Abstract:
:Panicle degeneration, also known as panicle abortion, is a serious defect and causes heavy losses to reproductive yield in cereals. Several mutants have been reported to display the phenotype of spikelet abortion in rice. Recent findings have resulted in significant breakthroughs, but comprehensive understanding about the molecular pathways and physiological basis of panicle degeneration still remain a dilemma. In this review, we have summarized all the responsible genes and mechanisms underlying the panicle development with a special focus on degeneration. Here, we hypothesized a model by using knowledge and coherent logic in order to understand the molecular regulation of panicle degeneration. In addition to this, we included all the previous discoveries, schools of thoughts, ancient working theories, and crosstalk of phytohormones and provided new insights for future studies.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Ali A,Xu P,Riaz A,Wu Xdoi
10.3390/ijms20071613subject
Has Abstractpub_date
2019-04-01 00:00:00issue
7issn
1422-0067pii
ijms20071613journal_volume
20pub_type
杂志文章,评审abstract::Advances in stem cell research have provided important understanding of the cell biology and offered great promise for developing new strategies for tissue regeneration. The beneficial effects of stem cell therapy depend also by the development of new approachs for the track of stem cells in living subjects over time ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms11031070
更新日期:2010-03-12 00:00:00
abstract::Osteoarthritis (OA) affects the integrity of the entire joint including the synovium. The most abundant cells in the synovium are fibroblasts (SF). Excessive mechanical loading might contribute to OA pathogenesis. Here, we investigate the effects of mechanical loading on SF derived from non-OA (N-SF) and OA patients (...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20030585
更新日期:2019-01-30 00:00:00
abstract::Understanding the molecular mechanisms of skeletal myoblast differentiation is essential for studying muscle developmental biology. In our previous study, we reported that knockdown of myocyte enhancer factor 2A (MEF2A) inhibited myoblast differentiation. Here in this study, we further identified that MEF2A controlled...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20112748
更新日期:2019-06-04 00:00:00
abstract::Acute erythroleukemia (AEL) is a rare disease typically associated with a poor prognosis. The median survival ranges between 3-9 months from initial diagnosis. Hypomethylating agents (HMAs) have been shown to prolong survival in patients with myelodysplastic syndromes (MDS) and AML, but there is limited data of their ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,多中心研究
doi:10.3390/ijms18040837
更新日期:2017-04-14 00:00:00
abstract::The selective binding of six (S)-quinuclidine-triazoles and their (R)-enantiomers to nicotinic acetylcholine receptor (nAChR) subtypes α3β4 and α7, respectively, were analyzed by in silico docking to provide the insight into the molecular basis for the observed stereospecific subtype discrimination. Homology modeling ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21176189
更新日期:2020-08-27 00:00:00
abstract::MicroRNAs (miRNAs), a class of single stranded, small (~22 nucleotides), non-coding RNAs, play an important role in muscle development. We focused on the role of the miR-30-5p family during bovine muscle development from previous high-throughput sequencing results and analyzed their expression profiles. MHC and MyoG m...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms17020182
更新日期:2016-01-29 00:00:00
abstract::ABA is involved in plant responses to a broad range of pathogens and exhibits complex antagonistic and synergistic relationships with salicylic acid (SA) and ethylene (ET) signaling pathways, respectively. However, the specific receptor of ABA that triggers the positive and negative responses of ABA during immune resp...
journal_title:International journal of molecular sciences
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doi:10.3390/ijms21165852
更新日期:2020-08-14 00:00:00
abstract::Obesity is an important aspect of the metabolic syndrome and is often associated with chronic inflammation. In this context, inflammation of organs participating in energy homeostasis (such as liver, adipose tissue, muscle and pancreas) leads to the recruitment and activation of macrophages, which secrete pro-inflamma...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
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更新日期:2020-12-30 00:00:00
abstract::Land plants are anchored in one place for most of their life cycle and therefore must constantly adapt their growth and metabolism to abiotic stresses such as light intensity, temperature and the availability of water and essential minerals. Thus, plants' subsistence depends on their ability to regulate rapidly gene e...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
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更新日期:2009-07-10 00:00:00
abstract::Aging leads to a loss of vasomotor control. Both vasodilation and vasoconstriction are affected. Decreased nitric oxide-cGMP-mediated relaxation is a hallmark of aging. It contributes to vascular disease, notably hypertension, infarction, and dementia. Decreased vasodilation can be caused by aging independently from c...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21134667
更新日期:2020-06-30 00:00:00
abstract::Streptococcus pneumoniae is a major meningitis-causing pathogen globally, bringing about significant morbidity and mortality, as well as long-term neurological sequelae in almost half of the survivors. Subsequent to nasopharyngeal colonisation and systemic invasion, translocation across the blood‒brain barrier (BBB) b...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19113555
更新日期:2018-11-11 00:00:00
abstract::Cisplatin is the first-line treatment for different types of solid tumors, such as ovarian, testicular, bladder, cervical, head and neck, lung, and esophageal cancers. The main problem related to its clinical use is the onset of drug resistance. In the last decades, among the studied molecular mechanisms of cisplatin ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21030937
更新日期:2020-01-31 00:00:00
abstract::In the central nervous system omega-3 fatty acids modulate cell signaling and affect dopaminergic and serotonergic pathways. On this basis, a new application for omega-3 fatty acids has been proposed, concerning the treatment of several psychiatric disorders. The present article is an update of a previous systematic r...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20215257
更新日期:2019-10-23 00:00:00
abstract::Phosphatidylcholine (PC) translocation into mucus of the intestine was shown to occur via a paracellular transport across the apical/lateral tight junction (TJ) barrier. In case this could also be operative in biliary epithelial cells, this may have implication for the pathogenesis of primary sclerosing cholangitis (P...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20164034
更新日期:2019-08-19 00:00:00
abstract::Accumulation of glycogen in the kidney and liver is the main feature of Fanconi-Bickel Syndrome (FBS), a rare disorder of carbohydrate metabolism inherited in an autosomal recessive manner due to SLC2A2 gene mutations. Missense, nonsense, frame-shift (fs), in-frame indels, splice site, and compound heterozygous varian...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21176286
更新日期:2020-08-31 00:00:00
abstract::MicroRNAs are tiny but powerful regulators of gene expression at the post-transcriptional level. Aberrant expression of oncogenic and tumor-suppressor microRNAs has been recognized as a common feature of human cancers. Colorectal cancer represents a major clinical challenge in the developed world and the design of inn...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21072423
更新日期:2020-03-31 00:00:00
abstract::Peanut samples were irradiated (0.0, 5.2, 7.2 or 10.0 kGy), stored for a year (room temperature) and examined every three months. Mycotoxic fungi (MF) were detected in non-irradiated blanched peanuts. A dose of 5.2 kGy was found suitable to prevent MF growth in blanched samples. No MF was detected in in-shell peanuts,...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms130910935
更新日期:2012-01-01 00:00:00
abstract::Antioxidant capacity (AOC) against peroxyl radical and 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt (ABTS) radical cation was measured for a series of p-hydroxybenzoic (HB) and p-hydroxycinnamic (HC) acids at different pH. Quantum-chemical computation was performed using Gaussian 3.0 softwa...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms150916351
更新日期:2014-09-16 00:00:00
abstract::Although the application of cardioprotective ischaemia/reperfusion (I/R) stimuli after myocardial infarction (MI) is a promising concept for salvaging the myocardium, translation to a clinical scenario has not fulfilled expectations. We have previously shown that in pigs, ischaemic postconditioning (IPostC) reduces my...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20020344
更新日期:2019-01-15 00:00:00
abstract::The common mutation BRAFV600 in primary melanomas activates the mitogen-activated protein kinase/extracellular-signal-regulated kinase (MAPK/ERK) pathway and the introduction of proto-oncogene B-Raf (BRAF) and mitogen-activated protein kinase kinase (MEK) inhibitors (BRAFi and MEKi) was a breakthrough in the treatment...
journal_title:International journal of molecular sciences
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doi:10.3390/ijms21134576
更新日期:2020-06-27 00:00:00
abstract::Recent studies suggested that sestrin2 is a crucial modulator for the production of reactive oxygen species (ROS). In addition, sestrin2 may also regulate ribosomal protein S6 (RpS6), a molecule important for protein synthesis, through the effect of mammalian target of rapamycin (mTOR) complex that is pivotal for long...
journal_title:International journal of molecular sciences
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doi:10.3390/ijms161125963
更新日期:2015-11-04 00:00:00
abstract::In recent years, citicoline has been the object of remarkable interest as a possible neuroprotectant. The aim of this study was to investigate if citicoline affected cell survival in primary retinal cultures and if it exerted neuroprotective activity in conditions modeling retinal neurodegeneration. Primary retinal cu...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms15046286
更新日期:2014-04-14 00:00:00
abstract::Argininosuccinate synthetase (ASS), a key enzyme to synthesize arginine is down regulated in many tumors including hepatocellular carcinoma (HCC). Similar to previous reports, we have found the decrease in ASS expression in poorly differentiated HCC. These ASS(-) tumors are auxotrophic for arginine. Pegylated arginine...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18061175
更新日期:2017-06-01 00:00:00
abstract::Renal proximal tubular epithelial cells are significantly damaged during acute kidney injury. Renal proximal tubular cell-specific autophagy-deficient mice show increased sensitivity against renal injury, while showing few pathological defects under normal fed conditions. Considering that autophagy protects the proxim...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21010155
更新日期:2019-12-25 00:00:00
abstract::The essential role of Hippo signaling pathway in cancer development has been elucidated by recent studies. In the gastrointestinal tissues, deregulation of the Hippo pathway is one of the most important driving events for tumorigenesis. It is widely known that Yes-associated protein 1 (YAP1) and WW domain that contain...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20071576
更新日期:2019-03-29 00:00:00
abstract::A common problem in the immunodetection of structurally close compounds is understanding the regularities of immune recognition, and elucidating the basic structural elements that provide it. Correct identification of these elements would allow for select immunogens to obtain antibodies with either wide specificity to...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20020265
更新日期:2019-01-11 00:00:00
abstract::Both long-term undernutrition and overnutrition disturb metabolic balance, which is mediated partially by the action of two adipokines, leptin and resistin (RSTN). In this study, we manipulated the diet of ewes to produce either a thin (lean) or fat (fat) body condition and investigated how RSTN affects endocrine and ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21124238
更新日期:2020-06-14 00:00:00
abstract::Multiple sclerosis (MS) is a chronic disabling disease of the central nervous system commonly affecting young adults. Pathologically, there are patches of inflammation (plaques) with demyelination of axons and oligodendrocyte loss. There is a global latitude gradient in MS prevalence, and incidence of MS is increasing...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms130911718
更新日期:2012-01-01 00:00:00
abstract::Genetic analysis of "InochinoIchi," an exceptionally large grain rice variety, was conducted through five continuous backcrosses with Koshihikari as a recurrent parent using the large grain F3 plant in Koshihikari × Inochinoichi as a nonrecurrent parent. Thorough the F2 and all BCnF2 generations, large, medium, and sm...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20215442
更新日期:2019-10-31 00:00:00
abstract::The high abundance of mitochondria and the expression of mitochondrial uncoupling protein 1 (UCP1) confer upon brown adipose tissue (BAT) the unique capacity to convert chemical energy into heat at the expense of ATP synthesis. It was long believed that BAT is present only in infants, and so, it was not considered as ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20143520
更新日期:2019-07-18 00:00:00