Abstract:
:Small guanosine triphosphatases (GTPases) of the Ras superfamily are key regulators of many key cellular events such as proliferation, differentiation, cell cycle regulation, migration, or apoptosis. To control these biological responses, GTPases activity is regulated by guanine nucleotide exchange factors (GEFs), GTPase activating proteins (GAPs), and in some small GTPases also guanine nucleotide dissociation inhibitors (GDIs). Moreover, small GTPases transduce signals by their downstream effector molecules. Many studies demonstrate that small GTPases of the Ras family are involved in neurodegeneration processes. Here, in this review, we focus on the signaling pathways controlled by these small protein superfamilies that culminate in neurodegenerative pathologies, such as Alzheimer's disease (AD) and Parkinson's disease (PD). Specifically, we concentrate on the two most studied families of the Ras superfamily: the Ras and Rho families. We summarize the latest findings of small GTPases of the Ras and Rho families in neurodegeneration in order to highlight these small proteins as potential therapeutic targets capable of slowing down different neurodegenerative diseases.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Arrazola Sastre A,Luque Montoro M,Gálvez-Martín P,Lacerda HM,Lucia AM,Llavero F,Zugaza JLdoi
10.3390/ijms21176312subject
Has Abstractpub_date
2020-08-31 00:00:00issue
17issn
1422-0067pii
ijms21176312journal_volume
21pub_type
杂志文章,评审abstract::Although radiotherapy is generally effective in the treatment of major nasopharyngeal carcinoma (NPC), this treatment still makes approximately 20% of patients radioresistant. Therefore, the identification of blood or biopsy biomarkers that can predict the treatment response to radioresistance and that can diagnosis e...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms160715497
更新日期:2015-07-08 00:00:00
abstract::Urinary tract infections (UTIs) and catheter-associated UTIs (CAUTIs) are the principal hospital-acquired infections. Proteus mirabilis is characterized by several virulence factors able to promote adhesion and biofilm formation and ameliorate the colonization of urinary tract and the formation of crystalline biofilms...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18020414
更新日期:2017-02-15 00:00:00
abstract::Polymer-based piezoelectric biomaterials have already proven their relevance for tissue engineering applications. Furthermore, the morphology of the scaffolds plays also an important role in cell proliferation and differentiation. The present work reports on poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV), a biocompat...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19082149
更新日期:2018-07-24 00:00:00
abstract::The aqueous solubility (logW) and n-octanol/water partition coefficient (logP(OW)) are important properties for pharmacology, toxicology and medicinal chemistry. Based on an understanding of the dissolution process, the frontier orbital interaction model was suggested in the present paper to describe the solvent-solut...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms9060962
更新日期:2008-06-01 00:00:00
abstract::Sericin is a major constituent of silk produced by silkworms. We previously found that the instillation of sericin enhanced the proliferation of corneal epithelial cells, and acted to promote corneal wound healing in both normal and diabetic model rats. However, the mechanisms by which sericin promotes the proliferati...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19041123
更新日期:2018-04-09 00:00:00
abstract::Triple-negative breast cancer (TNBC) is characterized by the lack of immunohistochemical staining for estrogen receptors (ER), progesterone receptors (PR), and lack of overexpression or amplification of human epidermal growth factor receptor 2 (HER2). Our aim was to investigate the expression of transmembrane protease...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms140714659
更新日期:2013-07-12 00:00:00
abstract::Cancer vaccines may be harnessed to incite immunity against poorly immunogenic tumors, however they have failed in therapeutic settings. Poor antigenicity coupled with systemic and intratumoral immune suppression have been significant drawbacks. RNA encoding for tumor associated or specific epitopes can serve as a mor...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19102890
更新日期:2018-09-23 00:00:00
abstract::Epigenetic modifications including DNA methylation, histone modifications, and chromatin remodeling are crucial regulators of chromatin architecture and gene expression in plants. Their dynamics are significantly influenced by oxidants, such as reactive oxygen species (ROS) and nitric oxide (NO), and antioxidants, lik...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21041419
更新日期:2020-02-19 00:00:00
abstract::Omics approaches for investigating biological systems were introduced in the mid-1990s and quickly consolidated to become a fundamental pillar of modern biology. The idea of measuring the whole complement of genes, transcripts, proteins, and metabolites has since become widespread and routinely adopted in the pursuit ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21238987
更新日期:2020-11-26 00:00:00
abstract::Rheumatoid arthritis (RA) is a chronic, inflammatory, and systemic autoimmune disease that affects the connective tissue and primarily the joints. If not treated, RA ultimately leads to progressive cartilage and bone degeneration. The etiology of the pathogenesis of RA is unknown, demonstrating heterogeneity in its cl...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21217916
更新日期:2020-10-25 00:00:00
abstract::Geopropolis is a resin mixed with mud, produced only by stingless bees. Despite being popularly known for its medicinal properties, few scientific studies have proven its biological activities. In this context, the objective of this study was to determine the chemical composition and antioxidant, anti-inflammatory, an...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18050953
更新日期:2017-05-03 00:00:00
abstract::Mitochondria-associated membranes (MAM) are a well-recognized contact link between the mitochondria and endoplasmic reticulum that affects mitochondrial biology and vascular smooth muscle cells (VSMCs) proliferation via the regulation of mitochondrial Ca2+(Ca2+m) influx. Nogo-B receptor (NgBR) plays a vital role in pr...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20092319
更新日期:2019-05-10 00:00:00
abstract::This study was performed to elucidate the molecular function of the synoviocyte proliferation-associated in collagen-induced arthritis (CIA) 1/serum amyloid A-like 1 (SPACIA1/SAAL1) in mice CIA, an animal model of rheumatoid arthritis (RA), and human RA-synovial fibroblasts (RASFs). SPACIA1/SAAL1-deficient mice were g...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19123828
更新日期:2018-11-30 00:00:00
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journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms13033431
更新日期:2012-01-01 00:00:00
abstract::Given the importance of the extracellular medium during tissue formation, it was wise to develop an artificial structure that mimics the extracellular matrix while having improved physico-chemical properties. That is why the choice was focused on gelatin methacryloyl (GelMA), an inexpensive biocompatible hydrogel. Phy...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18122675
更新日期:2017-12-10 00:00:00
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journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18030508
更新日期:2017-02-26 00:00:00
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journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21062108
更新日期:2020-03-19 00:00:00
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journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21062256
更新日期:2020-03-24 00:00:00
abstract::The physiological function of Arabidopsis thaliana universal stress protein (AtUSP) in plant has remained unclear. Thus, we report here the functional role of the Arabidopsis universal stress protein, AtUSP (At3g53990). To determine how AtUSP affects physiological responses towards cold stress, AtUSP overexpression (A...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18122546
更新日期:2017-11-27 00:00:00
abstract:BACKGROUND:The aim of this review was to evaluate the adjunctive effect of autologous platelet concentrates (APCs) for the treatment of furcation defects, in terms of scientific quality of the clinical trials and regeneration parameters assessment. METHODS:A systematic search was carried out in the electronic database...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,meta分析
doi:10.3390/ijms20061347
更新日期:2019-03-17 00:00:00
abstract::The objective of this study was to investigate the underlying mechanisms behind the radiation-sensitising effects of the antennapedia proteins (ANTP)-smacN7 fusion protein on tumour cells. ANTP-SmacN7 fusion proteins were synthesised, and the ability of this fusion protein to penetrate cells was observed. Effects of r...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms141224087
更新日期:2013-12-11 00:00:00
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journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20122927
更新日期:2019-06-15 00:00:00
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journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19051545
更新日期:2018-05-22 00:00:00
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journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms18122732
更新日期:2017-12-16 00:00:00
abstract::Internal transcribed spacer region (ITS) sequencing is the most extensively used technology for accurate molecular identification of fungal pathogens in clinical microbiology laboratories. Intra-genomic ITS sequence heterogeneity, which makes fungal identification based on direct sequencing of PCR products difficult, ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms161025067
更新日期:2015-10-22 00:00:00
abstract:PURPOSE:to evaluate the role of whole brain radiotherapy (WBRT) and radiation boost (RB) for 208 patients recursive partitioning analysis (RPA) II with 1 or 2 brain metastases (BM) at a single institution. METHODS AND MATERIALS:the dose of WBRT was 30 Gy (10 fractions of 3 Gy). One hundred thirty-two patients (63.5%) ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms15057554
更新日期:2014-05-02 00:00:00
abstract::Melanogenesis is a biological process resulting in the production of melanin pigment, which plays an important role in the prevention of sun-induced skin injury, and determines hair and skin color. So, a wide variety of approaches have been proposed to increase the synthesis of melanin. This study evaluated the effect...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19103211
更新日期:2018-10-17 00:00:00
abstract:BACKGROUND:Gadolinium chloride (GdCl3) has been reported to attenuate liver injury caused by a variety of toxicants. Gap junctional intercellular communication (GJIC) is thought to be essential in controlling liver homeostasis and pathology. Here we evaluate the effects of GdCl3 on functional GJIC and connexin expressi...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20153748
更新日期:2019-07-31 00:00:00
abstract::Bacterial pathogens expose on the cell surface a variety of complex carbohydrate molecules. Gram-negative bacteria produce lipopolysaccharides, which are the main components of the outer membrane of bacterial envelopes and play a major role in host-pathogen interactions. B. pertussis, B. parapertussis, B. bronchisepti...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
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更新日期:2021-01-21 00:00:00
abstract::Preimplantation horse conceptuses require nutrients and signals from histotroph, the composition of which is regulated by luteal progesterone and conceptus-secreted factors. To distinguish progesterone and conceptus effects we shortened the period of endometrial progesterone-priming by asynchronous embryo transfer. Da...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21072562
更新日期:2020-04-07 00:00:00