Abstract:
:Triple-negative breast cancer (TNBC) is characterized by the lack of immunohistochemical staining for estrogen receptors (ER), progesterone receptors (PR), and lack of overexpression or amplification of human epidermal growth factor receptor 2 (HER2). Our aim was to investigate the expression of transmembrane protease, serine 4 (TMPRSS4) in TNBC patients and its possible relationship to the outcome of the disease. A total of 72 TNBC patients and 109 non-TNBC patients who were diagnosed between 2003 and 2008 were enrolled in this study. Immunohistochemistry was used to compare the expression pattern of TMPRSS4 in TNBC and non-TNBC groups, and the prognostic significance was assessed by Kaplan-Meier analysis and Cox proportional hazards regression in TNBC patients. The rate of high expression of TMPRSS4 was significantly higher in TNBC group than that in non-TNBC group. High expression of TMPRSS4 was significantly correlated with lymph node metastasis, histological grade, and tumor size. TNBC patients with high TMPRSS4 expression showed the poorer overall survival (OS) and disease-free survival (DFS) than those patients with low TMPRSS4 expression. In multivariate analysis, only lymph node metastasis and TMPRSS4 expression were the independent prognostic factors for OS and DFS in TNBC. Our study provides evidence that TMPRSS4 expression is associated with lymph node metastasis, tumor size, and histological grade in TNBC patients, and also is an independent prognostic factor for TNBC.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Cheng D,Kong H,Li Ydoi
10.3390/ijms140714659subject
Has Abstractpub_date
2013-07-12 00:00:00pages
14659-68issue
7issn
1422-0067pii
ijms140714659journal_volume
14pub_type
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journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
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更新日期:2019-04-26 00:00:00
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journal_title:International journal of molecular sciences
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abstract::MicroRNAs are tiny but powerful regulators of gene expression at the post-transcriptional level. Aberrant expression of oncogenic and tumor-suppressor microRNAs has been recognized as a common feature of human cancers. Colorectal cancer represents a major clinical challenge in the developed world and the design of inn...
journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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doi:10.3390/ijms140918557
更新日期:2013-09-09 00:00:00
abstract::The conserved serine/threonine kinase mTOR (the mammalian target of rapamycin), a downstream effector of the PI3K/AKT pathway, forms two distinct multiprotein complexes: mTORC1 and mTORC2. mTORC1 is sensitive to rapamycin, activates S6K1 and 4EBP1, which are involved in mRNA translation. It is activated by diverse sti...
journal_title:International journal of molecular sciences
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更新日期:2012-01-01 00:00:00
abstract::Targeting cancer cells using chimeric-antigen-receptor (CAR-)T cells has propelled adoptive T-cell therapy (ATT) to the next level. A plentitude of durable complete responses using CD19-specific CAR-T cells in patients suffering from various lymphoid malignancies resulted in the approval by the food and drug administr...
journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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更新日期:2016-09-03 00:00:00
abstract::The rapid development of new generation sequencing technology has deepened the understanding of genomes and functional products. RNA-sequencing studies in mammals show that approximately 85% of the DNA sequences have RNA products, for which the length greater than 200 nucleotides (nt) is called long non-coding RNAs (l...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
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更新日期:2017-12-08 00:00:00
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journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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更新日期:2019-09-06 00:00:00
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journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms131114889
更新日期:2012-11-13 00:00:00
abstract::Enzymatic activation of irinotecan (CPT-11) is due to carboxylesterase (CES), and its pharmacological behavior is influenced by drug resistance-related proteins. We previously reported that the clinical response and prognosis of metastatic colorectal cancer (mCRC) patients did not differ in tumors with different thymi...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms150915767
更新日期:2014-09-05 00:00:00
abstract::In this work, we studied the antimicrobial properties of a nanocomposite system based on a lactose-substituted chitosan and silver nanoparticles: Chitlac-nAg. Twofold serial dilutions of the colloidal Chitlac-nAg solution were both tested on Streptococcus mitis, Streptococcus mutans, and Streptococcus oralis planktoni...
journal_title:International journal of molecular sciences
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doi:10.3390/ijms140713615
更新日期:2013-06-28 00:00:00
abstract::It has been hypothesized that genetic variation in base excision repair (BER) might modify colorectal adenoma risk. Thus, we evaluated the influence of APE1 T2197G (Asp148Glu) polymorphism on APE1, XRCC1, PARP1 and OGG1 expression in normal and tumor samples from patients with colorectal cancer. The results indicate a...
journal_title:International journal of molecular sciences
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doi:10.3390/ijms151017333
更新日期:2014-09-29 00:00:00
abstract::The epithelial sodium channel (ENaC) has a key role in modulating endothelial cell stiffness and this in turn regulates nitric oxide (NO) synthesis. The physiological relevance of endothelial ENaC in pathological conditions where reduced NO bioavailability plays an essential role remains largely unexplored. Renal isch...
journal_title:International journal of molecular sciences
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doi:10.3390/ijms20133132
更新日期:2019-06-27 00:00:00
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journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms160818741
更新日期:2015-08-11 00:00:00
abstract::In the protozoan ciliate Euplotes, a transduction pathway resulting in a mitogenic cell growth response is activated by autocrine receptor binding of cell type-specific, water-borne signaling protein pheromones. In Euplotes raikovi, a marine species of temperate waters, this transduction pathway was previously shown t...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms14047457
更新日期:2013-04-03 00:00:00
abstract::Cynoglossus semilaevis is an important economic fish species and has long been cultivated in China. Since the completion of its genome and transcriptome sequencing, genes relating to C. semilaevis development have been extensively studied. R-spondin 3 (Rspo3) is a member of the R-spondin family. It plays an important ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19071915
更新日期:2018-06-29 00:00:00
abstract::: The highly conserved transcription factor Pax6 is involved in the development of the eyes, brain, and pancreas in vertebrates and invertebrates, whereas the additional expression pattern in other organs is still elusive. In this study, we cloned and characterized two pax6 homologs in blunt snout bream (Megalobrama a...
journal_title:International journal of molecular sciences
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更新日期:2019-04-05 00:00:00
abstract::Microtubules are the main components of mitotic spindles, and are the pillars of the cellular cytoskeleton. They perform most of their cellular functions by virtue of their unique dynamic instability processes which alternate between polymerization and depolymerization phases. This in turn is driven by a precise balan...
journal_title:International journal of molecular sciences
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更新日期:2017-09-22 00:00:00
abstract::The use of mesenchymal stem cells (MSC) for the treatment of cutaneous wounds is currently of enormous interest. However, the broad translation of cell therapies into clinical use is hampered by their efficacy, safety, manufacturing and cost. MSCs release a broad repertoire of trophic factors and immunomodulatory cyto...
journal_title:International journal of molecular sciences
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更新日期:2020-09-24 00:00:00
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journal_title:International journal of molecular sciences
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更新日期:2020-10-30 00:00:00
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journal_title:International journal of molecular sciences
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doi:10.3390/ijms21186948
更新日期:2020-09-22 00:00:00
abstract::Tackling the first stages of the chondrogenic commitment is essential to drive chondrogenic differentiation to healthy hyaline cartilage and minimize hypertrophy. During chondrogenesis, the extracellular matrix continuously evolves, adapting to the tissue adhesive requirements at each stage. Here, we take advantage of...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21155269
更新日期:2020-07-24 00:00:00
abstract::RNAi technology has significant potential as a future therapeutic and could theoretically be used to knock down disease-specific RNAs. However, due to frequent off-target effects, low efficiency, and limited accessibility of nuclear transcripts, the clinical application of the technology remains challenging. In this s...
journal_title:International journal of molecular sciences
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doi:10.3390/ijms21238904
更新日期:2020-11-24 00:00:00
abstract::Maize can form symbiotic relationships with arbuscular mycorrhiza (AM) fungus to increase productivity and resistance, but the miRNAs in maize responsible for this process have not been discovered. In this study, 155 known and 28 novel miRNAs were identified by performing high-throughput sequencing of sRNA in maize ro...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19103201
更新日期:2018-10-16 00:00:00
abstract::Panicle degeneration, also known as panicle abortion, is a serious defect and causes heavy losses to reproductive yield in cereals. Several mutants have been reported to display the phenotype of spikelet abortion in rice. Recent findings have resulted in significant breakthroughs, but comprehensive understanding about...
journal_title:International journal of molecular sciences
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doi:10.3390/ijms20071613
更新日期:2019-04-01 00:00:00
abstract::Although most osmotic stresses are harmful to plant growth and development, certain drought- or polyethylene glycol (PEG)-induced mild osmotic stresses promote plant root growth. The underlying regulatory mechanisms of this response remain elusive. Here, we report that the GLYCOGEN SYNTHASE KINASE 3 (GSK3) genes ARABI...
journal_title:International journal of molecular sciences
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doi:10.3390/ijms21113991
更新日期:2020-06-02 00:00:00
abstract::Activation of the cannabinoid CB1 receptor induces different cellular signaling cascades through coupling to different effector proteins (G-proteins and β-arrestins), triggering numerous therapeutic effects. Conformational changes and rearrangements at the intracellular domain of this GPCR receptor that accompany liga...
journal_title:International journal of molecular sciences
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更新日期:2020-10-30 00:00:00
abstract::There is evidence that spaceflight poses acute and late risks to the central nervous system. To explore possible mechanisms, the proteomic changes following spaceflight in mouse brain were characterized. Space Shuttle Atlantis (STS-135) was launched from the Kennedy Space Center (KSC) on a 13-day mission. Within 3⁻5 h...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20010007
更新日期:2018-12-20 00:00:00