Abstract：
:Extracellular acidification occurs under physiologic and pathologic conditions, such as exercise, ischemia, and inflammation. It has been shown that acidosis has various adverse effects on bone. In recent years there has been increasing evidence which indicates that ovarian cancer G protein-coupled receptor 1 (OGR1) is a pH-sensing receptor and mediates a variety of extracellular acidification-induced actions on bone cells and other cell types. Recent studies have shown that OGR1 is involved in the regulation of osteoclast differentiation, survival, and function, as well as osteoblast differentiation and bone formation. Moreover, OGR1 also regulates acid-induced apoptosis of endplate chondrocytes in intervertebral discs. These observations demonstrate the importance of OGR1 in skeletal development and metabolism. Here, we provide an overview of OGR1 regulation ofosteoclasts, osteoblasts, and chondrocytes, and the molecular actions of OGR1 induced by extracellular acidification in the maintenance of bone health.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Yuan FL,Zhao MD,Jiang LB,Wang HR,Cao L,Zhou XG,Li XL,Dong Jdoi
10.3390/ijms151222365subject
Has Abstractpub_date
2014-12-03 00:00:00pages
22365-73issue
12issn
1422-0067pii
ijms151222365journal_volume
15pub_type
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