Molecular actions of ovarian cancer G protein-coupled receptor 1 caused by extracellular acidification in bone.

Abstract:

:Extracellular acidification occurs under physiologic and pathologic conditions, such as exercise, ischemia, and inflammation. It has been shown that acidosis has various adverse effects on bone. In recent years there has been increasing evidence which indicates that ovarian cancer G protein-coupled receptor 1 (OGR1) is a pH-sensing receptor and mediates a variety of extracellular acidification-induced actions on bone cells and other cell types. Recent studies have shown that OGR1 is involved in the regulation of osteoclast differentiation, survival, and function, as well as osteoblast differentiation and bone formation. Moreover, OGR1 also regulates acid-induced apoptosis of endplate chondrocytes in intervertebral discs. These observations demonstrate the importance of OGR1 in skeletal development and metabolism. Here, we provide an overview of OGR1 regulation ofosteoclasts, osteoblasts, and chondrocytes, and the molecular actions of OGR1 induced by extracellular acidification in the maintenance of bone health.

journal_name

Int J Mol Sci

authors

Yuan FL,Zhao MD,Jiang LB,Wang HR,Cao L,Zhou XG,Li XL,Dong J

doi

10.3390/ijms151222365

subject

Has Abstract

pub_date

2014-12-03 00:00:00

pages

22365-73

issue

12

issn

1422-0067

pii

ijms151222365

journal_volume

15

pub_type

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