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Characterization and expression of the gene encoding En-MAPK1, an intestinal cell kinase (ICK)-like kinase activated by the autocrine pheromone-signaling loop in the Polar Ciliate, Euplotes nobilii.

Abstract：

:In the protozoan ciliate Euplotes, a transduction pathway resulting in a mitogenic cell growth response is activated by autocrine receptor binding of cell type-specific, water-borne signaling protein pheromones. In Euplotes raikovi, a marine species of temperate waters, this transduction pathway was previously shown to involve the phosphorylation of a nuclear protein kinase structurally similar to the intestinal-cell and male germ cell-associated kinases described in mammals. In E. nobilii, which is phylogenetically closely related to E. raikovi but inhabits Antarctic and Arctic waters, we have now characterized a gene encoding a structurally homologous kinase. The expression of this gene requires +1 translational frameshifting and a process of intron splicing for the production of the active protein, designated En-MAPK1, which contains amino acid substitutions of potential significance for cold-adaptation.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Candelori A,Luporini P,Alimenti C,Vallesi A

doi

10.3390/ijms14047457

subject

Has Abstract

pub_date

2013-04-03 00:00:00

pages

7457-67

issue

4

issn

1422-0067

pii

ijms14047457

journal_volume

14

pub_type

杂志文章

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