Mapping Quantitative Trait Loci (QTL) for Resistance to Late Blight in Tomato.

Abstract:

:Late blight caused by Phytophthora infestans (Montagne, Bary) is a devastating disease of tomato worldwide. There are three known major genes, Ph-1, Ph-2, and Ph-3, conferring resistance to late blight. In addition to these three genes, it is also believed that there are additional factors or quantitative trait loci (QTL) conferring resistance to late blight. Precise molecular mapping of all those major genes and potential QTL is important in the development of suitable molecular markers and hence, marker-assisted selection (MAS). The objective of the present study was to map the genes and QTL associated with late blight resistance in a tomato population derived from intra-specific crosses. To achieve this objective, a population, derived from the crossings of NC 1CELBR × Fla. 7775, consisting of 250 individuals at F2 and F2-derived families, were evaluated in replicated trials. These were conducted at Mountain Horticultural Crops Reseach & Extension Center (MHCREC) at Mills River, NC, and Mountain Research Staion (MRS) at Waynesville, NC in 2011, 2014, and 2015. There were two major QTL associated with late blight resistance located on chromosomes 9 and 10 with likelihood of odd (LOD) scores of more than 42 and 6, explaining 67% and 14% of the total phenotypic variation, respectively. The major QTLs are probably caused by the Ph-2 and Ph-3 genes. Furthermore, there was a minor QTL on chromosomes 12, which has not been reported before. This minor QTL may be novel and may be worth investigating further. Source of resistance to Ph-2, Ph-3, and this minor QTL traces back to line L3707, or Richter's Wild Tomato. The combination of major genes and minor QTL may provide a durable resistance to late blight in tomato.

journal_name

Int J Mol Sci

authors

Panthee DR,Piotrowski A,Ibrahem R

doi

10.3390/ijms18071589

subject

Has Abstract

pub_date

2017-07-22 00:00:00

issue

7

issn

1422-0067

pii

ijms18071589

journal_volume

18

pub_type

杂志文章
  • Slow Dissolution Kinetics of Model Peptide Fibrils.

    abstract::Understanding the kinetics of peptide self-assembly is important because of the involvement of peptide amyloid fibrils in several neurodegenerative diseases. In this paper, we have studied the dissolution kinetics of self-assembled model peptide fibrils after a dilution quench. Due to the low concentrations involved, ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21207671

    authors: Koder Hamid M,Rüter A,Kuczera S,Olsson U

    更新日期:2020-10-16 00:00:00

  • Wheat Heat Shock Factor TaHsfA6f Increases ABA Levels and Enhances Tolerance to Multiple Abiotic Stresses in Transgenic Plants.

    abstract::Abiotic stresses are major constraints limiting crop growth and production. Heat shock factors (Hsfs) play significant roles in mediating plant resistance to various environmental stresses, including heat, drought and salinity. In this study, we explored the biological functions and underlying mechanisms of wheat TaHs...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21093121

    authors: Bi H,Zhao Y,Li H,Liu W

    更新日期:2020-04-28 00:00:00

  • Current Insights into Oral Cancer Epigenetics.

    abstract::Epigenetic modifications have emerged into one of the cancer hallmarks, replacing the concept of malignant pathologies as being solely genetic-based conditions. The epigenetic landscape is responsible for normal development but also for the heterogeneity among tissues in terms of gene expression patterns. Dysregulatio...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms19030670

    authors: Irimie AI,Ciocan C,Gulei D,Mehterov N,Atanasov AG,Dudea D,Berindan-Neagoe I

    更新日期:2018-02-27 00:00:00

  • Bone Regeneration Using Adipose-Derived Stem Cells in Injectable Thermo-Gelling Hydrogel Scaffold Containing Platelet-Rich Plasma and Biphasic Calcium Phosphate.

    abstract::For bone regeneration, a biocompatible thermo-gelling hydrogel, hyaluronic acid-g-chitosan-g-poly(N-isopropylacrylamide) (HA-CPN) was used as a three-dimensional organic gel matrix for entrapping rabbit adipose-derived stem cells (rASCs). Biphasic calcium phosphate (BCP) ceramic microparticles were embedded within the...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms19092537

    authors: Liao HT,Tsai MJ,Brahmayya M,Chen JP

    更新日期:2018-08-27 00:00:00

  • Three-Dimensional Electrodes for High-Performance Bioelectrochemical Systems.

    abstract::Bioelectrochemical systems (BES) are groups of bioelectrochemical technologies and platforms that could facilitate versatile environmental and biological applications. The performance of BES is mainly determined by the key process of electron transfer at the bacteria and electrode interface, which is known as extracel...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms18010090

    authors: Yu YY,Zhai DD,Si RW,Sun JZ,Liu X,Yong YC

    更新日期:2017-01-04 00:00:00

  • The Urinary Exosomal miRNA Expression Profile is Predictive of Clinical Response in Lupus Nephritis.

    abstract::Data on exosomal-derived urinary miRNAs have identified several miRNAs associated with disease activity and fibrosis formation, but studies on prognosis are lacking. We conducted a qPCR array screening on urinary exosomes from 14 patients with biopsy-proven proliferative lupus glomerulonephritis with a renal outcome o...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21041372

    authors: Garcia-Vives E,Solé C,Moliné T,Vidal M,Agraz I,Ordi-Ros J,Cortés-Hernández J

    更新日期:2020-02-18 00:00:00

  • Berry phenolics of grapevine under challenging environments.

    abstract::Plant phenolics have been for many years a theme of major scientific and applied interest. Grape berry phenolics contribute to organoleptic properties, color and protection against environmental challenges. Climate change has already caused significant warming in most grape-growing areas of the world, and the climatic...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms140918711

    authors: Teixeira A,Eiras-Dias J,Castellarin SD,Gerós H

    更新日期:2013-09-11 00:00:00

  • Whole Exome Sequencing in Psoriasis Patients Contributes to Studies of Acitretin Treatment Difference.

    abstract::Psoriasis vulgaris is an immune-mediated inflammatory skin disease. Although acitretin is a widely used synthetic retinoid for moderate to severe psoriasis, little is known about patients' genetics in response to this drug. In this study, 179 patients were enrolled in either the discovery set (13 patients) or replicat...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms18020295

    authors: Zhou X,He Y,Kuang Y,Li J,Zhang J,Chen M,Chen W,Su J,Zhao S,Liu P,Chen M,Shen M,Chen X,Zhu W,Chen X

    更新日期:2017-01-29 00:00:00

  • Argonaute and Argonaute-Bound Small RNAs in Stem Cells.

    abstract::Small RNAs are essential for a variety of cellular functions. Argonaute (AGO) proteins are associated with all of the different classes of small RNAs, and are indispensable in small RNA-mediated regulatory pathways. AGO proteins have been identified in various types of stem cells in diverse species from plants and ani...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms17020208

    authors: Zhai L,Wang L,Teng F,Zhou L,Zhang W,Xiao J,Liu Y,Deng W

    更新日期:2016-02-04 00:00:00

  • Low-Cost Cellulase-Hemicellulase Mixture Secreted by Trichoderma harzianum EM0925 with Complete Saccharification Efficacy of Lignocellulose.

    abstract::Fermentable sugars are important intermediate products in the conversion of lignocellulosic biomass to biofuels and other value-added bio-products. The main bottlenecks limiting the production of fermentable sugars from lignocellulosic biomass are the high cost and the low saccharification efficiency of degradation en...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21020371

    authors: Zhang Y,Yang J,Luo L,Wang E,Wang R,Liu L,Liu J,Yuan H

    更新日期:2020-01-07 00:00:00

  • A Human Antibody That Binds to the Sixth Ig-Like Domain of VCAM-1 Blocks Lung Cancer Cell Migration In Vitro.

    abstract::Vascular cell adhesion molecule-1 (VCAM-1) is closely associated with tumor progression and metastasis. However, the relevance and role of VCAM-1 in lung cancer have not been clearly elucidated. In this study, we found that VCAM-1 was highly overexpressed in lung cancer tissue compared with that of normal lung tissue,...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms18030566

    authors: Kim MR,Jang JH,Park CS,Kim TK,Kim YJ,Chung J,Shim H,Nam IH,Han JM,Lee S

    更新日期:2017-03-06 00:00:00

  • Impact and Intricacies of Bone Marrow Microenvironment in B-cell Lymphomas: From Biology to Therapy.

    abstract::Lymphoma, a group of widely prevalent hematological malignancies of lymphocyte origin, has become the focus of significant clinical research due to their high propensity for refractory/relapsed (R/R) disease, leading to poor prognostic outcomes. The complex molecular circuitry in lymphomas, especially in the aggressiv...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21030904

    authors: Sircar A,Chowdhury SM,Hart A,Bell WC,Singh S,Sehgal L,Epperla N

    更新日期:2020-01-30 00:00:00

  • Zinc Homeostasis in Platelet-Related Diseases.

    abstract::Zn2+ deficiency in the human population is frequent in underdeveloped countries. Worldwide, approximatively 2 billion people consume Zn2+-deficient diets, accounting for 1-4% of deaths each year, mainly in infants with a compromised immune system. Depending on the severity of Zn2+ deficiency, clinical symptoms are ass...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms20215258

    authors: Mammadova-Bach E,Braun A

    更新日期:2019-10-23 00:00:00

  • Genome-Wide Identification and Characterization of the OPR Gene Family in Wheat (Triticum aestivum L.).

    abstract::The 12-oxo-phytodienoic acid reductases (OPRs), which belong to the old yellow enzyme (OYE) family, are flavin mononucleotide (FMN)-dependent oxidoreductases with critical functions in plants. Despite the clear characteristics of growth and development, as well as the defense responses in Arabidopsis, tomato, rice, an...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20081914

    authors: Mou Y,Liu Y,Tian S,Guo Q,Wang C,Wen S

    更新日期:2019-04-18 00:00:00

  • A Pilot Study of the Predictive Potential of Chemosensitivity and Gene Expression Assays Using Circulating Tumour Cells from Patients with Recurrent Ovarian Cancer.

    abstract::Circulating tumour cells (CTCs) from liquid biopsies are under current investigation in several cancers, including epithelial ovarian cancer (EOC) but face significant drawbacks in terms of non-standardised methodology, low viable cell numbers and accuracy of CTC identification. In this pilot study, we report that che...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21134813

    authors: Guadagni S,Clementi M,Masedu F,Fiorentini G,Sarti D,Deraco M,Kusamura S,Papasotiriou I,Apostolou P,Aigner KR,Zavattieri G,Farina AR,Vizzielli G,Scambia G,Mackay AR

    更新日期:2020-07-07 00:00:00

  • Rack1 Mediates the Interaction of P-Glycoprotein with Anxa2 and Regulates Migration and Invasion of Multidrug-Resistant Breast Cancer Cells.

    abstract::The emergence of multidrug resistance is always associated with more rapid tumor recurrence and metastasis. P-glycoprotein (P-gp), which is a well-known multidrug-efflux transporter, confers enhanced invasion ability in drug-resistant cells. Previous studies have shown that P-gp probably exerts its tumor-promoting fun...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms17101718

    authors: Yang Y,Wu N,Wang Z,Zhang F,Tian R,Ji W,Ren X,Niu R

    更新日期:2016-10-13 00:00:00

  • Synthesis of Fmoc-Triazine Amino Acids and Its Application in the Synthesis of Short Antibacterial Peptidomimetics.

    abstract::To combat the escalating rise of antibacterial resistance, the development of antimicrobial peptides (AMPs) with a unique mode of action is considered an attractive strategy. However, proteolytic degradation of AMPs remains the greatest challenge in their transformation into therapeutics. Herein, we synthesized Fmoc-t...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21103602

    authors: Gunasekaran P,Kim EY,Lee J,Ryu EK,Shin SY,Bang JK

    更新日期:2020-05-20 00:00:00

  • The Molecular Mechanisms of Iron Metabolism and Its Role in Cardiac Dysfunction and Cardioprotection.

    abstract::Iron is an essential mineral participating in different functions of the organism under physiological conditions. Numerous biological processes, such as oxygen and lipid metabolism, protein production, cellular respiration, and DNA synthesis, require the presence of iron, and mitochondria play an important role in the...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21217889

    authors: Ravingerová T,Kindernay L,Barteková M,Ferko M,Adameová A,Zohdi V,Bernátová I,Ferenczyová K,Lazou A

    更新日期:2020-10-24 00:00:00

  • Metallothionein 3 Is a Hypoxia-Upregulated Oncogene Enhancing Cell Invasion and Tumorigenesis in Human Bladder Carcinoma Cells.

    abstract::Metallothioneins have been viewed as modulators in a number of biological regulations regarding cancerous development; however, the function of metallothionein 3 (MT3) in bladder cancer is unexplored. We determined the regulatory mechanisms and potential function of MT3 in bladder carcinoma cells. Real-Time Reverse Tr...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20040980

    authors: Tsui KH,Hou CP,Chang KS,Lin YH,Feng TH,Chen CC,Shin YS,Juang HH

    更新日期:2019-02-23 00:00:00

  • Selective binding, self-assembly and nanopatterning of the Creutz-Taube ion on surfaces.

    abstract::The surface attachment properties of the Creutz-Taube ion, i.e., [(NH(3))(5)Ru(pyrazine)Ru(NH(3))(5)](5+), on both hydrophilic and hydrophobic types of surfaces were investigated using X-ray photoelectron spectroscopy (XPS). The results indicated that the Creutz-Taube ions only bound to hydrophilic surfaces, such as S...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms10020533

    authors: Wang Y,Lieberman M,Hang Q,Bernstein G

    更新日期:2009-02-01 00:00:00

  • Implications of a Soy-Based Diet for Animal Models.

    abstract::The use of animal models in fundamental or pre-clinical research remains an absolute requirement for understanding human pathologies and developing new drugs. In order to transpose these results into clinical practice, many parameters must be taken into account to limit bias. Attention has recently been focused on the...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms22020774

    authors: Dhot J,Prat V,Ferron M,Aillerie V,Erraud A,Rozec B,Waard M,Gauthier C,Lauzier B

    更新日期:2021-01-14 00:00:00

  • P3HT:Bebq2-Based Photovoltaic Device Enhances Differentiation of hiPSC-Derived Retinal Ganglion Cells.

    abstract::Electric field stimulation is known to affect various cellular processes, including cell fate specification and differentiation, particularly towards neuronal lineages. This makes it a promising therapeutic strategy to stimulate regeneration of neuronal tissues. Retinal ganglion cells (RGCs) is a type of neural cells ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20112661

    authors: Hsu CC,Lin YY,Yang TC,Yarmishyn AA,Lin TW,Chang YL,Hwang DK,Wang CY,Liu YY,Lo WL,Peng CH,Chen SJ,Yang YP

    更新日期:2019-05-30 00:00:00

  • Plant MicroRNAs in Cross-Kingdom Regulation of Gene Expression.

    abstract::MicroRNAs (miRNAs) are a class of noncoding small RNAs, which play a crucial role in post-transcriptional gene regulation. Recently, various reports revealed that miRNAs could be transmitted between species to mediate cross-kingdom regulation by integrating into a specific target gene-mediated regulatory pathway to ex...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms19072007

    authors: Wang W,Liu D,Zhang X,Chen D,Cheng Y,Shen F

    更新日期:2018-07-10 00:00:00

  • Ectopic Expression of Testis Germ Cell Proteins in Cancer and Its Potential Role in Genomic Instability.

    abstract::Genomic instability is a hallmark of human cancer and an enabling factor for the genetic alterations that drive cancer development. The processes involved in genomic instability resemble those of meiosis, where genetic material is interchanged between homologous chromosomes. In most types of human cancer, epigenetic c...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms17060890

    authors: Nielsen AY,Gjerstorff MF

    更新日期:2016-06-06 00:00:00

  • Platelet-Rich Plasma Promotes the Proliferation of Human Keratinocytes via a Progression of the Cell Cycle. A Role of Prolidase.

    abstract::Although the role of platelet-rich plasma (PRP) in tissue regeneration has been confirmed in many studies, the mechanism of this process is still not fully understood. Human keratinocytes (HaCaT) cells were used as an experimental model for studies on the effects of PRP on cell proliferation, migration, collagen biosy...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms22020936

    authors: Misiura M,Guszczyn T,Oscilowska I,Baszanowska W,Palka J,Miltyk W

    更新日期:2021-01-19 00:00:00

  • Enhancement of immune activation activities of Spirulina maxima grown in deep-sea water.

    abstract::In this study, the immuno-modulatory and anticancer activities of marine algae, Spirulina maxima grown in deep-sea water (DSW), were investigated. It was found that the extract of S. maxima, cultured in DSW, effectively suppressed the expression of Bcl2 in A549 cells as well as inhibiting various human cancer cells wi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms140612205

    authors: Choi WY,Kang DH,Lee HY

    更新日期:2013-06-06 00:00:00

  • The Absence of Endothelial Sodium Channel α (αENaC) Reduces Renal Ischemia/Reperfusion Injury.

    abstract::The epithelial sodium channel (ENaC) has a key role in modulating endothelial cell stiffness and this in turn regulates nitric oxide (NO) synthesis. The physiological relevance of endothelial ENaC in pathological conditions where reduced NO bioavailability plays an essential role remains largely unexplored. Renal isch...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20133132

    authors: Tarjus A,González-Rivas C,Amador-Martínez I,Bonnard B,López-Marure R,Jaisser F,Barrera-Chimal J

    更新日期:2019-06-27 00:00:00

  • Plant Single-Cell Metabolomics-Challenges and Perspectives.

    abstract::Omics approaches for investigating biological systems were introduced in the mid-1990s and quickly consolidated to become a fundamental pillar of modern biology. The idea of measuring the whole complement of genes, transcripts, proteins, and metabolites has since become widespread and routinely adopted in the pursuit ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21238987

    authors: de Souza LP,Borghi M,Fernie A

    更新日期:2020-11-26 00:00:00

  • The Transcriptomic Landscape of Gastric Cancer: Insights into Epstein-Barr Virus Infected and Microsatellite Unstable Tumors.

    abstract:BACKGROUND:Epstein-Barr Virus (EBV) positive and microsatellite unstable (MSI-high) gastric cancer (GC) are molecular subgroups with distinctive molecular profiles. We explored the transcriptomic differences between EBV+ and MSI-high GCs, and the expression of current GC immunotherapy targets such as PD-1, PD-L1, CTLA4...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms19072079

    authors: Gullo I,Carvalho J,Martins D,Lemos D,Monteiro AR,Ferreira M,Das K,Tan P,Oliveira C,Carneiro F,Oliveira P

    更新日期:2018-07-17 00:00:00

  • Integrated Transcriptomics, Metabolomics, and Lipidomics Profiling in Rat Lung, Blood, and Serum for Assessment of Laser Printer-Emitted Nanoparticle Inhalation Exposure-Induced Disease Risks.

    abstract::Laser printer-emitted nanoparticles (PEPs) generated from toners during printing represent one of the most common types of life cycle released particulate matter from nano-enabled products. Toxicological assessment of PEPs is therefore important for occupational and consumer health protection. Our group recently repor...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20246348

    authors: Guo NL,Poh TY,Pirela S,Farcas MT,Chotirmall SH,Tham WK,Adav SS,Ye Q,Wei Y,Shen S,Christiani DC,Ng KW,Thomas T,Qian Y,Demokritou P

    更新日期:2019-12-16 00:00:00