Abstract:
:The surface attachment properties of the Creutz-Taube ion, i.e., [(NH(3))(5)Ru(pyrazine)Ru(NH(3))(5)](5+), on both hydrophilic and hydrophobic types of surfaces were investigated using X-ray photoelectron spectroscopy (XPS). The results indicated that the Creutz-Taube ions only bound to hydrophilic surfaces, such as SiO(2) and -OH terminated organic SAMs on gold substrates. No attachment of the ions on hydrophobic surfaces such as -CH(3) terminated organic SAMs and poly(methylmethacrylate) (PMMA) thin films covered gold or SiO(2) substrates was observed. Further ellipsometric, atomic force microscopy (AFM) and time-dependent XPS studies suggested that the attached cations could form an inorganic analog of the self-assembled monolayer on SiO(2) substrate with a "lying-down" orientation. The strong electrostatic interaction between the highly charged cations and the anionic SiO(2) surface was believed to account for these observations. Based on its selective binding property, patterning of wide ( approximately 200 nm) and narrow ( approximately 35 nm) lines of the Creutz-Taube ions on SiO(2) surface were demonstrated through PMMA electron resist masks written by electron beam lithography (EBL).
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Wang Y,Lieberman M,Hang Q,Bernstein Gdoi
10.3390/ijms10020533subject
Has Abstractpub_date
2009-02-01 00:00:00pages
533-58issue
2issn
1422-0067journal_volume
10pub_type
杂志文章abstract::Antibody drug conjugates (ADCs), consisting of a cancer-specific antibody and cytotoxic payload, are shown to be a potent class of anticancer therapeutics, with enhanced therapeutic efficacy and reduced "off-target" side effects. However, the therapeutic window of ADCs is narrowed by problems such as difficulty in sit...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21093286
更新日期:2020-05-06 00:00:00
abstract::Merging targeted systemic gene delivery and systemic chemotherapy against cancer, chemovirotherapy, has the potential to improve chemotherapy and gene therapy treatments and overcome cancer resistance. We introduced a bacteriophage (phage) vector, named human adeno-associated virus (AAV)/phage or AAVP, for the systemi...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21217867
更新日期:2020-10-23 00:00:00
abstract::A conformational analysis of nine macrocyclic thioether musks has been carried out using molecular mechanics (MMFF), density functional theory (DFT) using both B3LYP and M06 functionals, as well as Hartree-Fock and post-Hartree-Fock (MP2) ab initio methods. 6-Thia-, 10-thia- and 4-methyl-5-thia-14-tetradecananolide, 4...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms10083488
更新日期:2009-08-04 00:00:00
abstract::In this article we propose a systematic development method for rational drug design while reviewing paradigms in industry, emerging techniques and technologies in the field. Although the process of drug development today has been accelerated by emergence of computational methodologies, it is a herculean challenge requ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms12042262
更新日期:2011-01-01 00:00:00
abstract::For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ-mainly, the two families of claudins and TAMPs-several other functions have been discovered, a striking one...
journal_title:International journal of molecular sciences
pub_type: 社论
doi:10.3390/ijms21134612
更新日期:2020-06-29 00:00:00
abstract::Chlorothiophenols (CTPs) are known to be key and direct precursors of polychlorinated thianthrene/dibenzothiophenes (PCTA/DTs). Self/cross-coupling of the chlorothiophenoxy radicals (CTPRs), sulfydryl-substituted phenyl radicals and thiophenoxyl diradicals evolving from CTPs are initial and important steps for PCTA/DT...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20112623
更新日期:2019-05-28 00:00:00
abstract::Wheat and barley are the most highly produced and consumed grains in the world. Various pathogens-viruses, bacteria, fungi, insect pests, and nematode parasites-are major threats to yield and economic losses. Strategies for the management of disease control mainly depend on resistance or tolerance breeding, chemical c...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20010206
更新日期:2019-01-08 00:00:00
abstract::Autocrine signaling is defined as the production and secretion of an extracellular mediator by a cell followed by the binding of that mediator to receptors on the same cell to initiate signaling. Autocrine stimulation often operates in autocrine loops, a type of interaction, in which a cell produces a mediator, for wh...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms22020977
更新日期:2021-01-19 00:00:00
abstract::Interstitial telomeric sequences (ITSs) are short stretches of telomeric-like repeats (TTAGGG)n at nonterminal chromosomal sites. We previously demonstrated that, in the genomes of primates and rodents, ITSs were inserted during the repair of DNA double-strand breaks. These conclusions were derived from sequence compa...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21082838
更新日期:2020-04-18 00:00:00
abstract::The recent thriving development of biobanks and associated high-throughput phenotyping studies requires the elaboration of large-scale approaches for monitoring biological sample quality and compliance with standard protocols. We present a metabolomic investigation of human blood samples that delineates pitfalls and g...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms17122035
更新日期:2016-12-05 00:00:00
abstract::Brain-derived neurothrophic factor (BDNF) is a neurotrophin expressed in different tissues and cells, including neurons, endothelial cells, leukocytes, megakaryocytes and platelets. Modifications of BDNF in plasma and/or in serum are associated with neurodegenerative and psychiatric disorders, cardiovascular diseases,...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18091987
更新日期:2017-09-15 00:00:00
abstract::Despite the fact that G protein-coupled receptors (GPCRs) are the largest signal-conveying receptor family and mediate many physiological processes, their role in tumor biology is underappreciated. Numerous lines of evidence now associate GPCRs and their downstream signaling targets in cancer growth and development. I...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms17081320
更新日期:2016-08-12 00:00:00
abstract::Magnetic biomimetic scaffolds of poly(L-lactide) (PLLA) and nanoparticles of magnetite (nFe3O4) are prepared in a wide ratio of compositions by lyophilization for bone regeneration. The magnetic properties, cytotoxicity, and the in vitro degradation of these porous materials are closely studied. The addition of magnet...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20194664
更新日期:2019-09-20 00:00:00
abstract::Platelets and platelet microparticles (PMPs) play a key role in the pathophysiology of vascular disorders such as coronary artery disease and stroke. In atherosclerosis, for example, the disruption of the plaque exposes endogenous agonists such as collagen, which activates platelets. Platelet hyper-activation and the ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21010146
更新日期:2019-12-24 00:00:00
abstract::A psychrotolerant bacterium, strain T-3 (identified as Psychrobacter piscatorii), that exhibited an extraordinarily high catalase activity was isolated from the drain pool of a plant that uses H(2)O(2) as a bleaching agent. Its cell extract exhibited a catalase activity (19,700 U·mg protein(-1)) that was higher than t...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms13021733
更新日期:2012-01-01 00:00:00
abstract::The specific rates of solvolysis of neopentyl chloroformate (1) have been determined in 21 pure and binary solvents at 45.0 °C. In most solvents the values are essentially identical to those for ethyl and n-propyl chloroformates. However, in aqueous-1,1,1,3,3,3-hexafluoro-2-propanol mixtures (HFIP) rich in fluoroalcoh...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms12021161
更新日期:2011-02-15 00:00:00
abstract::Approximately 30 years ago, endoglin was identified as a transforming growth factor (TGF)-β coreceptor with a crucial role in developmental biology and tumor angiogenesis. Its selectively high expression on tumor vessels and its correlation with poor survival in cancer patients led to the exploration of endoglin as a ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms22010147
更新日期:2020-12-25 00:00:00
abstract::Matrix metalloproteinases (MMPs) are enzymes involved in periodontal tissue destruction. Hemagglutinin B (HagB) from the periodontal pathogen Porphyromonas gingivalis induces an elevated MMP response in dendritic cells, but responses from cultures of single-cell types do not reflect the local tissue environment. The o...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19123923
更新日期:2018-12-07 00:00:00
abstract::The DNA repair gene X-ray cross-complementary group 4 (XRCC4), an important caretaker of the overall genome stability, is thought to play a major role in human tumorigenesis. We investigated the association between an important polymorphic variant of this gene at codon 247 (rs373409) and diffusely infiltrating astrocy...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms15010250
更新日期:2013-12-27 00:00:00
abstract::The rhizome of Anemarrhena asphodeloides Bunge, used in Traditional Chinese Medicine as a brain function-improving herb, is a promising source of neuroprotective substances. The aim of this study was to evaluate the protective action of xanthones from A. asphodeloides rhizomes on the PC12 cell line exposed to the neur...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21072510
更新日期:2020-04-04 00:00:00
abstract::Smart or stimuli-responsive materials are an emerging class of materials used for tissue engineering and drug delivery. A variety of stimuli (including temperature, pH, redox-state, light, and magnet fields) are being investigated for their potential to change a material's properties, interactions, structure, and/or d...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21134724
更新日期:2020-07-02 00:00:00
abstract::(R,R)ZX-5 is a NO regulatory compound, which could significantly increase choroidal blood flow in New Zealand rabbit. The aim of this paper is to investigate the molecular mechanism of (R,R)ZX-5 promoting NO production. Besides this, we also investigated the antiangiogenic activity of (R,R)ZX-5. Analysis of Western bl...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms13032717
更新日期:2012-01-01 00:00:00
abstract::The Brassica genus contains abundant economically important vegetable and oilseed crops, which are under threat of diseases caused by fungal, bacterial and viral pathogens. Resistance gene analogues (RGAs) are associated with quantitative and qualitative disease resistance and the identification of candidate RGAs asso...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21238964
更新日期:2020-11-25 00:00:00
abstract::Evodiamine (Evo), a major alkaloid compound isolated from the dry unripened fruit of Evodia fructus, has a wide range of pharmacological activities. The present study sought to explore the neuroprotective effects of Evo in l-glutamate (l-Glu)-induced apoptosis of HT22 cells, and in a d-galactose and aluminum trichlori...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19051527
更新日期:2018-05-21 00:00:00
abstract:BACKGROUND:The peroxisome proliferator-activated receptors (PPARA, PPARG, PPARD) and their transcriptional coactivators' (PPARGC1A, PPARGC1B) gene polymorphisms have been associated with muscle morphology, oxygen uptake, power output and endurance performance. The purpose of this review is to determine whether the PPAR...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,meta分析,评审
doi:10.3390/ijms19051472
更新日期:2018-05-15 00:00:00
abstract::Bakanae disease (BD), caused by the fungal pathogen Fusarium fujikuroi, has become a serious threat in rice-cultivating regions worldwide. In the present study, quantitative trait locus (QTL) mapping was performed using F2 and F3 plants derived after crossing a BD-resistant and a BD-susceptible Korean japonica rice va...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20102598
更新日期:2019-05-27 00:00:00
abstract::Urinary tract infections (UTIs) and catheter-associated UTIs (CAUTIs) are the principal hospital-acquired infections. Proteus mirabilis is characterized by several virulence factors able to promote adhesion and biofilm formation and ameliorate the colonization of urinary tract and the formation of crystalline biofilms...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18020414
更新日期:2017-02-15 00:00:00
abstract::The author wishes to make a change to the published paper [1].[...]. ...
journal_title:International journal of molecular sciences
pub_type: 已发布勘误
doi:10.3390/ijms17091572
更新日期:2016-09-19 00:00:00
abstract::The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that has emerged as an important player in asthma control. AhR is responsive to environmental molecules and endogenous or dietary metabolites and regulates innate and adaptive immune responses. Binding of this receptor by different ligands ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21228797
更新日期:2020-11-20 00:00:00
abstract::The development of neural circuits is a complex process that relies on the proper navigation of axons through their environment to their appropriate targets. While axon-environment and axon-target interactions have long been known as essential for circuit formation, communication between axons themselves has only more...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21145170
更新日期:2020-07-21 00:00:00