL-assisted protein folding may proceed out of the complex with the chaperonin. The models of GroEL-as...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms10052066
更新日期：2009-05-12 00:00:00
abstract：:Spider silk is self-assembled from water-soluble silk proteins through changes in the environment, including pH, salt concentrations, and shear force. The N-terminal domains of major and minor ampullate silk proteins have been found to play an important role in the assembly process through salt- and pH-dependent dimer...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21124466
更新日期：2020-06-23 00:00:00
abstract：:The tumor microenvironment (TME) has become the focus of interest in cancer research and treatment. It includes the extracellular matrix (ECM) and ECM-modifying enzymes that are secreted by cancer and neighboring cells. The ECM serves both to anchor the tumor cells embedded in it and as a means of communication betwee...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms22010238
更新日期：2020-12-28 00:00:00
abstract：:Lonicera japonica Thunb. is a widely used medicinal plant and is rich in a variety of active ingredients. Flavonoids are one of the important components in L. japonica and their content is an important indicator for evaluating the quality of this herb. To study the regulation of flavonoid biosynthesis in L. japonica, ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20184494
更新日期：2019-09-11 00:00:00
abstract：:The human peptide GHK (glycyl-l-histidyl-l-lysine) has multiple biological actions, all of which, according to our current knowledge, appear to be health positive. It stimulates blood vessel and nerve outgrowth, increases collagen, elastin, and glycosaminoglycan synthesis, as well as supports the function of dermal fi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19071987
更新日期：2018-07-07 00:00:00
abstract：:Understanding the role of substituents is of great importance for the preparation of novel phenolic compounds with enhanced antioxidative properties. In this work, the antioxidative activity of isoflavonoid derivatives with different substituents placed at the C2 position was determined by density functional theory (D...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20020397
更新日期：2019-01-18 00:00:00
abstract：:Impairment of mucociliary clearance with reduced airway fluid secretion leads to chronically inflamed airways. Cystic fibrosis transmembrane conductance regulator (CFTR) is crucially involved in airway fluid secretion and dexamethasone (dexa) has previously been shown to elevate CFTR activity in airway epithelial cell...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18081807
更新日期：2017-08-19 00:00:00
abstract：:Molecular chaperones are key components of the protein homeostasis system against protein misfolding and aggregation. It has been recently shown that these molecules can be rationally modified to have an enhanced activity against specific amyloidogenic substrates. The resulting molecular chaperone variants can be effe...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19051443
更新日期：2018-05-12 00:00:00
abstract：:Soil salinization, which is primarily due to excessive Na+ levels, is a major abiotic stress adversely affecting plant growth and development. The Na+/H+ antiporter (NHX) is a transmembrane protein mediating the transport of Na+ or K+ and H+ across the membrane to modulate the ionic balance of plants in response to sa...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21207712
更新日期：2020-10-18 00:00:00
abstract：:Pasting properties are important characteristics of barley starch from a processing standpoint. Many studies reported the close relationship between pasting properties and malting quality, especially malt extract. However, most conclusions were derived from the correlation between pasting properties and malting qualit...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19113559
更新日期：2018-11-12 00:00:00
abstract：:The silencing of thyroid-related genes presents difficulties in radioiodine therapy for anaplastic thyroid cancers (ATCs). Tunicamycin (TM), an N-linked glycosylation inhibitor, is an anticancer drug. Herein, we investigated TM-induced restoration of responsiveness to radioiodine therapy in radioiodine refractory ATCs...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22031077
更新日期：2021-01-22 00:00:00
abstract：:Bone mass loss occurs with a decrease in osteoblast proliferation and differentiation, or the enhancement of bone resorption, which further leads to the impairment of bone mineral density and increase in bone fracture. Recent studies suggest that some phenolic compounds found in food play positive role in bone metabol...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21144909
更新日期：2020-07-11 00:00:00
abstract：:The high affinity immunoglobulin E (IgE) receptor-FcεR1 is mainly expressed on the surface of effector cells. Cross-linking of IgE Abs bound to FcεR1 by multi-valent antigens can induce the activation of these cells and the secretion of inflammatory mediators. Since FcεR1 plays a central role in the induction and main...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms16059504
更新日期：2015-04-27 00:00:00
abstract：:A conformational analysis of nine macrocyclic thioether musks has been carried out using molecular mechanics (MMFF), density functional theory (DFT) using both B3LYP and M06 functionals, as well as Hartree-Fock and post-Hartree-Fock (MP2) ab initio methods. 6-Thia-, 10-thia- and 4-methyl-5-thia-14-tetradecananolide, 4...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms10083488
更新日期：2009-08-04 00:00:00
abstract：:Attributed to the tropism for host microvascular endothelium lining the blood vessels, vascular inflammation and dysfunction represent salient features of rickettsial pathogenesis, yet the details of fundamentally important pathogen interactions with host endothelial cells (ECs) as the primary targets of infection rem...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21197179
更新日期：2020-09-29 00:00:00
abstract：:Paraoxonase 1 gene (PON1) polymorphisms and dietary vegetable and fruit intake are both established determinants of ischemic stroke (IS). However, little is known about whether these factors jointly influence the risk of IS. We analyzed the main effects of PON1, as well as the interactions between PON1 and dietary veg...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18122652
更新日期：2017-12-07 00:00:00
abstract：:Altered microRNA expression is implicated in cardiovascular diseases. Our objective was to determine microRNA signatures in thoracic aortic aneurysms (TAAs) and abdominal aortic aneurysms (AAAs) compared with control non-aneurysmal aortic specimens. We evaluated the expression of fifteen selected microRNA in human TAA...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18040875
更新日期：2017-04-20 00:00:00
abstract：:The aim of the present pilot study was the identification of micro-RNA changes over time during the development and progression of type 2 diabetes (T2D) in Zucker diabetic fatty rats (ZDF rats). T2D is a complex metabolic disorder that is characterized, inter alia, by progressive failure of pancreatic β cells to produ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17050665
更新日期：2016-05-03 00:00:00
abstract：:Early exercise is an effective strategy for stroke treatment, but the underlying mechanism remains poorly understood. Apoptosis plays a critical role after stroke. However, it is unclear whether early exercise inhibits apoptosis after stroke. The present study investigated the effect of early exercise on apoptosis ind...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms14036074
更新日期：2013-03-15 00:00:00
abstract：:Erythroid Differentiation Regulator 1 (Erdr1) is known as a hemoglobin synthesis factor which also regulates cell survival under conditions of stress. In addition, previous studies have revealed the effects of Erdr1 on cancer progression and its negative correlation with interleukin (IL)-18, a pro-inflammatory cytokin...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms17122059
更新日期：2016-12-08 00:00:00
