Abstract：
:MicroRNAs (miRNAs) are a class of noncoding small RNAs, which play a crucial role in post-transcriptional gene regulation. Recently, various reports revealed that miRNAs could be transmitted between species to mediate cross-kingdom regulation by integrating into a specific target gene-mediated regulatory pathway to exert relevant biological functions. Some scholars and researchers have observed this as an attractive hypothesis that may provide a foundation for novel approaches in the diagnosis, prognosis, and treatment of disease. Meanwhile, others deem the mentioned results were obtained from a “false positive effect” of performed experiments. Here, we focus on several current studies concerning plant miRNA-mediated cross-kingdom regulation (from both fronts) and discuss the existing issues that need further consideration. We also discuss possible miRNA horizontal transfer mechanisms from one species to another and analyze the relationship between miRNA-mediated cross-kingdom regulation and coevolution during a long-term specific host⁻pathogen interaction.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Wang W,Liu D,Zhang X,Chen D,Cheng Y,Shen Fdoi
10.3390/ijms19072007subject
Has Abstractpub_date
2018-07-10 00:00:00issue
7issn
1422-0067pii
ijms19072007journal_volume
19pub_type
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