Abstract：
:The present study was undertaken to develop a rat model for monitoring the early development of breast cancer. Twelve female rats were divided into two groups of six rats that were either treated with N-methyl-N-nitrosourea to induce breast cancer or with bacterial lipopolysaccharide to induce inflammation. Serum samples taken from the rats prior to the treatment were used as controls. By the 14th week, presence of the tumor was detectable by contrast enhanced magnetic resonance imaging and confirmed by histopathology. When the serum proteins of the rats were examined by 2-dimensional electrophoresis (2-DE), no difference could be detected in the profiles of all proteins before and 18 weeks after administration of N-methyl-N-nitrosourea. However, higher expression of alpha-1B glycoprotein was detectable by 2-DE in serum samples of rats at the 18th week post-treatment with lipopolysaccharide.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Golbabapour S,Pang WW,George J,Pasupati T,Abdul-Rahman PS,Hashim OHdoi
10.3390/ijms12021030subject
Has Abstractpub_date
2011-02-07 00:00:00pages
1030-40issue
2issn
1422-0067journal_volume
12pub_type
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