Abstract：
:Extracellular acidification occurs under physiologic and pathologic conditions, such as exercise, ischemia, and inflammation. It has been shown that acidosis has various adverse effects on bone. In recent years there has been increasing evidence which indicates that ovarian cancer G protein-coupled receptor 1 (OGR1) is a pH-sensing receptor and mediates a variety of extracellular acidification-induced actions on bone cells and other cell types. Recent studies have shown that OGR1 is involved in the regulation of osteoclast differentiation, survival, and function, as well as osteoblast differentiation and bone formation. Moreover, OGR1 also regulates acid-induced apoptosis of endplate chondrocytes in intervertebral discs. These observations demonstrate the importance of OGR1 in skeletal development and metabolism. Here, we provide an overview of OGR1 regulation ofosteoclasts, osteoblasts, and chondrocytes, and the molecular actions of OGR1 induced by extracellular acidification in the maintenance of bone health.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Yuan FL,Zhao MD,Jiang LB,Wang HR,Cao L,Zhou XG,Li XL,Dong Jdoi
10.3390/ijms151222365subject
Has Abstractpub_date
2014-12-03 00:00:00pages
22365-73issue
12issn
1422-0067pii
ijms151222365journal_volume
15pub_type
杂志文章,评审abstract：:Endocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. However, resistance to endocrine therapy leads to breast cancer relapse. The recent extension of adjuvant tamoxifen treatment up to 10 years actualizes the need for identifying biological markers that may be used to...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms161024243
更新日期：2015-10-14 00:00:00
abstract：:We have recently found that diabetes-induced premature senescence of retinal endothelial cells is accompanied by NOX2-NADPH oxidase-induced increases in the ureohydrolase enzyme arginase 1 (A1). Here, we used genetic strategies to determine the specific involvement of A1 in diabetes-induced endothelial cell senescence...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19041215
更新日期：2018-04-17 00:00:00
abstract：:Obesity is a major risk for diabetes. Brown adipose tissue (BAT) mediates production of heat while white adipose tissue (WAT) function in the storage of fat. Roles of BAT in the treatment of obesity and related disorders warrants more investigation. Peroxisome proliferator activator receptor gamma (PPAR-γ) is the mast...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20071618
更新日期：2019-04-01 00:00:00
abstract：:The edible and medicinal perennial herb Aster scaber is known to have anticancer, antioxidant, and immunomodulatory properties. However, the biological effects of its polysaccharides are not well understood. Here, we aimed to extract novel polysaccharides with enhanced biological properties from Aster scaber using enz...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19092839
更新日期：2018-09-19 00:00:00
abstract：:Trichoderma reesei is a biotechnologically important filamentous fungus with the remarkable ability to secrete large amounts of enzymes, whose production is strongly affected by both the carbon and nitrogen sources. While the carbon metabolism regulators are extensively studied, the regulation of enzyme production by ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20174100
更新日期：2019-08-22 00:00:00
abstract：:Apoptotic extrusion of cells from epithelial cell layers is of central importance for epithelial homeostasis. As a prerequisite cell-cell contacts between apoptotic cells and their neighbors have to be dissociated. Tricellular tight junctions (tTJs) represent specialized structures that seal polarized epithelial cells...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20194882
更新日期：2019-10-01 00:00:00
abstract：:The synthesis of Mobil Composition of Matter 41 (MCM-41) mesoporous silica nanoparticles (MSNs) of controlled sizes and porous structure has been performed at laboratory and pilot plant scales. Firstly, the effects of the main operating conditions (TEOS -Tetraethyl ortosilicate- addition rate, nanoparticle maturation ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21217899
更新日期：2020-10-24 00:00:00
abstract：:Riboflavin is the biological precursor of two important flavin cofactors-flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN)-that are critical prosthetic groups in several redox enzymes. While dietary supplementation with riboflavin is a recognized support therapy in several inborn errors of metabolism, ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21197063
更新日期：2020-09-25 00:00:00
abstract：:Trihelix transcription factors are thought to feature a typical DNA-binding trihelix (helix-loop-helix-loop-helix) domain that binds specifically to the GT motif, a light-responsive DNA element. Members of the trihelix family are known to function in a number of processes in plants. Here, we characterize 20 trihelix f...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17020198
更新日期：2016-02-02 00:00:00
abstract：:Mitochondria-associated membranes (MAM) are a well-recognized contact link between the mitochondria and endoplasmic reticulum that affects mitochondrial biology and vascular smooth muscle cells (VSMCs) proliferation via the regulation of mitochondrial Ca2+(Ca2+m) influx. Nogo-B receptor (NgBR) plays a vital role in pr...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20092319
更新日期：2019-05-10 00:00:00
abstract：:Neonatal hypoxia-ischemia (HI) is a major cause of death and disability in neonates. HI leads to a dramatic rise in intracellular calcium levels, which was originally thought to be detrimental to the brain. However, it has been increasingly recognized that this calcium signaling may also play an important protective r...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20092063
更新日期：2019-04-26 00:00:00
abstract：:Oenothein B is a unique macrocyclic ellagitannin dimer that has been found in various medicinal plants belonging to Onagraceae, Lythraceae, and Myrtaceae, with diverse biological activities. The immunological effects of tannins in terms of cytokine-release from macrophages and monocytes have been discussed, while the ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms14010046
更新日期：2012-12-20 00:00:00
abstract：:Jatropha curcas is a promising renewable feedstock for biodiesel and bio-jet fuel production. To study gene expression in Jatropha in different tissues throughout development and under stress conditions, we examined a total of 11 typical candidate reference genes using real-time quantitative polymerase chain reaction ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms141224338
更新日期：2013-12-13 00:00:00
abstract：:Pulmonary arterial hypertension (PAH) is a rare disease caused by pulmonary vascular remodeling. Current vasodilator treatments have substantially improved patients' survival. This improved survival has led to the appearance of complications related to conditions previously underdiagnosed or even ignored, such as pulm...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21072509
更新日期：2020-04-04 00:00:00
abstract：:Circulating tumour cells (CTCs) from liquid biopsies are under current investigation in several cancers, including epithelial ovarian cancer (EOC) but face significant drawbacks in terms of non-standardised methodology, low viable cell numbers and accuracy of CTC identification. In this pilot study, we report that che...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21134813
更新日期：2020-07-07 00:00:00
abstract：:Atherosclerosis is an arterial inflammatory disease. The circulating level of the C-C chemokine ligand (CCL4) is increased in atherosclerotic patients. This study aimed to investigate whether CCL4 inhibition could retard the progression of atherosclerosis. In ApoE knockout mice, CCL4 antibody treatment reduced circula...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21186567
更新日期：2020-09-08 00:00:00
abstract：:Pre-mRNA splicing is an essential mechanism for ensuring integrity of the transcriptome in eukaryotes. Therefore, splicing deficiency might cause a decrease in functional proteins and the production of nonfunctional, aberrant proteins. To prevent the production of such aberrant proteins, eukaryotic cells have several ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21228799
更新日期：2020-11-20 00:00:00
abstract：:The recent thriving development of biobanks and associated high-throughput phenotyping studies requires the elaboration of large-scale approaches for monitoring biological sample quality and compliance with standard protocols. We present a metabolomic investigation of human blood samples that delineates pitfalls and g...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17122035
更新日期：2016-12-05 00:00:00
abstract：:The rs10830963 variant of the Melatonin Receptor 1B (MTNR1B) gene is associated with the development of gestational diabetes mellitus (GDM). We hypothesized that carrying the rs10830963/G risk allele had effect on antenatal insulin therapy (AIT) initiation in GDM in a body mass index (BMI)-dependent manner. Design: In...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19123734
更新日期：2018-11-23 00:00:00
abstract：:Abstract: Cancer heterogeneity and progression are subject to complex interactions between neoplastic cells and their microenvironment, including the immune system. Although glioblastomas (GBMs) are classified as 'cold tumours' with very little lymphocyte infiltration, they can contain up to 30-40% of tumour-associate...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21030689
更新日期：2020-01-21 00:00:00
abstract：:Liposomes have been one of the most exploited drug delivery systems in recent decades. However, their large-scale production with low batch-to-batch differences is a challenge for industry, which ultimately delays the clinical translation of new products. We have investigated the effects of formulation parameters on t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21051611
更新日期：2020-02-26 00:00:00
abstract：:The Wnt signalling pathway is a central communication cascade between cells to orchestrate polarity and fate during development and adult tissue homeostasis in various organisms. This pathway can be regulated by different signalling molecules in several steps. One of the coordinators in this pathway is Nemo-like kinas...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21239203
更新日期：2020-12-02 00:00:00
abstract：:Parkinson's disease (PD) is the most common cause of movement disorders and is characterized by the progressive loss of dopaminergic neurons in the substantia nigra. It is increasingly recognized as a complex group of disorders presenting widely heterogeneous symptoms and pathology. With the exception of the rare mono...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19113343
更新日期：2018-10-26 00:00:00
abstract：:A thrombotic occlusion of the vessel fed by ruptured coronary atherosclerotic plaque may result in unstable angina, myocardial infarction or death, whereas embolization from a plaque in carotid arteries may result in transient ischemic attack or stroke. The atherosclerotic plaque prone to such clinical events is terme...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms160510121
更新日期：2015-05-05 00:00:00
abstract：:The mammalian or mechanistic target of rapamycin (mTOR) pathway plays a crucial role in regulation of cell survival, metabolism, growth and protein synthesis in response to upstream signals in both normal physiological and pathological conditions, especially in cancer. Aberrant mTOR signaling resulting from genetic al...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20030755
更新日期：2019-02-11 00:00:00
abstract：:This study was undertaken to test two therapies for acute kidney injury (AKI) prevention, IGF-1, which is renal protective, and BTP-2, which is a calcium entry (SOCE) inhibitor. We utilized lipopolysaccharide (LPS) IP, as a systemic model of AKI and studied in five groups of animals. Three experiments showed that at 7...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21114095
更新日期：2020-06-08 00:00:00
abstract：:Stable five-coordinate Pt(II) complexes have been highlighted as a promising and original platform for the development of new cytotoxic drugs. Their interaction with proteins has been scarcely studied. Here, the reactivity of the five-coordinate Pt(II) compound [Pt(I)(Me) (dmphen)(olefin)] (Me = methyl, dmphen = 2,9-d...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20030520
更新日期：2019-01-26 00:00:00
abstract：:Three quinary polar intermetallic compounds in the (Eu(1-x)Ca(x))9In8(Ge(1-y)Sn(y))8 (x = 0.66, y = 0.03) and the (Eu(1-x)Ca(x))3In(Ge(3-y)Sn(1+y)) (x = 0.66, 0.68; y = 0.13, 0.27) phases have been synthesized using the molten In-metal flux method, and the crystal structures are characterized by powder and single-crys...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms16049017
更新日期：2015-04-22 00:00:00
abstract：:Interleukin-18 (IL-18) is a multi-functional immuno-mediator in the development and progression of many types of infectious and inflammatory diseases. In this study, we evaluated the contribution of IL-18 genotypes to renal cell carcinoma (RCC) in Taiwan via the genotyping of IL-18 -656 (A/C), -607 (A/C), and -137 (G/...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20071563
更新日期：2019-03-28 00:00:00
abstract：:RNAi technology has significant potential as a future therapeutic and could theoretically be used to knock down disease-specific RNAs. However, due to frequent off-target effects, low efficiency, and limited accessibility of nuclear transcripts, the clinical application of the technology remains challenging. In this s...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21238904
更新日期：2020-11-24 00:00:00
