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Nuclear Phosphoinositides: Their Regulation and Roles in Nuclear Functions.

Abstract：

:Polyphosphoinositides (PPIns) are a family of seven lipid messengers that regulate a vast array of signalling pathways to control cell proliferation, migration, survival and differentiation. PPIns are differentially present in various sub-cellular compartments and, through the recruitment and regulation of specific proteins, are key regulators of compartment identity and function. Phosphoinositides and the enzymes that synthesise and degrade them are also present in the nuclear membrane and in nuclear membraneless compartments such as nuclear speckles. Here we discuss how PPIns in the nucleus are modulated in response to external cues and how they function to control downstream signalling. Finally we suggest a role for nuclear PPIns in liquid phase separations that are involved in the formation of membraneless compartments within the nucleus.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Fiume R,Faenza I,Sheth B,Poli A,Vidalle MC,Mazzetti C,Abdul SH,Campagnoli F,Fabbrini M,Kimber ST,Mariani GA,Xian J,Marvi MV,Mongiorgi S,Shah Z,Divecha N

doi

10.3390/ijms20122991

subject

Has Abstract

pub_date

2019-06-19 00:00:00

issue

12

issn

1422-0067

pii

ijms20122991

journal_volume

20

pub_type

杂志文章,评审

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