Special Issue "Selected Papers from the 8th Asia-Pacific NMR (APNMR) Symposium: Recent Advances in NMR Spectroscopy".

abstract：:Japanese scallop (Mizuhopecten yessoensis) is a cold-tolerant bivalve that was introduced to China for aquaculture in 1982. In this study, amplified fragment length polymorphism (AFLP) markers were used to investigate levels of genetic diversity within M. yessoensis cultured stocks and compare them with wild populatio...

journal_title：International journal of molecular sciences

authors： Liu WD,Li HJ,Bao XB,Gao XG,Li YF,He CB,Liu ZJ

更新日期：2010-10-15 00:00:00

abstract：:Virus-like nanoparticles (VLNPs) have been studied extensively as nanocarriers for targeted drug delivery to cancer cells. However, VLNPs have intrinsic drawbacks, in particular, potential antigenicity and immunogenicity, which hamper their clinical applications. Thus, they can be eliminated easily and rapidly by host...

journal_title：International journal of molecular sciences

authors： Fam SY,Chee CF,Yong CY,Ho KL,Mariatulqabtiah AR,Lau HY,Tan WS

更新日期：2019-10-03 00:00:00

abstract：:The bone marrow (BM) microenvironment plays an important role in supporting proliferation, survival and drug resistance of Multiple Myeloma (MM) cells. MM cells adhere to bone marrow stromal cells leading to the activation of tumour-promoting signaling pathways. Activation of the NFκB pathway, in particular, is centra...

journal_title：International journal of molecular sciences

authors： Morgan JJ,McAvera RM,Crawford LJ

更新日期：2019-02-06 00:00:00

abstract：:Age-related hearing loss (ARHL) is an irreversible, progressive neurodegenerative disorder and is presently untreatable. Previous studies using animal models have suggested mitochondrial damage and programmed cell death to be involved with ARHL. Thus, we further investigated the pathophysiologic role of mitochondria a...

journal_title：International journal of molecular sciences

authors： Lyu AR,Kim TH,Park SJ,Shin SA,Jeong SH,Yu Y,Huh YH,Je AR,Park MJ,Park YH

更新日期：2020-04-03 00:00:00

abstract：:This work assesses the effect of chemical induction with isopropyl β-D-1-thiogalactopyranoside (IPTG) on the expression of enhanced green fluorescent protein (eGFP) by planktonic and biofilm cells of Escherichia coli JM109(DE3) transformed with a plasmid containing a T7 promoter. It was shown that induction negatively...

journal_title：International journal of molecular sciences

authors： Gomes L,Monteiro G,Mergulhão F

更新日期：2020-01-16 00:00:00

abstract：:The importance of mitogen-activated protein kinases (MAPK) in human pathology is underlined by the relevance of abnormalities of MAPK-related signaling pathways to a number of different diseases, including inflammatory disorders and cancer. One of the key events in MAPK signaling, especially with respect to pro-prolif...

journal_title：International journal of molecular sciences

authors： Tubita A,Lombardi Z,Tusa I,Dello Sbarba P,Rovida E

更新日期：2020-01-31 00:00:00

abstract：:Lung cancer is the leading cause of death in the world, and the most common type of lung cancer is non-small-cell lung cancer (NSCLC), accounting for 85% of lung cancer. Patients with NSCLC, when detected, are mostly in a metastatic stage, and over half of patients diagnosed with NSCLC die within one year after diagno...

journal_title：International journal of molecular sciences

authors： Chang JM,Kam KH,Chao WY,Zhao PW,Chen SH,Chung HC,Li YZ,Wu JY,Lee YR

更新日期：2020-06-13 00:00:00

abstract：:Right ventricular failure (RVF) remains the leading cause of death in pulmonary arterial hypertension (PAH). We investigated the transcriptomic signature of RVF in hemodynamically well-phenotyped monocrotaline (MCT)-treated, male, Sprague-Dawley rats with severe PAH and decompensated RVF (increased right ventricular (...

journal_title：International journal of molecular sciences

authors： Potus F,Hindmarch CCT,Dunham-Snary KJ,Stafford J,Archer SL

更新日期：2018-09-12 00:00:00

abstract：:With age, our cognitive skills and abilities decline. Maybe starting as an annoyance, this decline can become a major impediment to normal daily life. Recent research shows that the neurodegenerative disorders responsible for age associated cognitive dysfunction are mechanistically linked to the state of the microvasc...

journal_title：International journal of molecular sciences

authors： Costea L,Mészáros Á,Bauer H,Bauer HC,Traweger A,Wilhelm I,Farkas AE,Krizbai IA

更新日期：2019-11-03 00:00:00

abstract：:Fetal programming implies that the maternal diet during pregnancy affects the long-term health of offspring. Although maternal diet influences metabolic disorders and non-alcoholic fatty liver disease in offspring, the hepatic mechanisms related to metabolites are still unknown. Here, we investigated the maternal diet...

journal_title：International journal of molecular sciences

authors： Du JE,You YA,Kwon EJ,Kim SM,Lee J,Han KH,Kim YJ

更新日期：2020-11-28 00:00:00

abstract：:The growing trend for women to postpone childbearing has resulted in a dramatic increase in the incidence of aneuploid pregnancies. Despite the importance to human reproductive health, the events precipitating female age-related meiotic errors are poorly understood. To gain new insight into the molecular basis of age-...

journal_title：International journal of molecular sciences

authors： Barone S,Sarogni P,Valli R,Pallotta MM,Silvia G,Frattini A,Khan AW,Rapalini E,Parri C,Musio A

更新日期：2020-03-12 00:00:00

abstract：BACKGROUND:Left atrial appendage closure (LAAC) represents the interventional alternative to oral anticoagulation for stroke prevention in atrial fibrillation (AF). The metabolism of acylcarnitines was shown to affect cardiovascular diseases. This study evaluates the influence of successful LAAC on the metabolism of ac...

journal_title：International journal of molecular sciences

authors： Fastner C,Behnes M,Sartorius B,Wenke A,Lang S,Yücel G,Sattler K,Rusnak J,Saleh A,Barth C,Mashayekhi K,Hoffmann U,Borggrefe M,Akin I

更新日期：2018-02-07 00:00:00

abstract：:Ile-Ala-Val-Pro-Gly-Glu-Val-Ala (IAVPGEVA), Ile-Ala-Val-Pro-Thr-Gly-Val-Ala (IAVPTGVA) and Leu-Pro-Tyr-Pro (LPYP), three peptides deriving from soy glycinin hydrolysis, are known to regulate cholesterol metabolism in human hepatic HepG2 cells. We have recently demonstrated that the mechanism of action involves the act...

journal_title：International journal of molecular sciences

authors： Lammi C,Zanoni C,Arnoldi A

更新日期：2015-11-16 00:00:00

abstract：:Frizzled receptors (FZDs) are a family of seven-span transmembrane receptors with hallmarks of G protein-coupled receptors (GPCRs) that serve as receptors for secreted Wingless-type (WNT) ligands in the WNT signaling pathway. Functionally, FZDs play crucial roles in regulating cell polarity, embryonic development, cel...

journal_title：International journal of molecular sciences

authors： Zeng CM,Chen Z,Fu L

更新日期：2018-05-22 00:00:00

abstract：:We have generated the transgenic Tabaco plants expressing multiple monoclonal antibody (mAb) CO7-1A × BR55 by cross-pollinating with mAb CO17-1A and mAb BR55. We have demonstrated the anti-cancer effect of plant-derived multiple mAb CO17-1A × BR55. We find that co-treatment of colorectal mAbs (anti-epithelial cellular...

journal_title：International journal of molecular sciences

authors： Kwak DH,Moussavou G,Lee JH,Heo SY,Ko K,Hwang KA,Jekal SJ,Choo YK

更新日期：2014-11-14 00:00:00

abstract：:Adenosine triphosphate (ATP) has been well established as an important extracellular ligand of autocrine signaling, intercellular communication, and neurotransmission with numerous physiological and pathophysiological roles. In addition to the classical exocytosis, non-vesicular mechanisms of cellular ATP release have...

journal_title：International journal of molecular sciences

authors： Taruno A

更新日期：2018-03-11 00:00:00

abstract：:Prior evidence indicates that homocysteine plays a role in the development of metabolic syndrome (MetS). Methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase reductase (MTRR) A66G polymorphisms are common genetic determinants of homocysteine levels. To investigate the associations of the MTHFR C67...

journal_title：International journal of molecular sciences

authors： Yang B,Fan S,Zhi X,Wang D,Li Y,Wang Y,Wang Y,Wei J,Zheng Q,Sun G

更新日期：2014-11-25 00:00:00

abstract：:Kaempferol, a flavonoid compound, is derived from the rhizome of Kaempferia galanga L., which is used in traditional medicine in Asia. Autophagy has pleiotropic functions that are involved in cell growth, survival, nutrient supply under starvation, defense against pathogens, and antigen presentation. There are many st...

journal_title：International journal of molecular sciences

authors： Kim CJ,Shin SH,Kim BJ,Kim CH,Kim JH,Kang HM,Park BS,Kim IR

更新日期：2018-01-02 00:00:00

abstract：:Astrocyte proliferation and migration toward injured Central Nervous System (CNS) areas are key features of astrogliosis and glial scar formation. Even though it is known that intracellular and environmental Reactive Oxygen and Nitrogen Species (RONS) affect astrocyte behaviour in physiological and pathophysiological ...

journal_title：International journal of molecular sciences

authors： Sardella E,Mola MG,Gristina R,Piccione M,Veronico V,Bellis M,Cibelli A,Buttiglione M,Armenise V,Favia P,Nicchia GP

更新日期：2020-05-08 00:00:00

abstract：:Antibiotics without selectivity for acne treatment may destroy the beneficial microbes in the human microbiome that helps to fight Cutibacterium acnes (C. acnes), a bacterium associated with inflammatory acne vulgaris. Probiotic treatment by direct application of live Staphylococcus epidermidis (S. epidermidis) onto t...

journal_title：International journal of molecular sciences

authors： Yang AJ,Marito S,Yang JJ,Keshari S,Chew CH,Chen CC,Huang CM

更新日期：2018-12-20 00:00:00

abstract：:A major hallmark of diabetes is a constant high blood glucose level (hyperglycaemia), resulting in endothelial dysfunction. Transient or prolonged hyperglycemia can cause diabetic vasculopathy, a secondary systemic damage. C-Peptide is a product of cleavage of proinsulin by a serine protease that occurs within the pan...

journal_title：International journal of molecular sciences

authors： Souto SB,Campos JR,Fangueiro JF,Silva AM,Cicero N,Lucarini M,Durazzo A,Santini A,Souto EB

更新日期：2020-01-18 00:00:00

abstract：:Statistical studies have demonstrated that various agents may reduce the risk of cancer's development. One of them is activity of flavin-dependent enzymes such as flavin-containing monooxygenase (FMO)(GS-OX1), FAD-dependent 5,10-methylenetetrahydrofolate reductase and flavin-dependent monoamine oxidase. In the last de...

journal_title：International journal of molecular sciences

authors： Wojcieszyńska D,Hupert-Kocurek K,Guzik U

更新日期：2012-12-07 00:00:00

abstract：:The proper functioning of the endoplasmic reticulum (ER) is crucial for multiple cellular activities and survival. Disturbances in the normal ER functions lead to the accumulation and aggregation of unfolded proteins, which initiates an adaptive response, the unfolded protein response (UPR), in order to regain normal ...

journal_title：International journal of molecular sciences

authors： Bahar E,Kim H,Yoon H

更新日期：2016-09-15 00:00:00

abstract：:Preimplantation horse conceptuses require nutrients and signals from histotroph, the composition of which is regulated by luteal progesterone and conceptus-secreted factors. To distinguish progesterone and conceptus effects we shortened the period of endometrial progesterone-priming by asynchronous embryo transfer. Da...

journal_title：International journal of molecular sciences

authors： Gibson C,de Ruijter-Villani M,Bauersachs S,Stout TAE

更新日期：2020-04-07 00:00:00

abstract：:Weight regulation and the magnitude of weight loss after a Roux-en-Y gastric bypass (RYGB) can be genetically determined. DNA methylation patterns and the expression of some genes can be altered after weight loss interventions, including RYGB. The present study aimed to evaluate how the gene expression and DNA methyla...

journal_title：International journal of molecular sciences

authors： Pinhel MAS,Noronha NY,Nicoletti CF,Pereira VA,de Oliveira BA,Cortes-Oliveira C,Salgado W Jr,Barbosa F Jr,Marchini JS,Souza DR,Nonino CB

更新日期：2020-06-24 00:00:00

abstract：:Mathematical models are key to systems biology where they typically describe the topology and dynamics of biological networks, listing biochemical entities and their relationships with one another. Some (hyper)thermophilic Archaea contain an enzyme, called non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (...

journal_title：International journal of molecular sciences

authors： Zhang Y,Kouril T,Snoep JL,Siebers B,Barberis M,Westerhoff HV

更新日期：2017-04-20 00:00:00

abstract：:Aquaporins (AQPs) play a pivotal role in gut homeostasis since their distribution and function is modulated both in physiological and in pathophysiological conditions. The transport of water and solutes through gut epithelia is essential for osmoregulation and digestive and absorptive functions. This passage is regula...

journal_title：International journal of molecular sciences

authors： Pelagalli A,Squillacioti C,Mirabella N,Meli R

更新日期：2016-07-27 00:00:00

abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) is a dangerous pathogen resistant to β-lactam antibiotics. Due to its resistance, it is difficult to manage the infections caused by this strain. We examined this issue in terms of observation of the growth properties and ability to form biofilms in sensitive S. aureu...

journal_title：International journal of molecular sciences

authors： Cihalova K,Chudobova D,Michalek P,Moulick A,Guran R,Kopel P,Adam V,Kizek R

更新日期：2015-10-16 00:00:00

abstract：:Diabetic retinopathy (DR) is a severe and recurrent microvascular complication in diabetes. The multifunctional response gene to complement 32 (RGC-32) is involved in the regulation of cell cycle, proliferation, and apoptosis. To investigate the role of RGC-32 in the development of DR, we used human retinal microvascu...

journal_title：International journal of molecular sciences

authors： Liao WL,Lin JM,Liu SP,Chen SY,Lin HJ,Wang YH,Lei YJ,Huang YC,Tsai FJ

更新日期：2018-11-17 00:00:00

abstract：:Chitosan, a naturally occurring polysaccharide with abundant resources, has been extensively exploited for various biomedical applications, typically as wound dressings owing to its unique biocompatibility, good biodegradability and excellent antibacterial properties. In this work, composite nanofibrous membranes of c...

journal_title：International journal of molecular sciences

authors： Cai ZX,Mo XM,Zhang KH,Fan LP,Yin AL,He CL,Wang HS

更新日期：2010-09-21 00:00:00