Abstract：
:microRNA-143(miR-143) is a well-known tumor suppressive microRNA that exhibits anti-tumoral function by targeting KRAS signaling pathways in various malignancies. We hypothesized that miR-143 suppresses breast cancer progression by targeting KRAS and its effector molecules. We further hypothesized that high expression of miR-143 is associated with a favorable tumor immune microenvironment of estrogen receptor (ER)-positive breast cancer patients which result in improved survival. Two major publicly available breast cancer cohorts; The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) were used. The miR-143 high expression group was associated with increased infiltration of anti-cancer immune cells and decreased pro-cancer immune cells, as well as enrichment of the genes relating to T helper (Th1) cells resulting in improved overall survival (OS) in ER-positive breast cancer patients. To the best of our knowledge, this is the first study to demonstrate that high expression of miR-143 in cancer cells associates with a favorable tumor immune microenvironment, upregulation of anti-cancer immune cells, and suppression of the pro-cancer immune cells, associating with better survival of the breast cancer patients.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Tokumaru Y,Asaoka M,Oshi M,Katsuta E,Yan L,Narayanan S,Sugito N,Matsuhashi N,Futamura M,Akao Y,Yoshida K,Takabe Kdoi
10.3390/ijms21093213subject
Has Abstractpub_date
2020-05-01 00:00:00issue
9issn
1422-0067pii
ijms21093213journal_volume
21pub_type
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