Calcium Signaling in Aging and Neurodegenerative Diseases 2019.


:The European Calcium Society (ECS) workshop, which is held every 2 years, is a dedicated meeting of scientists interested in the elucidation of the action of calcium binding, calcium signaling and the study of proteins and organelles, such as mitochondria and endoplasmic reticulum, thereby involved, either in health and disease conditions. The 8th edition of the ECS workshop was organized by a group of researchers from the University of Coimbra, Portugal, in close collaboration with ECS board members. Thanks to the central role of "Calcium Signaling in Aging and Neurodegenerative Disorders", the ECS 2019 workshop was attended by 62 experts who presented their results in a plenary lecture and five regular symposia, two oral communication sessions and two poster sessions, followed by a hands-on session on calcium imaging. All the scientific and social events were fully participated by the scientific community that allowed a close and fruitful interaction and discussion between junior researchers and senior experts in the field. In this report, the contributions in individual sessions are summarized.


Int J Mol Sci


Cortes L,Malva J,Rego AC,Pereira CF




Has Abstract


2020-02-07 00:00:00










  • ArtinM Mediates Murine T Cell Activation and Induces Cell Death in Jurkat Human Leukemic T Cells.

    abstract::The recognition of cell surface glycans by lectins may be critical for the innate and adaptive immune responses. ArtinM, a d-mannose-binding lectin from Artocarpus heterophyllus, activates antigen-presenting cells by recognizing TLR2 N-glycans and induces Th1 immunity. We recently demonstrated that ArtinM stimulated C...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: da Silva TA,Oliveira-Brito PKM,Gonçalves TE,Vendruscolo PE,Roque-Barreira MC

    更新日期:2017-06-30 00:00:00

  • Exploration and Development of PPAR Modulators in Health and Disease: An Update of Clinical Evidence.

    abstract::Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that govern the expression of genes responsible for energy metabolism, cellular development, and differentiation. Their crucial biological roles dictate the significance of PPAR-targeting synthetic ligands in medical research and drug discovery....

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Cheng HS,Tan WR,Low ZS,Marvalim C,Lee JYH,Tan NS

    更新日期:2019-10-11 00:00:00

  • Exosomal miRNA Signatures for Late-Onset Acute Graft-Versus-Host Disease in Allogenic Hematopoietic Stem Cell Transplantation.

    abstract::Recent studies have demonstrated that exosomal microRNAs (miRNAs) have the potential of facilitating molecular diagnosis. Currently, little is known about the underlying mechanism behind late-onset acute graft-versus-host disease (LA GVHD). Identifying differentially expressed miRNAs in exosomes should be useful for u...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Yoshizawa S,Umezu T,Saitoh Y,Gotoh M,Akahane D,Kobayashi C,Ohyashiki JH,Ohyashiki K

    更新日期:2018-08-23 00:00:00

  • Biological Responses to Cadmium Stress in Liverwort Conocephalum conicum (Marchantiales).

    abstract::Oxidative damage (production and localization of reactive oxygen species) and related response mechanisms (activity of antioxidant enzymes), and induction of Heat Shock Protein 70 expression, have been studied in the toxi-tolerant liverwort Conocephalum conicum (Marchantiales) in response to cadmium stress using two c...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Maresca V,Lettieri G,Sorbo S,Piscopo M,Basile A

    更新日期:2020-09-04 00:00:00

  • Evolution of Disease Defense Genes and Their Regulators in Plants.

    abstract::Biotic stresses do damage to the growth and development of plants, and yield losses for some crops. Confronted with microbial infections, plants have evolved multiple defense mechanisms, which play important roles in the never-ending molecular arms race of plant⁻pathogen interactions. The complicated defense systems i...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Zhang R,Zheng F,Wei S,Zhang S,Li G,Cao P,Zhao S

    更新日期:2019-01-15 00:00:00

  • Radiation-sensitising effects of antennapedia proteins (ANTP)-SmacN7 on tumour cells.

    abstract::The objective of this study was to investigate the underlying mechanisms behind the radiation-sensitising effects of the antennapedia proteins (ANTP)-smacN7 fusion protein on tumour cells. ANTP-SmacN7 fusion proteins were synthesised, and the ability of this fusion protein to penetrate cells was observed. Effects of r...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Du LQ,Wang Y,Xu C,Cao J,Wang Q,Zhao H,Fan FY,Wang B,Katsube T,Fan SJ,Liu Q

    更新日期:2013-12-11 00:00:00

  • Homozygous ALOXE3 Nonsense Variant Identified in a Patient with Non-Bullous Congenital Ichthyosiform Erythroderma Complicated by Superimposed Bullous Majocchi's Granuloma: The Consequences of Skin Barrier Dysfunction.

    abstract::Non-bullous congenital ichthyosiform erythroderma (NBCIE) is a hereditary disorder of keratinization caused by pathogenic variants in genes encoding enzymes important to lipid processing and terminal keratinocyte differentiation. Impaired function of these enzymes can cause pathologic epidermal scaling, significantly ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Wang T,Xu C,Zhou X,Li C,Zhang H,Lian BQ,Lee JJ,Shen J,Liu Y,Lian CG

    更新日期:2015-09-09 00:00:00

  • Therapeutic Potential of Antimicrobial Peptides in Polymicrobial Biofilm-Associated Infections.

    abstract::It is widely recognized that many chronic infections of the human body have a polymicrobial etiology. These include diabetic foot ulcer infections, lung infections in cystic fibrosis patients, periodontitis, otitis, urinary tract infections and even a proportion of systemic infections. The treatment of mixed infection...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Batoni G,Maisetta G,Esin S

    更新日期:2021-01-06 00:00:00

  • Isolation and heterologous expression of a polygalacturonase produced by Fusarium oxysporum f. sp. cubense race 1 and 4.

    abstract::Fusarium wilt (Panama disease) caused by Fusarium oxysporum f. sp. cubense (FOC) represents a significant threat to banana (Musa spp.) production. Musa AAB is susceptible to Race 1 (FOC1) and Race 4 (FOC4), while Cavendish Musa AAA is found to be resistant to FOC1 but still susceptible to Race 4. A polygalacturonase (...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Dong Z,Wang Z

    更新日期:2015-04-03 00:00:00

  • Potential Adverse Effects of Resveratrol: A Literature Review.

    abstract::Due to its health benefits, resveratrol (RE) is one of the most researched natural polyphenols. Resveratrol's health benefits were first highlighted in the early 1990s in the French paradox study, which opened extensive research activity into this compound. Ever since, several pharmacological activities including anti...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Shaito A,Posadino AM,Younes N,Hasan H,Halabi S,Alhababi D,Al-Mohannadi A,Abdel-Rahman WM,Eid AH,Nasrallah GK,Pintus G

    更新日期:2020-03-18 00:00:00

  • Optimization of the preparation of fish protein anti-obesity hydrolysates using response surface methodology.

    abstract::The enzymatic condition for producing the anti-obesity hydrolysates from fish water-soluble protein was optimized with the aid of response surface methodology, which also derived a statistical model for experimental validation. Compared with neutral protease, papain and protamex, the porcine pancreas lipase inhibitory...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Liu L,Wang Y,Peng C,Wang J

    更新日期:2013-02-01 00:00:00

  • Global and Complement Gene-Specific DNA Methylation in Grass Carp after Grass Carp Reovirus (GCRV) Infection.

    abstract::Grass carp reovirus (GCRV) causes huge economic loss to the grass carp cultivation industry but the mechanism remains largely unknown. In this study, we investigated the global and complement gene-specific DNA methylation in grass carp after GCRV infection aimed to uncover the mechanism underlying GCRV infection. The ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Xiong L,He L,Luo L,Li Y,Liao L,Huang R,Zhu Z,Wang Y

    更新日期:2018-04-07 00:00:00

  • Endoplasmic Reticulum Calcium Pumps and Tumor Cell Differentiation.

    abstract::Endoplasmic reticulum (ER) calcium homeostasis plays an essential role in cellular calcium signaling, intra-ER protein chaperoning and maturation, as well as in the interaction of the ER with other organelles. Calcium is accumulated in the ER by sarco/endoplasmic reticulum calcium ATPases (SERCA enzymes) that generate...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Papp B,Launay S,Gélébart P,Arbabian A,Enyedi A,Brouland JP,Carosella ED,Adle-Biassette H

    更新日期:2020-05-09 00:00:00

  • Cocoa and Grape Seed Byproducts as a Source of Antioxidant and Anti-Inflammatory Proanthocyanidins.

    abstract::Phenolic compounds, which are secondary plant metabolites, are considered an integral part of the human diet. Physiological properties of dietary polyphenols have come to the attention in recent years. Especially, proanthocyanidins (ranging from dimers to decamers) have demonstrated potential interactions with biologi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Cádiz-Gurrea ML,Borrás-Linares I,Lozano-Sánchez J,Joven J,Fernández-Arroyo S,Segura-Carretero A

    更新日期:2017-02-10 00:00:00

  • Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data.

    abstract::The human peptide GHK (glycyl-l-histidyl-l-lysine) has multiple biological actions, all of which, according to our current knowledge, appear to be health positive. It stimulates blood vessel and nerve outgrowth, increases collagen, elastin, and glycosaminoglycan synthesis, as well as supports the function of dermal fi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Pickart L,Margolina A

    更新日期:2018-07-07 00:00:00

  • Molecular Dynamics Simulations to Investigate How PZM21 Affects the Conformational State of the μ-Opioid Receptor Upon Activation.

    abstract::Opioid analgesics such as morphine have indispensable roles in analgesia. However, morphine use can elicit side effects such as respiratory depression and constipation. It has been reported that G protein-biased agonists as substitutes for classic opioid agonists can alleviate (or even eliminate) these side effects. T...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Zhao Z,Huang T,Li J

    更新日期:2020-07-01 00:00:00

  • Optimizing PCR Detection of West Nile Virus from Body Fluid Specimens to Delineate Natural History in an Infected Human Cohort.

    abstract::West Nile virus (WNV), a mosquito-borne arbovirus, remains a major global health concern. In this study, we optimized PCR methods then assessed serially-collected whole blood (WB), urine (UR), saliva, and semen specimens from a large cohort of WNV-positive participants to evaluate the natural history of infection and ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Gorchakov R,Gulas-Wroblewski BE,Ronca SE,Ruff JC,Nolan MS,Berry R,Alvarado RE,Gunter SM,Murray KO

    更新日期:2019-04-19 00:00:00

  • Abscisic Acid Represses Rice Lamina Joint Inclination by Antagonizing Brassinosteroid Biosynthesis and Signaling.

    abstract::Leaf angle is a key parameter that determines plant architecture and crop yield. Hormonal crosstalk involving brassinosteroid (BR) plays an essential role in leaf angle regulation in cereals. In this study, we investigated whether abscisic acid (ABA), an important stress-responsive hormone, co-regulates lamina joint i...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Li QF,Lu J,Zhou Y,Wu F,Tong HN,Wang JD,Yu JW,Zhang CQ,Fan XL,Liu QQ

    更新日期:2019-10-03 00:00:00

  • Burn-Induced Cardiac Mitochondrial Dysfunction via Interruption of the PDE5A-cGMP-PKG Pathway.

    abstract::Burn-induced heart dysfunction is a key factor for patient mortality. However, the molecular mechanisms are not yet fully elucidated. This study sought to understand whether burn-induced heart dysfunction is associated with cardiac mitochondrial dysfunction and interruption of the PDE5A-cGMP-PKG pathway. Sixty percent...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Wen JJ,Cummins CB,Radhakrishnan RS

    更新日期:2020-03-28 00:00:00

  • The Role of BRAF in Metastatic Colorectal Carcinoma-Past, Present, and Future.

    abstract::With a global incidence of 1.8 million cases, colorectal cancer represents one of the most common cancers worldwide. Despite impressive improvements in treatment efficacy through cytotoxic and biological agents, the cancer-related death burden of metastatic colorectal cancer (mCRC) is still high. mCRC is not a genetic...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Djanani A,Eller S,Öfner D,Troppmair J,Maglione M

    更新日期:2020-11-26 00:00:00

  • Effects of Protein-Iron Complex Concentrate Supplementation on Iron Metabolism, Oxidative and Immune Status in Preweaning Calves.

    abstract::The objective of this study was to determine the effects of feeding protein-iron complex (PIC) on productive performance and indicators of iron metabolism, hematology parameters, antioxidant and immune status during first 35 days of a calf's life. Preparation of the complex involved enzymatic hydrolysis of milk casein...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Kupczyński R,Bednarski M,Śpitalniak K,Pogoda-Sewerniak K

    更新日期:2017-07-12 00:00:00

  • A Mixture of Polyunsaturated Fatty Acids ω-3 and ω-6 Reduces Melanoma Growth by Inhibiting Inflammatory Mediators in the Murine Tumor Microenvironment.

    abstract:BACKGROUND:Although it has been previously demonstrated that acute inflammation can promote the tumor growth of a sub-tumorigenic dose of melanoma cells through of 5-lipoxygenase inflammatory pathway and its product leukotriene B4, and also that the peritumoral treatment with eicosapentaenoic acid and its product, leuk...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Almeida EB,Silva KPH,Paixão V,Amaral JBD,Rossi M,Xavier-Navarro RA,Barros KV,Silveira VLF,Vieira RP,Oliveira LVF,Perez EC,Jasiulionis MG,Bachi ALL

    更新日期:2019-08-01 00:00:00

  • Preoperative 3D FSE T1-Weighted MR Plaque Imaging for Severely Stenotic Cervical ICA: Accuracy of Predicting Emboli during Carotid Endarterectomy.

    abstract::The aim of the present study was to determine whether preoperative three-dimensional (3D) fast spin-echo (FSE) T1-weighted magnetic resonance (MR) plaque imaging for severely stenotic cervical carotid arteries could accurately predict the development of artery-to-artery emboli during exposure of the carotid arteries i...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Ogasawara Y,Sato Y,Narumi S,Sasaki M,Fujiwara S,Kobayashi M,Yoshida K,Terayama Y,Ogasawara K

    更新日期:2016-10-27 00:00:00

  • Targeted Therapy in Melanoma and Mechanisms of Resistance.

    abstract::The common mutation BRAFV600 in primary melanomas activates the mitogen-activated protein kinase/extracellular-signal-regulated kinase (MAPK/ERK) pathway and the introduction of proto-oncogene B-Raf (BRAF) and mitogen-activated protein kinase kinase (MEK) inhibitors (BRAFi and MEKi) was a breakthrough in the treatment...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Czarnecka AM,Bartnik E,Fiedorowicz M,Rutkowski P

    更新日期:2020-06-27 00:00:00

  • Translational Regulation of Pmt1 and Pmt2 by Bfr1 Affects Unfolded Protein O-Mannosylation.

    abstract::O-mannosylation is implicated in protein quality control in Saccharomyces cerevisiae due to the attachment of mannose to serine and threonine residues of un- or misfolded proteins in the endoplasmic reticulum (ER). This process also designated as unfolded protein O-mannosylation (UPOM) that ends futile folding cycles ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Castells-Ballester J,Rinis N,Kotan I,Gal L,Bausewein D,Kats I,Zatorska E,Kramer G,Bukau B,Schuldiner M,Strahl S

    更新日期:2019-12-10 00:00:00

  • The Effect of JAK Inhibitor on the Survival, Anagen Re-Entry, and Hair Follicle Immune Privilege Restoration in Human Dermal Papilla Cells.

    abstract::Topical or systemic administration of JAK inhibitors has been shown to be a new treatment modality for severe alopecia areata (AA). Some patients show a good response to JAK inhibitors, but frequently relapse after cessation of the treatment. There have been no guidelines about the indications and use of JAK inhibitor...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Kim JE,Lee YJ,Park HR,Lee DG,Jeong KH,Kang H

    更新日期:2020-07-20 00:00:00

  • Ethyl Acetate Extract of Scindapsus cf. hederaceus Exerts the Inhibitory Bioactivity on Human Non-Small Cell Lung Cancer Cells through Modulating ER Stress.

    abstract::Unfolded protein response (UPR) is a cytoprotective mechanism that alleviates the protein-folding burden in eukaryotic organisms. Moderate activation of UPR is required for maintaining endoplasmic reticulum (ER) homeostasis and profoundly contributes to tumorigenesis. Defects in UPR signaling are implicated in the att...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Chou CK,Liu W,Hong YJ,Dahms HU,Chiu CH,Chang WT,Chien CM,Yen CH,Cheng YB,Chiu CC

    更新日期:2018-06-21 00:00:00

  • Effects of Honokiol on CYP450 Activity and Transporter mRNA Expression in Type 2 Diabetic Rats.

    abstract::This study was aimed to clarify the effect of honokiol (Hon) on the activity of Cytochrome P450 (CYP450) enzymes, and the level of mRNA expression of liver and kidney transporters in type 2 diabetic rats induced by high-fat diet and strepotozotocin. Rats were randomly divided into normal control (NC) group, diabetic c...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Wang J,Zhai T,Chen Y

    更新日期:2018-03-12 00:00:00

  • Nephrocalcinosis: A Review of Monogenic Causes and Insights They Provide into This Heterogeneous Condition.

    abstract::The abnormal deposition of calcium within renal parenchyma, termed nephrocalcinosis, frequently occurs as a result of impaired renal calcium handling. It is closely associated with renal stone formation (nephrolithiasis) as elevated urinary calcium levels (hypercalciuria) are a key common pathological feature underlyi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Dickson FJ,Sayer JA

    更新日期:2020-01-06 00:00:00

  • Adiponectin in Chronic Kidney Disease.

    abstract::Adiponectin is the adipokine associated with insulin sensitization, reducing liver gluconeogenesis, and increasing fatty acid oxidation and glucose uptake. Adiponectin is present in the kidneys, mainly in the arterial endothelium and smooth muscle cells, as well as in the capillary endothelium, and might be considered...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Przybyciński J,Dziedziejko V,Puchałowicz K,Domański L,Pawlik A

    更新日期:2020-12-09 00:00:00