Abstract:
:Zn2+ deficiency in the human population is frequent in underdeveloped countries. Worldwide, approximatively 2 billion people consume Zn2+-deficient diets, accounting for 1-4% of deaths each year, mainly in infants with a compromised immune system. Depending on the severity of Zn2+ deficiency, clinical symptoms are associated with impaired wound healing, alopecia, diarrhea, poor growth, dysfunction of the immune and nervous system with congenital abnormalities and bleeding disorders. Poor nutritional Zn2+ status in patients with metastatic squamous cell carcinoma or with advanced non-Hodgkin lymphoma, was accompanied by cutaneous bleeding and platelet dysfunction. Forcing Zn2+ uptake in the gut using different nutritional supplementation of Zn2+ could ameliorate many of these pathological symptoms in humans. Feeding adult rodents with a low Zn2+ diet caused poor platelet aggregation and increased bleeding tendency, thereby attracting great scientific interest in investigating the role of Zn2+ in hemostasis. Storage protein metallothionein maintains or releases Zn2+ in the cytoplasm, and the dynamic change of this cytoplasmic Zn2+ pool is regulated by the redox status of the cell. An increase of labile Zn2+ pool can be toxic for the cells, and therefore cytoplasmic Zn2+ levels are tightly regulated by several Zn2+ transporters located on the cell surface and also on the intracellular membrane of Zn2+ storage organelles, such as secretory vesicles, endoplasmic reticulum or Golgi apparatus. Although Zn2+ is a critical cofactor for more than 2000 transcription factors and 300 enzymes, regulating cell differentiation, proliferation, and basic metabolic functions of the cells, the molecular mechanisms of Zn2+ transport and the physiological role of Zn2+ store in megakaryocyte and platelet function remain elusive. In this review, we summarize the contribution of extracellular or intracellular Zn2+ to megakaryocyte and platelet function and discuss the consequences of dysregulated Zn2+ homeostasis in platelet-related diseases by focusing on thrombosis, ischemic stroke and storage pool diseases.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Mammadova-Bach E,Braun Adoi
10.3390/ijms20215258subject
Has Abstractpub_date
2019-10-23 00:00:00issue
21issn
1422-0067pii
ijms20215258journal_volume
20pub_type
杂志文章,评审abstract::Altered microRNA expression is implicated in cardiovascular diseases. Our objective was to determine microRNA signatures in thoracic aortic aneurysms (TAAs) and abdominal aortic aneurysms (AAAs) compared with control non-aneurysmal aortic specimens. We evaluated the expression of fifteen selected microRNA in human TAA...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18040875
更新日期:2017-04-20 00:00:00
abstract::The mammalian HSP90 family of proteins is a cluster of highly conserved molecules that are involved in myriad cellular processes. Their distribution in various cellular compartments underlines their essential roles in cellular homeostasis. HSP90 and its co-chaperones orchestrate crucial physiological processes such as...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19092560
更新日期:2018-08-29 00:00:00
abstract::In this report, the use of fluorescence detection coupled capillary electrophoresis (CE-FL) allowed us to fully characterize the antigen-antibody interaction. CE-FL allowed separation of unbound quantum dots (QDs) and ligand bound QDs and also revealed an ordered assembly of biomolecules on QDs. Further, we observed F...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms140919146
更新日期:2013-09-17 00:00:00
abstract::One of the major current trends in cancer immunotherapy is the blockade of immune checkpoint proteins that negatively regulate the immune response. This has been achieved through antibodies blocking PD-1/PD-L1 and CTLA-4/CD80/CD86 interactions. Such antibodies have revolutionized oncological therapy and shown a new wa...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21228876
更新日期:2020-11-23 00:00:00
abstract::Modern strategies in adipose tissue engineering (ATE) take advantage of the easy harvest, abundance and differentiation potential towards mesenchymal lineages of hADSCs. The controlled conversion of hADSCs to committed adipogenic precursors and further mature adipocytes formation is important for good long-term result...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms131215881
更新日期:2012-11-27 00:00:00
abstract::The stingless bee, Melipona fasciculata Smith (Apidae, Meliponini), is a native species from Brazil. Their products have high biotechnological potential, however there are no studies about the biological activities of pollen collected by M. fasciculata. In this context, the present study investigated the chemical comp...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20184512
更新日期:2019-09-12 00:00:00
abstract::Extracellular vesicles (EVs) are membrane-bound particles involved in intercellular communication. They carry proteins, lipids, and nucleotides such as microRNAs (miRNAs) from the secreting cell that can modulate target cells. We and others have previously described the presence of EVs in peripheral blood of multiple ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19082448
更新日期:2018-08-19 00:00:00
abstract::In this study we used a laser ablation technique for preparation of silver nanoparticles. The fabrication process was carried out by ablation of a silver plate immersed in palm oil. A pulsed Nd:YAG laser at a wavelength of 1064 nm was used for ablation of the plate at different times. The palm coconut oil allowed form...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms11114764
更新日期:2010-11-22 00:00:00
abstract::Nowadays, it is well accepted that inflammation is a critical player in cancer, being, in most cases, the main character of the process. Different types of tumor arise from sites of infection or chronic inflammation. This non-resolving inflammation is responsible for tumor development at different levels: it promotes ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms22031224
更新日期:2021-01-27 00:00:00
abstract::This study aims to determine whether Lactobacillus casei (L. casei) could relieve liver injury in piglets challenged with lipopolysaccharide (LPS). Piglets were randomly allocated into one of the three groups: control, LPS, and L. casei. The control and LPS groups were fed a corn- and soybean meal-based diet, whereas ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18122535
更新日期:2017-11-26 00:00:00
abstract::The immune system has a substantial effect on colorectal cancer (CRC) progression. Additionally, the response to immunotherapeutics and conventional treatment options (e.g., chemotherapy, radiotherapy and targeted therapies) is influenced by the immune system. The molecular characterization of colorectal cancer (CRC) ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms18102229
更新日期:2017-10-24 00:00:00
abstract::Cell therapy has been evaluated to enhance heart function after injury. Delivered cells mostly act via paracrine mechanisms, including secreted growth factors, cytokines, and vesicles, such as exosomes (Exo). Intramyocardial injection of cardiac-resident progenitor cells (CPC)-derived Exo reduced scarring and improved...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20030468
更新日期:2019-01-22 00:00:00
abstract::Transcription factors are proteins able to bind DNA and induce the transcription of specific genes. Consequently, they play a pivotal role in multiple cellular pathways and are frequently over-expressed or dysregulated in cancer. Here, we will focus on a specific "signal transducer and activator of transcription" (STA...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19061591
更新日期:2018-05-28 00:00:00
abstract::Virus-like nanoparticles (VLNPs) have been studied extensively as nanocarriers for targeted drug delivery to cancer cells. However, VLNPs have intrinsic drawbacks, in particular, potential antigenicity and immunogenicity, which hamper their clinical applications. Thus, they can be eliminated easily and rapidly by host...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20194903
更新日期:2019-10-03 00:00:00
abstract::Leucine-rich repeat kinase 2 (LRRK2) is the causal molecule of familial Parkinson's disease. Although the characteristics of LRRK2 have gradually been revealed, its true physiological functions remain unknown. LRRK2 is highly expressed in immune cells such as B2 cells and macrophages, suggesting that it plays importan...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21051890
更新日期:2020-03-10 00:00:00
abstract::Wt% of aragonite, a CaCO(3) polymorph, increased with higher hydraulic activity ( degrees C) of limestone in precipitated calcium carbonate (PCC) from the lime-soda process (Ca(OH)(2)-NaOH-Na(2)CO(3)). Only calcite, the most stable polymorph, was crystallized at hydraulic activity under 10 degrees C, whereas aragonite...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms10114954
更新日期:2009-11-11 00:00:00
abstract::Benign prostate hyperplasia (BPH) is one of the most common urological problems in mid-aged to elderly men. Risk factors of BPH include family history, obesity, type 2 diabetes, and high oxidative stress. The main medication classes for BPH management are alpha blockers and 5α-reductase inhibitors. However, these conv...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19041137
更新日期:2018-04-10 00:00:00
abstract::Ischemic preconditioning (IPre) reduces ischemia/reperfusion (I/R) injury in the heart. The non-coding microRNA miR-125b-1-3p has been demonstrated to play a role in the mechanism of IPre. Hypercholesterolemia is known to attenuate the cardioprotective effect of preconditioning; nevertheless, the exact underlying mech...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21113744
更新日期:2020-05-26 00:00:00
abstract::The fms-like tyrosine kinase 3 (Flt3) is a cell surface receptor that is expressed by various hematopoietic progenitor cells (HPC) and Flt3-activating mutations are commonly present in acute myeloid and lymphoid leukemias. These findings underscore the importance of Flt3 to steady-state and malignant hematopoiesis. In...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18051037
更新日期:2017-05-12 00:00:00
abstract::Climate change-induced abiotic stress results in crop yield and production losses. These stresses result in changes at the physiological and molecular level that affect the development and growth of the plant. Reactive oxygen species (ROS) is formed at high levels due to abiotic stress within different organelles, lea...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21155208
更新日期:2020-07-23 00:00:00
abstract:BACKGROUND:Growth failure and delayed puberty are well known features of children and adolescents with inflammatory bowel disease (IBD), in addition to the chronic course of the disease. Urinary metabonomics was applied in order to better understand metabolic changes between healthy and IBD children. METHODS:21 Pediat...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms17081310
更新日期:2016-08-11 00:00:00
abstract::Idiopathic pulmonary fibrosis (IPF) is age-related interstitial lung disease of unknown etiology. About 100,000 people in the U.S have IPF, with a 3-year median life expectancy post-diagnosis. The development of an effective treatment for pulmonary fibrosis will require an improved understanding of its molecular patho...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21020643
更新日期:2020-01-18 00:00:00
abstract::Asia-Pacific NMR (APNMR) has been an important scientific event in the region, engaging a large number of NMR scientists from academia and industries [...]. ...
journal_title:International journal of molecular sciences
pub_type: 社论
doi:10.3390/ijms21124419
更新日期:2020-06-22 00:00:00
abstract::Serotonin (5-HT) is a critical player in brain development and neuropsychiatric disorders. Fetal 5-HT levels can be influenced by several gestational factors, such as maternal genotype, diet, stress, medication, and immune activation. In this review, addressing both human and animal studies, we discuss how these gesta...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21165850
更新日期:2020-08-14 00:00:00
abstract::Endothelial cells and astrocytes preferentially express metabotropic P2Y nucleotide receptors, which are involved in the maintenance of vascular and neural function. Among these, P2Y1 and P2Y2 receptors appear as main actors, since their stimulation induces intracellular calcium mobilization and activates signaling ca...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22020624
更新日期:2021-01-10 00:00:00
abstract:BACKGROUND:Patients with breast cancer-the deadliest cancer among women-are at constant risk of developing metastasis. Oxidative stress and hypoxia are common feature of tumor cells that can proliferate even in a resultant metabolic acidosis. Despite the low extracellular pH, intracellular pH of tumor cells remains rel...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18040170
更新日期:2017-03-23 00:00:00
abstract::Imaging living cells by atomic force microscopy (AFM) promises not only high-resolution topographical data, but additionally, mechanical contrast, both of which are not obtainable with other microscopy techniques. Such imaging is however challenging, as cells need to be measured with low interaction forces to prevent ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19102984
更新日期:2018-09-30 00:00:00
abstract::Copy number variants (CNVs) detected by chromosomal microarray analysis (CMA) significantly contribute to understanding the etiology of autism spectrum disorder (ASD) and other related conditions. In recognition of the value of CMA testing and its impact on medical management, CMA is in medical guidelines as a first-t...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms17122070
更新日期:2016-12-09 00:00:00
abstract::Two new eunicellin-based diterpenoids, cladieunicellins K (1) and L (2), were isolated from an octocoral Cladiella sp. The structures of 1 and 2 were elucidated by spectroscopic methods and 2 exhibited moderate cytotoxicity towards the MOLT-4 human leukemia. ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms141121781
更新日期:2013-11-04 00:00:00
abstract::Overexpression of epidermal growth factor receptors (EGFR) occurs in >90% of pancreatic ductal adenocarcinomas (PDACs) and is associated with a poorer prognosis. A systematic review of electronic databases identified studies exploring the addition of EGFR-targeted treatment to chemotherapy in patients with locally adv...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,meta分析,评审
doi:10.3390/ijms18050909
更新日期:2017-04-26 00:00:00