Calcium Signaling in Aging and Neurodegenerative Diseases 2019.


:The European Calcium Society (ECS) workshop, which is held every 2 years, is a dedicated meeting of scientists interested in the elucidation of the action of calcium binding, calcium signaling and the study of proteins and organelles, such as mitochondria and endoplasmic reticulum, thereby involved, either in health and disease conditions. The 8th edition of the ECS workshop was organized by a group of researchers from the University of Coimbra, Portugal, in close collaboration with ECS board members. Thanks to the central role of "Calcium Signaling in Aging and Neurodegenerative Disorders", the ECS 2019 workshop was attended by 62 experts who presented their results in a plenary lecture and five regular symposia, two oral communication sessions and two poster sessions, followed by a hands-on session on calcium imaging. All the scientific and social events were fully participated by the scientific community that allowed a close and fruitful interaction and discussion between junior researchers and senior experts in the field. In this report, the contributions in individual sessions are summarized.


Int J Mol Sci


Cortes L,Malva J,Rego AC,Pereira CF




Has Abstract


2020-02-07 00:00:00










  • Aronia melanocarpa (Black Chokeberry) Reduces Ethanol-Induced Gastric Damage via Regulation of HSP-70, NF-κB, and MCP-1 Signaling.

    abstract::Aronia melanocarpa (Michx.) Ell. belongs to the Rosaceae family. The purpose of this study is to explore the gastroprotective effect of the Aronia melanocarpa hydro-alcoholic extract (AMHAE) against ethanol-induced gastric ulcer in a rat model. Different concentrations (50, 100, and 200 mg/kg) of AMHAE, or 30 mg/kg of...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Paulrayer A,Adithan A,Lee JH,Moon KH,Kim DG,Im SY,Kang CW,Kim NS,Kim JH

    更新日期:2017-06-05 00:00:00

  • Isolation and heterologous expression of a polygalacturonase produced by Fusarium oxysporum f. sp. cubense race 1 and 4.

    abstract::Fusarium wilt (Panama disease) caused by Fusarium oxysporum f. sp. cubense (FOC) represents a significant threat to banana (Musa spp.) production. Musa AAB is susceptible to Race 1 (FOC1) and Race 4 (FOC4), while Cavendish Musa AAA is found to be resistant to FOC1 but still susceptible to Race 4. A polygalacturonase (...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Dong Z,Wang Z

    更新日期:2015-04-03 00:00:00

  • Investigations of the Copper Peptide Hepcidin-25 by LC-MS/MS and NMR.

    abstract::Hepcidin-25 was identified as the main iron regulator in the human body, and it by binds to the sole iron-exporter ferroportin. Studies showed that the N-terminus of hepcidin is responsible for this interaction, the same N-terminus that encompasses a small copper(II)-binding site known as the ATCUN (amino-terminal Cu(...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Abbas IM,Vranic M,Hoffmann H,El-Khatib AH,Montes-Bayón M,Möller HM,Weller MG

    更新日期:2018-08-02 00:00:00

  • Osteoporosis in Skin Diseases.

    abstract::Osteoporosis (OP) is defined as a generalized skeletal disease characterized by low bone mass and an alteration of the microarchitecture that lead to an increase in bone fragility and, therefore, an increased risk of fractures. It must be considered today as a true public health problem and the most widespread metabol...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Sirufo MM,De Pietro F,Bassino EM,Ginaldi L,De Martinis M

    更新日期:2020-07-03 00:00:00

  • Synthesis and characterization of novel purpurinimides as photosensitizers for photodynamic therapy.

    abstract::A series of novel purpurinimides with long wavelength absorption were designed and synthesized to develop novel and potential photosensitizers. These compounds were investigated through reduction, oxidation, rearrangement reaction and amidation reactions of methyl pheophorbide a. They demonstrated a considerable batho...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Cui BC,Yoon I,Li JZ,Lee WK,Shim YK

    更新日期:2014-05-08 00:00:00

  • Alpha-Smooth Muscle Actin-Positive Perivascular Cells in Diabetic Retina and Choroid.

    abstract::Structural alterations of pericytes in microvessels are important features of diabetic retinopathy. Although capillary pericytes had been known not to have α-smooth muscle actin (αSMA), a recent study revealed that a specific fixation method enabled the visualization of αSMA along retinal capillaries. In this study, w...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Kim SJ,Kim SA,Choi YA,Park DY,Lee J

    更新日期:2020-03-20 00:00:00

  • Are the Biological and Biomechanical Properties of Meniscal Scaffolds Reflected in Clinical Practice? A Systematic Review of the Literature.

    abstract::The aim of this PRISMA review was to assess whether the CMI and Actifit scaffolds, when used in clinical practice, improve clinical outcomes and demonstrate the ideal biological and biomechanical properties of scaffolds: being chondroprotective, porous, resorbable, able to mature and promote regeneration of tissue. Th...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Ranmuthu CDS,Ranmuthu CKI,Russell JC,Singhania D,Khan WS

    更新日期:2019-02-01 00:00:00

  • Gestational Alcohol Exposure Altered DNA Methylation Status in the Developing Fetus.

    abstract::Ethanol is well known as a teratogenic factor that is capable of inducing a wide range of developmental abnormalities if the developing fetus is exposed to it. Duration and dose are the critical parameters of exposure that affect teratogenic variation to the developing fetus. It is suggested that ethanol interferes wi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Mandal C,Halder D,Jung KH,Chai YG

    更新日期:2017-06-28 00:00:00

  • Ectopic expression of CsCTR1, a cucumber CTR-like gene, attenuates constitutive ethylene signaling in an Arabidopsis ctr1-1 mutant and expression pattern analysis of CsCTR1 in cucumber (Cucumis sativus).

    abstract::The gaseous plant hormone ethylene regulates many aspects of plant growth, development and responses to the environment. Constitutive triple response 1 (CTR1) is a central regulator involved in the ethylene signal transduction pathway. To obtain a better understanding of this particular pathway in cucumber, the cDNA-e...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Bie B,Sun J,Pan J,He H,Cai R

    更新日期:2014-09-15 00:00:00

  • DNA repair gene XRCC4 codon 247 polymorphism modified diffusely infiltrating astrocytoma risk and prognosis.

    abstract::The DNA repair gene X-ray cross-complementary group 4 (XRCC4), an important caretaker of the overall genome stability, is thought to play a major role in human tumorigenesis. We investigated the association between an important polymorphic variant of this gene at codon 247 (rs373409) and diffusely infiltrating astrocy...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Lin ZH,Chen JC,Wang YS,Huang TJ,Wang J,Long XD

    更新日期:2013-12-27 00:00:00

  • From Olive Fruits to Olive Oil: Phenolic Compound Transfer in Six Different Olive Cultivars Grown under the Same Agronomical Conditions.

    abstract::Phenolic compounds are responsible of the nutritional and sensory quality of extra-virgin olive oil (EVOO). The composition of phenolic compounds in EVOO is related to the initial content of phenolic compounds in the olive-fruit tissues and the activity of enzymes acting on these compounds during the industrial proces...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Talhaoui N,Gómez-Caravaca AM,León L,De la Rosa R,Fernández-Gutiérrez A,Segura-Carretero A

    更新日期:2016-03-04 00:00:00

  • Is the secret of VDAC Isoforms in their gene regulation? Characterization of human VDAC genes expression profile, promoter activity, and transcriptional regulators.

    abstract::VDACs (voltage-dependent anion-selective channels) are pore-forming proteins of the outer mitochondrial membrane, whose permeability is primarily due to VDACs' presence. In higher eukaryotes, three isoforms are raised during the evolution: they have the same exon-intron organization, and the proteins show the same cha...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Zinghirino F,Pappalardo XG,Messina A,Guarino F,De Pinto V

    更新日期:2020-10-07 00:00:00

  • Alterations of Fatty Acid Profile May Contribute to Dyslipidemia in Chronic Kidney Disease by Influencing Hepatocyte Metabolism.

    abstract::Chronic kidney disease (CKD) is associated with atherogenic dyslipidemia. Our aim was firstly to investigate patterns of fatty acids (FA) composition through various stages of CKD, and secondly, to evaluate the effect of CKD-specific FA disturbances on the expression of genes related to lipid metabolism at a cellular ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Czumaj A,Śledziński T,Carrero JJ,Stepnowski P,Sikorska-Wisniewska M,Chmielewski M,Mika A

    更新日期:2019-05-18 00:00:00

  • The Role of ERα36 in Development and Tumor Malignancy.

    abstract::Estrogen nuclear receptors, represented by the canonical forms ERα66 and ERβ1, are the main mediators of the estrogen-dependent pathophysiology in mammals. However, numerous isoforms have been identified, stimulating unconventional estrogen response pathways leading to complex cellular and tissue responses. The estrog...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Thiebaut C,Konan HP,Guerquin MJ,Chesnel A,Livera G,Le Romancer M,Dumond H

    更新日期:2020-06-09 00:00:00

  • Integration of a Gold-Specific Whole E. coli Cell Sensing and Adsorption Based on BioBrick.

    abstract::Detection and recovery of heavy metals from environmental sources is a major task in environmental protection and governance. Based on previous research into cell-based visual detection and biological adsorption, we have developed a novel system combining these two functions by the BioBrick technique. The gold-specifi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Yan L,Sun P,Xu Y,Zhang S,Wei W,Zhao J

    更新日期:2018-11-24 00:00:00

  • Special Issue "Selected Papers from the 8th Asia-Pacific NMR (APNMR) Symposium: Recent Advances in NMR Spectroscopy".

    abstract::Asia-Pacific NMR (APNMR) has been an important scientific event in the region, engaging a large number of NMR scientists from academia and industries [...]. ...

    journal_title:International journal of molecular sciences

    pub_type: 社论


    authors: Bhattacharjya S,Yang D,Yoon HS

    更新日期:2020-06-22 00:00:00

  • Evodiamine Attenuates PDGF-BB-Induced Migration of Rat Vascular Smooth Muscle Cells through Activating PPARγ.

    abstract::The uncontrolled migration of vascular smooth muscle cells (VSMCs) into the intima is a critical process in the development of atherosclerosis. Evodiamine, an indole alkaloid extracted from the Chinese medicine evodia, has been shown to inhibit tumor cell invasion and protect the cardiovascular system, but its effects...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Ge X,Chen S,Liu M,Liang T,Liu C

    更新日期:2015-11-26 00:00:00

  • Genome-wide investigation of multifocal and unifocal prostate cancer-are they genetically different?

    abstract::Prostate cancer is widely observed to be biologically heterogeneous. Its heterogeneity is manifested histologically as multifocal prostate cancer, which is observed more frequently than unifocal prostate cancer. The clinical and prognostic significance of either focal cancer type is not fully established. To investiga...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Ibeawuchi C,Schmidt H,Voss R,Titze U,Abbas M,Neumann J,Eltze E,Hoogland AM,Jenster G,Brandt B,Semjonow A

    更新日期:2013-06-03 00:00:00

  • Signalling Pathways Implicated in Alzheimer's Disease Neurodegeneration in Individuals with and without Down Syndrome.

    abstract::Down syndrome (DS), the most common cause of intellectual disability of genetic origin, is characterized by alterations in central nervous system morphology and function that appear from early prenatal stages. However, by the fourth decade of life, all individuals with DS develop neuropathology identical to that found...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Martínez-Cué C,Rueda N

    更新日期:2020-09-20 00:00:00

  • Effects of Long-Chain Fatty Acyl-CoA Synthetase 1 on Diglyceride Synthesis and Arachidonic Acid Metabolism in Sheep Adipocytes.

    abstract::Long-chain fatty acyl-CoA synthetase (ACSLs) is an essential enzyme for the synthesis of fatty acyl-CoA. ACSL1 plays a key role in the synthesis of triglycerides, phospholipids, and cholesterol esters. BACKGROUND:In the current study, triglyceride content did not increase after overexpression of the ACSL1 gene. METH...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Cao Y,Wang S,Liu S,Wang Y,Jin H,Ma H,Luo X,Cao Y,Lian Z

    更新日期:2020-03-17 00:00:00

  • Pro-Resolving Molecules-New Approaches to Treat Sepsis?

    abstract::Inflammation is a complex response of the body to exogenous and endogenous insults. Chronic and systemic diseases are attributed to uncontrolled inflammation. Molecules involved in the initiation of inflammation are very well studied while pathways regulating its resolution are insufficiently investigated. Approaches ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Buechler C,Pohl R,Aslanidis C

    更新日期:2017-02-23 00:00:00

  • Molecular Dynamics Simulations to Investigate How PZM21 Affects the Conformational State of the μ-Opioid Receptor Upon Activation.

    abstract::Opioid analgesics such as morphine have indispensable roles in analgesia. However, morphine use can elicit side effects such as respiratory depression and constipation. It has been reported that G protein-biased agonists as substitutes for classic opioid agonists can alleviate (or even eliminate) these side effects. T...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Zhao Z,Huang T,Li J

    更新日期:2020-07-01 00:00:00

  • Shear Bond Strength and Remineralisation Effect of a Casein Phosphopeptide-Amorphous Calcium Phosphate-Modified Glass Ionomer Cement on Artificial "Caries-Affected" Dentine.

    abstract::This study investigated the effect of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP)-modified glass ionomer cement (GIC) on shear bond strength (SBS) and remineralisation of artificial "caries-affected" dentine. Human dentine slices were demineralised and allocated to three groups: group 1, conventional G...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Zhao IS,Mei ML,Zhou ZL,Burrow MF,Lo EC,Chu CH

    更新日期:2017-08-07 00:00:00

  • Advances in carcinogenic metal toxicity and potential molecular markers.

    abstract::Metal compounds such as arsenic, cadmium, chromium, cobalt, lead, mercury, and nickel are classified as carcinogens affecting human health through occupational and environmental exposure. However, the underlying mechanisms involved in tumor formation are not well clarified. Interference of metal homeostasis may result...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Koedrith P,Seo YR

    更新日期:2011-01-01 00:00:00

  • Effect of Embryo Vitrification on the Steroid Biosynthesis of Liver Tissue in Rabbit Offspring.

    abstract::Preimplantation embryo manipulations during standard assisted reproductive technologies (ART) have significant repercussions on offspring. However, few studies to date have investigated the potential long-term outcomes associated with the vitrification procedure. Here, we performed an experiment to unravel the particu...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Marco-Jiménez F,Garcia-Dominguez X,Domínguez-Martínez M,Viudes-de-Castro MP,Diretto G,Peñaranda DS,Vicente JS

    更新日期:2020-11-16 00:00:00

  • Host-Induced Gene Silencing: A Powerful Strategy to Control Diseases of Wheat and Barley.

    abstract::Wheat and barley are the most highly produced and consumed grains in the world. Various pathogens-viruses, bacteria, fungi, insect pests, and nematode parasites-are major threats to yield and economic losses. Strategies for the management of disease control mainly depend on resistance or tolerance breeding, chemical c...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Qi T,Guo J,Peng H,Liu P,Kang Z,Guo J

    更新日期:2019-01-08 00:00:00

  • Platelets Boost Recruitment of CD133+ Bone Marrow Stem Cells to Endothelium and the Rodent Liver-The Role of P-Selectin/PSGL-1 Interactions.

    abstract::We previously demonstrated that clinical administration of mobilized CD133+ bone marrow stem cells (BMSC) accelerates hepatic regeneration. Here, we investigated the potential of platelets to modulate CD133+BMSC homing to hepatic endothelial cells and sequestration to warm ischemic livers. Modulatory effects of platel...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Lehwald N,Duhme C,Pinchuk I,Kirchner J,Wieferich K,Schmelzle M,Jurk K,Windmöller BA,Hübner W,Homey B,Bode J,Kubitz R,Benhidjeb T,Krüger M,Robson SC,Knoefel WT,Kehrel BE,Schulte Am Esch J

    更新日期:2020-09-03 00:00:00

  • Fluid Shear Stress Induces EMT of Circulating Tumor Cells via JNK Signaling in Favor of Their Survival during Hematogenous Dissemination.

    abstract::Tumor cells metastasize to distal organs mainly through hematogenous dissemination, where they experience considerable levels of fluid shear stress. Epithelial-mesenchymal transition (EMT) plays a critical role in tumor metastasis. However, how fluid shear stress influences the EMT phenotype of circulating tumor cells...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Xin Y,Li K,Yang M,Tan Y

    更新日期:2020-10-30 00:00:00

  • Effects of dietary conjugated linoleic acid and biopolymer encapsulation on lipid metabolism in mice.

    abstract::Forty mice were randomly divided into four groups on the basis of the diet to be fed as follows: 5% (low) fat diet (T1: LF); 20% (high) fat diet (T2: HF); 20% fat containing 1% conjugated linoleic acid (CLA) (T3: HFC); and 20% fat containing 1% CLA with 0.5% biopolymers (T4: HFCB). The high-fat with CLA diet groups (H...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Hur SJ,Kim DH,Chun SC,Lee SK

    更新日期:2013-03-26 00:00:00

  • Intestinal Permeability and Cellular Antioxidant Activity of Phenolic Compounds from Mango (Mangifera indica cv. Ataulfo) Peels.

    abstract::Mango (Mangifera indica cv. Ataulfo) peel contains bound phenolics that may be released by alkaline or acid hydrolysis and may be converted into less complex molecules. Free phenolics from mango cv. Ataulfo peel were obtained using a methanolic extraction, and their cellular antioxidant activity (CAA) and permeability...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Pacheco-Ordaz R,Antunes-Ricardo M,Gutiérrez-Uribe JA,González-Aguilar GA

    更新日期:2018-02-08 00:00:00