Abstract：
:The consumption of polyphenols has frequently been associated with low incidence of degenerative diseases. Most of these natural antioxidants come from fruits, vegetables, spices, grains and herbs. For this reason, there has been increasing interest in identifying plant extract compounds. Polymeric tannins and monomeric flavonoids, such as catechin and epicatechin, in pine bark and green tea extracts could be responsible for the higher antioxidant activities of these extracts. The aim of the present study was to characterize the phenolic compounds in pine bark and green tea concentrated extracts using high-performance liquid chromatography coupled to electrospray ionization mass spectrometry (HPLC-ESI-QTOF-MS). A total of 37 and 35 compounds from pine bark and green tea extracts, respectively, were identified as belonging to various structural classes, mainly flavan-3-ol and its derivatives (including procyanidins). The antioxidant capacity of both extracts was evaluated by three complementary antioxidant activity methods: Trolox equivalent antioxidant capacity (TEAC), ferric reducing antioxidant power (FRAP) and oxygen radical absorbance capacity (ORAC). Higher antioxidant activity values by each method were obtained. In addition, total polyphenol and flavan-3-ol contents, which were determined by Folin-Ciocalteu and vanillin assays, respectively, exhibited higher amounts of gallic acid and (+)-catechin equivalents.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
de la Luz Cádiz-Gurrea M,Fernández-Arroyo S,Segura-Carretero Adoi
10.3390/ijms151120382subject
Has Abstractpub_date
2014-11-06 00:00:00pages
20382-402issue
11issn
1422-0067pii
ijms151120382journal_volume
15pub_type
杂志文章abstract：:Maternal overweight in pregnancy alters the metabolic environment and generates chronic low-grade inflammation. This affects fetal development and programs the offspring's health for developing cardiovascular and metabolic disease later in life. MME (membrane-metalloendopeptidase, neprilysin) cleaves various peptides ...
journal_title：International journal of molecular sciences
pub_type： 临床试验,杂志文章
doi：10.3390/ijms21030834
更新日期：2020-01-28 00:00:00
abstract：:The use of herbicides is an effective and economic way to control weeds, but their availability for rapeseed is limited due to the shortage of herbicide-resistant cultivars in China. The single-point mutation in the acetohydroxyacidsynthase (AHAS) gene can lead to AHAS-inhibiting herbicide resistance. In this study, t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21041345
更新日期：2020-02-17 00:00:00
abstract：:The effects of acidic polysaccharides purified from Gastrodia rhizome on blood pressure and serum lipid levels in spontaneously hypertensive rats (SHR) fed a high-fat diet were investigated. Acidic polysaccharides were purified from crude polysaccharides by DEAE-Sepharose CL-6B. Thirty-six male SHR were randomly divid...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13010698
更新日期：2012-01-01 00:00:00
abstract：:Genome instability is an essential hallmark in tumor development, including colorectal cancer. We have recently identified the oxysterol binding protein-related protein 3 (ORP3), also known as oxysterol binding protein-like 3 (OSBPL3), as a novel ploidy-control gene, whose knock-out leads to aneuploidy induction and p...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21165894
更新日期：2020-08-16 00:00:00
abstract：:The WRKY web, which is comprised of a subset of WRKY transcription factors (TFs), plays a crucial role in the regulation of plant immunity, however, the mode of organization and operation of this network remains obscure, especially in non-model plants such as pepper (Capsicum annuum). Herein, CaWRKY22, a member of a s...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19051426
更新日期：2018-05-10 00:00:00
abstract：:Over the years, there have been many developments and advances in the field of integral membrane protein research. As important pharmaceutical targets, it is paramount to understand the mechanisms of action that govern their structure-function relationships. However, the study of integral membrane proteins is still in...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20102605
更新日期：2019-05-27 00:00:00
abstract：:Understanding how cell organelles and compartments communicate with each other has always been an important field of knowledge widely explored by many researchers. However, despite years of investigations, one point-and perhaps the only point that many agree on-is that our knowledge about cellular-signaling pathways s...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21176173
更新日期：2020-08-26 00:00:00
abstract：:Idiosyncratic drug-induced liver injury (DILI) is an underreported and underestimated adverse drug reaction. Information on the documented hepatotoxicity of drugs has recently been made available by a website that can be accessed in the public domain: LiverTox (http://livertox.nlm.nih.gov). According to critical analy...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms17020224
更新日期：2016-02-06 00:00:00
abstract：:Docking-i.e., interaction of a small molecule (ligand) with a proteic structure (receptor)-represents the ground of drug action mechanism of the vast majority of bioactive chemicals. Ligand and receptor accommodate their geometry and energy, within this interaction, in the benefit of receptor-ligand complex. In an ind...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18071377
更新日期：2017-06-27 00:00:00
abstract：:Current evidence indicates that postischemic brain injury is associated with the accumulation of folding proteins, such as amyloid and tau protein, in the intra- and extracellular spaces of neuronal cells. In this review, we summarize protein changes associated with Alzheimer's disease and their gene expression (amylo...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21134599
更新日期：2020-06-28 00:00:00
abstract：:Manganese oxidizing bacteria can produce biogenic manganese oxides (BMO) on their cell surface and have been applied in the fields of agriculture, bioremediation, and drinking water treatment to remove toxic contaminants based on their remarkable chemical reactivity. Herein, we report for the first time the synthetic ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21051709
更新日期：2020-03-02 00:00:00
abstract：:Antibacterial bonding agents and composites containing dimethylaminododecyl methacrylate (DMADDM) have been recently developed. The objectives of this study were to investigate the antibacterial effect of novel adhesives containing different mass fractions of DMADDM on Streptococcus mutans (S. mutans) biofilm at diffe...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms150712791
更新日期：2014-07-18 00:00:00
abstract：:The p38 MAPK pathway is known to influence the anti-tumor effects of several chemotherapeutics, including that of organometallic drugs. Previous studies have demonstrated the important role of p38 both as a regulator and a sensor of cellular reactive oxygen species (ROS) levels. Investigating the anti-cancer propertie...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19123964
更新日期：2018-12-09 00:00:00
abstract：:Inflammation is involved in the pathogenesis of seawater aspiration-induced acute lung injury (ALI). Although several studies have shown that Semaphorin 7A (SEMA7A) promotes inflammation, there are limited reports regarding immunological function of SEMA7A in seawater aspiration-induced ALI. Therefore, we investigated...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms151119650
更新日期：2014-10-28 00:00:00
abstract：:Ischemic stroke is a leading cause of human death in present times. Two phases of pathological impact occur during an ischemic stroke, namely, ischemia and reperfusion. Both periods include individual characteristic effects on cell injury and apoptosis. Moreover, these conditions can cause severe cell defects and harm...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20246168
更新日期：2019-12-06 00:00:00
abstract：:Although platelet-rich fibrin (PRF) has been used in clinical practice for some time, to date, few studies reveal its role as a bioactive scaffold in facilitating meniscal repair. Here, the positive anabolic effects of PRF on meniscocytes harvested from the primary culture of a rabbit meniscus were revealed. The rabbi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18081722
更新日期：2017-08-07 00:00:00
abstract：:Lattice degeneration involves thinning of the retina that occurs over time. Here we performed an immunohistological study of tissue sections of human peripheral retinal lattice degeneration to investigate if retinal pigment epithelium (RPE) cells are involved in the pathogenesis of this condition. In two cases of reti...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21197347
更新日期：2020-10-05 00:00:00
abstract：:Kinetic studies of the early events in cytochrome c folding are reviewed with a focus on the evidence for folding intermediates on the submillisecond timescale. Evidence from time-resolved absorption, circular dichroism, magnetic circular dichroism, fluorescence energy and electron transfer, small-angle X-ray scatteri...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms10041476
更新日期：2009-04-01 00:00:00
abstract：:Water limitation represents the main environmental constraint affecting crop yield worldwide. Photosynthesis is a primary drought target, resulting in over-reduction of the photosynthetic electron transport chain and increased production of reactive oxygen species in plastids. Manipulation of chloroplast electron dist...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21197199
更新日期：2020-09-29 00:00:00
abstract：:Jatropha curcas is a promising renewable feedstock for biodiesel and bio-jet fuel production. To study gene expression in Jatropha in different tissues throughout development and under stress conditions, we examined a total of 11 typical candidate reference genes using real-time quantitative polymerase chain reaction ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms141224338
更新日期：2013-12-13 00:00:00
abstract：:The emergence of the novel coronavirus in Wuhan, China, which causes severe respiratory tract infections in humans (COVID-19), has become a global health concern. Most coronaviruses infect animals but can evolve into strains that cross the species barrier and infect humans. At the present, there is no single specific ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21072272
更新日期：2020-03-25 00:00:00
abstract：:Hybrid materials constituted by peptides and synthetic polymers have nowadays a great interest since they can combine the properties and functions of each constitutive block, being also possible to modify the final characteristics by using different topologies. Poly(l-lactide-b-l-phenylalanine) copolymers with various...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms150813247
更新日期：2014-07-29 00:00:00
abstract：:The extracellular matrix (ECM) provides structural support for tissue architecture and is a major effector of cell behavior during skin repair and inflammation. Macrophages are involved in all stages of skin repair but only limited knowledge exists about macrophage-specific expression and regulation of ECM components....
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20205086
更新日期：2019-10-14 00:00:00
abstract：:Supercritical fluid extraction (SFE) was used in the analysis of bacterial respiratory quinone (RQ), bacterial phospholipid fatty acid (PLFA), and archaeal phospholipid ether lipid (PLEL) from anaerobically digested sludge. Bacterial RQ were determined using ultra performance liquid chromatography (UPLC). Determinatio...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13033022
更新日期：2012-01-01 00:00:00
abstract：:Aurora kinases have emerged as attractive targets for the design of anticancer drugs. 3D-QSAR (comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA)) and Surflex-docking studies were performed on a series of pyrrole-indoline-2-ones as Aurora A inhibitors. The CoMFA...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms12031605
更新日期：2011-01-01 00:00:00
abstract：:Adult Renal Stem/Progenitor Cells (ARPCs) have been recently identified in the human kidney and several studies show their active role in kidney repair processes during acute or chronic injury. However, little is known about their immunomodulatory properties and their capacity to regulate specific T cell subpopulation...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22010274
更新日期：2020-12-29 00:00:00
abstract：:DEFECTIVE IN ANTHER DEHISCENCE 1 (DAD1), a phospholipase A1, utilizes galactolipids (18:3) to generate α-linolenic acid (ALA) in the initial step of jasmonic acid (JA) biosynthesis in Arabidopsis thaliana. In this study, we isolated the JcDAD1 gene, an ortholog of Arabidopsis DAD1 in Jatropha curcas, and found that it...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21238923
更新日期：2020-11-24 00:00:00
abstract：:A defining challenge of the 21st century is meeting the nutritional demands of the growing human population, under a scenario of limited land and water resources and under the specter of climate change. The Vavilov seed bank contains numerous landraces collected nearly a hundred years ago, and thus may contain 'geneti...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21113952
更新日期：2020-05-31 00:00:00
abstract：:Immunological memory is fundamental to maintain immunity against re-invading pathogens. It is the basis for prolonged protection induced by vaccines and can be mediated by humoral or cellular responses-the latter largely mediated by T cells. Memory T cells belong to different subsets with specialized functions and dis...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21228565
更新日期：2020-11-13 00:00:00
abstract：:Mechanical unloading simultaneously induces muscle and bone loss, but its mechanisms are not fully understood. The interactions between skeletal muscle and bone have been recently noted. Although canonical wingless-related integration site (Wnt)/β-catenin signaling is crucial for bone metabolism, its roles in the musc...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21072547
更新日期：2020-04-06 00:00:00
