Molecular actions of ovarian cancer G protein-coupled receptor 1 caused by extracellular acidification in bone.


:Extracellular acidification occurs under physiologic and pathologic conditions, such as exercise, ischemia, and inflammation. It has been shown that acidosis has various adverse effects on bone. In recent years there has been increasing evidence which indicates that ovarian cancer G protein-coupled receptor 1 (OGR1) is a pH-sensing receptor and mediates a variety of extracellular acidification-induced actions on bone cells and other cell types. Recent studies have shown that OGR1 is involved in the regulation of osteoclast differentiation, survival, and function, as well as osteoblast differentiation and bone formation. Moreover, OGR1 also regulates acid-induced apoptosis of endplate chondrocytes in intervertebral discs. These observations demonstrate the importance of OGR1 in skeletal development and metabolism. Here, we provide an overview of OGR1 regulation ofosteoclasts, osteoblasts, and chondrocytes, and the molecular actions of OGR1 induced by extracellular acidification in the maintenance of bone health.


Int J Mol Sci


Yuan FL,Zhao MD,Jiang LB,Wang HR,Cao L,Zhou XG,Li XL,Dong J




Has Abstract


2014-12-03 00:00:00












  • Hamster Melatonin Receptors: Cloning and Binding Characterization of MT₁ and Attempt to Clone MT₂.

    abstract::For many years, it was of interest to identify the sequences encoding the two melatonin receptors (MT₁ and MT₂) from various species. After publishing the basic molecular characterization of the human, rat, mouse, sheep, and platypus MT₁, MT₂, or Mel1c receptors, we began cloning the genes from other animals, such as ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Gautier C,Dufour E,Dupré C,Lizzo G,Caignard S,Riest-Fery I,Brasseur C,Legros C,Delagrange P,Nosjean O,Simonneaux V,Boutin JA,Guenin SP

    更新日期:2018-07-04 00:00:00

  • ERα Mediates Estrogen-Induced Expression of the Breast Cancer Metastasis Suppressor Gene BRMS1.

    abstract::Recently, estrogen has been reported as putatively inhibiting cancer cell invasion and motility. This information is in direct contrast to the paradigm of estrogen as a tumor promoter. However, data suggests that the effects of estrogen are modulated by the receptor isoform with which it interacts. In order to gain a ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Ma H,Gollahon LS

    更新日期:2016-01-26 00:00:00

  • Carotenoid profile of tomato sauces: effect of cooking time and content of extra virgin olive oil.

    abstract::The consumption of carotenoid-rich vegetables such as tomatoes and tomato sauces is associated with reduced risk of several chronic diseases. The predominant carotenoids in tomato products are in the (all-E) configuration, but (Z) isomers can be formed during thermal processing. The effect of cooking time (15, 30, 45 ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Vallverdú-Queralt A,Regueiro J,de Alvarenga JF,Torrado X,Lamuela-Raventos RM

    更新日期:2015-04-28 00:00:00

  • Interactions of β-Conglycinin (7S) with Different Phenolic Acids-Impact on Structural Characteristics and Proteolytic Degradation of Proteins.

    abstract::p-Coumalic acid (PCA), caffeic acid (CA), gallic acid (GA) and chlorogenic acid (CGA) are the major phenolic acids that co-exist with soy protein components in foodstuffs. Surprisingly, there are only a handful of reports that describe their interaction with β-Conglycinin (7S), a major soy protein. In this report, we ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Gan J,Chen H,Liu J,Wang Y,Nirasawa S,Cheng Y

    更新日期:2016-10-02 00:00:00

  • Ethanol versus Phytochemicals in Wine: Oral Cancer Risk in a Light Drinking Perspective.

    abstract::This narrative review aims to summarize the current controversy on the balance between ethanol and phytochemicals in wine, focusing on light drinking and oral cancer. Extensive literature search included PUBMED and EMBASE databases to identify in human studies and systematic reviews (up to March 2015), which contribut...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Varoni EM,Lodi G,Iriti M

    更新日期:2015-07-27 00:00:00

  • SLC9A3 Protein Is Critical for Acrosomal Formation in Postmeiotic Male Germ Cells.

    abstract::Solute carrier family 9 isoform 3 (SLC9A3), a Na⁺/H⁺ exchanger, regulates the transepithelial absorption of Na⁺ and water and is primarily expressed on the apical membranes of the intestinal epithelium, renal proximal tubule, epididymis, and vas deferens. Loss of the Slc9a3 allele in mice enhances intestinal fluid and...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Wang YY,Chiang HS,Cheng CY,Wu YN,Lin YC,Liu HC,Tsai WK,Chen YL,Lin YH

    更新日期:2017-12-29 00:00:00

  • Bioinformatic Reconstruction and Analysis of Gene Networks Related to Glucose Variability in Diabetes and Its Complications.

    abstract::Glucose variability (GV) has been recognized recently as a promoter of complications and therapeutic targets in diabetes. The aim of this study was to reconstruct and analyze gene networks related to GV in diabetes and its complications. For network analysis, we used the ANDSystem that provides automatic network recon...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Saik OV,Klimontov VV

    更新日期:2020-11-18 00:00:00

  • Integrated Systems Pharmacology, Urinary Metabonomics, and Quantitative Real-Time PCR Analysis to Uncover Targets and Metabolic Pathways of the You-Gui Pill in Treating Kidney-Yang Deficiency Syndrome.

    abstract::Kidney-yang deficiency syndrome (KYDS) is a metabolic disease caused by a neuro-endocrine disorder. The You-gui pill (YGP) is a classic traditional Chinese medicine (TCM) formula for the treatment of KYDS and has been widely used to warm and recuperate KYDS clinically for hundreds of years in China. However, it is unk...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Chen R,Wang J,Zhan R,Zhang L,Wang X

    更新日期:2019-07-26 00:00:00

  • The GATA-Type Transcriptional Factor Are1 Modulates the Expression of Extracellular Proteases and Cellulases in Trichoderma reesei.

    abstract::Trichoderma reesei is a biotechnologically important filamentous fungus with the remarkable ability to secrete large amounts of enzymes, whose production is strongly affected by both the carbon and nitrogen sources. While the carbon metabolism regulators are extensively studied, the regulation of enzyme production by ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Qian Y,Sun Y,Zhong L,Sun N,Sheng Y,Qu Y,Zhong Y

    更新日期:2019-08-22 00:00:00

  • Morphine Protects Spinal Cord Astrocytes from Glutamate-Induced Apoptosis via Reducing Endoplasmic Reticulum Stress.

    abstract::Glutamate is not only a neurotransmitter but also an important neurotoxin in central nervous system (CNS). Chronic elevation of glutamate induces both neuronal and glial cell apoptosis. However, its effect on astrocytes is complex and still remains unclear. In this study, we investigated whether morphine, a common opi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Zhang C,Wang C,Ren J,Guo X,Yun K

    更新日期:2016-10-24 00:00:00

  • Aggregation of Mouse Serum Amyloid A Protein Was Promoted by Amyloid-Enhancing Factors with the More Genetically Homologous Serum Amyloid A.

    abstract::Amyloid A (AA) amyloidosis is a condition in which amyloid fibrils characterized by a linear morphology and a cross-β structure accumulate and are deposited extracellularly in organs, resulting in chronic inflammatory diseases and infections. The incidence of AA amyloidosis is high in humans and several animal species...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Lin X,Watanabe K,Kuragano M,Tokuraku K

    更新日期:2021-01-21 00:00:00

  • Role of the Genetic Background in Resistance to Plant Viruses.

    abstract::In view of major economic problems caused by viruses, the development of genetically resistant crops is critical for breeders but remains limited by the evolution of resistance-breaking virus mutants. During the plant breeding process, the introgression of traits from Crop Wild Relatives results in a dramatic change o...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,meta分析,评审


    authors: Gallois JL,Moury B,German-Retana S

    更新日期:2018-09-20 00:00:00

  • Magnetic nanoparticles as intraocular drug delivery system to target retinal pigmented epithelium (RPE).

    abstract::One of the most challenging efforts in drug delivery is the targeting of the eye. The eye structure and barriers render this organ poorly permeable to drugs. Quite recently the entrance of nanoscience in ocular drug delivery has improved the penetration and half-life of drugs, especially in the anterior eye chamber, w...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Giannaccini M,Giannini M,Calatayud MP,Goya GF,Cuschieri A,Dente L,Raffa V

    更新日期:2014-01-22 00:00:00

  • Comparison of Fatty Acid Profiles in a Group of Female Patients with Chronic Kidney Diseases (CKD) and Metabolic Syndrome (MetS)⁻Similar Trends of Changes, Different Pathophysiology.

    abstract::Fatty acid (FA) profiles in the plasma of patients with metabolic syndrome and chronic kidney disease (CKD) seem to be identical despite their different etiology (dietary mistakes vs. cachexia). The aim of this study was to compare both profiles and to highlight the differences that could influence the improvement of ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Szczuko M,Kaczkan M,Drozd A,Maciejewska D,Palma J,Owczarzak A,Marczuk N,Rutkowski P,Małgorzewicz S

    更新日期:2019-04-06 00:00:00

  • Resident Memory T Cells and Their Role within the Liver.

    abstract::Immunological memory is fundamental to maintain immunity against re-invading pathogens. It is the basis for prolonged protection induced by vaccines and can be mediated by humoral or cellular responses-the latter largely mediated by T cells. Memory T cells belong to different subsets with specialized functions and dis...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Ghilas S,Valencia-Hernandez AM,Enders MH,Heath WR,Fernandez-Ruiz D

    更新日期:2020-11-13 00:00:00

  • Mechanotransduction and Cytoskeleton Remodeling Shaping YAP1 in Gastric Tumorigenesis.

    abstract::The essential role of Hippo signaling pathway in cancer development has been elucidated by recent studies. In the gastrointestinal tissues, deregulation of the Hippo pathway is one of the most important driving events for tumorigenesis. It is widely known that Yes-associated protein 1 (YAP1) and WW domain that contain...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Zhang J,Zhou Y,Tang PMK,Cheng ASL,Yu J,To KF,Kang W

    更新日期:2019-03-29 00:00:00

  • Type 2 Diabetes Alters Intracellular Ca2+ Handling in Native Endothelium of Excised Rat Aorta.

    abstract::An increase in intracellular Ca2+ concentration ([Ca2+]i) plays a key role in controlling endothelial functions; however, it is still unclear whether endothelial Ca2+ handling is altered by type 2 diabetes mellitus, which results in severe endothelial dysfunction. Herein, we analyzed for the first time the Ca2+ respon...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Berra-Romani R,Guzmán-Silva A,Vargaz-Guadarrama A,Flores-Alonso JC,Alonso-Romero J,Treviño S,Sánchez-Gómez J,Coyotl-Santiago N,García-Carrasco M,Moccia F

    更新日期:2019-12-30 00:00:00

  • Antitumor mechanisms of amino Acid hydroxyurea derivatives in the metastatic colon cancer model.

    abstract::The paper presents a detailed study of the biological effects of two amino acid hydroxyurea derivatives that showed selective antiproliferative effects in vitro on the growth of human tumor cell line SW620. Tested compounds induced cell cycle perturbations and apoptosis. Proteins were identified by proteomics analyses...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Saban N,Stepanić V,Vučinić S,Horvatić A,Cindrić M,Perković I,Zorc B,Oršolić N,Mintas M,Pavelić K,Pavelić SK

    更新日期:2013-12-04 00:00:00

  • Crystal Structure of Non-Structural Protein 10 from Severe Acute Respiratory Syndrome Coronavirus-2.

    abstract::Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), causing Coronavirus Disease 19 (COVID-19), emerged at the end of 2019 and quickly spread to cause a global pandemic with severe socio-economic consequences. The early sequencing of its RNA genome revealed its high similarity to SARS, likely to have originat...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Rogstam A,Nyblom M,Christensen S,Sele C,Talibov VO,Lindvall T,Rasmussen AA,André I,Fisher Z,Knecht W,Kozielski F

    更新日期:2020-10-06 00:00:00

  • Identification of Salt Stress Responding Genes Using Transcriptome Analysis in Green Alga Chlamydomonas reinhardtii.

    abstract::Salinity is one of the most important abiotic stresses threatening plant growth and agricultural productivity worldwide. In green alga Chlamydomonas reinhardtii, physiological evidence indicates that saline stress increases intracellular peroxide levels and inhibits photosynthetic-electron flow. However, understanding...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Wang N,Qian Z,Luo M,Fan S,Zhang X,Zhang L

    更新日期:2018-10-26 00:00:00

  • Evidence of Altered Glycosylation of Serum Proteins Prior to Pancreatic Cancer Diagnosis.

    abstract::Biomarkers for the early detection of pancreatic cancer are urgently needed. The aim of this pilot study was to evaluate changes in serum N-glycoproteins and their glycosylation status prior to clinical presentation of pancreatic cancer that may be potential biomarkers. Prediagnosis serum samples pooled according to f...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Krishnan S,Whitwell HJ,Cuenco J,Gentry-Maharaj A,Menon U,Pereira SP,Gaspari M,Timms JF

    更新日期:2017-12-09 00:00:00

  • Ethnobotanic, Ethnopharmacologic Aspects and New Phytochemical Insights into Moroccan Argan Fruits.

    abstract::This review summarizes available data on argan fruit botany, geographical distribution, traditional uses, environmental interest, socioeconomic role, phytochemistry, as well as health beneficial effects and examination of future prospects. In particular, ethnomedical uses of argan fruits are carried out throughout Mor...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Khallouki F,Eddouks M,Mourad A,Breuer A,Owen RW

    更新日期:2017-10-30 00:00:00

  • A Census and Categorization Method of Epitranscriptomic Marks.

    abstract::In the past few years, thorough investigation of chemical modifications operated in the cells on ribonucleic acid (RNA) molecules is gaining momentum. This new field of research has been dubbed "epitranscriptomics", in analogy to best-known epigenomics, to stress the potential of ensembles of RNA modifications to cons...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Mathlin J,Le Pera L,Colombo T

    更新日期:2020-06-30 00:00:00

  • Encapsulation of Adipose-Derived Mesenchymal Stem Cells in Calcium Alginate Maintains Clonogenicity and Enhances their Secretory Profile.

    abstract::Adipose-derived mesenchymal stem cells (ASCs) are well known for their secretory potential, which confers them useful properties in cell therapy. Nevertheless, this therapeutic potential is reduced after transplantation due to their short survival in the human body and their migration property. This study proposes a m...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Capin L,Abbassi N,Lachat M,Calteau M,Barratier C,Mojallal A,Bourgeois S,Auxenfans C

    更新日期:2020-08-31 00:00:00

  • The mTOR signalling pathway in human cancer.

    abstract::The conserved serine/threonine kinase mTOR (the mammalian target of rapamycin), a downstream effector of the PI3K/AKT pathway, forms two distinct multiprotein complexes: mTORC1 and mTORC2. mTORC1 is sensitive to rapamycin, activates S6K1 and 4EBP1, which are involved in mRNA translation. It is activated by diverse sti...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Pópulo H,Lopes JM,Soares P

    更新日期:2012-01-01 00:00:00

  • A single-chamber microbial fuel cell without an air cathode.

    abstract::Microbial fuel cells (MFCs) represent a novel technology for wastewater treatment with electricity production. Electricity generation with simultaneous nitrate reduction in a single-chamber MFC without air cathode was studied, using glucose (1 mM) as the carbon source and nitrate (1 mM) as the final electron acceptor ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Nimje VR,Chen CC,Chen HR,Chen CY,Tseng MJ,Cheng KC,Shih RC,Chang YF

    更新日期:2012-01-01 00:00:00

  • Connexin Hemichannels Contribute to the Activation of cAMP Signaling Pathway and Renin Production.

    abstract::Connexin hemichannels play an important role in the control of cellular signaling and behaviors. Given that lowering extracellular Ca2+, a condition that activates hemichannels, is a well-characterized stimulator of renin in juxtaglomerular cells, we, therefore, tested a potential implication of hemichannels in the re...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Hong J,Yao J

    更新日期:2020-06-23 00:00:00

  • Key Developments in Ionic Liquid Crystals.

    abstract::Ionic liquid crystals are materials that combine the classes of liquid crystals and ionic liquids. The first one is based on the multi-billion-dollar flat panel display industry, whilst the latter quickly developed in the past decades into a family of highly-tunable non-volatile solvents. The combination yields materi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Alvarez Fernandez A,Kouwer PH

    更新日期:2016-05-16 00:00:00

  • Selection of Biophysical Methods for Characterisation of Membrane Proteins.

    abstract::Over the years, there have been many developments and advances in the field of integral membrane protein research. As important pharmaceutical targets, it is paramount to understand the mechanisms of action that govern their structure-function relationships. However, the study of integral membrane proteins is still in...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Kwan TOC,Reis R,Siligardi G,Hussain R,Cheruvara H,Moraes I

    更新日期:2019-05-27 00:00:00

  • Methrotexate Treatment Inmunomodulates Abnormal Cytokine Expression by T CD4 Lymphocytes Present in DMARD-Naïve Rheumatoid Arthritis Patients.

    abstract::CD4+T-lymphocytes are relevant in the pathogenesis of rheumatoid arthritis (RA), however, their potential involvement in early RA remains elusive. Methotrexate (MTX) is a commonly used disease-modifying antirheumatic drug (DMARD), but its mechanism has not been fully established. In 47 new-onset DMARD-naïve RA patient...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Monserrat Sanz J,Bohórquez C,Gómez AM,Movasat A,Pérez A,Ruíz L,Diaz D,Sánchez AI,Albarrán F,Sanz I,Álvarez-Mon M

    更新日期:2020-09-18 00:00:00