Abstract：
:Streptococcus pneumoniae is a major meningitis-causing pathogen globally, bringing about significant morbidity and mortality, as well as long-term neurological sequelae in almost half of the survivors. Subsequent to nasopharyngeal colonisation and systemic invasion, translocation across the blood‒brain barrier (BBB) by S. pneumoniae is a crucial early step in the pathogenesis of meningitis. The BBB, which normally protects the central nervous system (CNS) from deleterious molecules within the circulation, becomes dysfunctional in S. pneumoniae invasion due to the effects of pneumococcal toxins and a heightened host inflammatory environment of cytokines, chemokines and reactive oxygen species intracranially. The bacteria‒host interplay within the CNS likely determines not only the degree of BBB pathological changes, but also host survival and the extent of neurological damage. This review explores the relationship between S. pneumoniae bacteria and the host inflammatory response, with an emphasis on the BBB and its roles in CNS protection, as well as both the acute and long-term pathogenesis of meningitis.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Yau B,Hunt NH,Mitchell AJ,Too LKdoi
10.3390/ijms19113555subject
Has Abstractpub_date
2018-11-11 00:00:00issue
11issn
1422-0067pii
ijms19113555journal_volume
19pub_type
杂志文章,评审abstract：:Nitrate (NO3-) and auxin are key regulators of root growth and development, modulating the signalling cascades in auxin-induced lateral root formation. Auxin biosynthesis, transport, and transduction are significantly altered by nitrate. A decrease in nitrate (NO3-) supply tends to promote auxin translocation from sho...
journal_title：International journal of molecular sciences
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更新日期：2020-04-20 00:00:00
abstract：:Congenital dyserythropoietic anemia type II (CDA II) is a hypo-productive anemia defined by ineffective erythropoiesis through maturation arrest of erythroid precursors. CDA II is an autosomal recessive disorder due to loss-of-function mutations in SEC23B. Currently, management of patients with CDA II is based on tran...
journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2018-04-10 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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journal_title：International journal of molecular sciences
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更新日期：2021-01-19 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2018-12-20 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-03-30 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-02-09 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2016-03-30 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-11-11 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2016-08-12 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19071900
更新日期：2018-06-28 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2018-05-22 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-10-15 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2020-10-13 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2019-11-27 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2019-11-25 00:00:00
abstract：:Micro Electromechanical Systems (MEMS) based microfluidic devices have gained popularity in biomedicine field over the last few years. In this paper, a comprehensive overview of microfluidic devices such as micropumps and microneedles has been presented for biomedical applications. The aim of this paper is to present ...
journal_title：International journal of molecular sciences
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更新日期：2011-01-01 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2018-09-18 00:00:00
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journal_title：International journal of molecular sciences
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doi：10.3390/ijms18020366
更新日期：2017-02-09 00:00:00
