Molecular mechanisms of (R,R)ZX-5 on NO synthesis and its anti-angiogenic effect.

abstract：:In the present study, we aim to identify the effect of restrain stress (RS) on the expression of miRNAs in mouse serum. We used three genotypes of animals (mice with knock-out of the gene-encoding norepinephrine transporter, NET-KO; C57BL/6J, and SWR/J) which had previously been shown to display different sensitivity ...

journal_title：International journal of molecular sciences

authors： Solich J,Kuśmider M,Faron-Górecka A,Pabian P,Dziedzicka-Wasylewska M

更新日期：2020-12-12 00:00:00

abstract：:NLRP3 (NOD-like receptor family, pyrin domain-containing protein 3) activation has been linked to several chronic pathologies, including atherosclerosis, type-II diabetes, fibrosis, rheumatoid arthritis, and Alzheimer's disease. Therefore, NLRP3 represents an appealing target for the development of innovative therapeu...

journal_title：International journal of molecular sciences

authors： Mekni N,De Rosa M,Cipollina C,Gulotta MR,De Simone G,Lombino J,Padova A,Perricone U

更新日期：2019-10-09 00:00:00

abstract：:Platelets and platelet microparticles (PMPs) play a key role in the pathophysiology of vascular disorders such as coronary artery disease and stroke. In atherosclerosis, for example, the disruption of the plaque exposes endogenous agonists such as collagen, which activates platelets. Platelet hyper-activation and the ...

journal_title：International journal of molecular sciences

authors： Ed Nignpense B,Chinkwo KA,Blanchard CL,Santhakumar AB

更新日期：2019-12-24 00:00:00

abstract：:This study aims to determine whether Lactobacillus casei (L. casei) could relieve liver injury in piglets challenged with lipopolysaccharide (LPS). Piglets were randomly allocated into one of the three groups: control, LPS, and L. casei. The control and LPS groups were fed a corn- and soybean meal-based diet, whereas ...

journal_title：International journal of molecular sciences

authors： Zhao D,Wu T,Yi D,Wang L,Li P,Zhang J,Hou Y,Wu G

更新日期：2017-11-26 00:00:00

abstract：:Calmodulin (CaM) is the principal Ca2+ sensor in eukaryotic cells, orchestrating the activity of hundreds of proteins. Disease causing mutations at any of the three genes that encode identical CaM proteins lead to major cardiac dysfunction, revealing the importance in the regulation of excitability. In turn, some muta...

journal_title：International journal of molecular sciences

authors： Urrutia J,Aguado A,Muguruza-Montero A,Núñez E,Malo C,Casis O,Villarroel A

更新日期：2019-01-18 00:00:00

abstract：:The frequency and volume of Asian sand dust (ASD) (Kosa) are increasing in Japan, and it has been reported that ASD may cause adverse respiratory effects. The pulmonary toxicity of ASD has been previously analyzed in mice exposed to ASD particles by intratracheal instillation. To study the pulmonary toxicity induced b...

journal_title：International journal of molecular sciences

authors： Kobayashi Y,Shimada A,Morita T,Inoue K,Takano H

更新日期：2018-01-31 00:00:00

abstract：:Mucopolysaccharidosis type II is a lysosomal storage disorder caused by a deficiency of iduronate-2-sulfatase (IDS) and characterized by the accumulation of the primary storage substrate, glycosaminoglycans (GAGs). Understanding central nervous system (CNS) pathophysiology in neuronopathic MPS II (nMPS II) has been hi...

journal_title：International journal of molecular sciences

authors： Bhalla A,Ravi R,Fang M,Arguello A,Davis SS,Chiu CL,Blumenfeld JR,Nguyen HN,Earr TK,Wang J,Astarita G,Zhu Y,Fiore D,Scearce-Levie K,Diaz D,Cahan H,Troyer MD,Harris JM,Escolar ML

更新日期：2020-07-22 00:00:00

abstract：:Awns, which are either bristles or hair-like outgrowths of lemmas in the florets, are one of the typical morphological characteristics of grass species. These stiff structures contribute to grain dispersal and burial and fend off animal predators. However, their phenotypic and genetic associations with traits deciding...

journal_title：International journal of molecular sciences

authors： Ntakirutimana F,Xie W

更新日期：2020-10-14 00:00:00

abstract：:Sirtuins (SIRTs) are class III histone deacetylases (HDACs) that play important roles in aging and a wide range of cellular functions. Sirtuins are crucial to numerous biological processes, including proliferation, DNA repair, mitochondrial energy homeostasis, and antioxidant activity. Mammals have seven different sir...

journal_title：International journal of molecular sciences

authors： Hong YA,Kim JE,Jo M,Ko GJ

更新日期：2020-09-12 00:00:00

abstract：:The l-arginine/agmatine transporter AdiC is a prokaryotic member of the SLC7 family, which enables pathogenic enterobacteria to survive the extremely acidic gastric environment. Wild-type AdiC from Escherichia coli, as well as its previously reported point mutants N22A and S26A, were overexpressed homologously and pur...

journal_title：International journal of molecular sciences

authors： Ilgü H,Jeckelmann JM,Colas C,Ucurum Z,Schlessinger A,Fotiadis D

更新日期：2018-03-20 00:00:00

abstract：:Peripheral nerve injuries remain a significant source of long lasting morbidity, disability, and economic costs. Much research continues to be performed in areas related to improving the surgical outcomes of peripheral nerve repair. In this review, the physiology of peripheral nerve regeneration and the multitude of e...

journal_title：International journal of molecular sciences

authors： Jones S,Eisenberg HM,Jia X

更新日期：2016-09-07 00:00:00

abstract：:TSPO is a receptor involved in the regulation of cellular proliferation, apoptosis and mitochondrial functions. Previous studies showed that the expression of TSPO protein correlated positively with tumour malignancy and negatively with patient survival. The aim of this study was to determine the transcription of Tspo...

journal_title：International journal of molecular sciences

authors： Bhoola NH,Mbita Z,Hull R,Dlamini Z

更新日期：2018-07-25 00:00:00

abstract：:This study aimed to investigate the effects of cyclopamine, a specific inhibitor of Hedgehog signaling pathways, on the chondrogenic differentiation of mesenchymal stem cells (MSCs). During culture, the experimental groups were treated with cyclopamine and their cell proliferation status was assessed using the MTT tes...

journal_title：International journal of molecular sciences

authors： Wu X,Cai ZD,Lou LM,Chen ZR

更新日期：2013-03-14 00:00:00

abstract：:Clinical conditions leading to chronic pain show important sex-related differences in the prevalence, severity, and degree of functional disability. Decades of epidemiological and clinical studies have demonstrated that women are more sensitive to pain than men. Arthritis, including rheumatoid arthritis (RA) and osteo...

journal_title：International journal of molecular sciences

authors： Kim JR,Kim HA

更新日期：2020-10-26 00:00:00

abstract：:Environmental issues pose huge threats to public health, particularly the damage caused by fine particulate matter (PM2.5). However, the mechanisms of injury require further investigation and medical materials that can protect the lungs from PM2.5 are needed. We have found that Colla corii asini, a traditional Chinese...

journal_title：International journal of molecular sciences

authors： Liu T,Zhang P,Ling Y,Hu G,Gu J,Yang H,Wei J,Wang A,Jin H

更新日期：2018-12-23 00:00:00

abstract：:This review summarizes available data on argan fruit botany, geographical distribution, traditional uses, environmental interest, socioeconomic role, phytochemistry, as well as health beneficial effects and examination of future prospects. In particular, ethnomedical uses of argan fruits are carried out throughout Mor...

journal_title：International journal of molecular sciences

authors： Khallouki F,Eddouks M,Mourad A,Breuer A,Owen RW

更新日期：2017-10-30 00:00:00

abstract：:Autoimmune diabetes is a complex multifactorial disease with genetic and environmental factors playing pivotal roles. While many genes associated with the risk of diabetes have been identified to date, the mechanisms by which external triggers contribute to the genetic predisposition remain unclear. Here, we derived e...

journal_title：International journal of molecular sciences

authors： Kirak O,Ke E,Yang KY,Schwarz A,Plate L,Nham A,Abadejos JR,Valencia A,Wiseman RL,Lui KO,Ku M

更新日期：2020-08-11 00:00:00

abstract：:Despite the critical role of melanin in the protection of skin against UV radiation, excess production of melanin can lead to hyperpigmentation and skin cancer. Pear fruits are often used in traditional medicine for the treatment of melasma; therefore, we investigated the effects of pear extract (PE) and its component...

journal_title：International journal of molecular sciences

authors： Truong XT,Park SH,Lee YG,Jeong HY,Moon JH,Jeon TI

更新日期：2017-08-21 00:00:00

abstract：:MicroRNAs (miRNAs) are a major class of small, noncoding RNA molecules that regulate gene expression by targeting mRNAs to trigger either translational repression or mRNA degradation. They have recently been more widely investigated due to their potential role as targets for cancer therapy. Many miRNAs have been impli...

journal_title：International journal of molecular sciences

authors： Tang J,Ahmad A,Sarkar FH

更新日期：2012-10-18 00:00:00

abstract：:Phototropin2 (phot2) is a blue-light (BL) receptor protein that regulates the BL-dependent activities of plants for efficient photosynthesis. Phot2 is composed of two light-oxygen-voltage sensing domains (LOV1 and LOV2) to absorb BL, and a kinase domain. Photo-activated LOV domains, especially LOV2, play a major role ...

journal_title：International journal of molecular sciences

authors： Nakasako M,Oide M,Takayama Y,Oroguchi T,Okajima K

更新日期：2020-09-10 00:00:00

abstract：:Gender affects cancer susceptibility. Currently, there are only a few studies on Y chromosome-linked long noncoding RNAs (lncRNAs), and the potential association between lncRNAs and cancers in males has not been fully elucidated. Here, we examined the expression of testis-specific transcript Y-linked 15 (TTTY15) in 37...

journal_title：International journal of molecular sciences

authors： Lai IL,Chang YS,Chan WL,Lee YT,Yen JC,Yang CA,Hung SY,Chang JG

更新日期：2019-07-15 00:00:00

abstract：:The epiphyseal plate is a hyaline cartilage plate that sits between the diaphysis and the epiphysis. The objective of this study was to determine the impact of an injury in the growth plate chondrocytes through the study of histological morphology, immunohistochemistry, histomorphometry and Western Blot analyses of th...

journal_title：International journal of molecular sciences

authors： Musumeci G,Castrogiovanni P,Loreto C,Castorina S,Pichler K,Weinberg AM

更新日期：2013-07-29 00:00:00

abstract：BACKGROUND:Endothelial progenitor cells (EPCs) were indicated in vascular repair, angiogenesis of ischemic organs, and inhibition of formation of initial hyperplasia. Differentiation of endothelial cells (ECs) from human induced pluripotent stem cells (hiPSC)-derived endothelial cells (hiPSC-ECs) provides an unlimited ...

journal_title：International journal of molecular sciences

authors： Salingova B,Simara P,Matula P,Zajickova L,Synek P,Jasek O,Veverkova L,Sedlackova M,Nichtova Z,Koutna I

更新日期：2019-07-19 00:00:00

abstract：:Treatment with 1-methylcyclopropylene (1-MCP) is an effective technique to preserve fruits, but inappropriate treatment with 1-MCP causes a ripening disorder (rubbery texture) in papaya fruit. In this study, a combined metabolomic and transcriptomic analysis was conducted to reveal the possible mechanism of the ripeni...

journal_title：International journal of molecular sciences

authors： Zheng S,Hao Y,Fan S,Cai J,Chen W,Li X,Zhu X

更新日期：2021-01-18 00:00:00

abstract：:Enteroaggregative Escherichia coli (EAEC) is an emerging pathogen frequently associated with acute diarrhea in children and travelers to endemic regions. EAEC was found the most prevalent bacterial diarrheal pathogen from hospitalized Bolivian children less than five years of age with acute diarrhea from 2007 to 2010....

journal_title：International journal of molecular sciences

authors： Joffré E,Iñiguez Rojas V

更新日期：2020-12-15 00:00:00

abstract：:Obesity and diabetes are the most prevailing health concerns worldwide and their incidence is increasing at a high rate, resulting in enormous social costs. Obesity is a complex disease commonly accompanied by insulin resistance and increases in oxidative stress and inflammatory marker expression, leading to augmented...

journal_title：International journal of molecular sciences

authors： Kawser Hossain M,Abdal Dayem A,Han J,Yin Y,Kim K,Kumar Saha S,Yang GM,Choi HY,Cho SG

更新日期：2016-04-15 00:00:00

abstract：:Mucin1 (MUC1) is a highly glycosylated transmembrane protein that plays a crucial role in the lubrication and protection of normal epithelial cells. However, MUC1 has emerged as a potential target for cancer therapy because it is overexpressed and functions in several types of cancers. Recently, we produced a monoclon...

journal_title：International journal of molecular sciences

authors： Wu G,Maharjan S,Kim D,Kim JN,Park BK,Koh H,Moon K,Lee Y,Kwon HJ

更新日期：2018-07-09 00:00:00

abstract：:It is generally known that heat shock protein 27 (HSP27) is phosphorylated through p38 mitogen-activated protein (MAP) kinase. We have previously reported that HSP27 is released from human platelets associated with collagen-induced phosphorylation. In the present study, we conducted an investigation into the effect of...

journal_title：International journal of molecular sciences

authors： Tokuda H,Kuroyanagi G,Tsujimoto M,Matsushima-Nishiwaki R,Akamatsu S,Enomoto Y,Iida H,Otsuka T,Ogura S,Iwama T,Kojima K,Kozawa O

更新日期：2016-05-14 00:00:00

abstract：:The adhesion behavior of human tissue cells changes in vitro, when gravity forces affecting these cells are modified. To understand the mechanisms underlying these changes, proteins involved in cell-cell or cell-extracellular matrix adhesion, their expression, accumulation, localization, and posttranslational modifica...

journal_title：International journal of molecular sciences

authors： Bauer TJ,Gombocz E,Wehland M,Bauer J,Infanger M,Grimm D

更新日期：2020-03-04 00:00:00

abstract：:The core of micelles self-assembled from amphiphiles is hydrophobic and contains little water, whereas complex coacervate core micelles co-assembled from oppositely charged hydrophilic polymers have a hydrophilic core with a high water content. Co-assembly of ionic surfactants with ionic-neutral copolymers yields surf...

journal_title：International journal of molecular sciences

authors： Timmers EM,Magana JR,Schoenmakers SMC,Fransen PM,Janssen HM,Voets IK

更新日期：2020-12-30 00:00:00