Abstract：
:Despite recent progresses in its treatment, malignant cutaneous melanoma remains a cancer with very poor prognosis. Emerging evidences suggest that the receptor for advance glycation end products (RAGE) plays a key role in melanoma progression through its activation in both cancer and stromal cells. In tumors, RAGE activation is fueled by numerous ligands, S100B and HMGB1 being the most notable, but the role of many other ligands is not well understood and should not be underappreciated. Here, we provide a review of the current role of RAGE in melanoma and conclude that targeting RAGE in melanoma could be an approach to improve the outcomes of melanoma patients.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Olaoba OT,Kadasah S,Vetter SW,Leclerc Edoi
10.3390/ijms21238989subject
Has Abstractpub_date
2020-11-26 00:00:00issue
23issn
1422-0067pii
ijms21238989journal_volume
21pub_type
杂志文章,评审abstract：:The shortage of donor organs is a major global concern. Organ failure requires the transplantation of functional organs. Donor's organs are preserved for variable periods of warm and cold ischemia time, which requires placing them into a preservation device. Ischemia and reperfusion damage the organs, due to the lack ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20215511
更新日期：2019-11-05 00:00:00
abstract：:Humans are exposed to phthalates released from plastics, cosmetics, or food on a daily basis. Phthalates have low acute liver toxicity, but their chronic exposures could induce molecular and cellular effects linked to adverse health outcomes, such as liver tumor promotion or chronic liver diseases. The alternation of ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21176069
更新日期：2020-08-23 00:00:00
abstract：:Leaf angle is a key parameter that determines plant architecture and crop yield. Hormonal crosstalk involving brassinosteroid (BR) plays an essential role in leaf angle regulation in cereals. In this study, we investigated whether abscisic acid (ABA), an important stress-responsive hormone, co-regulates lamina joint i...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20194908
更新日期：2019-10-03 00:00:00
abstract：:Niemann-Pick disease type C (NPC) is a recessive hereditary disease caused by mutation of the NPC1 or NPC2 gene. It is characterized by abnormality of cellular cholesterol trafficking with severe neuronal and hepatic injury. In this study, we investigated the potential of glycoprotein nonmetastatic melanoma protein B ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22010452
更新日期：2021-01-05 00:00:00
abstract：:Statistical studies have demonstrated that various agents may reduce the risk of cancer's development. One of them is activity of flavin-dependent enzymes such as flavin-containing monooxygenase (FMO)(GS-OX1), FAD-dependent 5,10-methylenetetrahydrofolate reductase and flavin-dependent monoamine oxidase. In the last de...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms131216751
更新日期：2012-12-07 00:00:00
abstract：:Evaluation of relationships between molecular modeling structural parameters and high-performance liquid chromatography (HPLC) retention data of 11 cardiovascular system drugs by principal component analysis (PCA) in relation to their pharmacological activity was performed. The six retention data parameters were deter...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms11072681
更新日期：2010-07-09 00:00:00
abstract：:Intrinsically disordered proteins (IDPs) are proteins that usually do not adopt well-defined native structures when isolated in solution under physiological conditions. Numerous IDPs have close relationships with human diseases such as tumor, Parkinson disease, Alzheimer disease, diabetes, and so on. These disease-ass...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms12053205
更新日期：2011-01-01 00:00:00
abstract：:Esophageal squamous cell carcinoma (ESCC), a major histologic type of esophageal cancer, is one of the frequent causes of cancer-related death worldwide. Picropodophyllotoxin (PPT) is the main component of Podophyllum hexandrum root with antitumor activity via apoptosis-mediated mechanisms in several cancer cells. How...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21134640
更新日期：2020-06-30 00:00:00
abstract：:A new chemical pathway yielding A-type vitisins in red wines is proposed herein from the reaction between anthocyanins and oxaloacetic acid (OAA). This new chemical path is thought to occur in the first stages of the wine production even during the fermentation process. This is due to the revealed high reactivity of O...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18040762
更新日期：2017-04-04 00:00:00
abstract：:Nitrogen (N) is essential for plant growth and crop productivity. Organic N is a major form of remobilized N in plants' response to N limitation. It is necessary to understand the regulatory role of N limitation adaption (NLA) in organic N remobilization for this adaptive response. Transcriptional and proteomic analys...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21062171
更新日期：2020-03-21 00:00:00
abstract：:Severe hypogylcemia has been found to induce cerebral damage. While a number of illnesses can lead to hypoglycemic episodes, antidiabetic medications prescribed for glycemic control are a common cause. Considering the rising prevalence of diabetes mellitus in the population, we investigated neuroprotective strategies ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20030550
更新日期：2019-01-28 00:00:00
abstract：:Postmenopausal females display a chronic inflammatory phenotype with higher levels of circulating pro-inflammatory cytokines. Furthermore, the inflammatory response to injury may be altered under estrogen-deficiency, because it was shown previously that estrogen-deficient mice displayed increased levels of the inflamm...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19072070
更新日期：2018-07-16 00:00:00
abstract：:A T-maze test is an experimental approach that is used in congenital research. However, the food reward-based protocol for the T-maze test in fish has low efficiency and a long training period. The aim of this study is to facilitate the T-maze conditions by using a combination of the principles of passive avoidance an...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21041464
更新日期：2020-02-21 00:00:00
abstract：:The importance of mitogen-activated protein kinases (MAPK) in human pathology is underlined by the relevance of abnormalities of MAPK-related signaling pathways to a number of different diseases, including inflammatory disorders and cancer. One of the key events in MAPK signaling, especially with respect to pro-prolif...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21030938
更新日期：2020-01-31 00:00:00
abstract：:Circular dichroism (CD) is a useful technique for monitoring changes in the conformation of antimicrobial peptides or gelatin. In this study, interactions between cationic peptides and gelatin were observed without affecting the triple helical content of the gelatin, which was more strongly affected by anionic surfact...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13033229
更新日期：2012-01-01 00:00:00
abstract：:Poly(l-lactide-co-glycolide) (PLGA) porous scaffolds were modified with collagen type I (PLGA/coll) or hydroxyapatite (PLGA/HAp) and implanted in rabbits osteochondral defects to check their biocompatibility and bone tissue regeneration potential. The scaffolds were fabricated using solvent casting/particulate leachin...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21207541
更新日期：2020-10-13 00:00:00
abstract：:Chronic kidney disease (CKD) is a common progressive disease that is typically characterized by the permanent loss of functional nephrons. As injured nephrons become sclerotic and die, the remaining healthy nephrons undergo numerous structural, molecular, and functional changes in an attempt to compensate for the loss...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18051039
更新日期：2017-05-12 00:00:00
abstract：:The hyperthermophilic archaeon Thermococcus onnurineus NA1 has been shown to produce H₂ when using CO, formate, or starch as a growth substrate. This strain can also utilize elemental sulfur as a terminal electron acceptor for heterotrophic growth. To gain insight into sulfur metabolism, the proteome of T. onnurineus ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms16059167
更新日期：2015-04-23 00:00:00
abstract：:Cetirizine is a zwitterionic second-generation antihistamine containing R- and S-enantiomers, levocetirizine, and (S)-cetirizine. Levocetirizine is known to have a higher affinity for the histamine H₁ receptors than (S)-cetirizine; ligand-receptor docking simulations have suggested the importance of the formation of a...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19124067
更新日期：2018-12-15 00:00:00
abstract：:A series of diketopyrrolopyrrole-based small molecules have been designed to explore their optical, electronic, and charge transport properties as organic solar cell(OSCs) materials. The calculation results showed that the designed molecules can lower the band gap and extend the absorption spectrum towards longer wave...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160920326
更新日期：2015-08-27 00:00:00
abstract：:Emodin (1,3,8-trihydroxy-6-methylanthraquinone) has been identified to have the potential to improve lung fibrosis and lung cancer. To avoid the liver and kidney toxicities and the fast metabolism of emodin, emodin-loaded polylactic acid microspheres (ED-PLA-MS) were prepared and their characteristics were studied. ED...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms15046241
更新日期：2014-04-11 00:00:00
abstract：:Hepatocyte differentiation, proliferation, and apoptosis are affected by growth factors produced in liver. Insulin-like growth factor 1 and 2 (IGF1 and IGF2) act in response to growth hormone (GH). Other IGF family components include at least six binding proteins (IGFBP1 to 6), manifested by both IGFs develop due to i...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19051308
更新日期：2018-04-27 00:00:00
abstract：:Ion channels included in the family of Connexins (Cx) help to control cell proliferation and differentiation of neuronal progenitors. Here we explored the role of Connexin 50 (Cx50) in cell fate modulation of adult spinal cord derived neural precursors located in the ependymal canal (epSPC). epSPC from non-injured ani...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms161125981
更新日期：2015-11-06 00:00:00
abstract：:The present investigation was executed to reveal the protective mechanism of rosmarinic acid (RA) against cadmium (Cd)-induced nephrotoxicity. RA exhibited a concentration-dependent anti-apoptotic effect against CdCl2 in isolated mouse proximal tubular epithelial cells. Cd treatment significantly (p < 0.01) imparted o...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20082027
更新日期：2019-04-24 00:00:00
abstract：:Treatment with 1-methylcyclopropylene (1-MCP) is an effective technique to preserve fruits, but inappropriate treatment with 1-MCP causes a ripening disorder (rubbery texture) in papaya fruit. In this study, a combined metabolomic and transcriptomic analysis was conducted to reveal the possible mechanism of the ripeni...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22020916
更新日期：2021-01-18 00:00:00
abstract：:Phenolic compounds are responsible of the nutritional and sensory quality of extra-virgin olive oil (EVOO). The composition of phenolic compounds in EVOO is related to the initial content of phenolic compounds in the olive-fruit tissues and the activity of enzymes acting on these compounds during the industrial proces...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17030337
更新日期：2016-03-04 00:00:00
abstract：:Microwave-assisted depolymerization of black-liquor lignin in formic acid was studied, concentrating on the yield of liquid fractions as bio-oil 1 (mainly aromatic monomers) and bio-oil 2 (mainly aromatic oligomers) and the distribution of the specific compositions. Bio-oil 1 (9.69%) and bio-oil 2 (54.39%) achieved th...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18102082
更新日期：2017-10-01 00:00:00
abstract：:Selectively targeted nanoscale drug delivery systems have recently emerged as promising intravenously therapeutic option for most chronic joint diseases. Here, a newly synthetized dodecapeptide (GE11)-polylactide-co-glycolide (PLGA)-based conjugate was used to prepare smart nanoparticles (NPs) intended for intra-artic...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19082304
更新日期：2018-08-06 00:00:00
abstract：:Sensitive molecular assays are critical for coronavirus disease 2019 (COVID-19) diagnosis. Here, we designed and evaluated two single-tube nested (STN) real-time RT-PCR assays, targeting SARS-CoV-2 RdRp/Hel and N genes. Both STN assays had a low limit of detection and did not cross react with other human coronaviruses...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21165674
更新日期：2020-08-07 00:00:00
abstract：:The Kv4 family of voltage-gated K⁺ channels underlie the fast transient (A-type) outward K⁺ current. Although A-type currents are critical to determine somato-dendritic integration in central neurons, relatively little is known about the precise subcellular localisation of the underlying channels in hippocampal circui...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20020246
更新日期：2019-01-09 00:00:00
