Abstract：
:Staphylococcus argenteus is an emerging species responsible for infections comparable to those induced by Staphylococcus aureus. It has been involved in few chronic or persistent infections so far. In this study, we described a case of a persistent prosthetic-joint infection (PJI) affecting a young woman. We investigated in vitro the virulence traits of the incriminated S. argenteus strain (bone cell invasion, biofilm formation and induction of inflammation) and analyzed its genome, in comparison with two other strains of S. argenteus and two S. aureus isolates. It appeared that this S. argenteus PJI strain combined biofilm formation, osteoblast invasion and intracellular persistence abilities together with genes potentially involved in the escape of the host immune defenses, which might explain the chronicization of the infection.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Diot A,Dyon-Tafani V,Bergot M,Tasse J,Martins-Simões P,Josse J,Valour F,Laurent Fdoi
10.3390/ijms21176245subject
Has Abstractpub_date
2020-08-28 00:00:00issue
17issn
1422-0067pii
ijms21176245journal_volume
21pub_type
杂志文章abstract：:Neurological disorders are the most devastating and challenging diseases associated with the central nervous system (CNS). The blood-brain barrier (BBB) maintains homeostasis of the brain and contributes towards the maintenance of a very delicate microenvironment, impairing the transport of many therapeutics into the ...
journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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