Abstract：
:Calmodulin (CaM) is the principal Ca2+ sensor in eukaryotic cells, orchestrating the activity of hundreds of proteins. Disease causing mutations at any of the three genes that encode identical CaM proteins lead to major cardiac dysfunction, revealing the importance in the regulation of excitability. In turn, some mutations at the CaM binding site of ion channels cause similar diseases. Here we provide a summary of the two sides of the partnership between CaM and ion channels, describing the diversity of consequences of mutations at the complementary CaM binding domains.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Urrutia J,Aguado A,Muguruza-Montero A,Núñez E,Malo C,Casis O,Villarroel Adoi
10.3390/ijms20020400subject
Has Abstractpub_date
2019-01-18 00:00:00issue
2issn
1422-0067pii
ijms20020400journal_volume
20pub_type
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