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Structural Identification of Antibacterial Lipids from Amazonian Palm Tree Endophytes through the Molecular Network Approach.

Abstract：

:A library of 197 endophytic fungi and bacteria isolated from the Amazonian palm tree Astrocaryum sciophilum was extracted and screened for antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). Four out of five antibacterial ethyl acetate extracts were also cytotoxic for the MRC-5 cells line. Liquid chromatography coupled to tandem mass spectrometry (UPHLC-HRMS/MS) analyses combined with molecular networking data processing were carried out to allow the identification of depsipeptides and cyclopeptides responsible for the cytotoxicity in the dataset. Specific ion clusters from the active Luteibacter sp. extract were also highlighted using an MRSA activity filter. A chemical study of Luteibacter sp. was conducted leading to the structural characterization of eight fatty acid exhibiting antimicrobial activity against MRSA in the tens of µg/mL range.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Barthélemy M,Elie N,Pellissier L,Wolfender JL,Stien D,Touboul D,Eparvier V

doi

10.3390/ijms20082006

subject

Has Abstract

pub_date

2019-04-24 00:00:00

issue

8

issn

1422-0067

pii

ijms20082006

journal_volume

20

pub_type

杂志文章

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