Mechanisms of Arrhythmias in the Brugada Syndrome.

abstract：:Bacterial biofilm formation on wet surfaces represents a significant problem in medicine and environmental sciences. One of the strategies to prevent or eliminate surface adhesion of organisms is surface modification and coating. However, the current coating technologies possess several drawbacks, including limited du...

journal_title：International journal of molecular sciences

authors： Ya'ari S,Halperin-Sternfeld M,Rosin B,Adler-Abramovich L

更新日期：2020-10-06 00:00:00

abstract：:Cardiomyopathies affect individuals worldwide, without regard to age, sex and ethnicity and are associated with significant morbidity and mortality. Inherited cardiomyopathies account for a relevant part of these conditions. Although progresses have been made over the years, early diagnosis and curative therapies are ...

journal_title：International journal of molecular sciences

authors： Pecorari I,Mestroni L,Sbaizero O

更新日期：2020-08-15 00:00:00

abstract：:Obesity, characterized by excess lipid accumulation, has emerged as a leading public health problem. Excessive, adipocyte-induced lipid accumulation raises the risk of metabolic disorders. Adipose-derived stem cells (ASCs) are mesenchymal stem cells (MSCs) that can be obtained from abundant adipose tissue. High fat ma...

journal_title：International journal of molecular sciences

authors： Han GE,Kang HT,Chung S,Lim C,Linton JA,Lee JH,Kim W,Kim SH,Lee JH

更新日期：2018-07-29 00:00:00

abstract：:For malignant pleural mesothelioma (MPM) novel therapeutic strategies are urgently needed. In a previous study, we identified 51 putative cancer genes over-expressed in MPM tissues and cell lines. Here, we deepened the study on nine of them (ASS1, EIF4G1, GALNT7, GLUT1, IGF2BP3 (IMP3), ITGA4, RAN, SOD1, and THBS2) to ...

journal_title：International journal of molecular sciences

authors： Dell'Anno I,Barbarino M,Barone E,Giordano A,Luzzi L,Bottaro M,Migliore L,Agostini S,Melani A,Melaiu O,Catalano C,Cipollini M,Silvestri R,Corrado A,Gemignani F,Landi S

更新日期：2020-07-09 00:00:00

abstract：:Herbivore-induced plant volatiles (HIPVs) play important ecological roles in defense against stresses. In contrast to model plants, reports on HIPV formation and function in crops are limited. Tea (Camellia sinensis) is an important crop in China. α-Farnesene is a common HIPV produced in tea plants in response to diff...

journal_title：International journal of molecular sciences

authors： Wang X,Zeng L,Liao Y,Li J,Tang J,Yang Z

更新日期：2019-08-25 00:00:00

abstract：:Colon cancer is an aggressive tumor form with a poor prognosis. This study reports a comparative proteomic analysis performed by using two-dimensional differential in-gel electrophoresis (2D-DIGE) between 26 pooled colon cancer surgical tissues and adjacent non-tumoral tissues, to identify potential target proteins co...

journal_title：International journal of molecular sciences

authors： Buttacavoli M,Albanese NN,Roz E,Pucci-Minafra I,Feo S,Cancemi P

更新日期：2020-04-28 00:00:00

abstract：:Prior evidence indicates that homocysteine plays a role in the development of metabolic syndrome (MetS). Methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase reductase (MTRR) A66G polymorphisms are common genetic determinants of homocysteine levels. To investigate the associations of the MTHFR C67...

journal_title：International journal of molecular sciences

authors： Yang B,Fan S,Zhi X,Wang D,Li Y,Wang Y,Wang Y,Wei J,Zheng Q,Sun G

更新日期：2014-11-25 00:00:00

abstract：:Chitosan nanoparticles (CS NPs) showed promising results in drug, vaccine and gene delivery for the treatment of various diseases. The considerable attention towards CS was owning to its outstanding biological properties, however, the main challenge in the application of CS NPs was faced during their size-controlled s...

journal_title：International journal of molecular sciences

authors： Chiesa E,Greco A,Riva F,Tosca EM,Dorati R,Pisani S,Modena T,Conti B,Genta I

更新日期：2019-12-09 00:00:00

abstract：:Pterostilbene (PTE) is a natural sterbenoid contained in blueberries that has an antioxidant effect. In contrast, PTE also generates oxidative stress in cancer cells and provides an antitumor effect. Here, we examined the potential mechanism of this contrasting effect of PTE using three gastrointestinal cancer cell li...

journal_title：International journal of molecular sciences

authors： Mori S,Kishi S,Honoki K,Fujiwara-Tani R,Moriguchi T,Sasaki T,Fujii K,Tsukamoto S,Fujii H,Kido A,Tanaka Y,Luo Y,Kuniyasu H

更新日期：2020-12-08 00:00:00

abstract：:Extracellular vesicles (EVs) are shed by all eukaryotic cells and have emerged as important intercellular regulators. EVs released by osteoclasts were recently identified as important coupling factors in bone remodeling. They are shed as osteoclasts resorb bone and stimulate osteoblasts to form bone to replace the bon...

journal_title：International journal of molecular sciences

authors： Holliday LS,Faria LP,Rody WJ Jr

更新日期：2019-12-25 00:00:00

abstract：:microRNA-143(miR-143) is a well-known tumor suppressive microRNA that exhibits anti-tumoral function by targeting KRAS signaling pathways in various malignancies. We hypothesized that miR-143 suppresses breast cancer progression by targeting KRAS and its effector molecules. We further hypothesized that high expression...

journal_title：International journal of molecular sciences

authors： Tokumaru Y,Asaoka M,Oshi M,Katsuta E,Yan L,Narayanan S,Sugito N,Matsuhashi N,Futamura M,Akao Y,Yoshida K,Takabe K

更新日期：2020-05-01 00:00:00

abstract：:We previously discovered a novel sirtuin (SIRT) inhibitor, MHY2256, that exerts anticancer activity through p53 acetylation in MCF-7 human breast cancer cells. We investigated the anticancer activity of MHY2256 against hormone-related cancer, an endometrial cancer with a poor prognosis. The IC50 values of MHY2256 were...

journal_title：International journal of molecular sciences

authors： De U,Son JY,Sachan R,Park YJ,Kang D,Yoon K,Lee BM,Kim IS,Moon HR,Kim HS

更新日期：2018-09-13 00:00:00

abstract：:Sperm cryopreservation and artificial insemination are important methods for giant panda breeding and preservation of extant genetic diversity. Lower conception rates limit the use of artificial insemination with frozen-thawed giant panda sperm, due to the lack of understanding of the cryodamaging or cryoinjuring mech...

journal_title：International journal of molecular sciences

authors： Ran MX,Li Y,Zhang Y,Liang K,Ren YN,Zhang M,Zhou GB,Zhou YM,Wu K,Wang CD,Huang Y,Luo B,Qazi IH,Zhang HM,Zeng CJ

更新日期：2018-10-08 00:00:00

abstract：:Neuromuscular disorders (NMDs) affect 1 in 3000 people worldwide. There are more than 150 different types of NMDs, where the common feature is the loss of muscle strength. These disorders are classified according to their neuroanatomical location, as motor neuron diseases, peripheral nerve diseases, neuromuscular junc...

journal_title：International journal of molecular sciences

authors： Bachiller S,Alonso-Bellido IM,Real LM,Pérez-Villegas EM,Venero JL,Deierborg T,Armengol JÁ,Ruiz R

更新日期：2020-09-03 00:00:00

abstract：:The silk gland synthesizes and secretes a large amount of protein and stores liquid silk protein at an extremely high concentration. Interestingly, silk proteins and serine protease inhibitors are orderly arranged in the silk gland lumen and cocoon shells. Silk fiber formation and the spinning mechanism have not been ...

journal_title：International journal of molecular sciences

authors： Shi R,Ma S,He T,Peng J,Zhang T,Chen X,Wang X,Chang J,Xia Q,Zhao P

更新日期：2019-05-20 00:00:00

abstract：:Phostensin is encoded by KIAA1949. 5'-RACEanalysis has been used to identify the translation start site of phostensin mRNA, indicating that it encodes 165 amino acids with an apparent molecular weight of 26 kDa on SDS-PAGE. This low-molecular-weight phostensin is present in human peripheral blood mononuclear cells and...

journal_title：International journal of molecular sciences

authors： Lin YS,Huang HL,Liu WT,Lin TH,Huang HB

更新日期：2014-01-15 00:00:00

abstract：:Left ventricular remodeling (LVR) occurring after ST-segment elevation myocardial infarction (STEMI) is frequent and severe. We present a metabolomic approach as an attempt to reveal unknown biomarkers associated with post-STEMI LVR. Out of 192 consecutive patients with successfully revascularized STEMI, 32 presented ...

journal_title：International journal of molecular sciences

authors： Garcia G,Chao de la Barca JM,Mirebeau-Prunier D,Reynier P,Furber A,Prunier F,Bière L

更新日期：2019-01-12 00:00:00

abstract：:Antibacterial peptides (APMs) are a new type of antibacterial substance. The relationship between their structure and function remains indistinct; in particular, there is a lack of a definitive and fixed template for designing new antimicrobial peptides. Previous studies have shown that porcine Protegrin-1 (PG-1) exhi...

journal_title：International journal of molecular sciences

authors： Dong N,Wang C,Zhang T,Zhang L,Xue C,Feng X,Bi C,Shan A

更新日期：2019-08-14 00:00:00

abstract：:Modern strategies in adipose tissue engineering (ATE) take advantage of the easy harvest, abundance and differentiation potential towards mesenchymal lineages of hADSCs. The controlled conversion of hADSCs to committed adipogenic precursors and further mature adipocytes formation is important for good long-term result...

journal_title：International journal of molecular sciences

authors： Galateanu B,Dinescu S,Cimpean A,Dinischiotu A,Costache M

更新日期：2012-11-27 00:00:00

abstract：:Beclin 1 is a major regulator of autophagy, and it is a core component of the class III PI3K complexes. Beclin 1 is a highly conserved protein and its function is regulated in a number of ways, including post-translational modifications. Several studies indicate that receptor and non-receptor tyrosine kinases regulate...

journal_title：International journal of molecular sciences

authors： Vega-Rubín-de-Celis S,Kinch L,Peña-Llopis S

更新日期：2020-12-03 00:00:00

abstract：:Dendritic cells (DCs) are heterogeneous groups of innate immune cells, which orchestrate immune responses by presenting antigens to cognate T cells and stimulating other types of immune cells. Although the term 'DCs' generally represent highly mixed subsets with functional heterogeneity, the classical definition of DC...

journal_title：International journal of molecular sciences

authors： Kim TG,Kim SH,Lee MG

更新日期：2017-12-23 00:00:00

abstract：:The aim of this study was to develop and evaluate matrix assisted LASER desorption ionization (MALDI) time-of-flight (TOF) mass spectrometry imaging (MSI) of blood smear. Integrated light microscope and MALDI IT-TOF mass spectrometer, together with a matrix sublimation device, were used for analysis of blood smears co...

journal_title：International journal of molecular sciences

authors： Debeljak Ž,Niehoff AC,Bandjak A,Mandić D,Bošnjak B,Heffer M,Mrđenović S,Marković I,Zjalić M,Šerić V

更新日期：2021-01-08 00:00:00

abstract：:Most biological phenomena occur at the nanometer scale, which is not accessible by the conventional optical techniques because of the optical diffraction limitation. Tip-enhanced Raman spectroscopy (TERS), one of the burgeoning probing techniques, not only can provide the topography characterization with high resoluti...

journal_title：International journal of molecular sciences

authors： Gao L,Zhao H,Li T,Huo P,Chen D,Liu B

更新日期：2018-04-13 00:00:00

abstract：:Polysaccharides from Morchella esculenta have been proven to be functional and helpful for humans. The purpose of this study was to investigate the chemical structure and anti-proliferating and antitumor activities of a Morchella esculenta polysaccharide (MEP) extracted by pulsed electric field (PEF) in submerged ferm...

journal_title：International journal of molecular sciences

authors： Liu C,Sun Y,Mao Q,Guo X,Li P,Liu Y,Xu N

更新日期：2016-06-22 00:00:00

abstract：:Heme oxygenase (HO) catabolizes heme to produce HO metabolites, such as carbon monoxide (CO) and bilirubin (BR), which have gained recognition as biological signal transduction effectors. The neurovascular unit refers to a highly evolved network among endothelial cells, pericytes, astrocytes, microglia, neurons, and n...

journal_title：International journal of molecular sciences

authors： Lee H,Choi YK

更新日期：2018-12-25 00:00:00

abstract：:: Background: The aberrant expression of microRNAs (miRNAs) has been associated with several diseases, including cancer, inflammatory, and autoimmune conditions. Interest in salivary miRNAs as non-invasive tools for the diagnosis of malignancies and systemic diseases is rapidly increasing. The present systematic revie...

journal_title：International journal of molecular sciences

authors： Setti G,Pezzi ME,Viani MV,Pertinhez TA,Cassi D,Magnoni C,Bellini P,Musolino A,Vescovi P,Meleti M

更新日期：2020-01-30 00:00:00

abstract：:O6-alkylguanine-DNA alkyltransferase (AGT) is the main cause of tumor cell resistance to DNA-alkylating agents, so it is valuable to design tumor-targeted AGT inhibitors with hypoxia activation. Based on the existing benchmark inhibitor O6-benzylguanine (O6-BG), four derivatives with hypoxia-reduced potential and thei...

journal_title：International journal of molecular sciences

authors： Xiao W,Sun G,Fan T,Liu J,Zhang N,Zhao L,Zhong R

更新日期：2019-12-13 00:00:00

abstract：:The liver has a wide range of physiological functions in the body, and its health is maintained by complex cross-talk among hepatic cells, including parenchymal hepatocytes and nonparenchymal cells. Exosomes, which are one method of cellular communication, are endosomal-derived small vesicles that are released by dono...

journal_title：International journal of molecular sciences

authors： Sung S,Kim J,Jung Y

更新日期：2018-11-22 00:00:00

abstract：:Late blight caused by Phytophthora infestans (Montagne, Bary) is a devastating disease of tomato worldwide. There are three known major genes, Ph-1, Ph-2, and Ph-3, conferring resistance to late blight. In addition to these three genes, it is also believed that there are additional factors or quantitative trait loci (...

journal_title：International journal of molecular sciences

authors： Panthee DR,Piotrowski A,Ibrahem R

更新日期：2017-07-22 00:00:00

abstract：:Protein aggregation is classically considered the main cause of neuronal death in neurodegenerative diseases (NDDs). However, increasing evidence suggests that alteration of RNA metabolism is a key factor in the etiopathogenesis of these complex disorders. Non-coding RNAs are the major contributor to the human transcr...

journal_title：International journal of molecular sciences

authors： Moreno-García L,López-Royo T,Calvo AC,Toivonen JM,de la Torre M,Moreno-Martínez L,Molina N,Aparicio P,Zaragoza P,Manzano R,Osta R

更新日期：2020-12-16 00:00:00