当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES期刊下所有文献 > Endothelial Semaphorin 7A promotes inflammation in seawater aspiration-induced acute lung injury.

Endothelial Semaphorin 7A promotes inflammation in seawater aspiration-induced acute lung injury.

Abstract：

:Inflammation is involved in the pathogenesis of seawater aspiration-induced acute lung injury (ALI). Although several studies have shown that Semaphorin 7A (SEMA7A) promotes inflammation, there are limited reports regarding immunological function of SEMA7A in seawater aspiration-induced ALI. Therefore, we investigated the role of SEMA7A during seawater aspiration-induced ALI. Male Sprague-Dawley rats were underwent seawater instillation. Then, lung samples were collected at an indicated time for analysis. In addition, rat pulmonary microvascular endothelial cells (RPMVECs) were cultured and then stimulated with 25% seawater for indicated time point. After these treatments, cells samples were collected for analysis. In vivo, seawater instillation induced lung histopathologic changes, pro-inflammation cytokines release and increased expression of SEMA7A. In vitro, seawater stimulation led to pro-inflammation cytokine release, cytoskeleton remodeling and increased monolayer permeability in pulmonary microvascular endothelial cells. In addition, knockdown of hypoxia-inducible factor (HIF)-1α inhibited the seawater induced increase expression of SEMA7A. Meanwhile, knockdown of SEMA7A by specific siRNA inhibited the seawater induced aberrant inflammation, endothelial cytoskeleton remodeling and endothelial permeability. These results suggest that SEMA7A is critical in the development of lung inflammation and pulmonary edema in seawater aspiration-induced ALI, and may be a therapeutic target for this disease.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Zhang M,Wang L,Dong M,Li Z,Jin F

doi

10.3390/ijms151119650

subject

Has Abstract

pub_date

2014-10-28 00:00:00

pages

19650-61

issue

11

issn

1422-0067

pii

ijms151119650

journal_volume

15

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES文献大全
  • Regulation of GABAA Receptor Subunit Expression in Substance Use Disorders.

    abstract：:The modulation of neuronal cell firing is mediated by the release of the neurotransmitter GABA (γ-aminobuytric acid), which binds to two major families of receptors. The ionotropic GABAA receptors (GABAARs) are composed of five distinct subunits that vary in expression by brain region and cell type. The action of GABA...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21124445

    authors： Barker JS,Hines RM

    更新日期：2020-06-22 00:00:00

  • Estradiol-Induced Epigenetically Mediated Mechanisms and Regulation of Gene Expression.

    abstract：:Gonadal hormone 17β-estradiol (E2) and its receptors are key regulators of gene transcription by binding to estrogen responsive elements in the genome. Besides the classical genomic action, E2 regulates gene transcription via the modification of epigenetic marks on DNA and histone proteins. Depending on the reaction p...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21093177

    authors： Kovács T,Szabó-Meleg E,Ábrahám IM

    更新日期：2020-04-30 00:00:00

  • EIF4G1 and RAN as Possible Drivers for Malignant Pleural Mesothelioma.

    abstract：:For malignant pleural mesothelioma (MPM) novel therapeutic strategies are urgently needed. In a previous study, we identified 51 putative cancer genes over-expressed in MPM tissues and cell lines. Here, we deepened the study on nine of them (ASS1, EIF4G1, GALNT7, GLUT1, IGF2BP3 (IMP3), ITGA4, RAN, SOD1, and THBS2) to ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21144856

    authors： Dell'Anno I,Barbarino M,Barone E,Giordano A,Luzzi L,Bottaro M,Migliore L,Agostini S,Melani A,Melaiu O,Catalano C,Cipollini M,Silvestri R,Corrado A,Gemignani F,Landi S

    更新日期：2020-07-09 00:00:00

  • Combined Metabolome and Transcriptome Analyses Reveal the Effects of Mycorrhizal Fungus Ceratobasidium sp. AR2 on the Flavonoid Accumulation in Anoectochilus roxburghii during Different Growth Stages.

    abstract：:Anoectochilus roxburghii is a traditional Chinese herb with high medicinal value, with main bioactive constituents which are flavonoids. It commonly associates with mycorrhizal fungi for its growth and development. Moreover, mycorrhizal fungi can induce changes in the internal metabolism of host plants. However, its r...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21020564

    authors： Zhang Y,Li Y,Chen X,Meng Z,Guo S

    更新日期：2020-01-15 00:00:00

  • Suppression of SHROOM1 Improves In Vitro and In Vivo Gene Integration by Promoting Homology-Directed Repair.

    abstract：:Homologous recombination (HR) is often used to achieve targeted gene integration because of its higher precision and operability compared with microhomology-mediated end-joining (MMEJ) or non-homologous end-joining (NHEJ). It appears to be inefficient for gene integration in animal cells and embryos due to occurring o...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21165821

    authors： Zhao Z,Zhang H,Xiong T,Wang J,Yang D,Zhu D,Li J,Yang Y,Sun C,Zhao Y,Xi JJ

    更新日期：2020-08-13 00:00:00

  • Comparative microRNA-seq Analysis Depicts Candidate miRNAs Involved in Skin Color Differentiation in Red Tilapia.

    abstract：:Differentiation and variation in body color has been a growing limitation to the commercial value of red tilapia. Limited microRNA (miRNA) information is available on skin color differentiation and variation in fish so far. In this study, a high-throughput Illumina sequencing of sRNAs was conducted on three color vari...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19041209

    authors： Wang L,Zhu W,Dong Z,Song F,Dong J,Fu J

    更新日期：2018-04-16 00:00:00

  • Microglial Function across the Spectrum of Age and Gender.

    abstract：:Microglia constitute the resident immunocompetent cells of the central nervous system. Although much work has focused on their ability to mount an inflammatory response in reaction to pathology, recent studies have delved into their role in maintaining homeostasis in the healthy brain. It is important to note that the...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms18030561

    authors： Nissen JC

    更新日期：2017-03-04 00:00:00

  • An Updated View of Translocator Protein (TSPO).

    abstract：:Decades of study on the role of mitochondria in living cells have evidenced the importance of the 18 kDa mitochondrial translocator protein (TSPO), first discovered in the 1977 as an alternative binding site for the benzodiazepine diazepam in the kidneys. This protein participates in a variety of cellular functions, i...

    journal_title：International journal of molecular sciences

    pub_type： 社论

    doi：10.3390/ijms18122640

    authors： Denora N,Natile G

    更新日期：2017-12-06 00:00:00

  • Characterization and comparison of Fumonisin B(1)-protein conjugates by six methods.

    abstract：:In order to generate an antibody against a small hapten molecule, the hapten is cross-linked with carrier protein to make it immunogenic. In this study, the hapten (Fumonisin B(1), FB(1)) was coupled to ovalbumin (OVA) and bovine serum albumin (BSA), respectively by a short cross-linker reagent (glutaraldehyde, GA). T...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms13010084

    authors： Wang Y,He CH,Zheng H,Zhang HB

    更新日期：2012-01-01 00:00:00

  • Synthesis and properties of poly(L-lactide)-b-poly (L-phenylalanine) hybrid copolymers.

    abstract：:Hybrid materials constituted by peptides and synthetic polymers have nowadays a great interest since they can combine the properties and functions of each constitutive block, being also possible to modify the final characteristics by using different topologies. Poly(l-lactide-b-l-phenylalanine) copolymers with various...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms150813247

    authors： Planellas M,Puiggalí J

    更新日期：2014-07-29 00:00:00

  • Preparation of Radiation Cross-Linked Poly(Acrylic Acid) Hydrogel Containing Metronidazole with Enhanced Antibacterial Activity.

    abstract：:Metronidazole (MD) is known as a periodontitis medicine and has been widely used in antibiotics for resistance to anaerobic bacteria, periodontal disease, and other threats. To treat diseases, drug delivery carriers are needed with a high bioadhesive property and enhanced drug penetration. Poly (acrylic acid) (PAA) hy...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21010187

    authors： Jeong JO,Park JS,Kim EJ,Jeong SI,Lee JY,Lim YM

    更新日期：2019-12-26 00:00:00

  • Genetic and Hormonal Regulation of Chlorophyll Degradation during Maturation of Seeds with Green Embryos.

    abstract：:The embryos of some angiosperms (usually referred to as chloroembryos) contain chlorophylls during the whole period of embryogenesis. Developing embryos have photochemically active chloroplasts and are able to produce assimilates, further converted in reserve biopolymers, whereas at the late steps of embryogenesis, se...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms18091993

    authors： Smolikova G,Dolgikh E,Vikhnina M,Frolov A,Medvedev S

    更新日期：2017-09-16 00:00:00

  • The metalloporphyrin antioxidant, MnTE-2-PyP, inhibits Th2 cell immune responses in an asthma model.

    abstract：:MnTE-2-PyP, a superoxide dismutase mimetic, inhibited OVA-induced airway inflammation in mice suggesting an effect on Th2 responsiveness. Thus, we hypothesized that MnTE-2-PyP may alter dendritic cell-Th2 interactions. Bone marrow derived dendritic cells (DC) and OVA(323-339)-specific Th2 cells were cultured separatel...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms13089785

    authors： Jungsuwadee P,Weaver MR,Gally F,Oberley-Deegan RE

    更新日期：2012-01-01 00:00:00

  • Reactive oxygen species released from hypoxic hepatocytes regulates MMP-2 expression in hepatic stellate cells.

    abstract：:Hypoxia is a common environmental stress factor and is associated with fibrogenesis. Matrix metalloproteinase-2 (MMP-2), produced by hepatic stellate cells (HSCs), plays an important role in liver fibrogenesis. However, inconsistent results have been reported on the impact of hypoxia on MMP-2 expression and activity i...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms12042434

    authors： Li J,Fan R,Zhao S,Liu L,Guo S,Wu N,Zhang W,Chen P

    更新日期：2011-01-01 00:00:00

  • Targeting Tumor Endothelial Cells with Nanoparticles.

    abstract：:Because angiogenesis is a major contributor to cancer progression and metastasis, it is an attractive target for cancer therapy. Although a diverse number of small compounds for anti-angiogenic therapy have been developed, severe adverse effects commonly occur, since small compounds can affect not only tumor endotheli...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20235819

    authors： Sakurai Y,Akita H,Harashima H

    更新日期：2019-11-20 00:00:00

  • Characteristics and Antitumor Activity of Morchella esculenta Polysaccharide Extracted by Pulsed Electric Field.

    abstract：:Polysaccharides from Morchella esculenta have been proven to be functional and helpful for humans. The purpose of this study was to investigate the chemical structure and anti-proliferating and antitumor activities of a Morchella esculenta polysaccharide (MEP) extracted by pulsed electric field (PEF) in submerged ferm...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms17060986

    authors： Liu C,Sun Y,Mao Q,Guo X,Li P,Liu Y,Xu N

    更新日期：2016-06-22 00:00:00

  • Genome-Wide Identification and Characterization of the OPR Gene Family in Wheat (Triticum aestivum L.).

    abstract：:The 12-oxo-phytodienoic acid reductases (OPRs), which belong to the old yellow enzyme (OYE) family, are flavin mononucleotide (FMN)-dependent oxidoreductases with critical functions in plants. Despite the clear characteristics of growth and development, as well as the defense responses in Arabidopsis, tomato, rice, an...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20081914

    authors： Mou Y,Liu Y,Tian S,Guo Q,Wang C,Wen S

    更新日期：2019-04-18 00:00:00

  • Huntingtin Lowering Strategies.

    abstract：:Trials using antisense oligonucleotide technology to lower Huntingtin levels in Huntington's disease (HD) are currently ongoing. This progress, taking place only 27 years after the identification of the Huntingtin gene (HTT) in 1993 reflects the enormous development in genetic engineering in the last decades. It is al...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21062146

    authors： Marxreiter F,Stemick J,Kohl Z

    更新日期：2020-03-20 00:00:00

  • PTBP1 Positively Regulates the Translation of Circadian Clock Gene, Period1.

    abstract：:Circadian oscillations of mRNAs and proteins are the main features of circadian clock genes. Among them, Period1 (Per1) is a key component in negative-feedback regulation, which shows a robust diurnal oscillation and the importance of circadian rhythm and translational regulation of circadian clock genes has been reco...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21186921

    authors： Kim W,Shin JC,Lee KH,Kim KT

    更新日期：2020-09-21 00:00:00

  • HER-2 Expression in Brain Metastases from Colorectal Cancer and Corresponding Primary Tumors: A Case Cohort Series.

    abstract：:Brain metastases (BM) from colorectal cancer (CRC) are a rare but increasing event. Surgical resection of oligometastatic disease, including BM, may produce a survival benefit in selected patients. Previous studies described the HER-2 expression patterns in CRC patients, but its prognostic role still remains controver...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms14022370

    authors： Aprile G,De Maglio G,Menis J,Casagrande M,Tuniz F,Pisa EF,Fontanella C,Skrap M,Beltrami AC,Fasola G,Pizzolitto S

    更新日期：2013-01-24 00:00:00

  • The BET Bromodomain Inhibitor I-BET-151 Induces Structural and Functional Alterations of the Heart Mitochondria in Healthy Male Mice and Rats.

    abstract：:The bromodomain and extra-terminal domain family inhibitors (BETi) are a promising new class of anticancer agents. Since numerous anticancer drugs have been correlated to cardiomyopathy, and since BETi can affect non-cancerous tissues, we aimed to investigate in healthy animals any ultrastructural BETi-induced alterat...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20071527

    authors： Piquereau J,Boet A,Péchoux C,Antigny F,Lambert M,Gressette M,Ranchoux B,Gambaryan N,Domergue V,Mumby S,Montani D,Adcock IM,Humbert M,Garnier A,Rucker-Martin C,Perros F

    更新日期：2019-03-27 00:00:00

  • AHK3-Mediated Cytokinin Signaling Is Required for the Delayed Leaf Senescence Induced by SSPP.

    abstract：:Leaf senescence is a highly-programmed developmental process regulated by an array of multiple signaling pathways. Our group previously reported that overexpression of the protein phosphatase-encoding gene SSPP led to delayed leaf senescence and significantly enhanced cytokinin responses. However, it is still unclear ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20082043

    authors： Wang Y,Zhang X,Cui Y,Li L,Wang D,Mei Y,Wang NN

    更新日期：2019-04-25 00:00:00

  • 1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione Induces G1 Cell Cycle Arrest and Autophagy in HeLa Cervical Cancer Cells.

    abstract：:The natural agent, 1-(2-hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione (HMDB), has been reported to have growth inhibitory effects on several human cancer cells. However, the role of HMDB in cervical cancer remains unclear. Herein, we found that HMDB dose- and time-dependently inhibited growth of HeLa cervical canc...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms17081274

    authors： Tsai JH,Hsu LS,Huang HC,Lin CL,Pan MH,Hong HM,Chen WJ

    更新日期：2016-08-05 00:00:00

  • cGMP Imaging in Brain Slices Reveals Brain Region-Specific Activity of NO-Sensitive Guanylyl Cyclases (NO-GCs) and NO-GC Stimulators.

    abstract：:Impaired NO-cGMP signaling has been linked to several neurological disorders. NO-sensitive guanylyl cyclase (NO-GC), of which two isoforms-NO-GC1 and NO-GC2-are known, represents a promising drug target to increase cGMP in the brain. Drug-like small molecules have been discovered that work synergistically with NO to s...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19082313

    authors： Peters S,Paolillo M,Mergia E,Koesling D,Kennel L,Schmidtko A,Russwurm M,Feil R

    更新日期：2018-08-07 00:00:00

  • De Novo Assembly, Annotation, and Characterization of Root Transcriptomes of Three Caladium Cultivars with a Focus on Necrotrophic Pathogen Resistance/Defense-Related Genes.

    abstract：:Roots are vital to plant survival and crop yield, yet few efforts have been made to characterize the expressed genes in the roots of non-model plants (root transcriptomes). This study was conducted to sequence, assemble, annotate, and characterize the root transcriptomes of three caladium cultivars (Caladium × hortula...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms18040712

    authors： Cao Z,Deng Z

    更新日期：2017-03-27 00:00:00

  • Bioactivities of Phenolics by Focusing on Suppression of Chronic Diseases: A Review.

    abstract：:Phenolics, which are secondary metabolites of plants, exhibit remarkable bioactivities. In this contribution, we have focused on their protective effect against chronic diseases rather than their antioxidant activities, which have been widely discussed in the literature. A large body of epidemiological studies has pro...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms19061573

    authors： Shahidi F,Yeo J

    更新日期：2018-05-25 00:00:00

  • Intergeneric Relationships within the Early-Diverging Angiosperm Family Nymphaeaceae Based on Chloroplast Phylogenomics.

    abstract：:The order Nymphaeales, consisting of three families with a record of eight genera, has gained significant interest from botanists, probably due to its position as a basal angiosperm. The phylogenetic relationships within the order have been well studied; however, a few controversial nodes still remain in the Nymphaeac...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19123780

    authors： He D,Gichira AW,Li Z,Nzei JM,Guo Y,Wang Q,Chen J

    更新日期：2018-11-28 00:00:00

  • Podocyte Lysosome Dysfunction in Chronic Glomerular Diseases.

    abstract：:Podocytes are visceral epithelial cells covering the outer surface of glomerular capillaries in the kidney. Blood is filtered through the slit diaphragm of podocytes to form urine. The functional and structural integrity of podocytes is essential for the normal function of the kidney. As a membrane-bound organelle, ly...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21051559

    authors： Li G,Kidd J,Li PL

    更新日期：2020-02-25 00:00:00

  • Impact of Type 2 Diabetes Mellitus on Human Bone Marrow Stromal Cell Number and Phenotypic Characteristics.

    abstract：:Human bone marrow-derived mesenchymal stromal cells (MSCs) have been investigated in numerous disease settings involving impaired regeneration because of the crucial role they play in tissue maintenance and repair. Considering the number of comorbidities associated with type 2 diabetes mellitus (T2DM), the hypothesis ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21072476

    authors： Cassidy FC,Shortiss C,Murphy CG,Kearns SR,Curtin W,De Buitléir C,O'Brien T,Coleman CM

    更新日期：2020-04-02 00:00:00

  • The Roles of Cyclin-Dependent Kinases in Cell-Cycle Progression and Therapeutic Strategies in Human Breast Cancer.

    abstract：:Cyclin-dependent kinases (CDKs) are serine/threonine kinases whose catalytic activities are regulated by interactions with cyclins and CDK inhibitors (CKIs). CDKs are key regulatory enzymes involved in cell proliferation through regulating cell-cycle checkpoints and transcriptional events in response to extracellular ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21061960

    authors： Ding L,Cao J,Lin W,Chen H,Xiong X,Ao H,Yu M,Lin J,Cui Q

    更新日期：2020-03-13 00:00:00